Hosoe, Naoki



School of Medicine, Center for Preventive Medicine (Shinanomachi)


Associate Professor (Non-tenured)

Related Websites

Academic Degrees 【 Display / hide

  • 医学博士, Keio University


Research Areas 【 Display / hide

  • Life Science / Gastroenterology

Research Keywords 【 Display / hide

  • endoscopy


Books 【 Display / hide

Papers 【 Display / hide

  • Correction: Clinical utility of novel ultrathin single-balloon enteroscopy: a feasibility study

    K. Takabayashi, N. Hosoe, R. Miyanaga, S. Fukuhara, K. Kimura, S. Mizuno, M. Naganuma, N. Yahagi, H. Ogata and T. Kanai

    Endoscopy  2018.09

    ISSN  1438-8812

  • Clinical features of chronic enteropathy associated with SLCO2A1 gene: a new entity clinically distinct from Crohn's disease

    J. Umeno, M. Esaki, A. Hirano, Y. Fuyuno, N. Ohmiya, S. Yasukawa, F. Hirai, S. Kochi, K. Kurahara, S. Yanai, K. Uchida, S. Hosomi, K. Watanabe, N. Hosoe, H. Ogata, T. Hisamatsu, M. Nagayama, H. Yamamoto, D. Abukawa, F. Kakuta, K. Onodera, T. Matsui, T. Hibi, T. Yao, T. Kitazono and T. Matsumoto

    J Gastroenterol 53 ( 8 ) 907 - 915 2018.08

    ISSN  1435-5922

     View Summary

    BACKGROUND: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a hereditary disease caused by mutations in the SLCO2A1 gene and characterized by multiple small intestinal ulcers of nonspecific histology. SLCO2A1 is also a causal gene of primary hypertrophic osteoarthropathy (PHO). However, little is known about the clinical features of CEAS or PHO. METHODS: Sixty-five Japanese patients recruited by a nationwide survey of CEAS during 2012-2016 were enrolled in this present study. We reviewed the clinical information of the genetically confirmed CEAS patients. RESULTS: We identified recessive SLCO2A1 mutations at 11 sites in 46 patients. Among the 46 patients genetically confirmed as CEAS, 13 were men and 33 were women. The median age at disease onset was 16.5 years, and parental consanguinity was present in 13 patients (28%). Anemia was present in 45 patients (98%), while a single patient experienced gross hematochezia. All patients showed relatively low inflammatory markers in blood tests (median CRP 0.20 mg/dl). The most frequently involved gastrointestinal site was the ileum (98%), although no patient had mucosal injuries in the terminal ileum. Mild digital clubbing or periostosis was found in 13 patients (28%), with five male patients fulfilling the major diagnostic criteria of PHO. CONCLUSIONS: The clinical features of CEAS are distinct from those of Crohn's disease. Genetic analysis of the SLCO2A1 gene is therefore recommended in patients clinically suspected of having CEAS.

  • Establishment of a Novel Scoring System for Colon Capsule Endoscopy to Assess the Severity of Ulcerative Colitis-Capsule Scoring of Ulcerative Colitis

    N. Hosoe, M. Nakano, K. Takeuchi, Y. Endo, K. Matsuoka, T. Abe, T. Omori, M. Hayashida, T. Kobayashi, A. Yoshida, S. Mizuno, N. Yoshihiro, M. Naganuma, T. Kanai, M. Watanabe, F. Ueno, Y. Suzuki, T. Hibi and H. Ogata

    Inflamm Bowel Dis  2018.05

    ISSN  1536-4844

     View Summary

    Background: The usefulness of second-generation colon capsule endoscopy (CCE-2) for ulcerative colitis (UC) has not been fully demonstrated. This study aimed to develop an endoscopic severity score of UC for CCE-2. Methods: Patients diagnosed with UC were enrolled prospectively and underwent colonoscopy and CCE-2 on the same day. The collected CCE-2 videos were adopted for the development of the score. These videos were scored by 4 blinded inflammatory bowel disease experts. The items validated with the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) were used as the candidate items, some of which were automatically assessed using the workstation. Each item was divided into proximal and distal parts at the splenic flexure and then individually assessed. The image readers simultaneously evaluated the inflammation severity using the visual analog scale (VAS). The descriptors that contribute to this scale were evaluated, and a model to predict the VAS was constructed. The UCEIS was scored by other endoscopists using colonoscopy videos. The correlation coefficients with fecal calprotectin, blood tests, and Lichtiger index were calculated. Results: The final scoring system was fixed as "vascular pattern sum (proximal + distal) + bleeding sum + erosions and ulcers sum (minimum-maximum, 0-14)" and was named Capsule Scoring of Ulcerative Colitis (CSUC). The correlation coefficient of CSUC with biomarkers and clinical score was similar to that of the UCEIS. Conclusions: We developed a new simple score using the 3 descriptors of CCE-2.

