KEIO RESEARCHERS INFORMATION SYSTEM

Other Affiliation 【 Display / hide 】

Other Affiliation 【 Display / hide 】

• Keio Advanced Research Centers(KARC), Keio Advanced Research Centers(KARC)

Career 【 Display / hide 】

Career 【 Display / hide 】

• 1989.05

  -

  1990.04

  慶應義塾大学病院・研修医（外科学教室）

• 1990.05

  -

  1991.04

  東京都済生会中央病院・研修医（外科）

• 1991.05

  -

  1993.04

  慶應義塾大学医学部・助手（救急部）

• 1993.05

  -

  1995.04

  済生会神奈川県病院・神奈川県交通救急センター・医員（救急部）

• 1995.05

  -

  1998.04

  慶應義塾大学医学部・助手（救急部）

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1989.03

  Keio University, Faculty of Medicine

  University, Graduated

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• Doctor of Medical Science, Keio University, Dissertation, 2003.07

  外科的侵襲下における生体反応機構の研究

Licenses and Qualifications 【 Display / hide 】

Licenses and Qualifications 【 Display / hide 】

• 日本救急医学会　指導医, 2006.01

• 救急科専門医, 1994.01

• 社会医学系専門医協会　社会医学系指導医・専門医

• ICD (Infection Control Doctor)

• 日本外科感染症学会 外科周術期感染管理認定医・教育医

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Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Emergency medicine (Emergency Medicine)

• Life Science / Anesthesiology (Critical Care Medicine)

• Life Science / General surgery and pediatric surgery (Trauma)

• Life Science / Infectious disease medicine (Infection Control)

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Trauma

• Surgical stress

• Infection Control

• Burn

Research Themes 【 Display / hide 】

Research Themes 【 Display / hide 】

• Mechanism of bio-reaction under the surgical stress, 

  1995.05

  -

  Present

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Risk of Developing Lower Limb Ischemia in Patients With Extracorporeal Cardiopulmonary Resuscitation: A Secondary Analysis of the Study of Advanced Cardiac Life Support for Ventricular Fibrillation With Extracorporeal Circulation in Japan II (SAVE-J II) Study

  Matsumura K., Yamamoto R., Kaito D., Homma K., Inoue A., Hifumi T., Sakamoto T., Kuroda Y., Sasaki J.

  Critical Care Medicine 54 ( 3 ) 484 - 495 2026.03

  　View Summary

  OBJECTIVES: While potential risks for limb ischemia have been explored in studies of venoarterial extracorporeal membrane oxygenation (ECMO), they remain inadequately defined for patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR). We identified risk factors for the development of lower limb ischemia during ECPR using a large nationwide ECPR cohort. DESIGN: A post hoc analysis was conducted using a nationwide, multicenter, retrospective study (Study of Advanced Cardiac Life Support for Ventricular Fibrillation with Extracorporeal Circulation in Japan II [SAVE-J II]). SETTING: Thirty-six institutions from 2013 to 2018. PATIENTS: Adult patients who underwent ECPR for out-of-hospital cardiac arrest.None. MEASUREMENTS AND MAIN RESULTS: Lower limb ischemia was defined as the requirement for a therapeutic distal perfusion catheter (DPC), fasciotomy, or amputation. Risk factors for lower limb ischemia were assessed using multivariate logistic regression models that included patient characteristics, ECPR-related information, and resuscitation content as potential confounders. Of the 969 patients, 72 (7.4%) developed lower limb ischemia. No significant differences were observed regarding background characteristics, cannulation location, puncture method, or venoarterial ECMO catheter size between patients with and without limb ischemia. However, a prophylactic DPC was less frequently employed in patients with lower limb ischemia than in those without (4 [5.6%] vs. 219 [24.4%]; p < 0.001). Higher incidences of cannulation-related bleeding and cannula malposition were observed in patients with limb ischemia than in those in patients without limb ischemia (22 [30.6%] vs. 162 [18.1%]; p = 0.009 and 9 [12.5%] vs. 29 [3.2%]; p < 0.001, respectively). Multivariable analyses revealed that prophylactic DPC placement was associated with a lower risk of limb ischemia (0.20 [0.07-0.55]; p = 0.002), whereas cannulation-related bleeding and cannula malposition were linked to an increased risk of lower limb ischemia (1.83 [1.06-3.14]; p = 0.030 and 3.81 [1.68-8.64]; p = 0.001, respectively). CONCLUSIONS: Lower limb ischemia during ECPR would be anticipated in patients with cannulation-related complications, and prophylactic DPC placement may be considered to mitigate the risk of lower limb ischemia.

