Itabashi, Yuji



School of Medicine, Department of Laboratory Medicine (Shinanomachi)


Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

External Links


Papers 【 Display / hide

  • Successful Surgical Treatment Combined With Infliximab in a Patient With Acute Aortic Regurgitation Caused by Behçet Disease

    Kawakubo Y., Katsumata Y., Komuro J., Shiraishi Y., Yuasa S., Itabashi Y., Kohno T., Fukuda K.

    Canadian Journal of Cardiology (Canadian Journal of Cardiology)  36 ( 7 ) 1161.e3 - 1161.e5 2020.07

    ISSN  0828282X

     View Summary

    © 2020 Canadian Cardiovascular Society Standard aortic valve replacement for aortic regurgitation caused by Behçet disease (BD) is frequently complicated by postoperative recurrent prosthetic valve detachment. Tumour necrosis factor (TNF) α is known to be associated with higher inflammation activities. Therefore, the concomitant use of immunomodulatory agents with TNFα inhibitors may be the key to a better outcome. This is a case report of a 46-year-old woman with severe acute aortic regurgitation due to BD. Immunosuppressive therapy including the TNFα inhibitor infliximab, which has not been reported for perioperative use to date, resulted in the prompt remission of inflammation, leading to the success of Bentall surgery.

  • Clinical Impact of Size, Shape, and Orientation of the Tricuspid Annulus in Tricuspid Regurgitation as Assessed by Three-Dimensional Echocardiography

    Utsunomiya H., Itabashi Y., Kobayashi S., Rader F., Siegel R., Shiota T.

    Journal of the American Society of Echocardiography (Journal of the American Society of Echocardiography)  33 ( 2 ) 191 - 200.e1 2020.02

    ISSN  08947317

     View Summary

    © 2019 American Society of Echocardiography Background: Tricuspid annuloplasty for tricuspid regurgitation (TR) depends on the measurements of tricuspid annular diameter (TAD) obtained in an apical four-chamber view on two-dimensional (2D) transthoracic echocardiography (TTE). We performed a combined 2D and three-dimensional (3D) echocardiographic study to understand the impact of the size, shape, and orientation of a dilated annulus on the inconsistencies between measured 2D TTE-TAD and the actual annular diameter. Methods: A total of 185 patients with grade ≥3+ TR and 50 controls underwent 2D TTE and 3D transesophageal echocardiography (TEE) assessment of the tricuspid valve. The 3D TEE-TAD, defined as the longest dimension, and tricuspid annulus (TA) eccentricity index, defined as the shortest/longest dimension ratio, were obtained. The angle between the major tricuspid annulus axis and interatrial septum parallel to the vertical axis (α°) was measured as an index of TA orientation. Results: Compared with controls, TR subgroups had a larger α° irrespective of TR etiology and cardiac rhythm (P < .05), with the posteriorly displaced TA most frequently noted in patients with atrial fibrillation. An excellent correlation was found between 3D TEE-TAD and 2D TTE-TAD, but 2D TTE-TAD was significantly smaller than 3D TEE-TAD (35.9 ± 5.4 vs 39.8 ± 5.7 mm; P < .001; bias, 3.9 ± 2.6 mm; limits of agreement, −1.1-8.9 mm). After multivariate adjustment, a larger 3D TEE-TAD and larger absolute value of 90° − α° were independent determinants of the bias between 3D TEE-TAD and 2D TTE-TAD (both P < .001). Conclusions: The inconsistencies between measured 2D TTE-TAD and the actual annular diameter can be explained through morphologic factors such as TA size and orientation.

  • Characteristics of chronic obstructive pulmonary disease patients with pulmonary hypertension assessed by echocardiography in a three-year observational cohort study

    Nakayama S., Chubachi S., Sakurai K., Irie H., Tsutsumi A., Hashiguchi M., Itabashi Y., Murata M., Nakamura H., Asano K., Fukunaga K.

