Details of a Researcher - Jinzaki, Masahiro

Papers - Jinzaki, Masahiro

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Quantitative Assessment of Bone Metastasis in Prostate Cancer Using Synthetic Magnetic Resonance Imaging

Arita Y., Takahara T., Yoshida S., Kwee T.C., Yajima S., Ishii C., Ishii R., Okuda S., Jinzaki M., Fujii Y.

Investigative Radiology (Investigative Radiology) 54 ( 10 ) 638 - 644 2019.10

ISSN 00209996

© Wolters Kluwer Health, Inc. All rights reserved. Objectives The aims of this study were to evaluate the feasibility of quantitative synthetic magnetic resonance imaging (SyMRI) for characterizing bone lesions in prostate cancer and to discriminate viable progressive osteoblastic bone metastasis from nonviable bone metastases with treatment-induced sclerosis during the treatment course. Materials and Methods This institutional review board-approved prospective study included 96 consecutive prostate cancer patients who underwent whole-body MRI including diffusion-weighted imaging at the time of staging at diagnosis or starting a new line of anticancer treatment. Additional synthetic MRI of the lumbosacral spine, pelvis, and proximal femurs was performed. A region of interest of 1.0 cm in diameter was set in each bone lesion by 2 independent readers who were blinded to bone lesions' diagnosis. Differences in SyMRI variables between the different bone lesions were compared with the Wilcoxon rank sum test, and associations of SyMRI variables with active disease were analyzed with logistic regression analysis. Performance of T1, T2, and proton density (PD) for diagnosing active disease was assessed using the area under the receiver operating characteristic curve. Results Ninety-three bone lesions were eligible for analysis. The PD values of active (viable) bone metastatic lesions were significantly higher than those of inactive (nonviable) bone metastatic lesions without sclerosis and those of red bone marrow (P < 0.001 for both readers). The PD values of inactive bone metastatic lesions with sclerosis were significantly lower than those of inactive bone metastatic lesions without sclerosis and red bone marrow (P < 0.001 for both readers). The PD value proved to be an independent significant indicator (P < 0.001) for differentiating bone lesions. The areas under the curve of T1/T2/PD for identifying active disease were 0.81/0.69/0.93 for reader 1 and 0.78/0.70/0.92 for reader 2, respectively. Conclusions Signal quantification on SyMRI provides objective assessment of bone lesions in the lower trunk. The PD value can be useful to determine the viability of bone metastases in prostate cancer.

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Diagnostic imaging of retroperitoneal tumor

Akita H., Jinzaki M., Ikeda O.

Japanese Journal of Clinical Urology (Japanese Journal of Clinical Urology) 73 ( 11 ) 806 - 814 2019.10

ISSN 03852393

Glenohumeral translation during active external rotation with the shoulder abducted in cases with glenohumeral instability: a 4-dimensional computed tomography analysis

Matsumura N., Oki S., Fukasawa N., Matsumoto M., Nakamura M., Nagura T., Yamada Y., Jinzaki M.

Journal of Shoulder and Elbow Surgery (Journal of Shoulder and Elbow Surgery) 28 ( 10 ) 1903 - 1910 2019.10

ISSN 10582746

© 2019 Journal of Shoulder and Elbow Surgery Board of Trustees Background: Although glenohumeral instability is common, the mechanism of instability remains unclear. The purpose of this study was to quantitatively evaluate humeral head translation during active external rotation with abduction in patients with glenohumeral instability by use of 4-dimensional computed tomography scans. Methods: Ten patients with unilateral glenohumeral instability with a positive fulcrum test were prospectively included in this study. Sequential computed tomography of bilateral shoulders during active external rotation at 90° of shoulder abduction was performed for 6 seconds at 5 frames per second. The 3-dimensional positions of the humeral head center in the anteroposterior, superoinferior, and mediolateral directions were calculated at 0°, 20°, 40°, 60°, and maximum shoulder abduction–external rotation from the starting position. Translation of the humeral head center from the starting position was evaluated using Dunnett multiple-comparison tests, and the differences between the affected and intact shoulders were assessed using Wilcoxon signed rank tests. Results: The humeral head center translated posteriorly, inferiorly, and medially during glenohumeral external rotation with the shoulder in the abducted position on the intact side. However, the affected humeral head showed significantly less posterior translation (P = .028), greater inferior translation (P = .047), and less medial translation (P = .037) than the contralateral side. Conclusions: This study indicated that dysfunction of the anterior band of the inferior glenohumeral ligament causes decreased posterior, increased inferior, and decreased medial translation of the humeral head during active shoulder abduction–external rotation.

