Reviews, Commentaries, etc. - Hashimoto, Hisayuki

Epigenetic barrier against the propagation of fluctuating gene expression in embryonic stem cells

Saito Y., Kunitomi A., Seki T., Tohyama S., Kusumoto D., Takei M., Kashimura S., Hashimoto H., Yozu G., Motoda C., Shimojima M., Egashira T., Oda M., Fukuda K., Yuasa S.

FEBS Letters (FEBS Letters)  591 ( 18 ) 2879 - 2889 2017.09

ISSN  00145793

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© 2017 Federation of European Biochemical Societies The expression of pluripotency genes fluctuates in a population of embryonic stem (ES) cells and the fluctuations in the expression of some pluripotency genes correlate. However, no correlation in the fluctuation of Pou5f1, Zfp42, and Nanog expression was observed in ES cells. Correlation between Pou5f1 and Zfp42 fluctuations was demonstrated in ES cells containing a knockout in the NuRD component Mbd3. ES cells containing a triple knockout in the DNA methyltransferases Dnmt1, Dnmt3a, and Dnmt3b showed correlation between the fluctuation of Pou5f1, Zfp42, and Nanog gene expression. We suggest that an epigenetic barrier is key to preventing the propagation of fluctuating pluripotency gene expression in ES cells.

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Induction of Cardiac Cell Types by Direct Reprogramming

Hisayuki Hashimoto, Huanyu Zhou, Maria G. Morales, Maria Abad, Rhonda Bassel-Duby, Eric N. Olson

CIRCULATION RESEARCH (LIPPINCOTT WILLIAMS & WILKINS)  119 ( 12 ) E168 - E168 2016.12

Research paper, summary (international conference), Joint Work,  ISSN  0009-7330

Novel Method 'Fucci' Elucidated the Cardiomyocyte Cell Cycle Dynamics in Various Life Stages

Hisayuki Hashimoto, Shinsuke Yuasa, Shugo Tohyama, Tomohisa Seki, Toru Egashira, Kojiro Yae, Dai Kusumoto, Masaki Kodaira, Fumiyuki Hattori, Naoto Muraoka, Hidenori Tabata, Kazunori Nakajima, Asako Sakaue-Sawano, Atsushi Miyawaki, Keiichi Fukuda

CIRCULATION (LIPPINCOTT WILLIAMS & WILKINS)  122 ( 21 )  2010.11

Research paper, summary (international conference), Joint Work,  ISSN  0009-7322

ヒトiPS由来心筋細胞の電気生理学的特性について

遠山 周吾, 村田 光繁, 黒川 洵子, Fernando Lopez-Redondo, 服部 文幸, 水澤 美香, 山川 裕之, 橋本 寿之, 江頭 徹, 関 朋久, 扇野 泰行, 八戸 宏二郎, 湯浅 慎介, 福田 恵一

心電図 ((一社)日本不整脈心電学会)  30 ( Suppl.4 ) S - 4 2010.09

Other, Joint Work,  ISSN  0285-1660

Functional Characterization of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes

Shugo Tohyama, Mitsushige Murata, Fumiyuki Hattori, Tomofumi Tanaka, Hao Chen, Hiromi Yamashita, Yusuke Sato, Toru Egashira, Tomohisa Seki, Hisayuki Hashimoto, Yohei Ohno, Yuichi Tamura, Shinsuke Yuasa, Satoshi Ogawa, Keiichi Fukuda

CIRCULATION (LIPPINCOTT WILLIAMS & WILKINS)  120 ( 18 ) S723 - S723 2009.11

Research paper, summary (international conference), Joint Work,  ISSN  0009-7322

Molecular Characterization of Induced Pluripotent Stem (iPS) Cell-Derived Cardiomyocytes

Yohei Ohno, Shinsuke Yuasa, Toru Egashira, Tomohisa Seki, Hisayuki Hashimoto, Shugo Toyama, Sung Han Yoon, Takahide Arai, Chen Hao, Tomofumi Tanaka, Fumiyuki Hattori, Kojiro Yae, Mitsushige Murata, Satoshi Ogawa, Shinya Yamanaka, Keiichi Fukuda

CIRCULATION (LIPPINCOTT WILLIAMS & WILKINS)  120 ( 18 ) S765 - S765 2009.11

Research paper, summary (international conference), Joint Work,  ISSN  0009-7322

Generation of Induced Pluripotent Stem Cells in Healthy Volunteers and Patients With Hereditary Heart Disease

Toru Egashira, Shinsuke Yuasa, Yohei Ohno, Tomohisa Seki, Hisayuki Hashimoto, Shogo Toyama, Sung H. Yoon, Chen Hao, Tomofumi Tanaka, Fumiyuki Hattori, Kojiro Yae, Mitsushige Murata, Satoshi Ogawa, Keiichi Fukuda

CIRCULATION (LIPPINCOTT WILLIAMS & WILKINS)  120 ( 18 ) S619 - S619 2009.11

Research paper, summary (international conference), Joint Work,  ISSN  0009-7322