種瀬 啓士 (タネセ ケイジ)

Tanese, Keiji

写真a

所属(所属キャンパス)

医学部 皮膚科学教室 (信濃町)

職名

専任講師(有期)

学歴 【 表示 / 非表示

  • 1995年04月
    -
    2001年03月

    慶應義塾大学, 医学部

    大学, 卒業

  • 2003年04月
    -
    2007年03月

    慶應義塾大学, 医学部, 皮膚科学教室・医学系大学院博士課程

    大学院, 卒業, 博士

学位 【 表示 / 非表示

  • 医学博士, 慶應義塾大学, 課程, 2009年02月

    13. Tanese K, Fukuma M, Yamada T, Mori T, Yoshikawa T, Watanabe W, Ishiko A, Amagai M, Nishikawa T, Sakamoto M. G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation. The American journal of pathology. 2008;173(3):835-43.

免許・資格 【 表示 / 非表示

  • 医師免許, 2001年05月

  • 日本皮膚科学会皮膚科専門医, 2008年10月

 

研究分野 【 表示 / 非表示

  • 皮膚科学

研究キーワード 【 表示 / 非表示

  • 皮膚病理学

  • 腫瘍医学

  • 腫瘍病理学

  • 薬事行政

研究テーマ 【 表示 / 非表示

  • 悪性黒色腫における腫瘍微小周囲環境の解析, 

    2013年
    -
    継続中

 

論文 【 表示 / 非表示

  • Metastatic Cutaneous Squamous Cell Carcinoma in Liver Successfully Treated With Partial Hepatectomy and Adjuvant Irinotecan Chemotherapy

    Asahina Y, Nakamura Y, Tanese K, Hirai I, Fukuda K, Amagai M, Funakoshi T

    In Vivo 34 ( 2 ) 825 - 828 2020年03月

    共著, 査読有り,  ISSN  0258-851X

  • Case of metastatic cutaneous myoepithelial carcinoma lacking severe cytological atypia

    Hirai I, Tanese K, Nakamura Y, Amagai M, Mikami S, Funakoshi T

    J Dermatol 47 ( 3 ) e97 - e98 2020年03月

    共著, 査読有り,  ISSN  0385-2407

  • Serum cytokeratin 19 fragment 21-1 and carcinoembryonic antigen combination assay as a biomarker of tumour progression and treatment response in extramammary Paget disease

    Nakamura Y., Tanese K., Hirai I., Amagai M., Kawakami Y., Funakoshi T.

    British Journal of Dermatology (British Journal of Dermatology)  181 ( 3 ) 535 - 543 2019年09月

    共著, 査読有り,  ISSN  0007-0963

     概要を見る

    © 2019 British Association of Dermatologists Background: Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma affecting the genitals and axillary regions. As metastasis of these tumours is itself rare, solid disease management strategies have not been established. Serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment 21-1 (CYFRA 21-1) levels have been identified as candidate biomarkers for tumour progression in EMPD. Objectives: To determine the accuracy of and the correlation between these markers in patients with EMPD. Methods: Serum CEA and CYFRA 21-1 levels were examined in 30 patients with EMPD treated at Keio University Hospital, and compared against clinical information. Both assays were performed at the time of diagnosis, during the postoperative observation period, and following systemic treatment in those with confirmed metastasis. Serum levels were then correlated with tumour progression status and treatment responses. Results: Normal levels for both assays were observed in all 11 patients with primary localized disease (100%). In patients with metastatic disease the CEA positivity rate was 79% (15 of 19 patients), with a rate of 63% (12 of 19 patients) for CYFRA 21-1. Changes in CEA and CYFRA 21-1 levels were statistically independent; however, using a combined view, elevated levels of either marker improved the positivity rate to 95% (18 of 19 patients). Use of both markers also correlated well with treatment responses. Conclusions: The combination of CEA and CYFRA 21-1 is useful for predicting metastasis and treatment response in patients with EMPD, especially in those who only have elevation of a single marker. What's already known about this topic?. Serum levels of carcinoembryonic antigen (CEA) and cytokine 19 fragment 21-1 (CYFRA 21-1) have been shown to be elevated in patients with extramammary Paget disease (EMPD). Elevation of serum CEA levels is associated with tumour progression of EMPD. A single small study reported that serum CYFRA 21-1 levels are elevated in patients with EMPD with lymph node metastasis. What does this study add?. Serum CEA and CYFRA 21-1 were present in 79% and 63% of 19 cases of metastatic EMPD, respectively. Elevations of CEA and CYFRA 21-1 were statistically independent. CEA and CYFRA 21-1 combination assays were positive in 95% of cases of metastatic EMPD. What is the translational message?. Combination assays with CEA and CYFRA 21-1 are useful for monitoring treatment response in patients with metastatic EMPD, particularly in those with elevation of either marker.

  • Successful control of adrenal metastasis with transcatheter arterial chemoembolization in metastatic melanoma patient undergoing treatment with immune checkpoint inhibitor

    Tahara U, Tanese K, Nakamura Y, Hirai I, Amagai M, Oguro S, Funakoshi T

    J Dermatol 46 ( 8 ) e276 - e278 2019年08月

    共著, 査読有り,  ISSN  0385-2407

  • Basosquamous cell carcinoma arising from an infundibular cyst on the hip

    Shiina Y, Ogata D, Tanese K, Arai E, Tsuchida T

    J Dermatol 46 ( 8 ) e283 - e284 2019年08月

    共著, 査読有り,  ISSN  0385-2407

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総説・解説等 【 表示 / 非表示

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研究発表 【 表示 / 非表示

  • 高齢女性の左前胸部に生じたMammary-type myofibroblastomaの1例

    早川道太郎, 八代聖, 中村善雄, 種瀬啓士, 天谷雅行, 亀山香織, 山上淳

    第887回日本皮膚科学会東京地方会(城西地区) (東京) , 2019年12月

  • エキシマライトによる紫外線療法が著効した汎発型限局性強皮症の1例

    土屋茉里絵, 八代聖, 新川宏樹, 村上香織, 大内健嗣, 種瀬啓士, 天谷雅行, 谷川瑛子

    第83回日本皮膚科学会東京・東部支部合同学術大会 (東京) , 2019年11月

  • Combination assay of serum cytokertatin 19 fragment 21-1 and carcinoembryonic antigen as a biomarker of tumor progression and treatment response in extramammary Paget's disease

    Nakamura Y, Tanese K, Hirai I, Kawakami Y, Amagai M, Funakoshi T

    28th European Academy of Dermatology and Venereology congress(EADV2019) (Madrid, Spain) , 2019年10月

  • AMED治験・臨床研究推進事業の一環としての患者登録型マッチングシステムの構築

    舩越建, 石井麻貴, 平井郁子, 中村善雄, 種瀬啓士, 天谷雅行

    第70回日本皮膚科学会中部支部学術大会 (金沢) , 2019年10月

  • The MIF-CD74 interaction regulates the expression of PD-L1 in melanoma cells

    Tanese K, Imaoka M, Masugi Y, Hayashi M, Sakamoto M

    78th Annual Meeting of the Japanese Cancer Association (Kyoto, Japan) , 2019年09月

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競争的資金等の研究課題 【 表示 / 非表示

  • 悪性黒色腫におけるHedgehogシグナル伝達経路の活性化が示す臨床的意義の検討

    2020年04月
    -
    2023年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 種瀬 啓士, 基盤研究(C), 補助金,  代表

 

担当授業科目 【 表示 / 非表示

  • 皮膚科学講義

    2021年度

  • 皮膚科学講義

    2020年度