Details of a Researcher - Ando, Takayuki

Papers - Ando, Takayuki

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成人食物アレルギー診療支援アプリの開発と有用性の検証

正木克宜, 冨保紗希, 上條慎太郎, 安藤崇之, 加畑宏樹, 佐藤泰憲, 原田紀宏, 鈴木慎太郎, 藤澤隆夫, 福永興壱

日本内科学会雑誌 ((一社)日本内科学会) 112 ( 臨増 ) 190 - 190 2023.02

ISSN 0021-5384

How do medical students learn in an online community diagnostics program?

Junji Haruta, Takayuki Ando, Seitaro Fujishima

BMC medical education 23 ( 1 ) 15 - 15 2023.01

BACKGROUND: The need to engage medical students in understanding the social and environmental determinants of health in disparate communities is increasing. However, previous reviews have noted the limited community diagnosis programs and program evaluation. Given the feasibility of the programs, it is expected to be widely available online. Therefore, this study used a realist approach to identify learning patterns through an online community diagnosis program, namely context (C), mechanism (M), and outcomes (O) patterns. METHODS: A 2-week general medicine clinical practice program was conducted for 4th- and 5th-year medical students at a medical university in Japan. The program included a one-hour zoom-based lecture, feedback for students on their presentations on community diagnosis, and a structural report on community diagnosis. We developed the program based on variation theory, which views discernment and variation in situations having time, space, and social dimensions as core learning. The students' reflections on their learning through the program were thematically analyzed through CMO perspectives. The realist approach used in the online diagnosis program evaluation allows us to explore, test, and refine what mechanisms work under what conditions (context) and with what interventions (including opportunities and resources), from which we can describe iteratively explainable results. RESULTS: First, the medical students, who spent most of their time in the limited residential areas they lived in, discovered the characteristics of their own community by discovery learning and comparison among peers. Second, they increased their intrinsic interest in the community by discerning specific issues in their familiar community through community diagnosis. Third, they valued community diagnosis by identifying relationships between local data on health issues under their learning responsibility. Fourth, they become more flexible in their thinking and created new knowledge that would fit the local community, and their reflection on themselves was encouraged. CONCLUSION: In this online community diagnosis program, medical students learned about the community through four types of learning patterns. Medical students may develop an understanding of community with interest using variation theory as a program development perspective and cognitive flexibility theory surrounding the essential ambiguity and abstraction of community.

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リアルワールドデータに基づくBERTを用いた新しい医薬品安全性シグナル検出手法の提案

八重樫昇吾, 石川智貴, 安藤崇之, 原梓, 大石尚央, 漆原尚巳

AICカンファレンス予稿集 (慶應義塾大学AI・高度プログラミングコンソーシアム) 6 - 12 2023

オンライン・トークプロジェクト語ろう! 若手研究者の日常大学院にいくべきか

安藤崇之, 官澤洋平, 富田詩織, 日向佑樹

プライマリ・ケア : 実践誌 / 日本プライマリ・ケア連合学会実践誌編集委員会編 (東京 : 日本プライマリ・ケア連合学会) 8 ( 3 ) 38 - 41 2023

ISSN 24323098

オンライン・トークプロジェクト語ろう! 若手研究者の日常

安藤崇之, 官澤洋平, 富田詩織, 日向佑樹

プライマリ・ケア : 実践誌 / 日本プライマリ・ケア連合学会実践誌編集委員会編 (東京 : 日本プライマリ・ケア連合学会) 8 ( 2 ) 44 - 46 2023

ISSN 24323098

Disparities in co-payments for influenza vaccine among the elderly, during the COVID-19 pandemic in Japan

Takayuki Ando, Tomoki Maruyama, Aki Tamai, Taro Murakami, Yasuaki Kido, Toru Ishida, Hajime Taya, Junji Haruta, Daisuke Sugiyama, Seitaro Fujishima

Journal of Infection and Chemotherapy (Elsevier BV) 28 ( 7 ) 896 - 901 2022.07

Accepted, ISSN 1341-321X

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10 year summary of community generalist program at Kameda Medical Center

岡田唯男, 濱井彩乃, 濱井彩乃, 西野洋, 片多史明, 松田愉, 安藤崇之, 鈴木真央, 栖原とし子

医学教育 ((一社)日本医学教育学会) 53 ( Suppl. ) 177 - 177 2022.07

ISSN 0386-9644

日本の診療所における血液検査電子オーダーシステムのデザイン変更による医師の検査オーダー行動の変化

河田祥吾, 安藤崇之, 岡田唯男

日本プライマリ・ケア連合学会学術大会 ((一社)日本プライマリ・ケア連合学会) 13回 O - 102 2022.06

Association between multimorbidity, self-rated health and life satisfaction among independent, community-dwelling very old persons in Japan: longitudinal cohort analysis from the Kawasaki Ageing and Well-being Project.

