緒方 晴彦 (オガタ ハルヒコ)

Ogata, Haruhiko

写真a

所属(所属キャンパス)

医学部 内視鏡センター (信濃町)

職名

教授(有期)

外部リンク

学歴 【 表示 / 非表示

  • 1983年03月

    慶應義塾, 医学部

    大学, 卒業

学位 【 表示 / 非表示

  • 博士(医学), 慶應義塾, 1992年09月

    潰瘍性大腸炎患者末梢血および大腸粘膜における機能的T細胞subsetの動態

 

論文 【 表示 / 非表示

  • Combination therapy with infliximab and thiopurine compared to infliximab monotherapy in maintaining remission of postoperative crohn's disease

    Sakuraba Atsushi, Okamoto Susumu, Matsuoka Katsuyoshi, Sato Toshiro, Naganuma Makoto, Hisamatsu Tadakazu, Iwao Yasushi, Ogata Haruhiko, Kanai Takanori, Hibi Toshifumi

    Digestion 91 ( 3 ) 233 - 238 2015年05月

    ISSN  0012-2823

     概要を見る

    <p>Background and Aims: Infliximab is an efficacious agent used for the induction and maintenance of remission in Crohn's disease (CD), and recent studies suggested that it may also prevent the recurrence of this disease after surgery. The present study was performed to assess the efficacy and safety of infliximab in the postoperative setting, and to identify whether combination treatment with thiopurines had any additional beneficial effect as compared to mono-therapy. Methods: We performed a retrospective cohort study to compare the efficacy of infliximab mono-therapy and combination treatment with a thiopurine in preventing recurrence after surgery. Results: Forty-one patients who received infliximab as maintenance treatment following surgery from May 2002 to April 2010 were identified. Twenty-four were naive to infliximab, and 17 who underwent surgery during infliximab treatment were continued on it following surgery. The median follow-up period was 27 months (range 12-66 months). All patients continued infliximab as maintenance treatment, but 10 required dose intensification due to clinical recurrence. Kaplan-Meier analysis demonstrated that the use of concomitant thiopurine was correlated with the continuation of infliximab treatment at an 8-week interval (log-rank test p = 0.018). The rate of adverse event was 9.8% with no patient experiencing severe adverse reactions. Conclusion: Infliximab appears to be safe and it prevented clinical recurrence after surgery. Concomitant thiopurine use predicted response toward continuation of therapy at an 8-week interval. Prospective controlled studies to assess the efficacy of combination treatment in the postoperative setting are warranted.</p>

  • Magnetically guided capsule versus conventional gastroscopy for upper abdominal complaints

    Denzer Ulrike W., Rösch Thomas, Hoytat Bilal, Abdel-Hamid Mohammed, Hebuterne Xavier, Vanbiervielt Geoffroy, Filippi Jérôme, Ogata Haruiko, Hosoe Naoki, Ohtsuka Kazuo, Ogata Noriyuki, Ikeda Keiichi, Aihara Hiroyuki, Kudo Shin Ei, Tajiri Hisao, Treszl Andras, Wegscheider Karl, Greff Michel, Rey Jean Francois

    Journal of Clinical Gastroenterology 49 ( 2 ) 101 - 107 2015年02月

    ISSN  0192-0790

     概要を見る

    <p>OBJECTIVES:: Upper gastrointestinal endoscopy is mostly performed under sedation and has a low yield of relevant gastric lesions in patients without alarm symptoms. Simpler screening tests such as capsule endoscopy could be helpful, but gastric visualization is insufficient with the current passive capsules. A magnetically guided gastric capsule was prospectively evaluated in patients with routine indications for gastroscopy. METHODS:: A total of 189 symptomatic patients (105 male; mean age 53 y) from 2 French centers subsequently and blindly underwent capsule and conventional gastroscopy by 9 and 6 examiners, respectively. The final gold standard was unblinded conventional gastroscopy with biopsy under propofol sedation. Main outcome was accuracy (sensitivity/specificity) of capsule gastroscopy for diagnosis of major gastric lesions, defined as those lesions requiring conventional gastroscopy for biopsy or removal. RESULTS:: Twenty-three major lesions were found in 21 patients. Capsule accuracy was 90.5% [95% confidence interval (CI), 85.4%-94.3%] with a specificity of 94.1% (95% CI, 89.3%-97.1%) and a sensitivity of 61.9% (95% CI, 38%-82%). Accuracy did not correlate with lesion location, gastric luminal visibility, examiner case volume, or examination time. Of the remaining 168 patients, 94% had minor and mostly multiple lesions; the capsule made a correct diagnosis in 88.1% (95% CI, 82.2%-92.6%), with gastric visibility and lesion location in the proximal stomach having significant influence. All patients preferred capsule gastroscopy. CONCLUSIONS:: In a prospective and strictly blinded study, magnetically guided capsule gastroscopy was shown to be feasible in clinical practice and was clearly preferred by patients. Improvements in capsule technology may render this technique a future alternative to gastroscopy.</p>