    International Journal of COPD (International Journal of COPD)  15   487 - 499 2020

    ISSN  11769106

     View Summary

    © 2020 Nakayama et al. This work is published and licensed by Dove Medical Press Limited. Background: Pulmonary hypertension (PH) is a major comorbidity of chronic obstructive pulmonary disease (COPD). However, the association of PH detected by echocardiography and COPD-related outcome in longitudinal follow-up has not been elucidated. In this study, we aimed to investigate the relationship between clinical characteristics of COPD patients with PH detected by echocardiography and various outcome parameters such as COPD exacerbation and health status over a three-year observation period. Methods: In this observational study, we analyzed patients with COPD who underwent chest computed tomography and echocardiography at baseline (n = 183). Results: The prevalence of PH was 21.9% (40 patients). The median estimated systolic pulmonary artery pressure in patients with PH was 38.8 mmHg. COPD patients with PH were older, had a lower body mass index, scored worse in the COPD Assessment Test and St. George’s Respiratory Questionnaire, and exhibited a lower diffusing capacity of the lung for carbon monoxide in comparison to patients without PH. In computed tomography images, the percentages of low-attenuation areas (LAA%) and interstitial abnormalities were higher in COPD patients with PH than in those without PH. Higher values for LAA % (LAA ≥ 30%) and interstitial abnormalities independently increased the risk of PH. The ratio of main pulmonary diameter to aortic artery diameter was significantly correlated with estimated systolic pulmonary artery pressure. In the follow-up analysis, the frequency of exacerbations in three years was significantly higher in patients with PH compared to patients without PH. Conclusion: In this study, we identified the clinical characteristics of COPD patients with PH detected by echocardiography. The presence of PH assessed by echocardiography was related to future COPD exacerbations and closely related to radiographical emphysema.

  • Biventricular takotsubo cardiomyopathy with asymmetrical wall motion abnormality between left and right ventricle: a report of new case and literature review

    Tsugu T., Nagatomo Y., Nakajima Y., Kageyama T., Endo J., Itabashi Y., Kawakami T.

    Journal of Echocardiography (Journal of Echocardiography)  17 ( 3 ) 123 - 128 2019.09

    ISSN  13490222

     View Summary

    © 2019, Japanese Society of Echocardiography. Takotsubo cardiomyopathy (TC) is characterized by transient wall motion abnormalities most commonly involving the left ventricle (LV). Although biventricular TC had been considered uncommon condition, recently biventricular TC has been reported as a new variant observed in 19–42% of all TC presentations. Since biventricular TC has a poor prognosis as compared with isolated TC, it is important to distinguish between isolated LV TC and biventricular TC. We present a case of 70-year-old female with dyspnea persisting for 2 days. Electrocardiogram showed symmetrical T-wave inversion in leads V2–V4. Transthoracic echocardiography (TTE) revealed diffuse hypo-kinesis except for the apical inferior LV and LV ejection fraction of 32%. Hyper-kinesis of the right ventricular (RV) basal segment and dys-kinesis of the RV apical segment. 2 weeks after admission, coronary angiography showed no evidence of significant stenosis. LV ejection fraction improved to 51% and wall motion abnormalities of the RV basal and apical segments were ameliorated to normo-kinesis. Electrocardiogram revealed symmetrical and deepened T-wave inversion in leads V2–V3. The presence of a transient abnormality in biventricular wall motion beyond a single coronary artery perfusion territory with new electrocardiographic change met the diagnostic criteria of definite TC defined by Mayo Clinic criteria. 4 weeks after admission, no recurrence of wall motion abnormalities in both ventricles were found and T-wave inversion ameliorated. To our knowledge, this is the first report of biventricular TC with asymmetrical abnormities of wall motion between LV and RV.

  • Increasing mixed venous oxygen saturation is a predictor of improved renal function after balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension

    Isobe S., Itabashi Y., Kawakami T., Kataoka M., Kohsaka S., Tsugu T., Kimura M., Sawano M., Katsuki T., Kohno T., Endo J., Murata M., Fukuda K.

