論文 - 莇生田　整治

Jaw claudication is the only clinical predictor for GCA

Sato H, Inoue M, Muraoka W, Kamatani T, Asoda S, Kawana H, Nakagawa T, Wajima K

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology （J Oral Maxillofac Surg Med Pathol）  29 （ 3 ） 264 - 269 2017年

研究論文（学術雑誌）, 共著, 査読有り

12脳神経検査により早期診断された占拠性病変による有痛性三叉神経ニューロパチー

西須大徳, 村岡渡, 牧野泉, 遠藤友樹, 臼田頌, 佐藤仁, 池田浩子, 莇生田整治, 河奈裕正, 中川種昭, 西原真理, 和嶋浩一, 牛田享宏

日本口腔顔面痛学会雑誌 10 （ 1 ） 31 - 36 2017年

研究論文（学術雑誌）, 共著, 査読有り

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保険導入された「広範囲顎骨支持型埋入手術」，「広範囲顎骨支持型補綴」に関する全国アンケート集計

莇生田整治, 河奈裕正, 川本義明, 外木守雄, 朝波惣一郎

日本顎顔面インプラント学会雑誌 15 （ 4 ） 265 - 273 2016年12月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1347-894X

Primary cutaneous adenoid cystic carcinomaの1例

福田理紗, 臼田慎, 莇生田整治, 舩越建

日本臨床皮膚科医学会 （日臨皮会誌）  33 （ 3 ） 389 - 393 2016年07月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1349-7758

　概要を見る

要旨：66歳男． 5 年程前から左前頭部に腫瘤を自覚していた．2013年より，右舌癌化学療法後のPET-CTにて左前頭部皮下にfluorodeoxyglucose（以下，FDG）の軽度取り込みを認めており，2015年 5 月のPET-CTにてstandardized uptake valueの上昇を認めた．皮膚生検施行されたが，組織型が舌癌の扁平上皮癌とは異なるため，皮膚原発の腫瘍として当科に紹介された．病理組織学的に真皮から皮下組織，帽状腱膜にかけて好塩基性の腫瘍細胞が大小の管腔構造，篩状構造の集簇を形成しており，神経周囲への浸潤を認めた．以上の所見より，primary cutaneous adenoid cystic carcinomaと診断した．術後 5 か月経過し，再発所見を認めていない．本疾患は神経周囲に浸潤することが多く，局所再発をきたしやすいため，広範囲切除や長期間の経過観察を要する．

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Desmoid-type fibromatosis of the head and neck in children: a case report and review of the literature.

Miyashita H, Asoda S, Soma T, Munakata K, Yazawa M, Nakagawa T, Kawana H

Journal of Medical Case Reports （J Med Case Reports）  10   173 2016年

研究論文（学術雑誌）, 共著, 査読有り

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Background
Desmoid-type fibromatosis is defined as an intermediate tumor that rarely occurs in the head and neck of children. There is no doubt as to the value of complete surgical excision for desmoid-type fibromatosis. However, in pediatric patients, surgeons may often be concerned about making a wide excision because of the potential for functional morbidity. Some studies have reported a lack of correlation between margin status and recurrence. Therefore, we discussed our findings with a focus on the state of surgical margins.

Case presentation
We report an unusual case of a 9-month-old Japanese girl who prior to presenting at our hospital underwent debulking surgery twice with chemotherapy for desmoid-type fibromatosis of the tongue at another hospital. We performed a partial glossectomy and simultaneous reconstruction with local flap and achieved microscopic complete resection. We also reviewed available literature of pediatric desmoid-type fibromatosis in the head and neck.

Conclusions
We described successful treatment for the refractory case of pediatric desmoid-type fibromatosis. The review results showed that some microscopic incomplete resections of tumors in pediatric patients with desmoid-type fibromatosis tended to be acceptable with surgical treatment.

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IGF-II産生非膵島細胞腫瘍性低血糖症を発症した上顎歯肉癌の1例