  • Access to Document (DOI)

• Hydrogen Molecule Delivery System to Ischemic Intestine Using Resuscitative Endovascular Balloon Occlusion of Aorta in Hemorrhagic Shock—A Proof-of-Concept Study

  Yamanaka T., Matsuoka T., Homma K., Tamura T., Suzuki S., Suzuki S., Kaito D., Yoshizawa J., Yajima K., Ono S., Maeshima K., Kobayashi E., Sano M., Sasaki J.

  Biomedicines 14 ( 2 )  2026.02

  　View Summary

  Background: The use of resuscitative endovascular balloon occlusion of the aorta (REBOA) for hemorrhagic shock in the torso has become increasingly common as a bridge to definitive hemostasis. Hydrogen molecules, distributed throughout the bloodstream, alleviate ischemic injury but cannot reach ischemic organs during REBOA use. This study investigates whether intra-aortic irrigation with hydrogen-dissolved saline under REBOA use delivers hydrogen to the intestine in a swine hemorrhagic shock model. Methods: We induced volume-regulated hemorrhagic shock in a 40 kg female swine. Following this, hydrogen-dissolved saline irrigation was initiated through an intra-aortic catheter positioned distal to the REBOA balloon. Hydrogen concentration in the portal vein was determined in four models: controlled hemorrhagic shock with full REBOA inflation during the standard occlusion time, uncontrolled hemorrhagic shock with liver injury and full REBOA inflation during the extended occlusion time, uncontrolled hemorrhagic shock with liver injury and partial REBOA inflation during the extended occlusion time, and as the control model, controlled hemorrhagic shock with full REBOA inflation during the standard occlusion time with normal saline irrigation without hydrogen. Results: Hydrogen concentration in the portal vein was found to be 0.224 mg/L (13.998%) in the controlled hemorrhagic shock model with full REBOA inflation, 0.049 mg/L (3.063%) in the uncontrolled hemorrhagic shock model with liver injury and full REBOA inflation, 0.018 mg/L (1.125%) in the uncontrolled hemorrhagic shock model with liver injury and partial REBOA inflation, and 0.002 mg/L (0.015%) in the control model. These results demonstrate the presence of hydrogen in the portal vein under different REBOA applications. Conclusions: Increased hydrogen concentration in the portal vein indicated that hydrogen was delivered to the intestine. These findings suggest an approach for drug administration during REBOA use. However, further investigations are required to establish its application in clinical settings.

  • Access to Document (DOI)

• Impact of prophylactic drain placement on intra-abdominal infections after gastrectomy: nationwide inpatient database study in Japan

  Kouzu K., Aso S., Hirano Y., Matsui H., Fushimi K., Kitagawa H., Kato T., Yamane N., Hagiwara O., Miyoshi N., Matsuda S., Maruyama H., Morikane K., Sasaki J., Yasunaga H., Kitagawa Y., Tsujimoto H.

  Gastric Cancer 29 ( 1 ) 230 - 237 2026.01

  ISSN  14363291

  　View Summary

  Objective: This study aimed to evaluate the impact of drain placement on the incidence of postoperative complications in patients undergoing gastrectomy. Background: The effectiveness of prophylactic abdominal drain placement in gastrectomy remains unclear. Nevertheless, they are still commonly used following gastrectomy. Methods: We conducted a retrospective cohort study using a nationwide inpatient database in Japan. Patients who underwent gastrectomy for gastric cancer between January 2014 and March 2022 were included. We applied overlap weighting based on propensity scores to adjust for baseline characteristics. The primary outcome was the incidence of intra-abdominal infections. Secondary outcomes included postoperative percutaneous drainage, in-hospital death, length of hospital stay, and total hospitalization costs. Results: A total of 217,750 patients met the inclusion criteria, and 196,660 (90.3%) received prophylactic abdominal drains. After overlap weighting, the drain group had a significantly lower incidence of intra-abdominal infections compared to the no-drain group (6.3% vs. 7.6%; 95% confidence interval [CI] − 1.7 to − 1.0). The prophylactic drains were also associated with reduced in-hospital postoperative mortality (0.6% vs. 0.8%; 95% CI − 0.3 to − 0.1). No significant differences were observed between the two groups in postoperative percutaneous drainage or hospital stay duration. Conclusion: This study suggests that prophylactic abdominal drainage was associated with a reduced incidence of intra-abdominal infections after gastrectomy without increasing hospitalization duration or medical costs.