    Heart and Vessels (Heart and Vessels)  34 ( 4 ) 688 - 697 2019.04

    ISSN  09108327

     View Summary

    © 2018, Springer Japan KK, part of Springer Nature. Balloon pulmonary angioplasty (BPA) has emerged as an effective treatment for patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Renal function has been identified as a prognostic marker in patients with pulmonary hypertension in previous studies. We, therefore, aimed to investigate the clinical parameters associated with improvements in renal function in patients with CTEPH. A total of 45 consecutive patients with inoperable CTEPH undergoing BPA (mean age 62.2 ± 15.1 years) were included in the study. We evaluated the patients’ clinical characteristics at baseline and at 1-year post-BPA, and investigated the association between renal function and hemodynamic parameters, including right heart function. Hemodynamics and renal function showed sustained improvements at 1 year after BPA in 64.4% of patients. Improved estimated glomerular filtration rate (eGFR) was significantly correlated with increased cardiac index (r = 0.433, p = 0.003) and mixed venous oxygen saturation (SvO 2 ; r = 0.459, p = 0.002), and with decreased mean pulmonary arterial pressure (r = − 0.420, p = 0.004) and pulmonary vascular resistance (r = -− 0.465, p = 0.001). Multivariate analysis revealed that an increase in SvO 2 immediately after the final BPA was associated with improved eGFR after the 1st year (odds ratio 1.041; 95% confidence interval 1.004–1.078; P = 0.027). The cut-off value for predicting improved eGFR was an increase in SvO 2 after the final BPA of >125.4% over the baseline value (specificity 100%, sensitivity 24.1%). In conclusion, BPA improved symptoms, right heart function, hemodynamics, and renal function up to the chronic phase. Increasing SvO 2 by >125.4% above baseline in the acute phase is important for improving renal function at 1 year after BPA in CTEPH patients.

display all >>

Reviews, Commentaries, etc. 【 Display / hide

Presentations 【 Display / hide

  • Neurotrophin-3, a neurotrophic factor, is a new member of cardiomyocyte hypertrophic factors

    Kawaguchi Haruko, Suematsu Makoto, Tahara Satoko, Tomita Yuichi, Ieda Masaki, Fujita Jun, Manabe Tomohiro, Itabashi Yuji, Yagi Takashi, Yuasa Shinsuke, Kinosita Masaki, hayashida Kentaro, Yoshioka Masatoyo, Shibuya sao, Hisaka Yasuyo, Fukuda Keiichi

    第67回日本循環器学会学術集会, 2003.03, Oral Presentation(general)

  • 成獣ラット心筋細胞は心筋梗塞後に分裂像を呈する

    Yuasa Shinsuke, Ieda Masaki, Tomita Yuuichi, Tahara Satoko, Fujita Jun, Yagi Takashi, Itabashi Yuuji, Suzuki Yuusuke, Kawaguchi Haruko, Ogawa Satoshi, Hisaka Yasuyo, Shibuya Isao, Fukuda Keiichi

    第25回心筋代謝研究会, 2002.07, Oral Presentation(general)

  • Differential response between cardiomyocytes and cardiac fibroblasts in reactive oxygen spiecies(ROS)-mediated signal transduction pathways be endothelin-1

    Satoh Tosihiko, Satoh Keiichi Fukuda, Tomita Yuichi, Tahara Satoko, Fujita Jun, Itabashi Yuji, Yuasa Shinsuke, Shibuya Isao, Hisaka Yasuyo, Kawaguchi Haruko, Ogawa Satoshi

    第66回日本循環器学会学術集会, 2002.04, Oral Presentation(general)

  • Molecular characterization of endothelin-1-specific augmentation of nerve growth factor gene expression in cardiomyocyte

    Ieda Masaki, Fukuda Keiichi, Tomita Yuichi, Tahara Satoko, Fujita Jun, Itabashi Yuji, Yuasa Shinsuke, Shibuya Isao, Hisaka Yasuyo, Kawaguchi Haruko, Ogawa Satoshi

    第66回日本循環器学会学術集会, 2002.04, Oral Presentation(general)

  • Molecular mechanism of the changes in appearance of the action potentials in bone-marrow derived regenerated cardiomyocytes

    Tomita Yuichi, Fukuda Keiichi, Ieda Masaki, Tahara Satoko, Fujita Jun, Itabashi Yuji, Yuasa Shinsuke, Shibuya Isao, Hisaka Yasuyo, Kawaguchi Haruko, Ogawa Satoshi

    第66回日本循環器学会学術集会, 2002.04, Oral Presentation(general)

display all >>

Research Projects of Competitive Funds, etc. 【 Display / hide

  • 経皮的大動脈弁植え込み術後に遷延する低心機能の機序の調査と動物モデルでの検討


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 板橋 裕史, Grant-in-Aid for Scientific Research (C), Principal Investigator


Courses Taught 【 Display / hide