Details of a Researcher - Tsunoda, Kazuyuki

Papers - Tsunoda, Kazuyuki

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自己免疫性水疱症による粘膜病変

角田和之

(全日本病院出版会) 304 69 - 75 2021.01

ISSN 978-4-86519-636-8

一般的な口腔粘膜疾患を知ろう

角田和之

(デンタルダイヤモンド社) 46 103 - 106 2021

Value of labial salivary gland histopathology for diagnosis of Sjögren's syndrome in patients with anti-centromere antibody positivity

Tsukamoto, Masako Suzuki, Katsuya Tsunoda, Kazuyuki Ikeura, Kazuhiro Kameyama, Kaori Takeuchi, Tsutomu

International Journal of Rheumatic Diseases 23 1024 - 1029 2020

Research paper (scientific journal), Joint Work, Accepted

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Takeshita, M. Suzuki, K. Kaneda, Y. Yamane, H. Ikeura, K. Sato, H. Kato, S. Tsunoda, K. Arase, H. Takeuchi, T.

Antigen-driven selection of antibodies against SSA, SSB and the centromere 'complex', including a novel antigen, MIS12 complex, in human salivary glands

Annals of the Rheumatic Diseases 79 ( 1 ) 150 - 158 2020

Research paper (scientific journal), Joint Work, Accepted

Anti-centromere antibodies target centromere–kinetochore macrocomplex: a comprehensive autoantigen profiling

ajio, Nobuhiko Takeshita, Masaru Suzuki, Katsuya Kaneda, Yukari Yamane, Humitsugu Ikeura, Kazuhiro Sato, Hidekazu Kato, Shin Shimizu, Hiroyuki Tsunoda, Kazuyuki Takeuchi, Tsutomu

Annals of the Rheumatic Diseases 80 ( 5 ) 651 - 659 2020

Research paper (scientific journal), Accepted

口腔症状から診断に至った腸管Behcet病の1例

小池将人, 池浦一裕, 藤田康平, 清水博之, 加藤伸, 宮下英高, 中川種昭, 角田和之

日本口腔内科学会雑誌 ((一社)日本口腔内科学会) 25 ( 1 ) 25 - 30 2019.06

ISSN 2186-6147

Behcet病は多彩な症状を呈する原因不明の炎症性疾患で、腸管Behcet病は稀な病型である。今回われわれは長期経過を辿り診断に苦慮した腸管Behcet病を経験した。56歳女性で、10年前より再発性口腔内アフタ、発熱、皮膚紅斑、腹痛が散発的に生じるも診断に至らず、今回症状が同時に発症し、内視鏡検査にて腸管Behcetと診断された。再発性口腔内アフタを診断する際には、病歴や全身症状の把握が重要になる。(著者抄録)

口腔粘膜疾患から金属アレルギーを考える　-基礎と臨床-

角田和之

神歯会報 14 10 - 17 2019

口内炎が治らない

角田和之

(クインテッセンス出版) 2019

ISSN 7812-0723

顎関節部に発生した結節性偽痛風の1例

福田諒, 高森康次, 臼田聡, 道端彩, 池田浩子, 金生茉莉, 宮下英高, 角田和之, 河奈裕正,

日本口腔内科学会雑誌 25 ( 2 ) 37 - 43 2019

Research paper (scientific journal), Joint Work, Accepted

頬粘膜に発症したメトトレキサート関連リンパ増殖性疾患の1例

清水博之, 石井秀太郎, 佐藤英和, 古澤春佳, 加藤伸, 中川種昭, 角田和之,

日本口腔内科学会雑誌 25 ( 2 ) 44 - 50 2019

Research paper (scientific journal), Joint Work, Accepted

誤嚥性肺炎の予防

角田和之 and 池浦一裕

(中外医学社) 37 598 - 602 2019

食事の際に歯ぐきが痛い、歯ぐきがぶよぶよする

角田和之

(クインテッセンス出版) 2019

Laugier-Hunziker-Baran症候群の1例

金生茉莉, 藤田康平, 池浦一裕, 加藤伸, 小高利絵, 高森康次, 中川種昭, 角田和之

日本口腔内科学会雑誌 ((一社)日本口腔内科学会) 24 ( 2 ) 41 - 45 2018.12

ISSN 2186-6147

Laugier-Hunziker-Baran症候群(LHB)は、口腔、指趾の色素沈着と爪甲色素線条を特徴とし、全身症状を伴わない後天性疾患である。今回、経過観察中に症状推移の観察が可能であったLHB症候群の1例を経験した。71歳女性で初診時、下唇、頬粘膜に黒褐色色素斑があった。4年経過時に粘膜色素斑の増悪と指趾、爪甲色素線条が発生した。全身検索の結果LHBの診断となった。口腔粘膜色素斑の診断には全身疾患の精査と慎重な経過観察が重要である。(著者抄録)

Treatment of severe generalized chronic periodontitis in a patient with Behçet’s disease: A case report

Morikawa S., Ouchi T., Asoda S., Horie N., Tsunoda K., Kawana H., Nakagawa T.