  • Complications and outcomes of routine endoscopy in the very elderly

    R. Miyanaga, N. Hosoe, M. Naganuma, K. Hirata, S. Fukuhara, Y. Nakazato, K. Ojiro, E. Iwasaki, N. Yahagi, H. Ogata and T. Kanai

    Endosc Int Open 6 ( 2 ) E224 - E229 2018.02

    ISSN  2364-3722

     View Summary

    Background and study aims: In Japan, the elderly population has been increasing annually. The number of elderly patients for whom esophagogastroduodenoscopy (EGD) and colonoscopy (CS) is indicated also has been rising. The aim of this study was to evaluate the safety and efficacy of routine endoscopy in a cohort of octogenarians aged 85 years and older - defined by the World Health Organization as the very elderly. Patients and methods: A total of 5,586 patients underwent EGDs, and 2,484 patients underwent CSs performed at the Keio University Hospital from January to September 2014. One hundred eighty-five EGDs and 70 of the CS were performed in the very elderly. Six hundred nine EGDs and 262 CS were performed on younger patients (aged forties). Statistical analysis was performed by univariate and multivariate analyses. Results: On univariate analysis, the rate of adverse events (AEs) in the very elderly was significantly higher compared to the younger group (6.3 % vs. 1.1 %; P < 0.01). Moreover, the very elderly cohort received substantial therapeutic intervention as compared to the younger (16.9 % vs. 6.9 %; P < 0.01). On multivariate analysis, independent risk factors of AEs included: very elderly patients (odds ratio (OR) 3.30, 95 % confidence interval (CI) 1.05 - 10.35), inpatients (OR 3.22, 95 % CI 1.34 - 7.74), and use of pethidine hydrochloride prescription (OR 3.44, 95 % CI 1.51 - 7.81). Conclusions: Routine endoscopy in the very elderly incurs a significant risk of AEs, particularly when combined with pethidine hydrochloride prescription.

  • [Review of the small intestinal mucosal lesion]

    N. Hosoe, H. Ogata and T. Kanai

    Nihon Shokakibyo Gakkai Zasshi 115 ( 7 ) 605 - 611 2018

    ISSN  0446-6586

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Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • Developing a Colon Capsule Endoscopy Score to Assess the Severity of Ulcerative Colitis: the Capsule Scoring of Ulcerative Colitis (CSUC)

    Hosoe N, Takabayashi K, Ishikawa K, Horie T, Miyanaga R, Fukuhara S, Kimura K, Mizuno S, Naganuma M, Ogata H, Kanai T

    DDW 2018, 


    Poster presentation

  • 潰瘍性大腸炎患者に対する大腸カプセル内視鏡検査 前処置、運用法を含めて

    Hosoe Naoki



    Symposium, workshop panel (public)

  • 透析患者の全消化管をカプセル内視鏡でスクリーニングできるか?

    Hosoe Naoki



    Symposium, workshop panel (public)

  • 拡大シングルバルーン小腸内視鏡、プローブ型共焦点レーザー内視鏡を使用した小腸病変の観察

    Hosoe Naoki



    Symposium, workshop panel (public)

  • 拡大シングルバルーン小腸内視鏡、プローブ型共焦点レーザー内視鏡を使用した小腸観察

    Hosoe Naoki



    Symposium, workshop panel (public)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Understanding endoscopic morphology during immune reconstitution using single cell analysis of small intestinal disease


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 基盤研究(C), Principal investigator

  • 超拡大内視鏡観察、走査電顕によるナノレベル観察を用いたヒト腸管上皮機能解明


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator


Courses Taught 【 Display / hide











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