Details of a Researcher - Arai, Yasumichi

Papers - Arai, Yasumichi

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Inverse Association between Height-Increasing Alleles and Extreme Longevity in Japanese Women

Tanisawa K., Hirose N., Arai Y., Shimokata H., Yamada Y., Kawai H., Kojima M., Obuchi S., Hirano H., Suzuki H., Fujiwara Y., Taniguchi Y., Shinkai S., Ihara K., Sugaya M., Higuchi M., Arai T., Mori S., Sawabe M., Sato N., Muramatsu M., Tanaka M.

Journals of Gerontology - Series A Biological Sciences and Medical Sciences (Journals of Gerontology - Series A Biological Sciences and Medical Sciences) 73 ( 5 ) 588 - 595 2018.04

ISSN 10795006

© 2018 Oxford University Press. All rights reserved. Growth hormone (GH)/insulin-like growth factor-1 (IGF-1)/insulin signaling is one of the most plausible biological pathways regulating aging and longevity. Previous studies have demonstrated that several single nucleotide polymorphisms (SNPs) in the GH/IGF-1/insulin signaling-associated genes influence both longevity and adult height, suggesting the possibility of a shared genetic architecture between longevity and height. We therefore examined the relationship between 30 height-associated SNPs and extreme longevity in a Japanese population consisting of 428 centenarians and 4,026 younger controls. We confirmed that height-increasing genetic scores (HGSs) constructed based on 30 SNPs were significantly associated with height in the controls (p = 6.951023). HGS was significantly and inversely associated with extreme longevity in women (p = .011), but not in men, although no SNPs were significantly associated with extreme longevity after Bonferroni correction. The odds ratio for extreme longevity in the lowest HGS group (=27) and the second lowest HGS group (2830) relative to the highest HGS group (=37) was 1.71 (p = .056) and 1.69 (p = .034), respectively, for women. In conclusion, the present study demonstrated an inverse association between height-increasing alleles with extreme longevity in Japanese women, providing novel insight into the genetic architecture of longevity and aging.

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Occlusal force is correlated with cognitive function directly as well as indirectly via food intake in community-dwelling older Japanese: From the SONIC study

Ikebe K., Gondo Y., Kamide K., Masui Y., Ishizaki T., Arai Y., Inagaki H., Nakagawa T., Kabayama M., Ryuno H., Okubo H., Takeshita H., Inomata C., Kurushima Y., Mihara Y., Hatta K., Fukutake M., Enoki K., Ogawa T., Matsuda K., Sugimoto K., Oguro R., Takami Y., Itoh N., Takeya Y., Yamamoto K., Rakugi H., Murakami S., Kitamura M., Maeda Y.

PLoS ONE (PLoS ONE) 13 ( 1 ) 2018.01

© 2018 Ikebe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Growing evidence suggests that oral health may be an important factor associated with cognitive function in aged populations. However, many previous studies on this topic used insensitive oral indicators or did not include certain essential covariates. Thus, we examined the association between occlusal force and cognitive function in a large sample of older adults, controlling for dietary intake, vascular risk factors, inflammatory biomarkers, depression, and genetic factors. Methods In this cross-sectional study of older community-dwelling Japanese adults, we examined data collected from 994 persons aged 70 years and 968 persons aged 80 years. Cognitive function was measured using the Japanese version of the Montreal Cognitive Assessment (MoCA-J). Oral status and function were evaluated according to the number of remaining teeth, periodontal pocket depth, and maximal occlusal force. Associations between MoCA-J scores and occlusal force were investigated via bivariate and multivariate analyses. Results Education level, financial status, depression score, and intake of green and yellow vegetables, as well as number of teeth and occlusal force, were significantly correlated with MoCA-J scores in both age groups. Among individuals aged 80 years, CRP and periodontal status were weakly but significantly associated with MoCA-J score. After controlling for all significant variables via bivariate analyses, the correlation between maximal occlusal force and cognitive function persisted. A path analysis confirmed the hypothesis that cognitive function is associated with occlusal force directly as well as indirectly via food intake. Conclusions After controlling for possible factors, maximal occlusal force was positively associated with cognitive function directly as well as indirectly through dietary intake.

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Carotid plaque score and risk of cardiovascular mortality in the oldest old: Results from the TOOTH study

Hirata T., Arai Y., Takayama M., Abe Y., Ohkuma K., Takebayashi T.

Journal of Atherosclerosis and Thrombosis (Journal of Atherosclerosis and Thrombosis) 25 ( 1 ) 55 - 64 2018

ISSN 13403478

© 2018 Japan Atherosclerosis Society. Aim: Accumulating evidence suggests that predictability of traditional cardiovascular risk factors declines with advancing age. We investigated whether carotid plaque scores (CPSs) were associated with cardiovascular disease (CVD) death in the oldest old, and whether asymmetrical dimethylarginine (ADMA), a marker of endothelial dysfunction, moderated the association between the CPS and CVD death. Methods: We conducted a prospective cohort study of Japanese subjects aged ≥85 years without CVD at baseline. We followed this cohort for 6 years to investigate the association of CPS with CVD death via multivariable Cox proportional hazard analysis. We divided participants into three groups according to CPS (no, 0 points; low, 1.2–4.9 points; high, ≥5.0 points). The predictive value of CPS for estimating CVD death risk over CVD risk factors, including ADMA, was examined using C-statistics. Results: We analyzed 347 participants (151 men, 196 women; mean age, 87.6 years), of which 135 (38.9%) had no carotid plaque at baseline, and 48 (13.8%) had high CPS. Of the total, 29 (8.4%) participants experienced CVD-related death during the study period. Multivariable analysis revealed a significant association of high CPS with CVD-related mortality relative to no CPS (hazard ratio, 3.90; 95% confidence interval: 1.47–10.39). ADMA was not associated with CVD death, but the significant association between CPS and CVD death was observed only in lower ADMA level. The addition of CPS to other risk factors improved the predictability of CVD death (p=0.032). Conclusions: High CPS correlated significantly with a higher CVD death risk in the oldest old with low cardiovascular risk. Ultrasound carotid plaque evaluation might facilitate risk evaluations of CVD death in the very old.

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Deficiency of Choresteryl Ester Transfer Protein and Gene Polymorphisms of Lipoprotein Lipase and Hepatic Lipase are not associated with Longevity

Arai Y, Hirose N, Yamamura K, Nakazawa Susumu, Shimizu Kenichirou, Takayama Michiyo, Ebihara Yoshinori, Homma Satoshi, Gondo Yasuyuki, Masui Yukie, Inagaki Hiroki

Journal of molecular medicine 81 ( 1 ) 102 2003.01