Hasegawa, Naoki



School of Medicine, Department of Infectious Diseases (Shinanomachi)



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Career 【 Display / hide

  • 1985.04

    慶應義塾大学医学部内科, 研修医

  • 1987.04

    横浜市立市民病院, 内科医員

  • 1989.05

    慶應義塾大学医学部, 呼吸器内科, 専修医

  • 1994.10

    国立療養所南横浜病院, 内科医長

  • 1997.04

    国立療養所南横浜病院, 研究検査科長(兼任)

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Academic Background 【 Display / hide

  • 1985.03

    慶應義塾大学 , 医学部

    University, Graduated

Academic Degrees 【 Display / hide

  • モルモットエンドトキシン急性肺損傷における血漿ミエロペルオキシダーゼ測定の意義, KEIO University, Dissertation, 1992.03


Research Areas 【 Display / hide

  • Respiratory organ internal medicine

  • Infectious disease medicine

Research Keywords 【 Display / hide

  • HIV感染症

  • 抗酸菌感染症

  • 非結核性抗酸菌症


Papers 【 Display / hide

  • Amikacin Liposome Inhalation Suspension for Treatment-Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT): A Prospective, Open-Label, Randomized Study

    Griffith, D. E., Eagle, G., Thomson, R., Aksamit, T. R., Hasegawa, N., Morimoto, K., Addrizzo-Harris, D. J., O'Donnell, A. E., Marras, T. K., Flume, P. A., Loebinger, M. R., Morgan, L., Codecasa, L. R., Hill, A. T., Ruoss, S. J., Yim, J. J., Ringshausen, F. C., Field, S. K., Philley, J. V., Wallace, R. J., van Ingen, J., Coulter, C., Nezamis, J., Winthrop, K. L. and Group, CONVERT Study

    Am J Respir Crit Care Med  2018.09

    ISSN  1535-4970

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    Rationale Improved therapeutic options are needed for patients with treatment-refractory nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex (MAC). Objectives To evaluate the efficacy and safety of daily amikacin liposome inhalation suspension (ALIS) added to standard guideline-based therapy (GBT) in patients with refractory MAC lung disease. Methods Adults with amikacin-susceptible MAC lung disease and MAC-positive sputum cultures despite ≥6 months of stable GBT were randomly assigned (2:1) to receive ALIS with GBT (ALIS+GBT) or GBT alone. Once-daily ALIS was supplied in single-use vials delivering 590 mg amikacin to the nebulizer. The primary endpoint was culture conversion, defined as 3 consecutive monthly MAC-negative sputum cultures by month 6. Measurements and Main Results Enrolled patients (ALIS+GBT, n=224; GBT-alone, n=112) were a mean 64.7 years old and 69.3% female. Most had underlying bronchiectasis (62.5%), chronic obstructive pulmonary disease (14.3%), or both (11.9%). Culture conversion was achieved by 65 of 224 patients (29.0%) with ALIS+GBT and 10 of 112 (8.9%) with GBT alone (OR, 4.22; 95% CI [2.08, 8.57]; P<0.001). Patients in the ALIS+GBT arm vs GBT alone were more likely to achieve conversion (hazard ratio, 3.90; 95% CI, [2.00, 7.60]). Respiratory adverse events (primarily dysphonia, cough, and dyspnea) were reported in 87.4% of patients receiving ALIS+GBT and 50.0% receiving GBT alone; serious treatment-emergent adverse events occurred in 20.2% and 17.9% of patients, respectively. Conclusions Addition of ALIS to GBT for treatment-refractory MAC lung disease achieved significantly greater culture conversion by month 6 than GBT alone, with comparable rates of serious adverse events. Clinical trial registration available at www.clinicaltrials.gov, ID NCT02344004.

  • Risk of tuberculosis infection among health care workers and nursing students in Japan

    Nishimura, T., Ota, M., Mori, M., Fujiwara, H., Takano, Y., Kato, S., Kawabe, H. and Hasegawa, N.

    J Infect Chemother  2018.09

    ISSN  1437-7780

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    It is important to evaluate the risk of tuberculosis (TB) infection among health care workers (HCWs) and nursing students in Japan to propose the optimal countermeasure against new TB infection for them. To estimate the annual incidence of TB infection in HCWs at a Japanese university hospital without TB wards and in nursing students at a Japanese university using interferon-gamma release assay (IGRA). Serial IGRAs were prospectively conducted on the HCWs between August 2010 and December 2015. For nursing students, two IGRA tests were conducted before commencement of clinical training and at employment as nurses between April 2007 and December 2015. A total of 328 HCWs and 298 nursing students were followed for 670.15 and 1212.80 person-years, respectively. Assuming IGRA-positive conversions were all attributable to true infection, the incidence of TB infection in HCWs and nursing students was 0.149/100 and 0.0825/100 person-years, respectively. At a Japanese university hospital without TB wards and a Japanese university, the annual incidence of TB infection among HCWs and nursing students estimated from serial IGRA results was low, but continued vigilance for the prevention of TB infection is essential.

  • Sphingosine 1-phosphate receptor modulator ONO-4641 stimulates CD11b

    Asakura, T., Ishii, M., Namkoong, H., Suzuki, S., Kagawa, S., Yagi, K., Komiya, T., Hashimoto, T., Okamori, S., Kamata, H., Tasaka, S., Kihara, A., Hegab, A. E., Hasegawa, N. and Betsuyaku, T.