  • Current status of capsule endoscopy through a whole digestive tract

    Hosoe Naoki, Naganuma Makoto, Ogata Haruhiko

    Digestive Endoscopy 27 ( 2 ) 205 - 215 2015年01月

    ISSN  0915-5635

     概要を見る

    <p>More than a decade has passed since small-bowel capsule endoscopy (CE) was first reported. Small-bowel CE is a non-invasive tool that allows visualization of the entire small-intestinal mucosa and facilitates detection of small-intestinal abnormalities. Several studies have shown benefit of small-bowel CE for certain disorders. Because it is non-invasive, CE has been applied to other organs including the esophagus, stomach, and colon. The main indications for esophageal CE (ECE) are screening for gastroesophageal reflux disease/Barrett's esophagus, and esophageal varices. However, the clinical benefit of ECE is unconfirmed. Magnetically guided CE (MGCE) was developed to visualize the gastric mucosa. MGCE is a new concept with room for improvement of capsule navigation and the preparation protocol. Recently, two new small-bowel CE tools were released. First-generation colon CE (CCE-1) has moderate sensitivity and specificity compared with colonoscopy for colorectal neoplasia surveillance. To obtain higher accuracy, a second-generation CCE (CCE-2) was developed with a high sensitivity for detecting clinically relevant polypoid lesions. A possible application of CCE is for inflammatory bowel disease. In the near future, CE may include diagnostic and therapeutic functions such as magnifying endoscopy systems, targeted biopsy forceps, and drug delivery systems.</p>

  • Recent trends in diagnostic techniques for inflammatory bowel disease

    Naganuma Makoto, Hosoe Naoki, Kanai Takanori, Ogata Haruhiko

    Korean Journal of Internal Medicine 30 ( 3 ) 271 - 278 2015年

    ISSN  1226-3303

     概要を見る

    <p>Although ileocolonoscopy is the gold standard for diagnosis of inflammatory bowel disease and is useful for assessing the disease severity in the colon and terminal ileum, several alternative diagnostic techniques have been developed recently. For ulcerative colitis (UC), magnification colonoscopy, endocytoscopy, and confocal laser endomicroscopy enable assessment of histological inflammation without the need for biopsy. Capsule endoscopy is useful for detection of small intestinal and colonic lesions in both female and male patients. For UC, capsule endoscopy may be useful for evaluating colonic inflammation in patients with a previous poor colonoscopy experience, while it should be used only in Crohn’s disease (CD) patients with unexplained symptoms when other examinations are negative. Magnetic resonance enterography (MRE) is particularly useful for detecting transmural inflammation, stenosis, and extraintestinal lesions, including abscesses and fistulas. MRE is also useful when evaluating small and large intestinal lesions, even in cases with severe strictures in which full evaluation of the small bowel would be virtually impossible using other devices. Therefore, the appropriate diagnostic devices for detecting CD lesions in the small and large intestine should be used.</p>

  • Surveillance using trimodal imaging endoscopy after endoscopic submucosal dissection for superficial gastric neoplasia

    Imaeda Hiroyuki, Hosoe Naoki, Kashiwagi Kazuhiro, Ida Yosuke, Nakamura Rieko, Suzuki Hidekazu, Saito Yoshimasa, Yahagi Naohisa, Iwao Yasushi, Kitagawa Yuko, Hibi Toshifumi, Ogata Haruhiko, Kanai Takanori

