Papers - MATSUZAKI Juntaro

Burden of impaired sleep quality on work productivity in functional dyspepsia

J Matsuzaki, H Suzuki, K Togawa, T Yamane, H Mori, T Komori, ...

United European gastroenterology journal 6 (3), 398-406 (United European Gastroenterology Journal)  6 ( 3 ) 398 - 406 2018.04

Research paper (scientific journal), Lead author, Accepted

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© 2017, © Author(s) 2017. Background: Impaired sleep quality is common, and can reduce work productivity in patients with functional dyspepsia (FD). Objective: The objective of this article is to evaluate whether there is a direct association between the presence of FD and the severity of impaired sleep quality, and to calculate the economic loss due to the decreased work productivity associated with sleep quality. Methods: In Study 1, using a web-based survey completed by workers with and without FD, we evaluated impaired sleep quality, work and daily productivity, and the severity of reflux and bowel symptoms. In Study 2, the association between the presence of FD and the severity of impaired sleep quality was validated in a hospital-based cohort. Results: In both Study 1 and 2, although impaired sleep quality was more frequent in participants with FD than in those without FD, the independent association between the presence of FD and the severity of impaired sleep quality was not observed after adjustment for the severity of reflux and bowel symptoms. FD participants with impaired sleep quality reported additional economic loss of 53,500 Japanese yen/month. Conclusion: Although the association between impaired sleep quality and FD was indirect, concomitant impaired sleep quality could worsen economic loss.

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【Precision medicineをめざした胆道・膵悪性腫瘍ゲノム医療の最前線】血中マイクロRNA測定による膵癌・胆道癌の早期診断

松崎 潤太郎, 落谷 孝広

胆と膵 (医学図書出版(株))  39 ( 4 ) 323 - 326 2018.04

Joint Work,  ISSN  0388-9408

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マイクロRNAとは17～25塩基ほどで構成される小さな一本鎖non-coding RNAである。マイクロRNAは細胞内で遺伝子発現の調節機能を有しているのみならず、細胞外へ分泌され、細胞間コミュニケーションツールとしての機能を有している。がん細胞の多くが早期段階から能動的にマイクロRNAを含む小胞(エクソソーム)を分泌するため、血中マイクロRNAプロファイルを用いたがんの早期診断が可能と考えられている。膵癌、胆道癌においてもその実例は多く報告されており、またマイクロRNAが診断マーカーのみならず予後予測マーカーとしても使用可能であることが示されている。現在われわれは、『体液中マイクロRNA測定技術基盤開発プロジェクト』と称して血清中マイクロRNAの大規模データベース構築を進めており、この技術によるがん早期診断の実現にむけて前向き検証を開始している。(著者抄録)

【プレシジョンメディシンの現状と未来】癌のリキッドバイオプシーによるプレシジョンメディシン

松崎 潤太郎, 落谷 孝広

The Lipid ((株)メディカルレビュー社)  29 ( 2 ) 185 - 190 2018.04

Joint Work,  ISSN  0915-6607

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リキッドバイオプシーとは、血液などの体液の採取によって癌組織採取(バイオプシー)に匹敵する、あるいはそれを上回る情報を入手しうるものと期待される新技術である。その解析標的には、細胞外DNA、miRNA、血中循環腫瘍細胞、エクソソームなどがあげられる。治療方針の最適化や治療後のモニタリングには細胞外DNAや血中循環腫瘍細胞の有用性がよく報告されている。一方、癌の早期診断の領域ではマイクロRNAやエクソソームの有用性が期待される。いずれの標的も検出方法や評価方法が十分には成熟しておらず、今後ますます学問的理解が深まるとともに、早い段階での実用化に向けて技術開発が進められている。(著者抄録)

【「早期発見」をめぐる課題】がん早期診断に変革をもたらす新技術の可能性と課題

松崎 潤太郎, 落谷 孝広

公衆衛生 ((株)医学書院)  82 ( 2 ) 120 - 125 2018.02

Joint Work,  ISSN  0368-5187

【上部消化管疾患　ピロリ菌陰性時代への過渡期をむかえて】治療　実地医家が知っておくべき治療の進歩とその着目点　FD治療薬の使い方

松崎 潤太郎, 鈴木 秀和

Medical Practice ((株)文光堂)  35 ( 1 ) 123 - 127 2018.01

Joint Work,  ISSN  0910-1551

Predicting the risk of peripheral neuropathy by the combination of four serum microRNAs

S Narita, A Shimomura, Y Tanabe, J Kawachi, J Matsuzaki, S Takizawa, ...