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連載特集アドバンストコース『臨床画像』Vol.35,5月号特集　前立腺癌の画像診断 update

有田祐起, 秋田大宇, 陣崎雅弘

臨床画像 (メジカルビュー社) 35 ( 9 ) 1099 - 1103 2019.09

ISSN 0911-1069

誌上シンポジウム肩腱板断裂画像診断の進歩 MRIによる腱板の筋萎縮・脂肪変性評価 MRIによる筋萎縮および筋内脂肪浸潤の定量的評価

松村昇, 小黒草太, 奥田茂男, 陣崎雅弘, 中村雅也, 松本守雄

臨床整形外科 (株式会社医学書院) 54 ( 9 ) 897 - 903 2019.09

ISSN 0557-0433

救急疾患の鑑別診断のポイント第10章その他,石灰化など　2 動静脈の石灰化の鑑別

秋田大宇, 中尾千恵, 陣崎雅弘

画像診断 (学研メディカル秀潤社) 39 ( 11 ) A190 - A193 2019.09

ISSN 0285-0524

救急疾患の鑑別診断のポイント第2章臓器造影効果欠如・脈管内造影欠損　4 脾・腎など実質臓器造影欠損の鑑別

古後斗冴, 南康大, 杉浦弘明, 陣崎雅弘

画像診断 (学研メディカル秀潤社) 39 ( 11 ) A30 - A35 2019.09

ISSN 0285-0524

救急疾患の鑑別診断のポイント第11章肺野異常陰影　3 肺間質影の鑑別

杉浦弘明, 南康大, 山田祥岳, 陣崎雅弘

画像診断 (学研メディカル秀潤社) 39 ( 11 ) A210 - A215 2019.09

ISSN 0285-0524

救急疾患の鑑別診断のポイント第11章肺野異常陰影　2 肺野空洞性病変の鑑別

南康大, 山田祥岳, 杉浦弘明, 陣崎雅弘

画像診断 (学研メディカル秀潤社) 39 ( 11 ) A204 - A209 2019.09

ISSN 0285-0524

経鼻内視鏡手術における蝶形骨洞の発達度と下垂体腺腫海綿静脈洞浸潤部の摘出率について

小杉健三, 戸田正博, 田村亮太, 間瀬太郎, 田村遙, 陣崎雅弘, 吉田一成

日本内分泌学会雑誌 ((一社)日本内分泌学会) 95 ( Suppl.HPT ) 54 - 55 2019.09

ISSN 0029-0661

頭蓋底腫瘍のなかで、正中から外側方向に位置する海綿静脈洞部へ進展するような腫瘍では、その摘出手術において、蝶形骨洞の外側方向への発達(蝶形洞洞側窩の発達)が摘出率に影響を及ぼす可能性がある。そこで今回、海綿静脈洞内へ浸潤した下垂体腺腫の摘出率と蝶形骨洞側窩の発達度との関連ついて検討した。対象は当院で2012〜2018年に初発の下垂体腺腫に対して経鼻内視鏡手術を行った症例のうち、Knosp grade 3以上の海綿静脈洞浸潤があった23例とし、術前の頭部CT画像から蝶形骨洞側窩の体積を測定した。蝶形骨洞の冠状断像でvidian canalとforamen rotundumを結び、その線より外側を蝶形骨洞側窩と定義した。検討の結果、蝶形骨洞側窩体積と腫瘍全体摘出率との間に有意な相関関係は認めなかったが、海綿静脈洞内腫瘍摘出率との間には有意な正の相関が認められた。

