Riu, Meigen



School of Medicine (Mita)


Professor Emeritus

External Links


Books 【 Display / hide

  • 自信がもてる!リハビリテーション臨床実習―カード式評価集付 脳卒中ケースで臨場感を体験

    LIU MEIGEN, 医歯薬出版, 2015.03

  • リハビリテーション医学白書 2013年版「東日本大震災への対応」

    LIU MEIGEN, 医歯薬出版株式会社, 2013.07

  • リハビリテーション医学白書 2013年版「」リハビリテーション医学の現状と歩み

    LIU MEIGEN, 医歯薬出版株式会社, 2013.07

  • もう悩まない! 100症例から学ぶ リハビリテーション評価のコツ

    LIU MEIGEN, 全日本病院出版会, 2013

  • リハビリテーションレジデントマニュアル第3版

    LIU MEIGEN, 医学書院, 2010

    Scope: 呼吸器疾患

display all >>

Papers 【 Display / hide

  • Correlation between changes in functional connectivity in the dorsal attention network and the after-effects induced by prism adaptation in healthy humans: A dataset of resting-state fMRI and pointing after prism adaptation

    Tsujimoto K., Mizuno K., Nishida D., Tahara M., Yamada E., Shindo S., Watanabe Y., Kasuga S., Liu M.

    Data in Brief (Data in Brief)  22   583 - 589 2019.02

     View Summary

    © 2019 The Authors It has been reported that it is possible to observe transient changes in resting-state functional connectivity (FC) in the attention networks of healthy adults during treatment with prism adaptation. by using functional magnetic resonance imaging (fMRI) (see “Prism adaptation changes resting-state functional connectivity in the dorsal stream of visual attention networks in healthy adults: A fMRI study” (Tsujimoto et al., 2018) [1]. Recent neuroimaging and neurophysiological studies support the idea that prism adaptation (PA) affects the visual attention and sensorimotor networks, which include the parietal cortex and cerebellum. These data demonstrate the effect of PA on resting-state functional connectivity between the primary motor cortex and cerebellum. Additionally, it evaluates changes of resting-state FC before and after PA in healthy individuals using fMRI. Analyses focus on FC between the primary motor cortex and cerebellum, and the correlation between changes in FC and its after-effects following a single PA session. Here, we show data that demonstrate the change in resting-state FC between the primary motor cortex and cerebellum, as well as a correlation between the change ratio of FC and the amplitude of the after-effect.

  • Development of Rehabilitation System with Brain-Computer Interface for Subacute Stroke Patients

    Hashimoto Y., Kakui T., Ushiba J., Liu M., Kamada K., Ota T.

    Proceedings - 2018 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2018 (Proceedings - 2018 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2018)     51 - 56 2019.01

    ISSN  9781538666500

     View Summary

    © 2018 IEEE. There have been recent advances in brain-computer interfaces for post-stroke rehabilitation. In particular, compact and embedded brain-computer interface systems with neuromuscular electrical stimulation have been developed by industry and academia, and some of them can potentially be used at the bedside. However, limited studies have demonstrated their safety and feasibility for treatment in subacute stroke patients. The aim of this pilot study was to first develop a brain-computer interface system for subacute stroke inpatients that is usable at the bedside and to show the safety and feasibility using a small cohort of inpatients. Four hemiplegic stroke inpatients in the very early phase (7-24 days from stroke onset) participated in this study. The portable brain-computer interface system shows the amplitude of sensorimotor rhythms extracted from scalp electroencephalograms in real time. Patients attempted to extend the wrist on their affected side, and neuromuscular electrical stimulation was applied only when the brain-computer interface system detected significant movement intention-related electroencephalogram changes. Each brain-computer interface training lasted 40 minutes. On average, 120-200 training trials of the wrist extension task were successfully and safely conducted over 3.3 days (range 2-4 days) with the bedside brain-computer interface system. Furthermore, electroencephalogram results showed a new significant event-related desynchronization in the damaged hemisphere after training. These results clearly show the proposed bedside brain-computer interface system's safety and feasibility and also demonstrated electrophysiological plasticity in the damaged hemisphere in subacute patients with post-stroke hemiplegia. Larger clinical studies are needed to identify the brain-computer interface system's clinical efficacy and its effect size in the subacute post-stroke patient population.