Takayuki Ando, Yoshinori Nishimoto, Takumi Hirata, Yukiko Abe, Midori Takayama, Takashi Maeno, Seitaro Fujishima, Toru Takebayashi, Yasumichi Arai

BMJ open 12 ( 2 ) e049262 2022.02

Accepted, ISSN 2044-6055

OBJECTIVE: This study aimed to identify associations between multimorbidity and subjective health outcomes among the very old persons, after adjusting for coexisting conditions such as frailty and depression. STUDY SETTING AND PARTICIPANTS: This was an observational cross-sectional study involving 1012 independent, community-dwelling very old persons (507 men, 505 women; aged 85-89 years) in Kawasaki city, Japan. OUTCOME MEASURES: The primary outcome was the cross-sectional associations between multimorbidity and poor self-rated health (SRH) and life satisfaction using binary logistic regression. The secondary outcome was the association of subjective health with each chronic condition. RESULTS: The prevalence of multimorbidity (≥2 conditions) was 94.7%, and the average number of chronic conditions was 4.47±1.9. Multimorbidity was significantly associated with poor SRH in the adjusted model only when six or more chronic conditions were present (OR 4.80; 95% CI 1.34 to 17.11; p=0.016). Cerebrovascular disease, heart disease, respiratory disease, connective tissue disease and arthritis showed significant associations with poor SRH after multivariate adjustment. Sex-specific analysis replicated associations between multimorbidity with six or more conditions and SRH in both men and women, while the diseases with the greatest impact on SRH differed between men and women. Most conditions were not associated with low satisfaction with life scale, with the exception of arthritis (OR 1.92, 95% CI 1.32 to 2.78, p=0.001). CONCLUSIONS: Multimorbidity is prevalent in the independent, community-dwelling very old persons and is associated with poor SRH when six or more conditions are present; conditions causing mobility limitations, such as cerebrovascular disease, connective tissue disease and arthritis, have a negative impact on SRH. TRIAL REGISTRATION NUMBER: UMIN000026053.

多職種連携の秘訣(後編)現場の薬剤師,リハビリセラピストからのメッセージ

安藤崇之

Gノート (羊土社) 8 ( 3 ) 562 - 567 2021.04

ISSN 2188-3033

地域医療へのきっぷ私の資格取得エピソード(7)日本DMAT隊員

安藤崇之

Gノート (羊土社) 8 ( 1 ) 172 - 174 2021.02

ISSN 2188-3033

Community Assessment Using Google Map Based Geographic Information System (GIS) and Its Application to Driver's License Return Support for Elderly

Takayuki Ando, Tadao Okada

An Official Journal of the Japan Primary Care Association (The Japan Primary Care Association) 43 ( 4 ) 148 - 150 2020.12

Research paper (scientific journal), Single Work, Accepted, ISSN 2185-2928

Google mapを用いた簡便なGISの利用方法を開発し、地域診断・免許返納支援を行った。公開されている交通、食料品店、医療機関の位置データや人口データなどの情報をQGISというソフトを用いて変換し、Google map上に取り込んだ。このマップを用いて診療圏の地域のインフラを可視化して地域の医療機関や生鮮食料品店へのアクセスを可視化し、地域診断や高齢患者の免許返納支援を行った。(著者抄録)

Control of a Nosocomial Outbreak of COVID-19 in a University Hospital.