    World Journal of Gastroenterology 20 ( 43 ) 16311 - 16317 2014年11月

    ISSN  1007-9327

     概要を見る

    <p>AIM: To evaluate the effectiveness of trimodal imaging endoscopy (TME) to detect another lesion after endoscopic submucosal dissection (ESD) for superficial gastric neoplasia (SGN).</p><p>METHODS: Surveillance esophagogastroduodenoscopy (EGD) using a TME was conducted in 182 patients that had undergone ESD for SGN. Autofluorescence imaging (AFI) was conducted after white-light imaging (WLI). When SGN was suspicious, magnifying endoscopy with narrow-band imaging (ME-NBI) was conducted. Final diagnoses were made by histopathologic findings of biopsy specimens. The detection rates of lesions in WLI, AFI, and NBI, and the characteristics of lesions detected by WLI and ones missed by WLI but detected by AFI were examined. The sensitivity, specificity, and accuracy of endoscopic diagnosis using WLI, AFI and ME-NBI were evaluated.</p><p>RESULTS: In 242 surveillance EGDs, 27 lesions were determined pathologically to be neoplasias. Sixteen early gastric cancers and 6 gastric adenomas could be detected by WLI. Sixteen lesions were reddish and 6 were whitish. Five gastric neoplasias were missed by WLI but were detected by AFI, and all were whitish and protruded gastric adenomas. There was a significant difference in color and pathology between the two groups (P = 0.006). Sensitivity, specificity and accuracy in MENBI were higher than those in both WLI and AFI. Specificity and accuracy in AFI were lower than those in WLI.</p><p>CONCLUSION: Surveillance using trimodal imaging endoscopy might be useful for detecting another lesion after endoscopic submucosal dissection for superficial gastric neoplasia.</p>

全件表示 >>

KOARA(リポジトリ)収録論文等 【 表示 / 非表示

研究発表 【 表示 / 非表示

  • シンポジウム1「胃癌EMR後の再発例に学ぶ」早期胃癌EMR後遺残・再発例の検討

    今枝博之,熊井浩一郎,杉野吉則,緒方晴彦,岩男泰,相浦浩一,大谷吉秀,久保田哲朗,北島政樹,日比紀文,石井裕正

    第75回日本胃癌学会総会, 2003年02月, 口頭(一般)

  • ビデオシンポジウム3「治療困難例のEMR」前方斜視型処置用2チャンネル電子スコープ(プロトタイプXGIF-2TK240R1)による早期胃癌EMR大型一括切除

    熊井浩一郎,今枝博之,相浦浩一,緒方晴彦,吉田昌,才川義朗,大谷吉秀,久保田哲朗,北島政樹

    第75回日本胃癌学会総会, 2003年02月, 口頭(一般)

  • 早期胃癌EMRの工夫

    今枝博之,熊井浩一郎,緒方晴彦,相浦浩一,長沼誠,鈴木秀和,岩男泰,日比紀文,石井裕正,鈴木吉則

    第75回日本消化器内視鏡学会関東地方会, 2002年12月, 口頭(一般)

  • 早期胃癌EMRの工夫

    今枝博之,熊井浩一郎,緒方晴彦,相浦浩一,長沼誠,鈴木秀和,岩男泰,日比紀文,石井裕正,鈴木吉則

    第75回日本消化器内視鏡学会関東地方会, 2002年12月

  • 早期胃癌EMRの工夫.ビデオシンポジウム1 「上部消化管EMR―どうすればうまくできるか―」

    Imaeda Hiroyuki, Kumai Kouichirou, Naganuma Makoto, Suzuki Hidekazu, Ogata Haruhiko, Iwao Yasushi, Aiura Kouichi, Sugino Yoshinori, Hibi Toshifumi, Ishii Hiromasa

    第57回日本消化器内視鏡学会関東地方会, 2002年12月

全件表示 >>

 

担当授業科目 【 表示 / 非表示

  • 内科学特論

    2019年度

  • 内科学

    2019年度

  • 内科学実習

    2019年度

  • 内科学演習

    2019年度

  • 内科学(消化器)講義

    2019年度