  • Development of Shoulder Exoskeleton Toward BMI Triggered Rehabilitation Robot Therapy

    Ogura M., Furukawa J., Teramae T., Noda T., Okuyama K., Kawakami M., Liu M., Morimoto J.

    Proceedings - 2018 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2018 (Proceedings - 2018 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2018)     1105 - 1109 2019.01

    ISSN  9781538666500

     View Summary

    © 2018 IEEE. Since exoskeletons show potential for rehabilitation therapy, many scientists have been designing upper extremity exoskeletons. Unfortunately, few have successfully provided a shoulder exoskeleton for severe impairment. Toward Brain-Machine-Interface (BMI) rehabilitation robot therapies for severe upper extremity impairment, this paper introduces a shoulder exoskeleton robot with a modular joint and an off-board modular actuator. We applied a Modular Exoskeletal Joint (MEJ) to a shoulder exoskeleton that was driven by Pneumatic Artificial Muscles (PAMs) transmitted by a Bowden cable. Our objective is generating passive movements triggered by BMI. Since large torque has to be generated for assist a whole arm, we newly designed a more powerful Nested-cylinder PAMs (NcPAMs) than our previous work. As a proof of the concept of the mechatronics design, we show the tracking performance of the periodic trajectory of a joint angle with both human and mannequin arms as simulated impairments. Our result shows that the tracking error is sufficiently small in all of the conditions and that our developed shoulder exoskeleton is an adequate substitute for flexion/extension movements.

  • The Amelioration of Pain-Related Behavior in Mice with Chronic Spinal Cord Injury Treated with Neural Stem/Progenitor Cell Transplantation Combined with Treadmill Training

    Tashiro S., Nishimura S., Shinozaki M., Takano M., Konomi T., Tsuji O., Nagoshi N., Toyama Y., Liu M., Okano H., Nakamura M.

    Journal of Neurotrauma (Journal of Neurotrauma)  35 ( 21 ) 2561 - 2571 2018.11

    ISSN  08977151

     View Summary

    © Copyright 2018, Mary Ann Liebert, Inc., publishers 2018. Progress in regenerative medicine is realizing the possibility of neural regeneration and functional recovery in spinal cord injury (SCI). Recently, rehabilitation has attracted much attention with respect to the synergistic promotion of functional recovery in combination with neural stem/progenitor cell (NS/PC) transplantation, even in the chronic refractory phase of SCI. Nevertheless, sensory disturbance is one of the most prominent sequelae, even though the effects of combination or single therapies have been investigated mostly in the context of motor recovery. To determine how combination therapy with treadmill training (TMT) and NS/PC transplantation affects the manifestation of thermal allodynia and tactile hyperalgesia in chronic phase SCI, four groups of SCI mice were used to assess pain-related behavior and histological changes: combined transplantation and TMT therapy, transplantation only, TMT only, and control groups. Thermal allodynia and coarse touch-pressure hyperalgesia exhibited significant recovery in the combined therapy group in comparison with controls, whereas there were no significant differences with fine touch-pressure hyperalgesia and motor function. Further investigation revealed fewer fibers remaining in the posterior funiculus, which contained the tracts associated with the two modalities showing less recovery; that is, touch-pressure hyperalgesia and motor function. A significant correlation was only observed between these two modalities. Although no remarkable histological recovery was found within the lesion epicenter, changes indicating amelioration of pain were observed in the lumbar enlargement of the combination therapy group. Our results suggest that amelioration of thermal allodynia and tactile hyperalgesia can be brought about by the additive effect of NS/PC transplantation and TMT. The degree of recovery seems dependent on the distribution of damage.

  • Predictors for achieving oral intake in older patients with aspiration pneumonia: Videofluoroscopic evaluation of swallowing function

    Ito M., Kawakami M., Ohara E., Muraoka K., Liu M.

