Hukuhara, Kayoko



School of Medicine, Center for Preventive Medicine (Shinanomachi)




Research Areas 【 Display / hide

  • Gastroenterology


Papers 【 Display / hide

  • Cutoff Pepsinogen Level for Predicting Unintendedly Eradicated Cases of Helicobacter pylori Infection in Subjects with Seemingly Normal Pepsinogen Levels

    Kishikawa Hiroshi, Kimura Kayoko, Ito Asako, Arahata Kyoko, Takarabe Sakiko, Kaida Shogo, Miyauchi Jun, Miura Soichiro, Kanai Takanori, Nishida Jiro

    Digestion    229 - 236 2017.03

    ISSN  0012-2823

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    <p>Backgrounds/Aims: In the ABC method, which is a method for risk stratification of gastric cancer using serum anti-Helicobacter pylori antibody and pepsinogen (PG) test, subjects with normal PG and seronegative for H. pylori are named as “Group A” and are regarded as having a low risk of gastric cancer. These “Group A” subjects include unintentionally eradicated cases at relatively high risk, and this study aimed to identify these subjects. Methods: Of the 109 subjects, 76 were classified as uninfected Group A subjects with negative histologic H. pylori infection and no histologic and endoscopic atrophy, and 33 subjects were classified serologically as Group A after successful eradication, which are serologically equal to the unintendedly eradicated cases in Group A. The usefulness of measuring PG levels to detect post-eradication cases was validated by using a receiver operating characteristic (ROC) curve analysis. Results: The area under the ROC curve for PGI level was 0.736 ± 0.06 (p &lt; 0.01; cutoff value, 37.0 ng/mL; sensitivity, 77.6%; specificity, 72.7%), and that for the PGI/II ratio was 0.660 ± 0.06 (p &lt; 0.01; cutoff value, 5.1; sensitivity, 84.2%; specificity, 43.4%). Conclusion: PGI levels of ≤37 ng/mL and PGI/II ratios of ≤5.1 effectively identified unintendedly eradicated cases in Group A.</p>

  • Two cases of cystic artery pseudoaneurysm rupture due to acute cholecystitis with gallstone impaction in the neck

    Kaida Shogo, Arahata Kyouko, Itou Asako, Takarabe Sakiko, Kimura Kayoko, Kishikawa Hiroshi, Nishida Jiro, Fujiyama Yoshiki, Takigawa Yutaka, Matsui Junichi

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 113 ( 9 ) 1572 - 1581 2016.09

    ISSN  0446-6586

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    <p>A cystic artery aneurysm is a rare cause of hemobilia. Herein, we report two cases of acute cholecystitis with a ruptured cystic artery pseudoaneurysm. Two patients (a 69-year-old man and an 83-year-old man) were admitted to our hospital because of acute cholecystitis with gallstone impaction in the neck. Percutaneous transhepatic gallbladder drainage (PTGBD) was performed for both patients. After a few days of PTGBD, gallbladder hemorrhage was observed. Abdominal angiography showed cystic artery aneurysm. A transcatheter arterial embolization was therefore performed, followed by an open cholecystectomy. </p>

  • Small bowel obstruction due to rice cake (Mochi)

    Baba Akira, Okuyama Yumi, Kimura Kayoko, Mogami Takuji

    Internal Medicine 55 ( 14 ) 1933 - 1934 2016

    ISSN  0918-2918

  • Predictors of Gastric Neoplasia in Cases Negative for Helicobacter pylori Antibody and with Normal Pepsinogen

    Kishikawa Hiroshi, Kimura Kayoko, Ito Asako, Arahata Kyoko, Takarabe Sakiko, Kaida Shogo, Miyauchi Jun, Miura Soichiro, Nishida Jiro

    Anticancer research 35 ( 12 ) 6765 - 6771 2015.12

    ISSN  0250-7005

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    <p>RESULTS: Ten gastric neoplasia cases (gastric cancer and adenoma) were found to be included. Multiple logistic regression analyses identified H. pylori antibody titer ≥3 U/ml (odds ratio=14.4, 95% confidence interval=2.7-76.9; p&lt;0.01) and pepsinogen-I/II ratio ≤4.3 ng/ml (odds ratio=10.0, 95% confidence interval=2.1-47.9; p&lt;0.01), but not age as independent predictive factors of neoplasia.</p><p>CONCLUSION: Endoscopy should be considered in individuals with H. pylori antibody titer of ≥3 U/ml and a pepsinogen-I/II ratio of ≤4.3 in those classed as group A by ABC method.</p><p>BACKGROUND/AIM: Individuals negative for Helicbacter pylori antibody and with a normal pepsinogen test (group A) are regarded as being at low risk in serum gastric cancer screening known as the ABC method, and endoscopy is not recommended; however, this group may include 2-10% of gastric cancer cases.</p><p>PATIENTS AND METHODS: A total of 345 individuals who underwent upper gastrointestinal endoscopy and were classified by ABC as group A (H. pylori antibody titer &lt;10 U/ml, and pepsinogen-I &gt;70 ng/ml or I/II ratio &gt;3) were enrolled, and predictors of gastric neoplasia were investigated.</p>

  • Helicobacter pylori antibody titer and gastric cancer screening

    Kishikawa Hiroshi, Kimura Kayoko, Takarabe Sakiko, Kaida Shogo, Nishida Jiro

    Disease Markers 2015 2015

    ISSN  0278-0240

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    <p>The "ABC method" is a serum gastric cancer screening method, and the subjects were divided based on H. pylori serology and atrophic gastritis as detected by serum pepsinogen (PG): Group A [H. pylori (-) PG (-)], Group B [H. pylori (+) PG (-)], Group C [H. pylori (+) PG (+)], and Group D [H. pylori (-) PG (+)]. The risk of gastric cancer is highest in Group D, followed by Groups C, B, and A. Groups B, C, and D are advised to undergo endoscopy, and the recommended surveillance is every three years, every two years, and annually, respectively. In this report, the reported results with respect to further risk stratification by anti-H. pylori antibody titer in each subgroup are reviewed: (1) high-negative antibody titer subjects in Group A, representing posteradicated individuals with high risk for intestinal-type cancer; (2) high-positive antibody titer subjects in Group B, representing active inflammation with high risk for diffuse-type cancer; and (3) low-positive antibody titer subjects in Group C, representing advanced atrophy with increased risk for intestinal-type cancer. In these subjects, careful follow-up with intervals of surveillance of every three years in (1), every two years in (2), and annually in (3) should be considered.</p>

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Social Activities 【 Display / hide

  • 日本カプセル内視鏡学会

  • 日本消化管学会

  • 日本内視鏡学会

  • 日本消化器病学会

  • 日本内科学会