Asoda, Seiji



School of Medicine, Department of Dentistry and Oral Surgery (Shinanomachi)


Assistant Professor/Senior Assistant Professor

External Links

Academic Background 【 Display / hide

  • 1995.03

    Tohoku University, 歯学部

    University, Graduated

  • 2008.03

    Tokyo Medical and Dental University, 医歯学総合研究科, 顎顔面頸部機能再建学系専攻

    Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(歯学), Tokyo Medical and Dental University, Coursework, 2008.03

Licenses and Qualifications 【 Display / hide

  • 日本口腔外科学会 専門医, 日本口腔外科学会 専門医, 2005.10

  • 日本がん治療認定医機構 暫定教育医(歯科口腔外科), 日本がん治療認定医機構 暫定教育医(歯科口腔外科), 2009.01

  • 日本がん治療認定医機構 がん治療認定医(歯科口腔外科), 日本がん治療認定医機構 がん治療認定医(歯科口腔外科), 2010.04

  • 独立行政法人医薬品医療機器総合機構(PMDA)専門委員, 独立行政法人医薬品医療機器総合機構(PMDA)専門委員, 2010.10

  • 日本顎顔面インプラント学会 専門医, 日本顎顔面インプラント学会 専門医, 2012.01

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Research Areas 【 Display / hide

  • Surgical dentistry (Surgical Odontology)

Research Keywords 【 Display / hide

  • 口腔がん

  • 口腔外科学

  • 口腔機能ケア

  • 口腔腫瘍

  • 顎口腔インプラント再建

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Books 【 Display / hide

  • 臨床現場で役に立つ”痛み”の教科書

    莇生田整治, 株式会社デンタルダイヤモンド社, 2020.10,  Page: 106-108

    Scope: Q22 抜歯部の痛みがおさまらない、抜歯窩は治っている、何が原因か.

  • 新・口腔外科はじめましょう

    莇生田整治, 株式会社デンタルダイヤモンド社, 2020.01,  Page: 116-119

    Scope: Chapter 3 病棟での基本的な処置 2 手術創の処置

  • 口腔癌診療ガイドライン 2019年版 第3版

    莇生田整治, 武田大介, 山田慎一, 佐藤春樹, 足立雅利, 湯浅秀道, 金原出版株式会社, 2019.10,  Page: 178-182

    Scope: Part 2 GRADEアプローチによる推奨 Ⅱ推奨と根拠 2. 切除可能な進展例の治療

  • ザ・ペリオドントロジー 第3版

    莇生田整治, 中川種昭, 永末書店, 2019.02

    Scope: 第9章 特殊な歯周病 12. 白血病性歯肉炎,  Contact page: 280-281

  • ザ・ペリオドントロジー 第3版

    莇生田整治, 中川種昭, 永末書店, 2019.02

    Scope: 第9章 特殊な歯周病 11. 良性腫瘍と悪性腫瘍との鑑別診断,  Contact page: 278-279

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Papers 【 Display / hide

  • Development of a microsurgery-assisted robot for high-precision thread traction and tension control, and confirmation of its applicability

    Hangai S, Nozaki T, Soma T, Miyashita H, Asoda S, Yazawa M, Sato K, Kawana H, Ohnishi K, Kobayashi E

    The International Journal of Medical Robotics and Computer Assisted Surgery (The International Journal of Medical Robotics and Computer Assisted Surgery)  17 ( 2 ) 2205 2021.04


     View Summary

    Background: Microsurgery requires high skills for suturing using fragile threads, often within narrow surgical fields. Precise tension is required for good healing and to avoid the risk of thread breakage.

    Methods: To meet the demands, we developed a novel assist robot utilizing high-precision sensorless haptic technology. The robot adopts a cable-driven mechanism to maintain a distance from the surgical area and enhances compatibility with surgical equipment such as microscopes. The robot performance was verified through in vitro and in vivo experiments using a rat model.

