Yamada, Yuka



School of Medicine, Department of Dentistry and Oral Surgery (Shinanomachi)



Academic Degrees 【 Display / hide

  • 博士(医学), Keio University, Coursework, 2019.02


Books 【 Display / hide

  • 口腔乾燥症がみられる要介護者の口腔ケアマニュアル


    Scope: 第4章口腔乾燥への対処法 5味覚刺激,第5章口腔ケアに用いる便利な物品とその使い方 1保湿剤 2含嗽剤 3保湿スプレー 4唾液腺マッサージ

Papers 【 Display / hide

  • Remarkable response of diffuse sclerosing osteomyelitis of the mandible to zoledronate by single infusion without prior treatment of other bisphosphonates

    Yamada M., Iwata S., Nishi K., Ochiai S., Araki D., Soma T., Yamada Y., Miyashita H., Suga K., Asoda S.

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology (Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology)  34 ( 6 ) 777 - 783 2022

    ISSN  22125558

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    Diffuse sclerosing osteomyelitis of the mandible (DSOM) is a nonsuppurative osteomyelitis mainly characterized by recurrent local mandibular swelling and pain. Because of the unknown pathophysiological mechanism underlying DSOM, treatment can be challenging. Reported treatment options include long-term analgesic medication, non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, corticosteroids, hyperbaric oxygen, and surgical treatment. However, these treatments cannot reliably lead to a long-lasting reduction of complaints. Recently, bisphosphonates has been reported effective in managing DSOM. We herein report a case of DSOM with a favorable response to a single infusion of zoledronate without prior treatment of other bisphosphonates. The patient was a 19-year-old woman who visited our hospital complaining of swelling and remarkable spontaneous pain in the right mandibular angle region. Under the diagnosis of osteomyelitis of the mandible, the clinical symptoms were improved by administering an antimicrobial agent and anti-inflammatory analgesic, but computed tomography (CT) showed exacerbation of bone resorption. A biopsy showed fibrosis between the bone tissue and trabeculae, a finding consistent with post-inflammatory changes. 99mTc scintigraphy showed an abnormal accumulation in the right mandibular ramus. Based on these results, she was diagnosed with DSOM. As a result of discussing with the physician in charge of internal medicine, it became the policy of the bisphosphonates and the intravenous administration of zoledronate 4 mg was enforced. Her bone sclerosis and bone resorption showed an improving trend on CT three months after the zoledronate administration, and there have been no symptoms or exacerbation of findings in three years since the administration.

  • Clinical value of entire-circumferential intraoperative frozen section analysis for the complete resection of superficial squamous cell carcinoma of the tongue

    Asoda S., Miyashita H., Soma T., Munakata K., Yamada Y., Yasui Y., Kudo Y., Usuda S., Hasegawa T., Nakagawa T., Kawana H.

    Oral Oncology (Oral Oncology)  123 2021.12

    ISSN  13688375

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    Objectives: We aimed to evaluate the clinical value of an entire-circumferential intraoperative frozen section analysis (e-IFSA) for the complete resection of superficial squamous cell carcinoma (SCC) of the tongue. Materials and Methods: A total 276 specimens from 51 patients with pT1-2, N0, mucosal or submucosal invasion SCC were analyzed to evaluate the diagnostic accuracy of the e-IFSA and the added value of the e-IFSA to iodine staining. The e-IFSA results were compared with the final histologic results obtained using permanent sections. All specimens for the e-IFSA were taken over the entire circumference 5 mm outside from the iodine unstained areas. The outline of the main resected specimen after taking these outer mucosal specimens were defined as the surgical margins determined by iodine staining alone. Results: The e-IFSA results were in excellent agreement with final histological results (Cohen's kappa value: 0.85) and the e-IFSA showed high sensitivity (100%) and high negative predictive value (100%). The actual complete resection rate with an e-IFSA was 100% (51/51), and no patient required additional resection after surgery. In contrast, 10/51 patients (20%) patients showed residual atypical mucosal epithelium at or beyond the margin determined by iodine staining alone; this difference was statistically significant (P = 0.002). The 5-year local control rate and 5-year overall survival rate after this procedure were both 100%. Conclusion: An e-IFSA has additional value when performed in conjunction with iodine staining. An e-IFSA would be useful for achieving complete resection of superficial SCC of the tongue.

  • Giant peripheral ossifying fibroma with coincidental squamous cell carcinoma: a case report

    Karube T., Munakata K., Yamada Y., Yasui Y., Yajima S., Horie N., Kawana H., Mikami S., Nakagawa T., Asoda S.

