Ishikawa, Aiko



School of Medicine, Department of Rehabilitation Medicine (Shinanomachi)


Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

External Links

Academic Degrees 【 Display / hide

  • 博士(医学), Keio University, Dissertation, 2019.02

    Factors affecting lower limb muscle strength and cardiopulmonary fitness after allogeneic hematopoietic stem cell transplantation

Licenses and Qualifications 【 Display / hide

  • 日本リハビリテーション医学会専門医, 2006.03

  • 日本リハビリテーション医学会指導責任者, 2011.06


Research Areas 【 Display / hide

  • Life Science / Orthopedics (リハビリテーション科学・福祉工学)

Research Keywords 【 Display / hide

  • rehabilitation


Books 【 Display / hide

  • がんのリハビリテーションQ&A

    Ishikawa Aiko, 中外医学社, 2015.06

    Scope: 化学療法・放射線療法の副作用とリスク管理. リハビリテーション処方上でのポイント・注意点など

  • みんなに役立つ 造血幹細胞移植の基礎と臨床 改訂版

    Ishikawa Aiko, 医薬ジャーナル社, 2012.08

    Scope: 移植前後のリハビリテーション

  • がんのリハビリテーションマニュアル. 周術期から緩和ケアまで

    Ishikawa Aiko, 医学書院, 2011.06

    Scope: 造血器腫瘍. 造血器腫瘍の特徴・治療・リハビリテーションの概要

  • チーム医療で行う造血幹細胞移植プラクティカルガイド

    Ishikawa Aiko, 南江堂, 2010.12

    Scope: チーム医療のサポートの実際. リハビリテーション.

  • 癌のリハビリテーション

    Ishikawa Aiko, 金原出版, 2006.03

    Scope: 造血器癌.リハビリテーションの要点(幹細胞移植後).

Papers 【 Display / hide

  • Association of preoperative sarcopenia with postoperative dysphagia in patients with thoracic esophageal cancer.

    Mayanagi S, Ishikawa A, Matsui K, Matsuda S, Irino T, Nakamura R, Fukuda K, Wada N, Kawakubo H, Hijikata N, Ando M, Tsuji T, Kitagawa Y

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus  2020.12

    ISSN  1120-8694

  • Successful Treatment with a Combination of Spinal Cord Stimulation and Physical Therapy for Complex Regional Pain Syndrome:A Case Report

    Shinohara Yuta, Ishikawa Aiko, Nishimura Daisuke, Kawakami Michiyuki, Kosugi Shizuko, Liu Meigen, Morisaki Hiroshi

    The Japanese Journal of Rehabilitation Medicine (The Japanese Association of Rehabilitation Medicine)  57 ( 6 ) 558 - 564 2020.06

    ISSN  1881-3526

     View Summary

    <p>Spinal cord stimulation (SCS) has been reported to be effective for complex regional pain syndrome (CRPS). This is a case report of a patient with CRPS who was successfully treated with a combination of temporary SCS lead placement and physical therapy. A 19-year-old man presented with severe pain for a few months since receiving plaster cast fixation as treatment for an ankle sprain injury at the previous hospital. At his first visit to our pain center, he could not walk without crutches because of severe pain accompanied by symptoms such as allodynia, decreased skin temperature, redness, edema, muscle weakness, and changes in the appearance of the affected area. The symptoms met the diagnostic criteria for CRPS. Temporary SCS lead placement was performed to alleviate the pain and peripheral circulatory disorder, along with physiotherapy to improve the flexibility and restore the normal appearance of the affected limb. The interdisciplinary treatment effectively improved our patient's leg edema and walking ability, which consequently led to pain relief.</p>

  • Malnutrition among elderly patients with severe aortic stenosis

    Fukui S, Kawakami M, Otaka Y, Ishikawa A, Muraoka K, Yashima F, Hayashida K, Liu M

    Aging Clinical and Experimental Research (Aging Clinical and Experimental Research)  32 ( 3 ) 373 - 379 2020.03