宮下英高, 莇生田整治, 森泰昌, 山田有佳, 相馬智也, 河奈裕正

日本口腔外科学会雑誌 （日本口腔外科学会）  62 （ 9 ） 448 - 453 2016年

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0021-5163

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Abstract:Non-islet-cell tumor hypoglycemia (NICTH), a condition characterized by recurrent episodes of hypoglycemia, rarely occurs in association with oral cancer. Here, we report a case of carcinoma of the maxillary gingiva with NICTH caused by paraneoplastic production of insulin-like growth factor II (IGF-II). A 72-year-old man with a painful swelling in the left maxillary region was referred to our hospital. A mass with induration was observed in the buccal and palatal regions from the first premolar to the second molar. The clinical diagnosis was carcinoma of the maxillary gingiva, and a biopsy revealed squamous cell carcinoma. The patient received concurrent radiation and chemotherapy with cisplatin. Three weeks after the completion of treatment, three episodes of hypoglycemia developed despite normal intake of meals. On the basis of the results of endocrinological examinations, typical diseases causing hypoglycemia, such as insulinoma and adrenal insufficiency, were ruled out. Furthermore, decreased IGF-I levels were found, which indirectly revealed an increase in IGF-II levels. On the basis of these findings, we diagnosed this case as carcinoma of the maxillary gingiva with NICTH. Continuous intravenous glucose infusion was needed for 3 months from the diagnosis of NICTH until death. NICTH should be borne in mind as one of the complications that can occur during treatment of oral cancer.

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増大傾向を示した舌下腺による静止性骨空洞の長期観察例

軽部健史, 安居孝純, 鬼澤勝弘, 佐藤仁, 莇生田整治, 河奈裕正

日本口腔外科学会雑誌 （日本口腔外科学会）  62 （ 6 ） 299 - 303 2016年

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0021-5163

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Abstract:Lingual bone defects are usually asymptomatic local concavities of the lingual cortical bone of the mandible, frequently caused by soft-tissue inclusion. In most cases, the soft tissue is the submandibular gland. Only 7 cases of developing lingual bone defects were previously reported in Japan, but none of these cases involved the sublingual gland. We report a rare case of a developing lingual bone defect associated with the sublingual gland, which we followed up for 21 years. The patient was a 58-year-old man who had a developing lingual bone defect in the anterior right side of the mandible. A panoramic X-ray film showed an oval radiolucent area in the apical region of the lower right canine and first premolar tooth. Moreover, electric pulp testing confirmed that all teeth in the lower-right quadrant were vital. A panoramic X-ray film obtained at a nearby dental clinic demonstrated a radiolucent area 15 years before presentation to our department, and the area showed evidence of gradual expansion. Computed tomography revealed a local concavity in the lingual cortical bone of the right side of the mandible. The concavity measured 13 × 9 mm. The signal intensity of the inner tissue of the bone defect was nearly equivalent to that of the sublingual gland on T1-, T2-weighted magnetic resonance imaging. The suspected clinical diagnosis was a lingual bone defect. We performed an incisional biopsy to rule out a neoplastic lesion, and the histopathological diagnosis was normal sublingual gland tissue. On the basis of these results, the final diagnosis was a developing lingual bone defect associated with the sublingual gland. Two years have elapsed, but there is no swelling or induration in the right sublingual gland. The radiolucent area on the panoramic X-ray film showed decreased radiolucency and increased bone volume. Moreover, computed tomography revealed that the concavity of the bone had shrunk.

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Auricular malformation treated by placement of an osseointegrated implant-supported epithesis using telenavigation and model simulation

Usuda Shin, Truppe Michael, Kaneko Tsuyoshi, Ogawa Kaoru, Asoda Seiji, Hatazawa Chika, Usuda Sho, Yamada Yuka, Ewers Rolf, Nakagawa Taneaki, Kawana Hiromasa

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 27 （ 1 ） 49 - 55 2015年01月

ISSN  2212-5558

　概要を見る

<p>We report a case of auricular malformation treated by placement of an osseointegrated implant-supported epithesis using telenavigation and model simulation. A 66-year-old male suffering from auricular malformation and atresia auris of his right ear since birth visited our department in October 2006. The patient desired placement of an ear epithesis supported by osseointegrated implants. Computed tomographic (CT) scans were obtained for use in the navigation system as a prerequisite for the telenavigation and the operative plan was designed in consultation with an overseas oral and maxillofacial surgeon having rich experience in telenavigation surgery. We also constructed a preoperative simulation model and a mirror model of the unaffected left ear based on laser lithography to produce successful operation and symmetrical form of a symmetrical ear epithesis as contrast with identical to that on the left side. The osseointegrated implant surgery was carried out under telenavigation guidance. As a result, safe and accurate positioning of the implants was achieved and a symmetrical and elaborate epithesis could be fabricated.</p>

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A titanium screw-retaining temporary denture on the raw surface muscular flap for the immediate maxillary reconstruction

Miyashita Hidetaka, Asoda Seiji, Horie Nobuyuki, Usuda Shin, Kato Shin, Muraoka Wataru, Yamada Yuka, Yoshikawa Momoko, Hasegawa Toshihiro, Onizawa Katsuhiro, Tanaka Ichiro, Yazawa Masaki, Ogata Hisao, Kishi Kazuo, Tomita Toshiki, Nakagawa Taneaki, Kawana Hiromasa