    Geriatrics and Gerontology International (Geriatrics and Gerontology International)  18 ( 10 ) 1469 - 1473 2018.10

    ISSN  14441586

     View Summary

    © 2018 Japan Geriatrics Society Aim: Pneumonia is a common disease that is often fatal, particularly in older persons. Dysphagia is known to be closely associated with aspiration pneumonia, and hospitalized patients with aspiration pneumonia often have difficulty with oral intake. However, the relationship between acquisition of oral intake and detailed swallowing data has not been explored. The purpose of the present study was to examine the predictors, including videofluoroscopic swallowing evaluation, for achieving oral intake in older patients with aspiration pneumonia. Methods: This study included older patients, aged ≥65 years, who were admitted to Kawasaki Municipal Hospital (Kawasaki, Japan) from April 2012 through March 2014 as a result of aspiration pneumonia. Factors likely related to oral intake, including swallowing, nutritional, metabolic, and functional status, pneumonia severity and comorbidities were extracted from the medical records. Multiple logistic regression analysis was carried out to identify independent predictors for acquisition of oral intake. Results: A total of 160 patients were assigned to either the “oral intake” group (n = 104) or the “non-oral intake” group (n = 56). Multiple regression analysis showed that a low penetration aspiration scale on videofluoroscopy using 3 mL of moderately thick liquid water with tilting 30–60°, high albumin values, short duration of non-oral intake and a high Food Intake Level Scale score before admission were significantly associated with achievement of oral intake. Conclusions: Aspiration on videofluoroscopy, swallowing status before admission, nutritional status and duration of non-oral intake are important factors for acquiring oral intake. These results might be helpful for the management of older patients with aspiration pneumonia. Geriatr Gerontol Int 2018; 18: 1469–1473.

display all >>

Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 【各地で進む災害リハビリテーション支援システム】 災害に備える 大規模災害リハビリテーション支援関連団体協議会(JRAT)の活動


    地域リハビリテーション 10   80 - 85 2015

    Article, review, commentary, editorial, etc. (scientific journal), Single Work

  • 可変重力環境における全身運動制御と等身大ヒト型ロボットを用いた検証


    バイオメカニズム学会誌 34   5 - 11 2010

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • Brain Machine Interfaceはリハビリテーションに何をもたらすか Brain Machine Interface研究の方向性とリハビリテーション


    The Japanese Journal of Rehabilitation Medicine 47   75 - 79 2010

    Article, review, commentary, editorial, etc. (scientific journal), Single Work

  • Development of rehabilitation medicine in Japan.


    JMAJ 52   259 - 262 2009

    Article, review, commentary, editorial, etc. (scientific journal)

  • 宇宙からみたリハビリテーション医学 宇宙飛行士のリハビリテーションの現状と未来

    LIU MEIGEN大島博(宇宙航空研究開発機構 宇宙医学生物学研究室), 向井千秋, 里宇明元

    The Japanese Journal of Rehabilitation Medicine 46   753 - 757 2009

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

display all >>

Presentations 【 Display / hide

  • Brain Machine Interface (BM)Iの臨床応用:脳卒中重度上肢麻痺の機能回復に向けて


    第40回日本脳卒中学会 (広島) , 


    Symposium, workshop panel (nominated)

  • リハビリテーションの立場から災害に備える「首都圏大規模災害に備えるー地域リハビリテーションの視点からー」


    第20回集団災害医学会総会 (東京) , 


    Symposium, workshop panel (nominated)

  • ブレイン・マシン・インターフェースが拓く脳卒中リハビリテーションの新たな可能性


    第44回大阪脳卒中臨床研究会 (大阪) , 


    Public lecture, seminar, tutorial, course, or other speech

  • BMIの臨床応用:脳卒中重度上肢麻痺の機能回復に向けて




    Symposium, workshop panel (nominated)

  • Altered spatial representation of event related desynchronization during finger and shoulder motor imagery

    LIU MEIGENKeita Hasegawa, Takashi Ono,Meigen Liu, Shoko Kasuga, Junichi Ushiba

    The 44th Annual Meeting of the Societyfor Neurocience, 


    Poster presentation

display all >>

Works 【 Display / hide

  • 学務委員会委員



  • EEP小委員会委員




Courses Taught 【 Display / hide











display all >>

Courses Previously Taught 【 Display / hide

  • Rehabilitation Medicine

    Keio University


    Autumn Semester, Lecture, Within own faculty, 2h, 100people

    rehabilitation medicine

Educational Activities and Special Notes 【 Display / hide

  • Frontline of neuroscience and rehabilitation


    , Development of Textbook and Teaching Material

     View Details

    Explain the up-to-date trend of neuroscience and the possibilities of its application to rehabilitation practice


Memberships in Academic Societies 【 Display / hide

  • Japanese Association of Rehabilitation Medicine,