Sei Harada, Shunsuke Uno, Takayuki Ando, Miho Iida, Yaoko Takano, Yoshiki Ishibashi, Yoshifumi Uwamino, Tomoyasu Nishimura, Ayano Takeda, Sho Uchida, Aya Hirata, Mizuki Sata, Minako Matsumoto, Ayano Takeuchi, Hideaki Obara, Hirokazu Yokoyama, Koichi Fukunaga, Masayuki Amagai, Yuko Kitagawa, Toru Takebayashi, Naoki Hasegawa

Open forum infectious diseases 7 ( 12 ) ofaa512 2020.12

Research paper (scientific journal), Joint Work, Accepted, ISSN 2328-8957

Background: Nosocomial spread of coronavirus disease 2019 (COVID-19) causes clusters of infection among high-risk individuals. Controlling this spread is critical to reducing COVID-19 morbidity and mortality. We describe an outbreak of COVID-19 in Keio University Hospital, Japan, and its control and propose effective control measures. Methods: When an outbreak was suspected, immediate isolation and thorough polymerase chain reaction (PCR) testing of patients and health care workers (HCWs) using an in-house system, together with extensive contact tracing and social distancing measures, were conducted. Nosocomial infections (NIs) were defined as having an onset or positive test after the fifth day of admission for patients and having high-risk contacts in our hospital for HCWs. We performed descriptive analyses for this outbreak. Results: Between March 24 and April 24, 2020, 27 of 562 tested patients were confirmed positive, of whom 5 (18.5%) were suspected as NIs. For HCWs, 52 of 697 tested positive, and 40 (76.9%) were considered NIs. Among transmissions, 95.5% were suspected of having occurred during the asymptomatic period. Large-scale isolation and testing at the first sign of outbreak terminated NIs. The number of secondary cases directly generated by a single primary case found before March 31 was 1.74, compared with 0 after April 1. Only 4 of 28 primary cases generated definite secondary infection; these were all asymptomatic. Conclusions: Viral shedding from asymptomatic cases played a major role in NIs. PCR screening of asymptomatic individuals helped clarify the pattern of spread. Immediate large-scale isolation, contact tracing, and social distancing measures were essential to containing outbreaks.

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特集総合診療医の"若手ロールモデル"を紹介します!-私たちはどう生きるか【若手ロールモデル & データファイル集】私の総合診療=❺(卒前教育＋アカデミックGP)×大学

安藤崇之

総合診療 (株式会社医学書院) 30 ( 1 ) 39 - 41 2020.01

ISSN 21888051

プライマリ・ケア医による性感染症スクリーニングと予防

安藤崇之

日本臨床 = Japanese journal of clinical medicine (日本臨床社) 77 ( 2 ) 338 - 343 2019.02

ISSN 00471852

プライマリ・ケア医だからこそできる性感染症スクリーニング・予防 (特集お母さんを守ろう : 家庭医は産前家族の応援団) -- (次世代のための予防医療)

安藤崇之

治療 (南山堂) 100 ( 4 ) 380 - 385 2018.04

ISSN 0022-5207

Third UK-Japan Primary Care Exchange Programme

Yao Masahiro, Moroi Kunitake, Sakurai Hiroko, Matsuo Ryoko, Ando Takaaki, Sawa Noriaki

An Official Journal of the Japan Primary Care Association (JAPAN PRIMARY CARE ASSOCIATION) 41 ( 1 ) 24 - 28 2018

ISSN 2185-2928

<p>This article is a short report on the third Japan-UK Primary Care Exchange Programme. Japanese delegates visited Scotland in September of 2015. They watched GP surgeries and attended the Royal College of General Practitioners (RCGP) Annual Primary Care Conference. The following topics are covered as some of the most insightful experiences: NHS Cancer screening programmes, support for people with cancer and their families, working conditions for GPs, and the Half-Day Release Programme for GP specialist training. In addition, the delegates reflected on their experiences.</p>

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Changeability of the fully methylated status of the 15q11.2 region in induced pluripotent stem cells derived from a patient with Prader-Willi syndrome.

Hironobu Okuno, Kazuhiko Nakabayashi, Kousei Abe, Takayuki Ando, Tsukasa Sanosaka, Jun Kohyama, Wado Akamatsu, Manabu Ohyama, Takao Takahashi, Kenjiro Kosaki, Hideyuki Okano