Journal of International Medical Research (Journal of International Medical Research) 46 ( 5 ) 2037 - 2045 2018.05

ISSN 03000605

© 2018, © The Author(s) 2018. Behçet’s disease is a systemic disorder of unknown etiology. It involves multiple organ systems and is characterized by recurring episodes of oral ulcers as well as ocular, genital, and skin lesions. Oral ulcers can affect tooth brushing and impair proper oral hygiene. As a result, a dental biofilm accumulates, and the condition of the teeth and periodontal tissue deteriorates. The aim of this case report is to highlight the efficacy of periodontal treatment for patients with Behçet’s disease. A 51-year-old man with Behçet’s disease presented with generalized severe periodontitis. After basic treatment of the periodontal tissues, periodontal surgery was performed at several sites with bony defects. However, the patient developed severe stomatitis in the oral mucosa and gingiva after periodontal surgery. Administration of the antimicrobial agent cefdinir had little effect on recovery; however, subsequent administration of sitafloxacin resulted in significant improvement of the stomatitis. This case demonstrates that periodontal therapy is very useful for alleviating the oral signs and symptoms of Behçet’s disease. Systemic antibiotic treatment with sitafloxacin (but not cefdinir) and mechanical debridement were effective in preventing the recurrence of aphthous ulcer outbreaks after periodontal surgery.

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嚥下障害患者における口腔ケアの意義・内科医が知っておくべき口腔保清

角田和之 and 池浦一裕

(診断と治療社) 106 1235 - 1240 2018

教えて歯医者さん　Q and A

角田和之

(クインテッセンス出版) 4 50 - 51 2018

歯肉腫脹を初発症状としたクローン病の1例

角田和之, 佐藤英和, 石井秀太郎, 小澤夏生, 角田博之 and 中川種昭

日本口腔内科学会雑誌 ((一社)日本口腔内科学会) 23 ( 2 ) 84 - 89 2017.12

ISSN 2186-6147

クローン病は慢性の肉芽腫性炎症性疾患で、口腔に症状を伴うことがある。今回われわれは、歯肉腫脹が初発したクローン病を経験した。63歳女性で、歯肉腫脹を主訴に紹介受診した。経過中にアフタ性潰瘍、結節性紅斑が出現するもベーチェット病は否定された。その後、腹痛、下痢と体重減少があり、内視鏡検査にてクローン病と診断された。クローン病では口腔症状が先行することもあるため、口腔の腫脹、潰瘍病変の鑑別疾患として重要である。(著者抄録)

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjogren's syndrome

Tasaki, S., Suzuki, K., Nishikawa, A., Kassai, Y., Takiguchi, M., Kurisu, R., Okuzono, Y., Miyazaki, T., Takeshita, M., Yoshimoto, K., Yasuoka, H., Yamaoka, K., Ikeura, K., Tsunoda, K., Morita, R., Yoshimura, A., Toyoshiba, H. and Takeuchi, T.

Ann Rheum Dis 76 ( 8 ) 1458 - 1466 2017.08

ISSN 1468-2060

OBJECTIVES: Multiomics study was conducted to elucidate the crucial molecular mechanisms of primary Sjogren's syndrome (SS) pathology. METHODS: We generated multiple data set from well-defined patients with SS, which includes whole-blood transcriptomes, serum proteomes and peripheral immunophenotyping. Based on our newly generated data, we performed an extensive bioinformatic investigation. RESULTS: Our integrative analysis identified SS gene signatures (SGS) dysregulated in widespread omics layers, including epigenomes, mRNAs and proteins. SGS predominantly involved the interferon signature and ADAMs substrates. Besides, SGS was significantly overlapped with SS-causing genes indicated by a genome-wide association study and expression trait loci analyses. Combining the molecular signatures with immunophenotypic profiles revealed that cytotoxic CD8 -T cells- were associated with SGS. Further, we observed the activation of SGS in cytotoxic CD8 T cells isolated from patients with SS. CONCLUSIONS: Our multiomics investigation identified gene signatures deeply associated with SS pathology and showed the involvement of cytotoxic CD8 T cells. These integrative relations across multiple layers will facilitate our understanding of SS at the system level.

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Successful treatment with bendamustine and rituximab for paraneoplastic pemphigus

Kikuchi, T., Mori, T., Shimizu, T., Koda, Y., Abe, R., Kurihara, Y., Funakoshi, T., Yamagami, J., Sato, H., Tsunoda, K., Amagai, M. and Okamoto, S.

Ann Hematol 96 ( 7 ) 1221 - 1222 2017.07

ISSN 0939-5555

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The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report

Morita, M., Asoda, S., Tsunoda, K., Soma, T., Nakagawa, T., Shirakawa, M., Shoji, H., Yagishita, H., Nishikawa, T. and Kawana, H.

Odontology 105 ( 2 ) 262 - 266 2017.04

ISSN 1618-1255

Oral lichen planus is a chronic inflammatory mucocutaneous disease. Topical use of steroids and other immuno-modulating therapies have been tried for this intractable condition. Nowadays, tacrolimus ointment is used more commonly as a choice for treatment. However, a number of discussions have taken place after tacrolimus was reported to be carcinogenic. This report describes a patient who applied tacrolimus ointment to the lower lip after being diagnosed with oral lichen planus in 2008, and whose lesion developed squamous cell carcinoma in 2010. Since the relationship between tacrolimus and cancer development has been reported in only a few cases, including this case report, the clinician must be careful selecting tacrolimus as a second-line treatment for oral lichen planus.

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