  • Access to Document (DOI)

• The risks and benefits of disseminated intravascular coagulation-targeted anticoagulant therapy in abdominal sepsis

  Matsuoka T., Yamakawa K., Ushio N., Hisamune R., Homma K., Sasaki J.

  Thrombosis Research 257 2026.01

  ISSN  00493848

  　View Summary

  Background: Abdominal sepsis frequently leads to disseminated intravascular coagulation (DIC), exacerbating organ dysfunction and bleeding complications. Although anticoagulant therapy is a potential treatment for DIC, its use in this context raises concerns about bleeding risks. Objectives: The purpose of this study is to investigate the risks and benefits of DIC-targeted anticoagulant therapy in patients with abdominal sepsis. Methods: Data were analyzed from a dataset from a multicenter nationwide retrospective cohort study (J-Septic DIC registry) in Japan between 2011 and 2013. The study included 987 patients with abdominal sepsis-induced DIC, diagnosed within three days of ICU admission. Patients were divided into DIC-targeted anticoagulant therapy (recombinant thrombomodulin or antithrombin) and non-use groups. Propensity score matching was used to adjust for confounding factors. The primary outcome was all-cause 90-day mortality, with bleeding complications requiring blood transfusion as the primary safety outcome. Results: The results indicated that anticoagulant therapy was associated with improved survival (hazard ratio: 0.662, 95 % confidential interval: 0.472–0.929), but a higher risk of bleeding complications (OR: 2.451, 95 % confidential interval:1.372–4.379). Dual combination of anticoagulant therapy did not provide additional survival benefits and increased bleeding risks. The efficacy of DIC-targeted anticoagulant therapy correlated with disease severity, while bleeding risk was inversely correlated with severity. Conclusion: DIC-targeted anticoagulant therapy in patients with abdominal sepsis was related with improved prognosis but increased bleeding risks. The risk-benefit profile varies with disease severity, suggesting a need for cautious and personalized treatment strategies.

  • Access to Document (DOI)

• Effect of Broad-Spectrum Antibiotic Prophylaxis on Post-Pancreatoduodenectomy Infectious Complications: Nationwide Inpatient Database Study in Japan

  Kitagawa H., Aso S., Hirano Y., Uemura K., Kouzu K., Matsuda S., Matsui H., Fushimi K., Sasaki J., Kitagawa Y., Yasunaga H.

  Annals of Gastroenterological Surgery  2026

  　View Summary

  Background: Despite improvements in surgical techniques and perioperative management, the incidence of postoperative surgical site infection after pancreatoduodenectomy remains high. This study aim to assess whether broad-spectrum antibiotic prophylaxis can reduce complications after pancreatoduodenectomy compared with standard care antibiotics. Methods: Data of patients who underwent pancreatoduodenectomy between July 2010 and March 2022 were extracted from a nationwide Japanese inpatient database. First- and second-generation cephalosporins were designated as narrow-spectrum, and third- and fourth-generation cephalosporins and piperacillin–tazobactam as broad-spectrum antibiotics. Patients who received either narrow- or broad-spectrum antibiotics on the day of surgery were included in the analysis. Using propensity-score stabilized inverse probability of treatment weighting, the postoperative complications were compared between patients who received antimicrobial prophylaxis with narrow-spectrum antibiotics versus broad-spectrum antibiotics. Results: From among 45 099 eligible patients, 36 742 (81.5%) and 8357 (18.5%) patients received narrow- and broad-spectrum antibiotics, respectively. After stabilized inverse probability of treatment weighting, the use of broad-spectrum antibiotics bore a significant association with the reduction in intra-abdominal infections [risk difference (RD), −7.4; 95% confidence interval (CI), −8.7 to −6.0], postoperative pancreatic fistula (RD, −3.0; 95% CI, −4.0 to −1.9), post-pancreatectomy hemorrhage (RD, −1.5; 95% CI, −1.9 to −1.1). The use of broad-spectrum antibiotics was also associated with a shorter postoperative length of hospital stay and lower total hospitalization costs. The proportion of Clostridioides difficile infection did not differ between the groups. Conclusions: The administration of broad-spectrum antibiotics as antimicrobial prophylaxis was associated with better in-hospital postoperative outcomes compared with narrow-spectrum in patients undergoing pancreatoduodenectomy.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Elucidating the pathophysiology of post-cardiac arrest syndrome and developing novel therapies through omics analysis

