福原 誠一郎 (フクハラ セイイチロウ)

Fukuhara, Seiichiro

写真a

所属(所属キャンパス)

医学部 内視鏡センター (信濃町)

職名

助教(有期)

学歴 【 表示 / 非表示

  • 1999年04月
    -
    2006年03月

    慶應義塾大学, 医学部

    大学, 卒業

免許・資格 【 表示 / 非表示

  • 日本がん治療認定医機構がん治療認定医

  • 日本ヘリコバクター学会ピロリ菌感染症認定医

  • 日本肝臓学会肝臓専門医

  • 日本消化器内視鏡学会指導医

  • 日本消化器内視鏡学会専門医

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研究分野 【 表示 / 非表示

  • 消化器内科学

研究キーワード 【 表示 / 非表示

  • 上部消化管疾患

  • 胆道・膵臓疾患

 

論文 【 表示 / 非表示

  • Pancreatic Fat Content Detected by Computed Tomography and Its Significant Relationship With Intraductal Papillary Mucinous Neoplasm

    Kashiwagi, K., Seino, T., Fukuhara, S., Minami, K., Horibe, M., Iwasaki, E., Takaishi, H., Itoh, K., Sugino, Y., Inoue, N., Iwao, Y. and Kanai, T.

    Pancreas 47 ( 9 ) 1087 - 1092 2018年10月

    ISSN  1536-4828

     概要を見る

    OBJECTIVES: Intraductal papillary mucinous neoplasms (IPMNs) are premalignant lesions of pancreatic ductal adenocarcinomas (PDACs). Fat accumulation in the pancreas is increasingly recognized as a cause of PDAC. We aimed to identify factors that are relevant between IPMN and metabolic-related factors, including pancreatic fat. METHODS: The database for 781 subjects who underwent a health checkup and upper abdominal magnetic resonance imaging was searched and computed tomography attenuation indexes (pancreatic and spleen attenuation, pancreas-to-spleen attenuation ratio) were decided by measuring the regions of interest in the pancreas and spleen on nonenhanced images, using Hounsfield units. Eighty-five subjects from each of the IPMN and noncyst groups were matched for age, sex, and glycemic status and statistically compared in clinical characteristics. RESULTS: There was no difference in metabolic-related factors except for apolipoprotein A1 and high-density lipoprotein cholesterol between the 2 groups in univariate analysis. Multivariate logistic regression analysis showed that both indexes were significantly associated with IPMN (odds ratio, 0.905 [95% confidence intervals, 0.851-0.963; P = 0.002]; odds ratio, 0.006 [95% confidence intervals, 0.000-0.152; P = 0.002]). CONCLUSIONS: Pancreatic fat content measured by computed tomography was significantly associated with IPMN. These results suggest that IPMN may develop secondary to pancreatic steatosis that could be an overlapping risk factor for PDAC and IPMN.

  • Correction: Clinical utility of novel ultrathin single-balloon enteroscopy: a feasibility study

    Takabayashi, K., Hosoe, N., Miyanaga, R., Fukuhara, S., Kimura, K., Mizuno, S., Naganuma, M., Yahagi, N., Ogata, H. and Kanai, T.

    Endoscopy 2018年09月

    ISSN  1438-8812

  • Clinical impact of closure of the mucosal defect after duodenal endoscopic submucosal dissection

    Kato, M., Ochiai, Y., Fukuhara, S., Maehata, T., Sasaki, M., Kiguchi, Y., Akimoto, T., Fujimoto, A., Nakayama, A., Kanai, T. and Yahagi, N.

    Gastrointest Endosc 2018年07月

    ISSN  1097-6779

     概要を見る

    BACKGROUND AND AIMS: Delayed adverse events (bleeding or perforation) are major concerns associated with duodenal endoscopic submucosal dissection (ESD). The aim of this study was to assess the efficacy of prophylactic closure of the mucosal defect after duodenal ESD. METHODS: This is a retrospective study from a university hospital. One hundred sixty-eight patients (173 lesions) who underwent duodenal ESD between July 2010 and June 2017 were included in this study. The study participants were divided into 3 subgroups according to the degree of closure: complete group, incomplete group, and unclosed group. The proportion of delayed adverse events, maximum serum level of C-reactive protein (CRP), and total length of hospital stay were compared among these subgroups. Moreover, a multivariate logistic regression model was constructed to identify the risk factors for delayed adverse events. RESULTS: The proportion of delayed adverse events in the complete group, incomplete group, and unclosed group were 1.7%, 25%, and 15.6%, respectively. The difference between the complete group and the other groups was significant (P < .01). The maximum serum CRP level was much lower (1.51 +/- 2.18 mg/dL vs 6.28 +/- 10.0 mg/dL, P < .01), and the length of hospital stay was significantly shorter in the complete group than in the incomplete/unclosed group (median [range] 5 [5-14] days vs 8 [4-59] days, P < .01). Multivariate analysis revealed that complete closure had a significant decrease in delayed adverse events (odds ratio [OR], 0.055; 95% confidence interval [CI], 0.01-0.29; P < .01), and a lesion located distal from the descending part showed a statistical tendency to an increase in delayed adverse events (OR, 4.48; 95% CI, 0.85-23.6; P = .08). CONCLUSION: The present study revealed that complete closure of the mucosal defect after duodenal ESD significantly decreased the number of delayed adverse events and improved other outcomes.

