Tanaka, Karin



School of Medicine, Center for Preventive Medicine (Shinanomachi)




Papers 【 Display / hide

  • C-peptide immunoreactivity index is associated with improvement of HbA1c

    Nishimura Takeshi, Meguro Shu, Sekioka Risa, Tanaka Karin, Saisho Yoshifumi, Irie Junichiro, Tanaka Masami, Kawai Toshihide, Itoh Hiroshi

    Diabetes Research and Clinical Practice 108 ( 3 ) 441 - 447 2015.06

    ISSN  0168-8227

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    <p>Aims: This retrospective study aimed to determine the hypoglycaemic effect of 2 years of sitagliptin administration in terms of changes in HbA1c and C-peptide immunoreactivity (CPR) index (plasma CPR [ng/mL]/glucose [mg/dL]. ×. 100). Methods: The inclusion criteria for DPP-4 inhibitor-naive outpatients with type 2 diabetes (. n=. 285) were: continuation of sitagliptin for ≥700 days from initial administration and measurement of HbA1c, serum CPR, and plasma glucose levels at 0, 3, 6, 12, 18, and 24 months after sitagliptin initiation. Logistic regression analyses determined the factors contributing to the response to sitagliptin, based on responder (δHbA1c ≤-0.4% [≤-4. mmol/mol]) and non-responder (δHbA1c &gt;-0.4% [&gt;-4. mmol/mol]) groups. Results: The HbA1c level decreased and CPR index increased from baseline to 3, 6, 12, 18, and 24 months after the start of sitagliptin administration (HbA1c: 7.4. ±. 0.8% [57. ±. 9. mmol/mol], 7.3. ±. 0.9% [57. ±. 9. mmol/mol], 7.4. ±. 0.9% [58. ±. 10. mmol/mol], 7.1. ±. 0.8% [55. ±. 9. mmol/mol], and 7.3. ±. 0.9% [57. ±. 10. mmol/mol], respectively, all P&lt;. 0.001 vs. baseline [8.0. ±. 1.0%, 64. ±. 11. mmol/mol] and CPR index: 1.69. ±. 0.96, 1.71. ±. 1.10, 1.62. ±. 0.96, 1.64. ±. 0.92, and 1.66. ±. 0.96, respectively, all P&lt;. 0.05 vs. baseline [1.47. ±. 0.81]). Higher baseline HbA1c level, shorter diabetes duration, and greater CPR index increase after sitagliptin administration were associated with the response to sitagliptin. Conclusions: Our results suggest that sitagliptin improves glycaemic control via an improved intrinsic insulin response.</p>

  • Past obesity as well as present body weight status is a risk factor for diabetic nephropathy

    Meguro Shu, Kabeya Yusuke, Tanaka Karin, Kawai Toshihide, Tomita Masuomi, Katsuki Takeshi, Oikawa Yoichi, Atsumi Yoshihito, Shimada Akira, Tanaka Masami, Irie Junichiro, Saisho Yoshifumi, Itoh Hiroshi

    International Journal of Endocrinology 2013 2013

    ISSN  1687-8337

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    <p>Aims. We analyzed the prevalence of nephropathy according to past body weight status in Japanese subjects with type 2 diabetes because the influence of past obesity on diabetic complications is not certain. Methods. We examined the prevalence of nephropathy in 2927 subjects with type 2 diabetes mellitus according to current BMI and maximum BMI in the past. We defined "current obesity" as BMI on hospitalization of 25 or more, "previous obesity" as BMI on hospitalization of less than 25 and self-reported maximum BMI in the past of 25 or more, and "continuously lean" as maximum BMI of less than 25. Results. The prevalence of nephropathy was significantly higher in subjects with current obesity (40.6%) or previous obesity (35.6%) than in those who were continuously lean (24.3%) (P&lt;0.017). In logistic regression analysis, previous obesity, as well as current obesity, was a significant risk factor for nephropathy, independent of sex, age, disease duration, hypertension, dyslipidemia, HbA1c, and diabetic retinopathy. Conclusions. Obesity in the past, as well as the present body weight status, was a risk factor for diabetic nephropathy. © 2013 Shu Meguro et al.</p>

  • Successful treatment of recurrent intracardiac thrombus in Behçet's disease with immunosuppressive therapy

    Kaneko Yuko, Tanaka Karin, Yoshizawa Akihiro, Yasuoka Hidekata, Suwa Akira, Satoh Toru, Iwanaga Shiro, Ogawa Satoshi, Ikeda Yasuo, Hirakata Michito

    Clinical and Experimental Rheumatology 23 ( 6 ) 885 - 887 2005.11

    ISSN  0392-856X

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    <p>Behçet's disease (BD) is a chronic multisystem inflammatory disorder characterized by recurrent oral and genital ulcers, skin eruptions and uveitis. Neurological, gastrointestinal, and musculoskeletal systems are also involved. Although venous and arterial vasculitis occur in up to one-third of patients, intracardiac thrombus is a very rare complication. We herein report the case of a 46-year-old man with BD who presented with a large right atrial thrombus. Within a month after surgical removal, the thrombus recurred and was successfully treated with immunosuppressants that included prednisolone and cyclophosphamide. © Copyright Clinical and Experimental Rheumatology 2005.</p>

Presentations 【 Display / hide

  • グリコアルブミンとHbA1cの季節変動の違い

    Tanaka Karin

    European Association for the Study of Diabetes (barcelona) , 2013.09, Poster (general)