特集循環器疾患の画像診断-現状と進歩序文

陣崎雅弘

循環器ジャーナル (株式会社　医学書院) 67 ( 3 ) 320 - 321 2019.07

ISSN 2432-3284

特集循環器疾患の画像診断-現状と進歩 Ⅴ.肺循環疾患 MRIを用いた右室機能評価を知る

奥田茂男, 山田祥岳, 陣崎雅弘

循環器ジャーナル (株式会社　医学書院) 67 ( 3 ) 420 - 426 2019.07

ISSN 2432-3284

特集循環器疾患の画像診断-現状と進歩 Ⅴ.肺循環疾患 CT angiographyおよびCT perfusionを活用する

田村全, 杉浦弘明, 山田祥岳, 川上崇史, 陣崎雅弘

循環器ジャーナル (株式会社　医学書院) 67 ( 3 ) 410 - 419 2019.07

ISSN 2432-3284

特集循環器疾患の画像診断-現状と進歩 Ⅳ.弁膜疾患 CTでTAVIの術前評価を行う

山田祥岳, 松本俊亮, 山田稔, 中原健裕, 陣崎雅弘

循環器ジャーナル (株式会社　医学書院) 67 ( 3 ) 388 - 401 2019.07

ISSN 2432-3284

特集循環器疾患の画像診断-現状と進歩 Ⅰ.総論非侵襲的画像診断の近年の進歩と位置づけ

中原健裕, 奥田茂男, 陣崎雅弘

循環器ジャーナル (株式会社　医学書院) 67 ( 3 ) 322 - 330 2019.07

ISSN 2432-3284

Effect of natural full weight-bearing during standing on the rotation of the first metatarsal bone

Ota T., Nagura T., Yamada Y., Yamada M., Yokoyama Y., Ogihara N., Matsumoto M., Nakamura M., Jinzaki M.

Clinical Anatomy (Clinical Anatomy) 32 ( 5 ) 715 - 721 2019.07

ISSN 08973806

© 2019 Wiley Periodicals, Inc. To evaluate the rotational change in the first metatarsal bone (1MT) of the foot during natural standing using an upright computed tomography (CT) scanner with 320-detector rows. A total of 52 feet of 28 asymptomatic subjects (aged 23–39 years) were evaluated in the natural standing position with or without weight-bearing. A foot pressure plate was used to determine the non-weight-bearing (NWB) or single leg full-weight-bearing (s-FWB) conditions. CT examinations were performed using a noise index of 15 for a slice thickness of 5 mm, rotation speed of 0.5 sec, and slice thickness of 0.5 mm. The rotation of the 1MT was measured on the coronal CT image, which cut the sesamoids' bellies in the frontal slide of the first metatarsal and sesamoids perpendicular to the longitudinal bisection of the third metatarsal, and compared between the weight-bearing conditions. Intra- and inter-observer reliabilities of the rotation angle were also evaluated. The intra- and inter-observer correlation coefficients were 0.961 and 0.934, respectively. The 1MT pronation angle was significantly greater in the s-FWB condition than in the NWB condition (15.2° ± 5.4° vs. 12.5° ± 5.3°, P < 0.01). No sex difference was found in the magnitude of the 1MT pronation angle as a result of weight-bearing. This study first demonstrated that pronation of 1MT occurs due to natural full-weight-bearing in asymptomatic feet. The 1MT's rotational movement under weight-bearing conditions may relate to the onset and pathogenesis of the hallux valgus. Clin. Anat. 32:715–721, 2019. © 2019 Wiley Periodicals, Inc.

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Clinical value of 3D SPECT/CT imaging for assessing jaw bone invasion in oral cancer patients

Miyashita H., Nakahara T., Asoda S., Kameyama K., Kawaida M., Enomoto R., Shiba H., Jinzaki M., Kawana H., Nakagawa T.

Journal of Cranio-Maxillofacial Surgery (Journal of Cranio-Maxillofacial Surgery) 47 ( 7 ) 1139 - 1146 2019.07

ISSN 10105182

© 2019 European Association for Cranio-Maxillo-Facial Surgery Purpose: This study compared the diagnostic accuracy of jaw bone invasion (JBI) of oral cancer observed with three-dimensional (3D) SPECT/CT, CT, and MRI, and evaluated the clinical advantages of 3D SPECT/CT compared to conventional two-dimensional (2D) SPECT/CT. Materials and methods: From April 2014 to January 2018, consecutive 16 oral cancer patients with suspected JBI, who had preoperatively undergone the imaging tests, were retrospectively enrolled. The likelihood of JBI was independently scored by a radiologist and oral surgeon. Using 2D or 3D SPECT/CT images, 20 oral surgeons delineated virtual surgical areas on 3D-printed jaws for 3 cases in which the extent of JBI was fully pathologically confirmed. The surgeons completed questionnaires regarding surgical planning and explanations for patients using Likert scales. Results: JBI was found in 9 patients including 5 (56%) with initial bone invasion. 3D SPECT/CT showed very high negative predictive value (100%) and inter-observer agreement (kappa = 0.917). 3D SPECT/CT was more sensitive than CT and MRI when inconclusive findings for JBI were considered negative. Compared to 2D SPECT/CT, 3D SPECT/CT had greater clinical advantages such as surgical planning and explanation to patients (p < 0.005). Conclusion: 3D SPECT/CT is useful not only for detecting JBI but also for surgical planning.

