和田　彩子 （ ワダ　アヤコ ）

Wada, Ayako

写真a

所属（所属キャンパス）

医学部 リハビリテーション医学教室 （ 信濃町 ）

職名

専任講師（有期）
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経歴 【 表示 ／ 非表示 】

  • 2007年04月
    -
    継続中

    慶應義塾大学医学部リハビリテーション医学教室

  • 2009年04月
    -
    継続中

    独立行政法人国立病院機構　東埼玉病院, リハビリテーション科

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学歴 【 表示 ／ 非表示 】

  • 1999年04月
    -
    2005年03月

    富山大学, 医学部

    大学, 卒業

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研究分野 【 表示 ／ 非表示 】

  • ライフサイエンス / 内科学一般 （リハビリテーション医学）

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研究テーマ 【 表示 ／ 非表示 】

  • リハビリテーション医学, 

    2007年04月
    -
    継続中

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論文 【 表示 ／ 非表示 】

  • Impact of early postoperative factors on changes in skeletal muscle mass after esophagectomy in older patients with esophageal cancer

    Harada T., Tatematsu N., Ueno J., Koishihara Y., Konishi N., Fukushima T., Fujiwara H., Fujita T., Hijikata N., Wada A., Ishikawa A., Tsuji T.

    European Geriatric Medicine 14 （ 1 ） 203 - 210 2023年02月

    ISSN  18787649

    　概要を見る

    Background: Loss of skeletal muscle mass, measured by the skeletal muscle mass index (SMI), after esophagectomy negatively impacts prognosis. However, the information to develop novel supportive care options for preventing loss of skeletal muscle mass is limited. The purpose of this retrospective cohort study was to investigate the impact of early postoperative factors on change in SMI 4 months after curative esophagectomy in older patients with esophageal cancer. Methods: This study included 113 subjects who underwent esophagectomy between 2015 and 2020. Preoperative and postoperative SMI (cm<sup>2</sup>/m<sup>2</sup>) were calculated from computed tomography images. The percentage change in SMI 4 months after surgery (SMI%) was calculated as follows: ([postoperative SMI – preoperative SMI] ÷ preoperative SMI) × 100. Potential factors affecting percentage change of SMI after surgery were analyzed by multiple regression. Results: The mean SMI% was – 5.6%. The percentage change (per 1%) in quadriceps muscle strength in the first month after surgery (standardized β = 0.190, p = 0.048) impacted the SMI%, which was independent of age, sex, preoperative SMI, comorbidity, pathological stage, and neoadjuvant chemotherapy. Conclusion: Quadriceps muscle weakness in the first month after esophagectomy impacted the SMI% in a dose-dependent relationship.

  • Preoperative maximum phonation time as a predictor of pneumonia in patients undergoing esophagectomy

    Ozawa H., Kawakubo H., Matsuda S., Mayanagi S., Takemura R., Irino T., Fukuda K., Nakamura R., Wada N., Ishikawa A., Wada A., Ando M., Tsuji T., Kitagawa Y.

    Surgery Today 52 （ 9 ） 1299 - 1306 2022年09月

    ISSN  09411291

    　概要を見る

    Purpose: Esophagectomy is a highly invasive procedure, associated with several postoperative complications including pneumonia, anastomotic leakage, and sepsis, which may result in multiorgan failure. Pneumonia is considered a major predictor of poor long-term prognosis, so its prevention is important for patients undergoing surgery for esophageal cancer. Methods: The subjects of this study were 137 patients who underwent esophagectomy at Keio University Hospital, Tokyo, Japan, between January, 2012 and December, 2016. Patients who underwent R0 or R1 resection or esophagectomy with organ excision were included. Patients who underwent salvage surgery or resection of recurrent laryngeal nerve, and those with preoperative recurrent laryngeal nerve palsy, were excluded. We investigated the effect of the maximum phonation time on the development of postoperative pneumonia. Results: Pneumonia developed more frequently in patients with a long operative time, clinically left recurrent nerve lymph node metastasis, and a short preoperative maximum phonation time (p = 0.074, 0.046, and 0.080, respectively). Pneumonia was also more common in men with an abnormal maximum phonation time (p = 0.010). Conclusions: The maximum phonation time is a significant predictor of postoperative pneumonia after esophagectomy in men.

  • Relationship Between Pneumonia and Dysphagia in Patients With Multiple System Atrophy

    Wada A., Kawakami M., Yamada Y., Kaji K., Hijikata N., Liu F., Otsuka T., Tsuji T.

