Nishimoto, Yoshinori

写真a

Affiliation

School of Medicine, Department of Internal Medicine (Neurology) （Shinanomachi）

Position

Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)
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Profile Summary 【 Display / hide 】

  • Clinical research
    Keio University School of Medicine, Ethics Committee Approval Number：20221155
    「Clinical studies to elucidate the molecular mechanisms associated with the pathogenesis of amyotrophic lateral sclerosis (ALS) and to identify eff ective drug targets」(UMIN000051823)(ver 2.3/updated on July 6, 2023)

    Frontiers Editor Board member (Frontiers in Molecular Neuroscience journal)

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Career 【 Display / hide 】

  • 2022.04
    -
    Present

    慶應義塾大学 医学部, 神経内科, 専任講師

  • 2020.04
    -
    2022.03

    慶應義塾大学医学部, 神経内科, 助教

  • 2018.04
    -
    2020.03

    慶應義塾大学医学部, 百寿総合研究センター, 特任助教

  • 2016.10
    -
    2018.03

    東京都済生会中央病院, 神経内科, 医員

  • 2016.08
    -
    2018.03

    慶應義塾大学 医学部, 生理学教室, 助教

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Academic Background 【 Display / hide 】

  • 2003.04

    Keio University Graduate School of Medicine, Internal Medicine, Neurology

    Graduate School, Graduated, Doctoral course

  • 1997.04

    Keio University, Shool of Medicine

    University, Graduated

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Academic Degrees 【 Display / hide 】

  • MD, Keio University, Coursework, 2003.03

  • PhD, Keio University, Coursework, 2008.10

    Determination of editors at the novel A-to-I editing positions.

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Licenses and Qualifications 【 Display / hide 】

  • 日本国 医師免許

  • 日本内科学会認定 総合内科専門医

  • 日本内科学会認定 認定内科医

  • 日本内科学会認定 指導医

  • 日本神経学会認定 神経内科専門医

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Matters concerning Career Achievements 【 Display / hide 】

  • 2023.01
    -
    Present

    臨床研究 承認番号：20221155 「筋萎縮性側索硬化症(ALS)の病態に関連する分子メカニズムの解明と効果的薬剤標的を同定するための臨床研究」

    　View Details

    臨床研究
    慶應義塾大学医学部・病院　倫理委員会　承認番号：20221155
    「筋萎縮性側索硬化症(ALS)の病態に関連する分子メカニズムの解明と効果的薬剤標的を同定するための臨床研究」(第1.2版/2023年1月12日承認)

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Research Areas 【 Display / hide 】

  • Life Science / Neurology

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Research Keywords 【 Display / hide 】

  • 筋萎縮性側索硬化症 (ALS)

  • 神経変性疾患

  • 神経分子生物学

  • 神経再生医学

  • RNA/ノンコーディングRNA

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Research Themes 【 Display / hide 】

  • Establishment of full-care system for the patients with amyotrophic lateral sclerosis (ALS), 

    2003.04
    -
    Present

  • 筋萎縮性側索硬化症(ALS)の核酸医薬による分子標的療法の開発, 

    2010.07
    -
    Present

  • 次世代シークエンス技術を活用した認知症の遺伝的リスク算出法の確立, 

    2018.04
    -
    Present

  • 認知症のオンライン診療データを活用した自動病態評価技術の開発, 

    2020.07
    -
    Present

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Books 【 Display / hide 】

  • 脳神経内科ゴールデンハンドブック (ALSほか運動ニューロン疾患 分担執筆)

    西本 祥仁, 南江堂, 2020.06

    Scope: 運動ニューロン疾患及び類縁疾患

  • Chapter I 高齢者社会の現状とフレイル・ロコモ・サルコペニアの意義 3．百寿とはどのような方か？

    西本祥仁, 新井康通, クリニコ出版, 2019.11

  • Drosophila Oogenesis: Methods and Protocols

    Shibata S, Murota Y, Nishimoto Y, Yoshimura M, Nagai T, Okano H, Siomi MC., 2015

    Scope: Immuno-Electron Microscopy and Electron Microscopic In Situ Hybridization for Visualizing piRNA Biogenesis Bodies in Drosophila Ovaries.

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Papers 【 Display / hide 】

  • Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS-ALS.

    Kensuke Okada, Daisuke Ito, Satoru Morimoto, Chris Kato, Yuki Oguma, Hitoshi Warita, Naoki Suzuki, Masashi Aoki, Junko Kuramoto, Reona Kobayashi, Munehisa Shinozaki, Jin Nakahara, Shinichi Takahashi, Yoshinori Nishimoto, Shinsuke Shibata, Hideyuki Okano

    Brain  2024

    Accepted

  • Depressive symptoms and carotid arteriosclerosis in very old people aged 85 years and older: A cross-sectional study by the Kawasaki Aging and Wellbeing Project.