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Can we predict amyloid deposition by objective cognition and regional cerebral blood flow in patients with subjective cognitive decline?

Funaki K., Nakajima S., Noda Y., Wake T., Ito D., Yamagata B., Yoshizaki T., Kameyama M., Nakahara T., Murakami K., Jinzaki M., Mimura M., Tabuchi H.

Psychogeriatrics (Psychogeriatrics) 19 ( 4 ) 325 - 332 2019.07

ISSN 13463500

© 2019 Japanese Psychogeriatric Society Background: Subjective cognitive decline (SCD) may herald the first symptoms of Alzheimer's disease (AD) whereas individuals with beta-amyloid (Aβ) deposition are regarded as a high-risk group for AD. Recently, amyloid positron emission tomography (PET) studies have demonstrated clinical and cognitive feature differences between Aβ-positive and negative SCD, but details of their differences remain unclear. We aimed to investigate the relationships among Aβ deposition, clinical, and cognitive features in patients with SCD. Methods: Forty-two patients with SCD (22 women, 74.5 ± 4.7 years) were examined using fluorine-18 florbetaben PET and were divided into Aβ-positive (n = 10) and negative (n = 32) groups. We compared cognitive and psychological outcomes, and single photon emission computed tomography (SPECT) imaging data between the two groups. In addition, a linear regression analysis was performed to assess relationships between the severity of SCD and neuropsychological tests, affective scores, and demographic factors. Results: The rate of score changes from the immediate recall to delayed recall in the logical memory subtest of the Wechsler's Memory Scale Revised were different between the groups (P = 0.04). However, the binary logistic regression analysis showed no significant differences between the two. In addition, the severity of SCD was significantly strong in women (P = 0.002). Furthermore, within the Aβ-negative group, subjective memory loss correlated with word fluency category score (P = 0.023) and apathy scale (P = 0.037). Conclusions: No significant differences were observed between Aβ-positive and -negative SCD on any of the neuropsychological measures, clinical measures, or SPECT imaging. Further, the severity of SCD was not predicted by the symptoms of anxiety, depression, or neuropsychological examination.

全身撮影可能な立位CTの開発　ファントムスタディ、人体に対する重力の影響

横山陽一, 山田祥岳, 名倉武雄, 中原健裕, 成田啓一, 山田稔, 南島一也, 荻原直道, 陣崎雅弘

日本医用画像工学会大会予稿集 ((一社)日本医用画像工学会) 38回 471 - 475 2019.07

【目的】(1)立位CTの物理特性の評価,(2)大血管と骨盤底への重力の影響を評価すること.【方法】ファントムを用いて立位CTと臥位CT,それぞれの物理特性の評価を行った.健常人ボランティアを対象に立位CTと臥位CTを同日に施行,大静脈と大動脈の面積と骨盤底の変化を評価した.【結果】立位CTと臥位CT両者の物理特性に有意差は見られなかった.仰臥位と比較して直立位では,上大静脈の面積は有意に小さく,横隔膜の高さでの下大静脈の面積に有意差は見られず,下大静脈下端部での面積は有意に大きくなった.一方,大動脈の面積に関しては姿勢による有意差は見られなかった.骨盤底は直立位で下降した.【結論】立位CTと臥位CTの性能はほぼ同等であり,立位CTは,人体に対する重力の影響を評価するのに有用であった.(著者抄録)

Picked-up Knowledge from Foreign Journals 心筋の線維化

中原健裕, 奥田茂男, 陣崎雅弘

画像診断 (学研メディカル秀潤社) 39 ( 8 ) 924 - 926 2019.06

ISSN 0285-0524

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