    Mucosal Immunol  2018.08

    ISSN  1935-3456

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    Sphingolipids play a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, little is known about the precise roles of sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, and its receptor modulation in COPD. In this study, we demonstrated that the S1P receptor modulator ONO-4641 induced the expansion of lung CD11b

  • Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease

    Yagi, K., Asakura, T., Namkoong, H., Suzuki, S., Asami, T., Okamori, S., Kusumoto, T., Funatsu, Y., Kamata, H., Nishimura, T., Ishii, M., Betsuyaku, T. and Hasegawa, N.

    BMC Pulm Med 18 ( 1 ) 114 2018.07

    ISSN  1471-2466

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    Pulmonary Mycobacterium avium complex (pMAC) disease is a chronic, slowly progressive disease. The aim of the present study was to determine the association of six-minute walk test (6MWT) parameters with pulmonary function and the health-related quality of life (HRQL) in patients with pMAC disease.|This cross-sectional study included adult patients with pMAC and was conducted at Keio University Hospital. We investigated the relationship of 6MWT parameters with clinical parameters, including pulmonary function, and HRQL, which was assessed using the 36-Item Short Form Health Survey (SF-36) and St. George's Respiratory Questionnaire (SGRQ).|In total, 103 consecutive patients with pMAC participated in 6MWT (median age, 64 years; 80 women) and completed SF-36 and SGRQ. The six-minute walk distance (6MWD) showed significant negative and positive correlations with all SGRQ domain scores [ρ = (- 0.54)-(- 0.32)] and the physical component summary (PCS) score (ρ = 0.39) in SF-36, respectively; the opposite was observed for the final Borg scale (FBS) score (all SGRQ scores, ρ = 0.34-0.58; PCS score, ρ = - 0.50). The distance-saturation product showed significant negative and positive correlations with all SGRQ scores [ρ = (- 0.29)-(- 0.55)] and the PCS score (ρ = 0.40), respectively. Multivariate analysis revealed that 6MWD and the FBS score were significant predictors of HRQL.|Our findings suggest that 6MWD and the FBS score are useful parameters for evaluating HRQL in patients with pMAC. Further studies should investigate the impact of 6WMT parameters on disease progression, treatment responses, and prognosis.

  • Invasive hepatic mucormycosis: A case report and review of the literature

    Karigane, D., Kikuchi, T., Sakurai, M., Kato, J., Yamane, Y., Hashida, R., Abe, R., Hatano, M., Hasegawa, N., Wakayama, M., Shibuya, K., Okamoto, S. and Mori, T.

    J Infect Chemother  2018.07

    ISSN  1437-7780

     View Summary

    Mucormycosis generally develops under immunocompromised conditions, including hematological malignancies and solid organ or hematopoietic stem cell transplantation. Although mucormycosis usually affects the lungs and paranasal sinuses, sporadic cases of invasive mucormycosis of the liver have been reported. We hereby report a patient with myelofibrosis who developed hepatic mucormycosis diagnosed by post-mortem examination. An extensive literature review identified 13 reported cases of hepatic mucormycosis, including ours, without lung involvement. Most of the underlying diseases or conditions were hematological malignancies and solid organ transplantation. Three cases had splenic lesions and four had gastrointestinal lesions, suggesting the possibility of translocation to the liver and/or spleen from the gastrointestinal tracts. Hepatic mucormycosis should be recognized as one of the presentations of invasive mucormycosis, especially when hepatic nodules are found in immunocompromised patients such as those with hematological malignancy or recipients of solid organ transplantation.

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Papers, etc., Registered in KOARA 【 Display / hide

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Presentations 【 Display / hide

  • エンドトキシン気道内投与のシグナル伝達に対する抗CD14抗体とtoll-like receptor4遺伝子変異の影響


    第44回日本呼吸器学会総会 (東京) , 2004.03, Oral Presentation(general)

  • エンドトキシン(LPS)投与マウス肺損傷モデルにおける抗VEGF抗体投与の効果


    第44回日本呼吸器学会総会 (東京) , 2004.03, Poster (general)

  • 日本人軽症喘息患者におけるロイコトリエン受容体拮抗薬反応性規定因子の解析


    第44回日本呼吸器学会総会 (東京) , 2004.03, Poster (general)

  • エンドトキシン(LPS)気道内注入肺損傷モデルにおけるTNF-α Converting Enzyme(TACE)阻害薬の効果


    第44回日本呼吸器学会総会 (東京) , 2004.03, Poster (general)

  • 肺非定型抗酸菌症(MAC)症の治療例における血清KL-6およびSPD値の経時的変化


    第44回日本呼吸器学会総会 (東京) , 2004.03, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Investigation on pathogenesis of pulmonary diseases due to nontuberculous mycobacteria using human genomic analysis


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 長谷川 直樹, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • miRNAを介した肺MAC症の病態解明


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 長谷川 直樹, Grant-in-Aid for Scientific Research (C), Principal Investigator


Courses Taught 【 Display / hide











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Courses Previously Taught 【 Display / hide

  • 感染症学

    Keio University, 2015