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2014年10月

ISSN  2212-5558

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<p>Objective: In any immediate reconstruction of the maxillofacial defect after total maxillectomy, the defect is often covered with a flap, however, dentures cannot be maintained stably by the flap, because of the high mobility and large amount of displacement of the flap under pressure. Therefore, we developed a method in which a muscle flap is transplanted without creating a skin island in the oral cavity and a denture is immediately fixed with titanium screws, and obtained favorable results. Patients and methods: The subjects were 9 patients who underwent resection for maxillary sinus cancer. In all patients, a free rectus abdominis muscle flap was used for the reconstruction and the raw surface of the muscle tissue was left in the oral cavity without creating a skin island. Dentures that had been made preoperatively were fixed on the remaining palate and alveolus with titanium screws for one month, so that they covered the muscle tissue. Results: Good palatal morphology was formed without hanging down after epithelialization of the surface of the muscle tissue. In comparison with the preoperative levels, the masticatory and conversational functions recovered to 77% and 90%, on average. Conclusions: Our method is considered to be one of the useful reconstruction methods for maxillofacial defects.</p>

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鼻腔内に萌出した逆性過剰歯の1例

鬼澤勝弘, 安居孝純, 軽部健史, 岩崎良太郎, 莇生田整治, 臼田慎, 宮下英高, 小高利絵, 兵藤朋子, 内山公男

日本小児口腔外科学会雑誌,  24 （ 1 ） 45 - 55 2014年06月

研究論文（学術雑誌）, 共著, 査読有り

抗精神病薬による薬剤性口顎ジストニアの1例

西須大徳, 落合駿介, 鳩貝翔, 佐藤仁, 臼田頌, 村岡渡, 莇生田整治, 河奈裕正, 中川種昭, 和嶋浩一

日本顎関節学会雑誌,  26 （ 1 ） 15 - 19 2014年04月

研究論文（学術雑誌）, 共著, 査読有り

顎関節症・咀嚼筋痛障害に伴う慢性疼痛へのトラマドール塩酸塩/アセトアミノフェン配合錠の使用経験

佐藤仁, 村岡渡, 西須大徳, 臼田頌, 莇生田整治, 河奈裕正, 中川種昭, 和嶋浩一

日本顎関節学会雑誌,  26 （ 1 ） 9 - 14 2014年04月

研究論文（学術雑誌）, 共著, 査読有り

Mechanical attachment of soft tissue to dental and maxillofacial implants with mesh structures

Asoda Seiji, Arita Takayuki, Takakuda Kazuo

Journal of Biomedical Materials Research - Part B Applied Biomaterials 101 （ 4 ） 553 - 559 2013年05月

研究論文（学術雑誌）, 共著, 筆頭著者, 査読有り,  ISSN  1552-4973

　概要を見る

<p>Soft tissue attachment is a major concern for the improved design of dental and maxillofacial implants. This study evaluated the efficacy of mesh structures for soft tissue attachment in a rat percutaneous model. Four kinds of implant specimens were prepared-TI implants made of titanium cylinders, HA implants of hydroxyapatite-coated titanium, TI-Mesh implants with a titanium mesh covering a groove machined around a titanium cylinder, and similar HA-Mesh implants with a hydroxyapatite-coated mesh. These specimens were implanted percutaneously into the skin tissue of rats. The detachments of the implants were examined during the experimental period of 4 weeks. Survived implants were subjected to mechanical tests for the attachment strength and histological examinations. TI and HA implants demonstrated 0% of survival rates, while TI-Mesh and HA-Mesh showed significantly higher rates of 93.3% and 100% respectively. The attachment strengths were 159 ± 47 kPa in the TI-Mesh and 135 ± 16 kPa in the HA-Mesh. Histological observations revealed that collagen fibers originating from surrounding subcutaneous tissues were anchored to the mesh structures of the TI- and HA-Mesh implants. The results demonstrated the efficacy of the mesh structures for the attachment of soft connective tissues to implants. © 2012 Wiley Periodicals, Inc.</p>

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XCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma

Yoshikawa Momoko, Tsuchihashi Kenji, Ishimoto Takatsugu, Yae Toshifumi, Motohara Takeshi, Sugihara Eiji, Onishi Nobuyuki, Masuko Takashi, Yoshizawa Kunio, Kawashiri Shuichi, Mukai Makio, Asoda Seiji, Kawana Hiromasa, Nakagawa Taneaki, Saya Hideyuki, Nagano Osamu