    Ryo Shikimoto, Takashi Sasaki, Yukiko Abe, Yoshinori Nishimoto, Takumi Hirata, Masaru Mimura, Yasumichi Arai

    Psychiatry and Clinical Neurosciences 78 （ 3 ） 209 - 211 2024

    Accepted

  • Determinants of polydoctoring among multimorbid older adults; a cross-sectional study in an urban area of Japan

    Takayuki Ando, Takashi Sasaki, Yukiko Abe, Yoshinori Nishimoto, Takumi Hirata, Junji Haruta, Yasumichi Arai

    Journal of General and Family Medicine  2024

    Accepted

  • Impact of Amyloid and Tau PET on Changes in Diagnosis and Patient Management

    Sho Shimohama, Toshiki Tezuka, Takahata Keisuke, Shogyoku Bun, Hajime Tabuchi, Morinobu Seki, Yuki Momota, Natsumi Suzuki, Ayaka Morimoto, Yu Iwabuchi, Masahito Kubota, Yasuharu Yamamoto, Yasunori Sano, Ryo Shikimoto, Kei Funaki, Yu Mimura, Yoshinori Nishimoto, Ryo Ueda, Masahiro Jinzaki, Jin Nakahara, Masaru Mimura, Daisuke Ito

    Neurology （Neurology)  100 （ 3 ） e264 - E274 2023

    Accepted,  ISSN  00283878

    　View Summary

    Background and Objectives: Previous studies have evaluated the diagnostic effect of amyloid PET in selected research cohorts. However, these studies did not assess the clinical impact of the combination of amyloid and tau PETs. Our objective was to evaluate the association of the combination of 2 PETs with changes in diagnosis, treatment, and management in a memory clinic cohort.Methods: All participants underwent amyloid [18F]florbetaben PET and tau PET using [18F]PI-2620 or [18F]Florzolotau, which are potentially useful for the diagnosis of non-Alzheimer disease (AD) tauopathies. Dementia specialists determined a pre- and post-PET diagnosis that existed in both a clinical syndrome (cognitive normal [CN], mild cognitive impairment [MCI], and dementia) and suspected etiology, with a confidence level. In addition, the dementia specialists determined patient treatment in terms of ancillary investigations and management. Results: Among 126 registered participants, 84.9% completed the study procedures and were included in the analysis (CN [n = 40], MCI [n = 25], AD [n = 20], and non-AD dementia [n = 22]). The etiologic diagnosis changed in 25.0% in the CN, 68.0% in the MCI, and 23.8% with dementia. Overall changes in management between pre- and post-PET occurred in 5.0% of CN, 52.0% of MCI, and 38.1% of dementia. Logistic regression analysis revealed that tau PET has stronger associations with change management than amyloid PET in all participants and dementia groups. Discussion: The combination of amyloid and tau PETs was associated with changes in management and diagnosis of MCI and dementia, and the second-generation tau PET has a strong impact on the changes in diagnosis and management in memory clinics. Classification of Evidence: This study provides Class I evidence that the combination of amyloid and tau PETs was associated with changes in management and diagnosis of MCI and dementia.

  • Status and physiological significance of circulating adiponectin in the very old and centenarians: an observational study

    Takashi Sasaki, Yoshinori Nishimoto, Takumi Hirata, Yukiko Abe, Nobuyoshi Hirose, Michiyo Takayama, Toru Takebayashi, Hideyuki Okano, and Yasumichi Arai.