  • Complications and outcomes of routine endoscopy in the very elderly

    Miyanaga, R., Hosoe, N., Naganuma, M., Hirata, K., Fukuhara, S., Nakazato, Y., Ojiro, K., Iwasaki, E., Yahagi, N., Ogata, H. and Kanai, T.

    Endosc Int Open 6 ( 2 ) E224 - E229 2018年02月

    ISSN  2364-3722

     概要を見る

    Background and study aims: In Japan, the elderly population has been increasing annually. The number of elderly patients for whom esophagogastroduodenoscopy (EGD) and colonoscopy (CS) is indicated also has been rising. The aim of this study was to evaluate the safety and efficacy of routine endoscopy in a cohort of octogenarians aged 85 years and older - defined by the World Health Organization as the very elderly. Patients and methods: A total of 5,586 patients underwent EGDs, and 2,484 patients underwent CSs performed at the Keio University Hospital from January to September 2014. One hundred eighty-five EGDs and 70 of the CS were performed in the very elderly. Six hundred nine EGDs and 262 CS were performed on younger patients (aged forties). Statistical analysis was performed by univariate and multivariate analyses. Results: On univariate analysis, the rate of adverse events (AEs) in the very elderly was significantly higher compared to the younger group (6.3 % vs. 1.1 %; P < 0.01). Moreover, the very elderly cohort received substantial therapeutic intervention as compared to the younger (16.9 % vs. 6.9 %; P < 0.01). On multivariate analysis, independent risk factors of AEs included: very elderly patients (odds ratio (OR) 3.30, 95 % confidence interval (CI) 1.05 - 10.35), inpatients (OR 3.22, 95 % CI 1.34 - 7.74), and use of pethidine hydrochloride prescription (OR 3.44, 95 % CI 1.51 - 7.81). Conclusions: Routine endoscopy in the very elderly incurs a significant risk of AEs, particularly when combined with pethidine hydrochloride prescription.

  • Enteric Glial Dysfunction Evoked by Apolipoprotein E Deficiency Contributes to Delayed Gastric Emptying

    Fukuhara, S., Masaoka, T., Nishimura, S., Nakamura, M., Matsuzaki, J., Tsugawa, H., Miyoshi, S., Mori, H., Kawase, S., Shibata, S., Okano, H., Kanai, T. and Suzuki, H.

    Dig Dis Sci 62 ( 12 ) 3359 - 3369 2017年12月

    ISSN  1573-2568

     概要を見る

    BACKGROUND AND AIM: Diabetes is the main cause of gastroparesis accompanying decreased neuronal nitric oxide synthase (nNOS) in myenteric ganglia of the stomach. Decreased nNOS expression in the stomach also results from defects in apolipoprotein E (ApoE), which is secreted by astrocytes and has neuroprotective effects on the central nervous system. However, the roles of ApoE and enteric glial cells on gastric motility are uncertain. In this study, ApoE and enteric glial cell alterations in gastroparesis were investigated. METHODS: Type 2 diabetic (db/db) mice and ApoE-knockout mice were analyzed. Gastric emptying was measured using the (13)C acetic acid breath test. Expression levels of the pan-neuronal marker, protein gene product 9.5 (PGP 9.5), and glial marker, glial fibrillary acidic protein (GFAP) were examined by immunohistochemistry. Neural stem cells (NSCs) were injected into the gastric antral wall of ApoE-knockout mice. RESULTS: Delayed gastric emptying was observed in 27% of db/db mice with significant decreases in serum ApoE levels and GFAP expression in the gastric antrum. Gastric emptying was also delayed in ApoE-knockout mice, with a significant decrease in GFAP expression, but no change in PGP 9.5 expression. Transplantation of NSCs improved gastric emptying in ApoE-knockout mice through supplementation of GFAP-positive cells. CONCLUSIONS: Our results suggest that decreased enteric glial cells in ApoE-knockout mice are crucial for development of delayed gastric emptying, and NSC transplantation is effective in restoring myenteric ganglia and gastric motility.

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

受賞 【 表示 / 非表示

  • Best Presentation Award

    2012年, The 14th Meeting of International Conference on Ulcer Research, Dynamics of aquaporin-4 in gastric parietal cells in the gastric fundic mucosa of histamine type 2 receptor knockout mice with H.pylori infection

  • 最優秀賞

    2012年, 神経消化器病学会, 胃運動障害惹起モデル動物での胃排出能評価における13C酢酸呼気試験の応用

  • 最優秀賞

    2012年, J-FD研究会, 機能性ディスペプシアの病態生理に重要な胃運動障害を惹起したモデル動物での胃排出能評価における13C呼気試験の応用

  • Gastrointestinal Response to Injury travel scholarship

    2010年, Japanese-American Association of Gastrointestinal and Ulcer-Acid Researchers (JAAGUAR), Enhanced expression of aquaporin-4 and KCNQ1 in gastric parietal cells in histamine type 2 receptor (H2R) knockout mice