Congenital anomalies 57 ( 4 ) 96 - 103 2017.07

Accepted, ISSN 0914-3505

Prader-Will syndrome (PWS) is characterized by hyperphagia, growth hormone deficiency and central hypogonadism caused by the dysfunction of the hypothalamus. Patients with PWS present with methylation abnormalities of the PWS-imprinting control region in chromosome 15q11.2, subject to parent-of-origin-specific methylation and controlling the parent-of-origin-specific expression of other paternally expressed genes flanking the region. In theory, the reversal of hypermethylation in the hypothalamic cells could be a promising strategy for the treatment of PWS patients, since cardinal symptoms of PWS patients are correlated with dysfunction of the hypothalamus. The genome-wide methylation status dramatically changes during the reprograming of somatic cells into induced pluripotent stem cells (iPSCs) and during the in vitro culture of iPSCs. Here, we tested the methylation status of the chromosome 15q11.2 region in iPSCs from a PWS patient using pyrosequencing and a more detailed method of genome-wide DNA methylation profiling to reveal whether iPSCs with a partially unmethylated status for the chromosome 15q11.2 region exhibit global methylation aberrations. As a result, we were able to show that a fully methylated status for chromosome 15q11.2 in a PWS patient could be reversed to a partially unmethylated status in at least some of the PWS-iPSC lines. Genome-wide DNA methylation profiling revealed that the partial unmethylation occurred at differentially methylated regions located in chromosome 15q11.2, but not at other differentially methylated regions associated with genome imprinting. The present data potentially opens a door to cell-based therapy for PWS patients and, possibly, patients with other disorders associated with genomic imprinting.

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Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells for Neurological Disease Modeling

Takuya Matsumoto, Koki Fujimori, Tomoko Andoh-Noda, Takayuki Ando, Naoko Kuzumaki, Manabu Toyoshima, Hirobumi Tada, Kent Imaizumi, Mitsuru Ishikawa, Ryo Yamaguchi, Miho Isoda, Zhi Zhou, Shigeto Sato, Tetsuro Kobayashi, Manami Ohtaka, Ken Nishimura, Hiroshi Kurosawa, Takeo Yoshikawa, Takuya Takahashi, Mahito Nakanishi, Manabu Ohyama, Nobutaka Hattori, Wado Akamatsu, Hideyuki Okano

STEM CELL REPORTS (CELL PRESS) 6 ( 3 ) 422 - 35 2016.03

Accepted, ISSN 2213-6711

Modeling of neurological diseases using induced pluripotent stem cells (iPSCs) derived from the somatic cells of patients has provided a means of elucidating pathogenic mechanisms and performing drug screening. T cells are an ideal source of patient-specific iPSCs because they can be easily obtained from samples. Recent studies indicated that iPSCs retain an epigenetic memory relating to their cell of origin that restricts their differentiation potential. The classical method of differentiation via embryoid body formation was not suitable for T cell-derived iPSCs (TiPSCs). We developed a neurosphere-based robust differentiation protocol, which enabled TiPSCs to differentiate into functional neurons, despite differences in global gene expression between TiPSCs and adult human dermal fibroblast-derived iPSCs. Furthermore, neurons derived from TiPSCs generated from a juvenile patient with Parkinson's disease exhibited several Parkinson's disease phenotypes. Therefore, we conclude that TiPSCs are a useful tool for modeling neurological diseases.

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Comparison of two large earthquakes: the 2008 Sichuan Earthquake and the 2011 East Japan Earthquake.

Yuki Otani, Takayuki Ando, Kaori Atobe, Akina Haiden, Sheng-Yuan Kao, Kohei Saito, Marie Shimanuki, Norifumi Yoshimoto, Koichi Fukunaga

The Keio journal of medicine 61 ( 1 ) 35 - 9 2012

Accepted, ISSN 0022-9717

Between August 15th and 19th, 2011, eight 5th-year medical students from the Keio University School of Medicine had the opportunity to visit the Peking University School of Medicine and hold a discussion session titled "What is the most effective way to educate people for survival in an acute disaster situation (before the mental health care stage)?" During the session, we discussed the following six points: basic information regarding the Sichuan Earthquake and the East Japan Earthquake, differences in preparedness for earthquakes, government actions, acceptance of medical rescue teams, earthquake-induced secondary effects, and media restrictions. Although comparison of the two earthquakes was not simple, we concluded that three major points should be emphasized to facilitate the most effective course of disaster planning and action. First, all relevant agencies should formulate emergency plans and should supply information regarding the emergency to the general public and health professionals on a normal basis. Second, each citizen should be educated and trained in how to minimize the risks from earthquake-induced secondary effects. Finally, the central government should establish a single headquarters responsible for command, control, and coordination during a natural disaster emergency and should centralize all powers in this single authority. We hope this discussion may be of some use in future natural disasters in China, Japan, and worldwide.

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