    Frontiers in Neurology 13 2022年07月

    　概要を見る

    Introduction: Dysphagia is one of the most clinically significant disabilities in patients with multiple system atrophy (MSA), because it can cause aspiration pneumonia, which is potentially fatal. In this study, the Neuromuscular disease Swallowing Status Scale (NdSSS), which was developed to evaluate dysphagia in patients with neuromuscular diseases, was used to evaluate patients with MSA. In addition, correlation between a history of pneumonia and swallowing function was evaluated. Methods: Study 1: Reliability, concurrent validity, and responsiveness of the NdSSS in patients with MSA. In 81 patients for whom evaluation items could be collected, the NdSSS was tested for its interrater and intrarater reliability using weighted kappa statistics. Concurrent validity was assessed by correlating the NdSSS with existing scales (Functional Oral Intake Scale (FOIS), Functional Intake LEVEL Scale (FILS), and the unified MSA rating scale (UMSARS)) using Spearman's rank correlation coefficients. Sixty-three patients were evaluated by videofluorographic (VF) swallowing examination. To evaluate concurrent validity, Spearman's rank correlation coefficients were calculated between the NdSSS and VF swallowing assessments. Additionally, scale responsiveness was determined using the standardized response mean (SRM) in 23 patients who could be followed up to assess their long-term course. Study 2: Cross-sectional survey of swallowing function and history of pneumonia. Data regarding history of pneumonia, UMSARS, NdSSS, age, sex, MSA subtype, and disease duration were retrospectively obtained from the medical records of 113 patients with MSA. Differences in these parameters and NdSSS stage between those with and without a history of pneumonia were examined using the Mann-Whitney test or chi-squared test. Furthermore, clinical factors related to a history of pneumonia were examined by binomial logistic regression analysis. Results: The NdSSS showed satisfactory reliability, concurrent validity, and responsiveness. A history of pneumonia was related to the severity of MSA, age, MSA subtype, and NdSSS stage. Binomial logistic regression analysis showed that NdSSS stage (odds ratio (OR), 0.490; 95% confidence interval (CI), 0.301–0.797, p = 0.001) and MSA subtype (OR, 4.031; 95% CI, 1.225–13.269, p = 0.021) were significantly associated with a history of pneumonia. Conclusions: In patients with MSA, the NdSSS has sufficient reliability, concurrent validity, and responsiveness for assessing dysphagia. Patients with a history of pneumonia have more severe dysphagia. We found that the pneumonia risk was related to NdSSS stage and MSA-p (predominantly parkinsonism). Meticulous care to prevent aspiration is needed from early stages of the disease.

  • Rehabilitation in Acute COVID-19 Patients: A Japanese Retrospective, Observational, Multi-Institutional Survey

    Yamada Y., Kawakami M., Tashiro S., Omori M., Matsuura D., Abe R., Osada M., Tashima H., Shimomura T., Mori N., Wada A., Ishikawa A., Tsuji T.

    Archives of Physical Medicine and Rehabilitation 103 （ 5 ） 929 - 936 2022年05月

    ISSN  00039993

    　概要を見る

    Objective: : To investigate the changes in activities of daily living (ADLs) and the conditions of rehabilitation for acute COVID-19 patients in Japan. Design: : Retrospective, observational survey. Setting: : Four tertiary hospitals with intensive care units and one secondary hospital in Japan. Participants: : COVID-19 patients (N=478) admitted to 5 hospitals Interventions: : Not applicable. Main Outcome Measures: : Walking ability and swallowing status were assessed using the FIM locomotion item and Food Intake Scale at admission and discharge. The physiatrists of each hospital were also surveyed regarding the factors that influenced decisions to provide rehabilitation. Results: : Excluding patients who died, the proportion of critical patients who could walk independently at discharge was 63%, and the proportion of those who were able to take 3 meals orally at discharge was 90%. Rehabilitation was provided to 13.4% of all patients and to 58.3% of patients with critical symptoms. Conclusions: : After COVID-19 treatment, patients, especially those with critical symptoms, still have functional disabilities related to walking and swallowing. It is possible that sufficient rehabilitation could not be provided during the period studied.

  • Assessment of dysarthria with Frenchay dysarthria assessment (FDA-2) in patients with Duchenne muscular dystrophy

    Hijikata N., Kawakami M., Wada A., Ikezawa M., Kaji K., Chiba Y., Ito M., Fujino E., Otsuka T., Liu M.

    Disability and Rehabilitation （Disability and Rehabilitation）  2020年

    ISSN  09638288

    　概要を見る

    Purpose: The purpose of this study was to test the psychometric properties of the Japanese version of Frenchay Dysarthria Assessment (FDA-2) and to use this tool to describe the features of speech in patients with Duchenne muscular dystrophy (DMD). Materials and methods: The Japanese version of FDA-2 was culturally adapted, and reliability and validity were examined in 22 and 50 patients, respectively. The Japanese version of FDA-2 was administered to 51 patients with DMD. Multiple regression analysis was performed to identify factors related to FDA-2 scores. Results: Inter-/intra-rater reliabilities (ICCs) and internal consistency (Cronbach’s α) for total scores were 0.76, 0.97, and 0.94 respectively. For construct validity, two-way ANOVA showed a significant interaction between the disorders and FDA-2 sections (p < 0.05). In DMD patients, the item of tongue at rest was most severely affected, reflecting tongue hypertrophy. Multiple regression analysis identified age, swallowing status, and ventilator use as significantly related. Conclusions: The results showed that the Japanese version of FDA-2 has satisfactory reliability and validity. The present study demonstrated the features of dysarthria and related factors in patients with DMD.Implications for rehabilitation In Duchenne muscular dystrophy (DMD), an absent or defective dystrophin protein causes progressive weakness of respiratory and oropharyngeal muscles, both of which are crucial contributors to speech production. This study shows that the Japanese version of FDA-2 has satisfactory reliability and validity compared to original version. The Japanese version of FDA-2 characterizes dysarthria in patients with DMD in this cohort.

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競争的研究費の研究課題 【 表示 ／ 非表示 】

  • 5G時代に適う遠隔嚥下機能障害評価法の開発

    2023年04月
    -
    2026年03月

    和田 彩子, 若手研究, 補助金,  研究代表者

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