    Results: The realization of precise tension control was confirmed in both experiments. In particular, in the in vivo experiments, the developed robot succeeded to produce a knot with an accurate tension of 0.66% error.

    Conclusions: The developed robot can realize to control traction force precisely. This technology might open up the window for a full assist robot for microsurgery with haptic feeling.

  • Influence of prostate cancer status on the prevalence of medication-related osteonecrosis of the jaw.

    Yasui T, Kimura M, Nagamine H, Yajima S, Karube T, Sato H, Asoda S, Hara S, Onizawa K

    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)  131 ( 3 ) 312 - 318 2021.03


     View Summary

    Objective: The aim of this study was to evaluate the risk of osteonecrosis of the jaw (ONJ) in patients with prostate cancer, particularly the relationship between prostate cancer progression and ONJ development.

    Study design: This single-center, retrospective, observational study included 113 patients who received zoledronic acid or denosumab for prostate cancer with bone metastasis between January 2012 and March 2020. The risk of ONJ was evaluated regarding age; antiresorptive drugs; duration of antiresorptive treatment; prostate cancer status, including castration-resistant prostate cancer (CRPC) and prostate-specific antigen level; chemotherapy; radium-223 treatment; corticosteroid treatment; diabetes mellitus; and dental extractions.

    Results: Overall, 28 patients had ONJ; 10 patients received zoledronic acid and 18 patients received denosumab. Multiple logistic regression analysis demonstrated that CRPC (odds ratio = 6.01; 95% confidence interval, 1.76-20.05; P = .004) and dental extractions (odds ratio = 12.40; 95% confidence interval, 3.42-44.70; P < .001) were significantly associated with ONJ. In addition, antiresorptive treatment lasting more than 1 year partially mediated between CRPC and development of ONJ.

    Conclusion: CRPC and dental extraction are risk factors for developing ONJ, and antiresorptive treatment lasting more than 1 year is a partial mediator between CRPC and ONJ.

  • Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw

    Soma T., Iwasaki R., Sato Y., Kobayashi T., Nakamura S., Keneko Y., Ito E., Okada H., Watanabe H., Miyamoto K., Matsumoto M., Nakamura M., Asoda S., Kawana H., Nakagawa T., Miyamoto T.

    Journal of Bone and Mineral Metabolism (Journal of Bone and Mineral Metabolism)  39   372 - 384 2020.11

    Joint Work, Accepted

     View Summary

    Osteonecrosis of the jaw (ONJ) occurring after invasive dental treatment often adversely affects patients’ activities of daily living. Long-term administration of strong anti-bone resorptive agents such as bisphosphonates prior to invasive dental treatment is considered an ONJ risk factor; however, pathological mechanisms underlying ONJ development remain unclear.

    Materials and Methods
    We developed an ONJ mouse model in which a tooth is extracted during treatment with the bisphosphonate zoledronate.

    We observed induction of apoptosis in osteocytes, resulting in formation of empty lacunae in jaw bones at sites of tooth extraction but not in other bones of the same mice. We also observed elevated levels of inflammatory cytokines such as TNFα, IL-6 and IL-1 in jaw bone at the extraction site relative to other sites in zoledronate-treated mice. We also report that treatment in vitro with either zoledronate or an extract from Porphyromonas gingivalis, an oral bacteria, promotes expression of inflammatory cytokines in osteoclast progenitor cells. We demonstrate that gene-targeting of either TNFα, IL-6 or IL-1 or treatment with etanercept, a TNFα inhibitor, or a neutralizing antibody against IL-6 can antagonize ONJ development caused by combined tooth extraction and zoledronate treatment.

    Taken together, the cytokine storm induced by invasive dental treatment under bisphosphonate treatment promotes ONJ development due to elevated levels of inflammatory cytokine-producing cells. Our work identifies novel targets potentially useful to prevent ONJ.