    Journal of Medical Case Reports (Journal of Medical Case Reports)  15 ( 1 )  2021.12

     View Summary

    Background: Peripheral ossifying fibroma is an inflammatory or reactive hyperplasia of the gingiva that is usually small. It is formed by hard tissue in fibrous tissue, and the name “neoplastic lesion” has tended to be used frequently in Europe and America. Clinically, peripheral ossifying fibromas are painless, solitary, exophytic, sessile, or pedunculated and more frequently found in females than in males. To the best of our knowledge, there have been no reports of malignant cases. We herein report the case of giant peripheral ossifying fibroma with squamous cell carcinoma. Case presentation: The patient was an 83-year-old Japanese woman who visited our hospital with a gingival massive mass. She was referred to us for an examination and treatment because it was difficult to perform tracheal intubation for surgery of sigmoid colon cancer at another hospital. The mass measured 83 × 58 × 35 mm, and it protruded to the extra-oral region from the right maxillary premolar alveolar region. Panoramic X-ray revealed the shadow of the mass in the right maxillary premolar region, which included some hard tissue. Computed tomography showed scattering calcified images in the mass. Magnetic resonance imaging was not performed because she had vertebral artery clips and screws in her forehead. Given the above findings, we performed a biopsy under local anesthesia. However, we were unable to diagnose absolutely whether the dysplastic squamous epithelia were pseudocarcinomatous hyperplasia of the gingiva or well-differentiated squamous cell carcinoma. Therefore, tumor resection was performed under general anesthesia. The histopathological diagnosis was peripheral ossifying fibroma with coincidental squamous cell carcinoma. There have been no signs of recurrence during follow-up as of 2 years after surgery. Conclusions: The etiology of giant peripheral ossifying fibroma with squamous cell carcinoma is still not definite. Therefore, careful observation is necessary. It needs to be examined by accumulation of more cases in the future. We herein report the case of giant peripheral ossifying fibroma coincidental squamous cell carcinoma.

  • Oral hamartoma with an advanced elevation of the tongue

    Yamada Y., Okita H., Nakagawa T., Asoda S.

    BMJ case reports (BMJ case reports)  14 ( 10 )  2021.10

  • Prospective feasibility study of indigo naturalis ointment for chemotherapy-induced oral mucositis

    Kenro Hirata, Yuka Yamada, Yasuo Hamamoto, Kazuyuki Tsunoda, Hiroshi Muramatsu, Sara Horie, Yasutaka Sukawa, Makoto Naganuma, Taneaki Nakagawa, Takanori Kanai

    BMJ Supportive & Palliative Care (BMJ Supportive and Palliative Care)   2021

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  2045435X

     View Summary

    Objectives: Indigo naturalis, a herbal medicine effective against ulcerative colitis, exhibits anti-inflammatory effects and induces interleukin-22-mediated antimicrobial peptide production. Anti-inflammatory activity and the prevention of secondary infection are essential for the management of chemotherapy-induced oral mucositis (CIOM); therefore, we developed an indigo naturalis ointment to be administered topically for CIOM and evaluated its feasibility. Methods: We performed a single-centre, open-label, prospective feasibility study from March 2017 to December 2018. The key eligibility criteria for the subjects were as follows: (1) receiving chemotherapy for a malignant tumour; (2) grade 1 or 2 CIOM and (3) receiving continuous oral care. The treatment protocol comprised topical indigo naturalis ointment application three times a day for 7 days. The primary endpoint assessed was feasibility. The secondary endpoints assessed were the changes in oral findings, oral cavity pain and safety. Results: Nineteen patients with CIOM were enrolled. The average feasibility (the proportion of prescribed applications that were carried out) observed in this study was 94.7%±8.9% (95% CI 90.5% to 99.0%), which was higher than the expected feasibility. The revised oral assessment guide scores of the mucous membrane domain and total scores were significantly improved. All patients reported a reduction in oral cavity pain, with a median pain resolution duration of 6 days. No serious adverse events were observed. Conclusions: The indigo naturalis ointment was feasible, and showed the potential for efficacy and safety. Larger randomised controlled trials are needed to further assess the efficacy and safety of indigo naturalis compared with a placebo. Trial registration number: UMIN000024271.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 義歯不適合の影響・義歯装着と清掃・禁食中の内科医が知っておくべき口腔衛生


    診断と治療 106 ( 10 ) 1241 - 1243 2018.10

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

  • 慶應義塾大学病院におけるNST活動

    YAMADA Yuka

    日本臨床栄養学会雑誌 40 ( 2 ) 114 - 117 2018.07

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • 【よくわかる歯科小手術の基本 抜歯から歯周外科まで】 歯科小手術 実践編 口腔外科 外傷

    YAMADA Yuka

    DENTAL DIAMOND 41 ( 14 ) 74 - 77 2016.10

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

Presentations 【 Display / hide

  • 口腔乾燥症シンポジウムの口腔乾燥症への対処法1 主に唾液腺マッサージの効果について



    Symposium, workshop panel (nominated)

  • 悪性骨・軟部腫瘍の化学療法における口腔外科医による口腔管理



    Oral presentation (general)

  • 悪性骨軟部腫瘍の化学療法における口腔関連有害事象の検討



    Oral presentation (general)

  • 口腔がん患者家族支援:がんの親を持つ子供のサポートプログラムCLIMB®


    Oral presentation (general)

  • Oral-related adverse events during the neutropenia resulting the chemotherapy for malignant musculoskeletal tumor

    第57 回日本癌治療学会学術集会, 


    Poster presentation

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