  Sasaki, Junichi

  科学研究費補助金研究成果報告書 2023

• Clarification of the mechanism of acute kidney injury by administration of contrast media and pharmaceutical application

  Sasaki, Jun'ichi

  科学研究費補助金研究成果報告書 2020

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• A second update on mapping the human genetic architecture of COVID-19

  Kanai M., Andrews S.J., Cordioli M., Stevens C., Neale B.M., Daly M., Ganna A., Pathak G.A., Iwasaki A., Karjalainen J., Mehtonen J., Pirinen M., Chwialkowska K., Trankiem A., Balaconis M.K., Veerapen K., Wolford B.N., Ahmad H.F., von Hohenstaufen Puoti K.A., Boer C., Boua P.R., Butler-Laporte G., Cadilla C.L., Colombo F., Douillard V., Dueker N., Dutta A.K., El-Sherbiny Y.M., Eltoukhy M.M., Esmaeeli S., Faucon A., Fave M.J., Cadenas I.F., Francescatto M., Francioli L., Franke L., Fuentes M., Durán R.G., Cabrero D.G., Harry E.N., Jansen P., Szentpéteri J.L., Kaja E., Kirk C., Kousathanas A., Krieger J.E., Patel S.K., Lemaçon A., Limou S., Lió P., Marouli E., Marttila M.M., Medina-Gómez C., Michaeli Y., Migeotte I., Mondal S., Moreno-Estrada A., Moya L., Nakanishi T., Nasir J., Pasko D., Pearson N.M., Pereira A.C., Priest J., Prijatelj V., Prokic I., Teumer A., Várnai R., Romero-Gómez M., Roos C., Rosenfeld J., Ruolin L., Schulte E.C., Schurmann C., Sedaghati-khayat B., Shaheen D., Shivanathan I., Sipeky C., Sirui Z., Striano P., Tanigawa Y., Remesal A.U., Vadgama N., Vallerga C.L., van der Laan S., Verdugo R.A., Wang Q.S., Wei Z., Zainulabid U.A., Zárate R.N., Auton A., Shelton J.F., Shastri A.J., Weldon C.H., Filshtein-Sonmez T., Coker D., Symons A.

  Nature 621 ( 7977 ) E7 - E26 2023.09

  ISSN  00280836

  • Access to Document (DOI)

• Reply to Swinging the pendulum in prehospital trauma mortality needs a more holistic approach

  Yamamoto R., Suzuki M., Sasaki J.

  Journal of Trauma and Acute Care Surgery 91 ( 3 ) E81 - E82 2021.09

  ISSN  21630755

  • Access to Document (DOI)

• Reply to Methodological issues on developing a novel scale for prediction of delayed intubation in patients with inhalation injury

  Yamamoto R., Matsumura K., Sasaki J.

  Burns 47 ( 1 )  2021.02

  ISSN  03054179

  • Access to Document (DOI)

Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 心停止蘇生後患者のバイオバンクを機転とするリバーストランスレーショナル・リサーチ

  2024.04

  -

  2027.03

  基盤研究(B), Principal investigator

• オミクス解析から心停止症候群の病態を解明し新規治療法を開発する

  2021.04

  -

  2024.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

• 造影剤投与による急性腎障害の機序解明および医薬応用

  2018.04

  -

  2021.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• LECTURE SERIES, EMERGENCY MEDICINE

  2026

• EMERGENCY MEDICINE AND NURSING

  2026

• CLINICAL CLERKSHIP IN EMERGENCY MEDICINE

  2026

• EMERGENCY AND CRITICAL CARE MEDICINE: SEMINAR

  2026

• CLINICAL EXPERIENCE PROGRAM

  2026

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• 医療系三学部合同教育

  Keio University

  2015.04

  -

  2016.03

• 看護医療学部　救急医学・救急看護

  Keio University

  2015.04

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  2016.03

• Emergency medicine

  Keio University

  2015.04

  -

  2016.03

Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• Japanese Association of Acute Medicine

  　

Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2023.10

  -

  Present

  連携会員, 日本学術会議

• 2008.01

  -

  Present

  専門委員, 独立行政法人医薬品医療機器総合開発機構（PMDA）