Cancer Research 73 （ 6 ） 1855 - 1866 2013年03月

共著, 査読有り,  ISSN  0008-5472

　概要を見る

<p>The targeting of antioxidant systems that allow stem-like cancer cells to avoid the adverse consequences of oxidative stress might be expected to improve the efficacy of cancer treatment. Here, we show that head and neck squamous cell carcinoma (HNSCC) cells that express variant isoforms of CD44 (CD44v) rely on the activity of the cystine transporter subunit xCT for control of their redox status. xCT inhibition selectively induces apoptosis in CD44v-expressing tumor cells without affecting CD44v-negative differentiated cells in the same tumor. In contrast to CD44v-expressing undifferentiated cells, CD44v-negative differentiated cells manifest EGF receptor (EGFR) activation and rely on EGFR activity for their survival. Combined treatment with inhibitors of xCT-dependent cystine transport and of EGFR resulted in a synergistic reduction of EGFR-expressing HNSCC tumor growth. Thus, xCT-targeted therapy may deplete CD44v-expressing undifferentiated HNSCC cells and concurrently sensitize the remaining differentiating cells to available treatments including EGFR-targeted therapy. © 2012 AACR.</p>

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難治性の口腔内出血に対し直接穿刺による塞栓が有効であった上顎動静脈奇形の1例

秋山武紀, 柴尾俊輔, 冨尾亮介, 小野塚聡, 莇生田整冶, 吉田一成

脳神経血管内治療 7 （ 1 ） 32 - 39 2013年03月

研究論文（学術雑誌）, 共著, 査読有り

高齢者の頬部に発生した多形型横紋筋肉腫の1例

大山定男, 吉田俊一, 莇生田整治, 内田育宏, 高野正行, 元井亨

日本口腔外科学会雑誌,  59 （ 5 ） 357 - 361 2013年

研究論文（学術雑誌）, 共著, 査読有り

Transoral anterior approach using median mandibular splitting in upper spinal tumor extirpation

Hiromasa Kawana, Shin Kato, Seiji Asoda, Akihiko Koike, Ryotaro Iwasaki, Morio Matsumoto, Kota Watanebe, Yorihisa Imanishi, Kaoru Ogawa, Taneaki Nakagawa

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 114 （ 5 ）  2012年11月

ISSN  2212-4403

　概要を見る

<p>Objective: Transoral approach from the anterior direction is necessary if an upper spinal tumor is too big to extirpate via the posterior approach alone. To obtain a good anterior view of the surgical field, the mandible, tongue, and soft palate have to be split, and we developed a criterion to select the surgical strategy. Study Design: We indicated a decision-making process of splitting techniques and indications with actual cases and review of literatures. Result: Tumors were located from the level of C1 to the lower part of C3. Computerized tomography and magnetic resonance imaging were important to decide approaches. The orthopedic surgical team invited oral and maxillofacial surgeons team to assist in all transoral anterior approach cases. Conclusions: Vertical splitting of the mandible, incising the skin of the mental region, and splitting the middle of the tongue were combined according to the position of the spinal tumor. © 2012 Elsevier Inc. All rights reserved.</p>

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Oral and maxillofacial tissue penetration of levofloxacin following oral administration of a single 500 mg dose

Asoda Seiji, Iwasaki Ryotaro, Fukaya Chie, Hosaka Yasuo, Usuda Shin, Kawana Hiromasa, Nakagawa Taneaki

Japanese Journal of Chemotherapy 60 （ 6 ） 643 - 645 2012年11月

ISSN  1340-7007

　概要を見る

<p>We examined the transfer of levofloxacin (LVFX) into serum, gingiva, dental follicles, and mandibular bone following oral administration of a single 500 mg dose of LVFX to 10 subjects, comprising 3 males and 7 females. The mean concentrations 2.0 to 4.5 h after administration in serum, gingiva, dental follicles, and mandibular bone were 4.85 ± 0.82 μg/mL, 7.76 ± 3.21, 7.38 ± 2.04 μg/g, and 2.90 ± 1.94, respectively. The mean ratios of concentrations in gingiva/serum, dental follicle/serum, and mandibular bone/serum were 1.58 ± 0.53, 1.54 ± 0.50, and 0.59 ± 0.35, respectively. The mean LVFX concentrations in gingival tissue, dental follicles and mandibular bone exceeded the MIC for 90% of clinically isolated oral strains of streptococci and most of the anaerobic bacteria. These results indicated that LVFX penetrated well into oral and maxillofacial tissue and that LVFX 500 mg q.d. treatment was as effective as, or more effective than, 100 mg t.i.d. for the clinical treatment of oral infections.</p>

人工材料と生体軟組織の機械的結合

高久田 和夫, 莇生田 整治, 有田 隆之

生体材料工学研究所年報,  45   27 - 30 2012年03月

共著

全身疾患を有する患者の抜歯―医科との対診のポイント

莇生田整治

日本歯科評論 72 （ 6 ） 51 - 60 2012年

単著