    eLife  12 2023

    Accepted

    　View Summary

    Background: High levels of circulating adiponectin are associated with increased insulin sensitivity, low prevalence of diabetes, and low body mass index (BMI); however, high levels of circulating adiponectin are also associated with increased mortality in the 60–70 age group. In this study, we aimed to clarify factors associated with circulating high-molecular-weight (cHMW) adiponectin levels and their association with mortality in the very old (85–89 years of age) and centenarians. Methods: The study included 812 (women: 84.4%) for centenarians and 1498 (women: 51.7%) for the very old. The genomic DNA sequence data were obtained by whole-genome sequencing or DNA microarray-imputation methods. Least Absolute Shrinkage and Selection Operator (LASSO) and multivariate regression analyses were used to evaluate cHMW adiponectin characteristics and associated factors. All-cause mortality was analyzed in three quantile groups of cHMW adiponectin levels using Cox regression. Results: The cHMW adiponectin levels were increased significantly beyond 100 years of age, were negatively associated with diabetes prevalence, and were associated with SNVs in CDH13 (p=2.21 × 10-22) and ADIPOQ (p=5.72 × 10-7). Multivariate regression analysis revealed that genetic variants, BMI, and high-density lipoprotein cholesterol (HDLC) were the main factors associated with cHMW adiponectin levels in the very old, whereas the BMI showed no association in centenarians. The hazard ratios for all-cause mortality in the intermediate and high cHMW adiponectin groups in very old men were significantly higher rather than those for all-cause mortality in the low-level cHMW adiponectin group, even after adjustment with BMI. In contrast, the hazard ratios for all-cause mortality were significantly higher for high cHMW adiponectin groups in very old women, but were not significant after adjustment with BMI. Conclusions: cHMW adiponectin levels increased with age until centenarians, and the contribution of known major factors associated with cHMW adiponectin levels, including BMI and HDLC, varies with age, suggesting that its physiological significance also varies with age in the oldest old. Funding: This study was supported by grants from the Ministry of Health, Welfare, and Labour for the Scientific Research Projects for Longevity; a Grant-in-Aid for Scientific Research (No 21590775, 24590898, 15KT0009, 18H03055, 20K20409, 20K07792, 23H03337) from the Japan Society for the Promotion of Science; Keio University Global Research Institute (KGRI), Kanagawa Institute of Industrial Science and Technology (KISTEC), Japan Science and Technology Agency (JST) Research Complex Program "Tonomachi Research Complex" Wellbeing Research Campus: Creating new values through technological and social innovation (JP15667051), the Program for an Integrated Database of Clinical and Genomic Information from the Japan Agency for Medical Research and Development (No. 16kk0205009h001, 17jm0210051h0001, 19dk0207045h0001); the medical-welfare-food-agriculture collaborative consortium project from the Japan Ministry of Agriculture, Forestry, and Fisheries; and the Biobank Japan Program from the Ministry of Education, Culture, Sports, and Technology.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 2024年度「ALS基金」研究奨励金「ALS傷害運動ニューロンにおけるトランスポゾン制御異常の病態解明」

    2024

    日本ALS協会, 2024年度「ALS基金」研究奨励金, Principal investigator

  • 武田科学振興財団 医学系研究助成 (精神・神経・脳領域) 「核内非翻訳RNA制御によるALS患者由来運動ニューロン変性抑制の試み」

    2022

    Principal investigator

  • 文部科学省 科学研究費補助金　基盤研究(C)　「ALSゲノム編集マウスを用いたGC/UGリッチRNA配列での病態考察と治療法開発」

    2021.04
    -
    2025.03

    Research grant, Principal investigator

  • KGRI (Keio University Global Research Institute)スタートアップ研究補助 (KGRI startup award) 「オンライン診療を用いた認知症診療の有効性、安全性評価」

    2020.07
    -
    2022.03

    Research grant, Principal investigator

  • 日本学術振興会 海外特別研究員 「Investigating the regulatory function of the exosome complex in RNA metabolism a nd motor neuron disease」

    2014
    -
    2015

    Principal investigator

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Works 【 Display / hide 】

  • 朝日学生新聞連載コラム「からだの教室 -知識の玉手箱-」

    西本 祥仁

    朝日学生新聞 毎週金曜日 全26回, 

    2014.04
    -
    2014.09
    , 

    Other

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Awards 【 Display / hide 】

  • Neurogenetics Editor’s Pick 2021 (Frontiers in Neurology)

    2021.08

    Type of Award： Honored in official journal of a scientific society, scientific journal

  • KGRI (Keio University Global Research Institute) Startup Award

    2020.06, Keio University Global Research Institute, 「オンライン診療を用いた認知症診療の有効性、安全性評価」

    Type of Award： Keio commendation etc.

  • Selected key poster (Harvard Stem Cell Institute Retreat)

    2016.05, 11th Annual Harvard Stem Cell Institute Malkin Retreat 2016, 「Altered tRNA metabolism links RNA Exosome deficiency with motor neuron disease」

  • Physician's Recognition Award

    2015.08, American Medical Association, 「Pediatric Advanced Care Team Rounds」

  • 日本学術振興会 海外特別研究員

    2014.08

    Type of Award： Other

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Courses Taught 【 Display / hide 】

  • LECTURE SERIES, INTERNAL MEDICINE (NEUROLOGY)

    2024

  • LECTURE SERIES, INTERNAL MEDICINE (NEUROLOGY)

    2023

  • LECTURE SERIES, INTERNAL MEDICINE (NEUROLOGY)

    2022

  • LECTURE SERIES, INTERNAL MEDICINE (NEUROLOGY)

    2021

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