    Joint Work,  ISSN  15940667

     View Summary

    © 2019, Springer Nature Switzerland AG. Background: Most patients with aortic stenosis (AS) are elderly. To achieve favorable outcomes after interventional treatments, careful management including adequate nutritional support is required. However, there has been a lack of knowledge about the prevalence of malnutrition and factors related to it. Aims: To explore the prevalence of malnutrition and its related factors in patients with severe AS. Methods: This was a single-institution, cross-sectional study. A total of 300 consecutive older patients (mean age, 83.8 ± 0.5 years) with AS were prospectively enrolled. Nutritional status was evaluated with the Mini Nutritional Assessment-Short Form (MNA-SF). Cardiac, kidney, physical, cognitive functions, instrumental activities of daily living (IADL) as measured with the Frenchay Activities Index (FAI), medical history, and comorbidities were evaluated as potentially related factors. Multiple logistic regression analysis was performed to identify factors that were significantly associated with the MNA-SF. Results: The mean (SD) score of the MNA-SF was 10.9 (2.5). 34 patients (11.3%) and 127 patients (42.3%) met the criteria for malnutrition and at risk of malnutrition, respectively. On multiple logistic regression analysis, female sex (OR 3.455, 95% CI 1.045–11.42, P = 0.042), NYHA class (OR 3.625, 95% CI 1.627–8.074, P = 0.002), left ventricular ejection fraction (/10%) (OR 0.961, 95% CI 0.932–0.991, P = 0.010), and FAI score (/10 points) (OR 0.911, 95% CI 0.864–0.961, P < 0.001) were significantly related to malnutrition. Conclusions: The prevalence of malnutrition was high among older persons with severe AS, and female sex, poor cardiac function, and lower IADL were independently related to it.

  • Preoperative Instrumental Activities of Daily Living Predicts Survival After Transcatheter Aortic Valve Implantation

    Fukui Shogo, Kawakami Michiyuki, Otaka Yohei, Ishikawa Aiko, Yashima Fumiaki, Hayashida Kentaro, Oguma Yuko, Fukuda Keiichi, Liu Meigen

    Circulation Reports (一般社団法人 日本循環器学会)  2 ( 2 ) 83 - 88 2020

     View Summary

    <p><b><i>Background:</i></b>This aim of this study was to clarify prognosis after transcatheter aortic valve implantation (TAVI) in patients with aortic stenosis (AS) and to identify baseline factors associated with mortality.</p><p><b><i>Methods and Results:</i></b>We prospectively enrolled 257 consecutive elderly persons with AS who were referred to Keio University Hospital and who underwent assessment of cardiac, physical (walking speed), cognitive, and renal functions, nutritional status, activities of daily living (ADL), instrumental ADL (IADL) assessed with the Frenchay activities index (FAI), and comorbidities. The primary outcome was postoperative death. Differences in basic characteristics were compared between a group that survived for a median of 661 days (IQR, 0–1,289 days) after TAVI and a group that did not. Multivariate hazard ratios (HR) were calculated for independent factors selected in Cox proportional hazard models. Thirty-one individuals died during follow-up. Walking speed was significantly faster (0.87±0.25 vs. 0.70±0.24 m/s, P<0.001) and FAI was significantly higher (21.2±8.0 vs. 15.7±8.0, P=0.026) in the survival group compared with those who died. Multivariate HR for mortality according to walking speed was 0.05 (95% CI: 0.028–0.091) in model 1 and 0.04 (95% CI: 0.020–0.081) in model 2, and those for FAI were 0.94 (95% CI: 0.92–0.95) and 0.92 (95% CI: 0.90–0.92), respectively.</p><p><b><i>Conclusions:</i></b>Preoperative walking speed and IADL are crucial factors associated with prognosis after TAVI even after adjustment.</p>

  • Factors affecting lower limb muscle strength and cardiopulmonary fitness after allogeneic hematopoietic stem cell transplantation

    Ishikawa A., Otaka Y., Kamisako M., Suzuki T., Miyata C., Tsuji T., Matsumoto H., Kato J., Mori T., Okamoto S., Liu M.

    Supportive Care in Cancer (Supportive Care in Cancer)  27 ( 5 ) 1793 - 1800 2019.05

    ISSN  09414355

     View Summary

    © 2018, The Author(s). Purpose: The aim of this study is to clarify the factors affecting physical function after allogeneic hematopoietic stem cell transplantation (HSCT). Methods: We retrospectively analyzed 88 patients (median age, 44.5 years) who received allogeneic HSCT. Leg extension torque and peak oxygen consumption (VO 2 ) were evaluated before and after HSCT. Patient factors (age, sex, underlying diseases, hemoglobin, serum albumin, and Karnofsky performance status score before transplant) and transplant factors (conditioning regimen, days to neutrophil engraftment, grades of acute graft-versus-host disease [GVHD], infections, and the interval between pre- and post-evaluation) were collected via chart review, and were used for correlational and comparison analyses in order to identify the variables associated with reduced post-HSCT leg extension torque and peak VO 2 . Stepwise multiple regression analyses for post-HSCT leg extension torque and post-HSCT peak VO 2 were performed using age, sex, and the related variables with a p value < 0.2 in the correlational and comparison analyses. Results: Leg extension torque and peak VO 2 were significantly reduced after HSCT (p < 0.001). Pre-HSCT leg extension torque, grades of acute GVHD, age, and the interval between pre- and post-evaluation were identified as significant factors associated with reduced post-HSCT leg extension torque. However, none of these factors were significantly associated with reduced post-HSCT peak VO 2 , and only its pre-transplant value was identified as a significant factor. Conclusions: These findings suggest that improvements in muscle strength and cardiopulmonary fitness before HSCT are crucial for maintaining post-treatment physical function, especially in elderly individuals with acute GVHD requiring a long-term stay in a protective environment.