Annals of Oncology 29, vii57-vii58 29   vii57 - vii58 2018

Research paper (international conference proceedings)

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A tissue microRNA signature that predicts breast cancer recurrence in young women

HM Ai, J Matsuzaki, RT Takahashi, M Yoshida, Y Nezu, Y Yamamoto, ...

CANCER SCIENCE 109, 656-656  2018

Research paper (international conference proceedings)

A serum microRNA classifier for the diagnosis of bone and soft tissue sarcomas of various histological subtypes

N Asano, J Matsuzaki, J Kawauchi, S Takizawa, E Kobayashi, ...

CANCER SCIENCE 109, 503-503  2018

Research paper (international conference proceedings)

302-The Efficacy and Safety of Immediate Versus Gradually Increasing Oral Intake of Low-Fat Solid Food after Fasting in the Recovery Phase of Mild Acute Pancreatitis: A Single …

M Horibe, E Iwasaki, A Nakagawa, J Matsuzaki, K Minami, H Tamagawa, ...

Gastroenterology 154 (6), S-73  2018

Research paper (international conference proceedings)

117 THE MULTICENTER VALIDATION STUDY OF THE SIMPLE SCORE, WHICH PREDICTS NEED FOR AN URGENT ENDOSCOPIC INTERVENTION FOR SUSPECTED UPPER GASTROINTESTINAL BLEEDING

M Horibe, Y Ogura, J Matsuzaki, K Minami, S Fukuhara, E Iwasaki, ...

Gastrointestinal Endoscopy 87 (6), AB53  2018

Research paper (international conference proceedings)

Circulating microRNA classifiers to distinguish among gastric, esophageal, and colorectal cancers

J Matsuzaki, S Abe, H Takamaru, K Sudo, H Katai, Y Kanemitsu, H Daiko, ...

CANCER SCIENCE 109, 549-549  2018

Research paper (international conference proceedings), Lead author

Serum microRNAs as a potential biomarker for evaluating axillary lymph nodes metastasis in breast cancer

S Shiino, J Matsuzaki, A Shimomura, J Kawauchi, S Takizawa, ...

European Journal of Cancer 92, S127  2018

Research paper (international conference proceedings)

Prediction of response to trasutuzumab/pertuzumab/taxane therapy by microRNA in HER2 positive advanced breast cancer

A Kawachi, A Shimomura, J Matsuzaki, J Kawauchi, S Takizawa, ...

Annals of Oncology 29, iii27-iii28  2018

Research paper (international conference proceedings)

Prediction of pathological complete response by microRNA in breast cancer patients treated with neoadjuvant chemotherapy

A Shimomura, S Shiino, J Kawauchi, S Takizawa, M Ichikawa, ...

CANCER SCIENCE 109, 394-394  2018

Research paper (international conference proceedings)

PLASMA GHRELIN IS A USEFUL MARKER OF GASTRIC MUCOSAL ATROPHY AFTER HELICOBACTER PYLORI ERADICATION: A PROSPECTIVE CLINICAL STUDY

H Mori, H Suzuki, J Matsuzaki, T Masaoka, K Igarashi, T Kanai

Gastroenterology 154 (6), S925-S926  2018

Research paper (international conference proceedings)

Overexpression of CAPZA1, a novel negative regulator of autophagy, develops CD44v9-expressing cancer stem-like cells in Helicobacter pylori-infected gastric mucosa

H Tsugawa, J Matsuzaki, C Kato, H Mori, M Suematsu, H Suzuki

HELICOBACTER 23  2018

Research paper (international conference proceedings)

NapA polymorphism determine the risk of Helicobacter pylori-associated dyspepsia

J Matsuzaki, H Tsugawa, H Suzuki

HELICOBACTER 23  2018

Research paper (international conference proceedings), Lead author

Investigating serum microRNAs predicting new lesions after eribulin for patients with metastatic breast cancer

NT Kitamura, S Akihiko, J Kawauchi, S Takizawa, J Matsuzaki, ...

CANCER SCIENCE 109, 469-469  2018

Research paper (international conference proceedings)

Identification of serum microRNAs predicting the response to nivolumab in patients with advanced gastric cancer

T Miyamoto, K Kato, J Matsuzaki, S Takizawa, K Sudo, H Shoji, S Iwasa, ...

Annals of Oncology 29, x3  2018

Research paper (international conference proceedings)

Development of diagnostic method for bone and soft tissue sarcomas of various histological subtypes using serum microRNA profiles.

N Asano, J Matsuzaki, J Kawauchi, S Takizawa, E Kobayashi, ...

Journal of Clinical Oncology 36 (15_suppl), 12019-12019  2018

Research paper (international conference proceedings)