論文 - 谷川原　祐介

New method for the evaluation of in vitro dissolution time and disintegration time

Tanigawara Y. Yamaoka K. Nakagawa T. Uno T.

Chem.Pharm. Bull 30 （ 3 ） 1088 - 1090 1982年

Capacity-limited elimination of cefmetazole in rat

Yamaoka K., Tanigawara Y., Nakagawa T., Uno T.

International Journal of Pharmaceutics 10 （ 4 ） 291 - 300 1982年

ISSN  0378-5173

　概要を見る

<p>Elimination kinetics of cefmetazole (CMZ) in the rat is studied with changing the dosing amount (D). The normalized area under plasma concentration-time curve (AUC/D) and the mean residence time (MRT) increase with increasing amount of i.v. dose of CMZ. These increases prove the capacity-limited elimination of CMZ without regard to any pharmacokinetic model. The apparent steady-state volume of distribution (V^a_ss) which is defined by D β MRT/AUC is almost independent of D. The simultaneous multi-lines fitting using time course curves following different doses is also attempted to determine the pharmacokinetic model by the application of the minimum AIC estimation (MAICE). AIC, consequently, shows the minimum for the two-compartment model with the Michaelis-Menten elimination. The Y_ss estimated from this model is about 450 ml/kg which agrees with V^a_ss estimated by moment analysis. © 1982.</p>

• Access to Document (DOI)

Moment analysis for the separation of mean in vivo disintegration, dissolution, absorption, and disposition time of ampicillin products

Tanigawara Y., Yamaoka K., Nakagawa T., Uno T.

Journal of Pharmaceutical Sciences 71 （ 10 ） 1129 - 1133 1982年

ISSN  0022-3549

　概要を見る

<p>The in vivo disintegration, dissolution, absorption, and disposition processes of ampicillin products are separated by means of moment analysis. This method is model-independent, that is, any specific model is not assumed. The mean residence time (MRT), mean absorption time (MAT), mean dissolution time (MDT), and mean disintegration time (MDIT) are calculated for several dosage forms of ampicillin. The fraction of dose absorbed (F) is also separated into several fractions corresponding to these in vivo processes. Bioavailability and bioequivalence are discussed in terms of the zero and first moments. The flip-flop behavior of ampicillin is proved by the fact that the MRT following intravenous injection is less than the MAT of any oral dosage form. Absorption of released ampicillin is proved to be a rate-determining step, since the MRT of released ampicillin in the GI tract is the greatest of all MRT corresponding to the in vivo processes. Moment analysis is compared with classical compartment theory, and a new component concept is introduced.</p>

Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products

Tanigawara Y., Yamaoka K., Nakagawa T., Uno T.

Journal of Pharmacobio-Dynamics 5 （ 5 ） 370 - 372 1982年

ISSN  0386-846X

Absorption kinetics of carbenicillin phenyl sodium and carbenicillin indanyl sodium in man

Tanigawara Y., Yamaoka K., Nakagawa T., Uno T.

Chemical and Pharmaceutical Bulletin 30 （ 6 ） 2174 - 2180 1982年

ISSN  0009-2363

A pharmacokinetic analysis program (MULTI) for microcomputer

Yamaoka K., Tanigawara Y., Nakagawa T., Uno T.

Journal of Pharmacobio-Dynamics 4 （ 11 ） 879 - 885 1981年

ISSN  0386-846X