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Reviews, Commentaries, etc. 【 Display / hide

  • 認知症患者に生じた骨髄炎を伴う褥瘡への包括的介入

    野崎 祥子, 岡部 圭介, 石川 愛子, 相良 麻由, 秋山 結実子, 大木 いづみ, 山上 淳

    日本褥瘡学会誌 ((一社)日本褥瘡学会)  22 ( 3 ) 282 - 282 2020.08

    ISSN  1345-0417

  • 退院時に経管栄養または嚥下調整食を必要とした食道癌根治術後患者の後方視的分析

    宮崎 裕大, 石川 愛子, 安藤 牧子, 長田 麻衣子, 大森 まいこ, 村岡 香織, 辻 哲也, 里宇 明元

    The Japanese Journal of Rehabilitation Medicine ((公社)日本リハビリテーション医学会)  57 ( 特別号 ) 3 - 15 2020.07

    ISSN  1881-3526

  • 食道癌根治術後のpeak expiratory flow(PEF)に影響する因子の検討

    石川 愛子, 宮崎 裕大, 土方 奈奈子, 安藤 牧子, 長田 麻衣子, 大森 まいこ, 村岡 香織, 辻 哲也, 里宇 明元

    The Japanese Journal of Rehabilitation Medicine ((公社)日本リハビリテーション医学会)  57 ( 特別号 ) 3 - 15 2020.07

    ISSN  1881-3526

  • 食道がんのリハビリテーション診療エビデンス&プラクティス 食道がん術後の発声障害、嚥下障害の診断とリハビリテーション治療の実際

    石川 愛子

    The Japanese Journal of Rehabilitation Medicine ((公社)日本リハビリテーション医学会)  57 ( 特別号 ) S209 - S209 2020.07

    ISSN  1881-3526

  • 重度の血圧調節障害を含む多様な脳幹症状を呈した脳幹部腫瘍術後患者の急性期リハビリテーション治療の1例

    南雲 美里, 田代 祥一, 石川 愛子, 土方 奈奈子, 南 朝香, 十見 恭平, 辻 哲也, 里宇 明元

    The Japanese Journal of Rehabilitation Medicine ((公社)日本リハビリテーション医学会)  57 ( 特別号 ) 1 - 13 2020.07

    ISSN  1881-3526

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Presentations 【 Display / hide

  • 食道癌根治術後患者の最長発声持続時間(MPT)、反回神経麻痺と嚥下障害の関係

    Ishikawa Aiko

    第52回日本リハビリテーション医学会学術集会 (新潟) , 


    Oral presentation (general)

  • 食道癌根治術後患者の最長発声持続時間(MPT)と反回神経麻痺の関係

    Ishikawa Aiko

    第52回日本リハビリテーション医学会学術集会 (新潟) , 


    Oral presentation (general)

  • 同種造血幹細胞移植患者のフィジカルフィットネスの構造分析

    Ishikawa Aiko



    Poster presentation

  • 同種造血幹細胞移植患者の身体活動量計測からの知見

    Ishikawa Aiko

    第50回日本リハビリテーション医学会学術集会 (東京) , 


    Oral presentation (general)

  • 断端部皮膚潰瘍より皮下気腫を呈した下腿切断の1症例

    Ishikawa Aiko

    第49回日本リハビリテーション医学会学術集会 (福岡) , 


    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Research on the efficacy and treatment strategies of repetitive peripheral magnetic stimulation for chronic low back pain


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 若手研究, Principal investigator

  • 骨髄移植患者のフィジカルフィットネスの構造分析とリハビリテーションに関する研究


    文部科学省/日本学術振興会, 科学研究費助成事業, Ishikawa Aiko, Tsuji Tetsuya, 基盤研究(C), Research grant, Principal investigator

  • リンパ浮腫に対する圧迫療法の効果と生理学的機序に関する研究


    文部科学省/日本学術振興会, 科学研究費助成事業, 基盤研究(C), Research grant, Coinvestigator(s)