  • Clear Cell Carcinoma in the Retromolar Area: A Case Report

    Yasui Y, Asoda S, Soma T, Miyashita H, Hasegawa T, Ouchi T, Karube T, Yasui T, Onizawa K, Nakagawa T, Kawana H

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology (J Oral Maxillofac Surg Med Pathol)  32 ( 6 ) 507 - 513 2020.11

    Joint Work, Accepted

  • 広範囲顎骨支持型装置を用いて咬合再建したランゲルハンス細胞組織球症の1例

    宗像花楠子, 宮下英高, 堀江伸行, 森田麻友, 小高利絵, 莇生田整治, 内田育宏, 中川種昭, 河奈裕正

    日本顎顔面インプラント学会誌 (日本顎顔面インプラント学会)  19 ( 1 ) 19 - 25 2020.04

    Research paper (scientific journal), Joint Work, Accepted

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Presentations 【 Display / hide

  • 再発・転移口腔癌におけるゲノム医療導入の1例

    金生茉莉, 相馬智也, 宮下英高, 宗像花楠子, 山田有佳, 中川種昭, 莇生田整治

    第211回(公社)日本口腔外科学会関東地方会 (東京) , 2021.05, Oral Presentation(general)

  • Cetuximab併用療法が著効した進行舌癌の1例

    日浅香保, 宮下英高, 相馬智也, 宗像花楠子, 山田有佳, 木村萌美, 中川種昭, 莇生田整治

    第39回日本口腔腫瘍学会総会 (軽井沢(WEB)) , 2021.01, Poster (general)

  • 仮性動脈瘤による抜歯後出血に対して動脈塞栓術を行った1例

    田中健太, 相馬智也, 竹内照美, 宗像花楠子, 長嶺宏樹, 西健太郎, 中川種昭, 莇生田整治

    第210回(公社)日本口腔外科学会関東地方会 (東京) , 2020.12, Oral Presentation(general)

  • 交通顎顔面外傷に対する集学的インプラント治療の1例

    二宮真希, 相馬智也, 堀江伸行, 臼田頌, 河奈裕正, 中川種昭, 莇生田整治

    第24回日本顎顔面インプラント学会総会・学術大会 (秋田) , 2020.12, Poster (general)

  • 下顎頭吸収性疾患における骨SPECT/CT画像と下顎頭形態の解析

    宗像花楠子, 宮下英高, 柴秀行, 加藤伸, 菅原圭亮, 莇生田整治, 片倉朗, 中川種昭

    第65回(公社)日本口腔外科学会総会 (名古屋) , 2020.11, Oral Presentation(general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • PDXモデルを用いたCD44v陽性口腔がん幹細胞の特性評価と新規薬剤治療の確立


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 莇生田 整治, Grant-in-Aid for Scientific Research (C), Co-investigator

  • 標準治療抵抗性口腔扁平上皮癌における標的可能遺伝子変異の同定と個別化治療の確立


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 莇生田 整治, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • Development of μm order ultra-precise surgical system for artificial reproduction of skilled micromanipulation


    AMED, 未来医療を実現する医療機器・システム研究開発事業, 莇生田 整治, Principal Investigator

  • 標準治療抵抗性口腔扁平上皮癌における癌間質細胞を標的とした新規治療法の開発


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 莇生田 整治, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • 機能的癌幹細胞マーカーCD44vの発現に基づく口腔扁平上皮癌の治療感受性評価


    MEXT,JSPS, 科学研究費助成事業, 莇生田 整治, Grant-in-Aid for Scientific Research (C), Principal Investigator

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Awards 【 Display / hide

  • 日本口腔腫瘍学会賞

    2009,  Japanese Society of Oral Oncology

    Type of Award: Awards of National Conference, Council and Symposium

  • 日本口腔インプラント学会 デンツプライ賞(最優秀ポスター賞)

    2006, Japanese Society of Oral Implantology


Courses Taught 【 Display / hide