陣崎 雅弘 (ジンザキ マサヒロ)

Jinzaki, Masahiro

写真a

所属(所属キャンパス)

医学部 放射線科学教室(診断) (信濃町)

職名

教授

外部リンク

経歴 【 表示 / 非表示

  • 1987年04月
    -
    1991年03月

    慶應義塾大学医学部, 放射線診断科, 研修医

  • 1990年04月
    -
    1994年06月

    日本鋼管病院, 放射線科, 医員

  • 1994年07月
    -
    1997年04月

    慶應義塾大学医学部, 放射線診断科, 助手

  • 1997年05月
    -
    1999年01月

    慶應義塾大学医学部, がんセンター, 医員

  • 1999年02月
    -
    2000年04月

    Harvard 大学付属Brigham and Women’s Hospital, 放射線科, 研究員

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学歴 【 表示 / 非表示

  • 1981年04月
    -
    1987年03月

    慶應義塾, 医学部

    大学, 卒業

学位 【 表示 / 非表示

  • 医学博士, 慶應義塾, 論文, 1999年03月

    Small solid renal lesions: Usefulness of power Doppler US

 

研究分野 【 表示 / 非表示

  • 放射線科学

研究キーワード 【 表示 / 非表示

  • Computed Tomography

  • Magnetic Resonance Imaging

  • 循環器疾患

  • 泌尿器腫瘍

  • 画像診断

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研究テーマ 【 表示 / 非表示

  • 画像診断への人工知能の活用, 

    2017年
    -
    継続中

  • PETのアミロイドイメージング研究, 

    2016年
    -
    継続中

  • 全身立位CTの開発と臨床応用, 

    2014年
    -
    継続中

  • 4次元画像診断の脈管疾患及び整形疾患における活用, 

    2010年
    -
    継続中

  • 2重エネルギーCTの臨床応用, 

    2006年
    -
    継続中

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著書 【 表示 / 非表示

  • Coronary CT angiography.

    Lehmkuhl L, Martuscelli E, JINZAKI MASAHIRO, Springer, 2014年

    担当範囲: General Electric LightSpeed VCT, Optima CT660 and Discovery CT750 HD

  • Computed Tomography Imaging.

    JINZAKI MASAHIRO, Akita H, Kikuchi E., Taylor and Francis, 2013年

    担当範囲: Urinary bladder.

  • Computed Tomography Imaging.

    JINZAKI MASAHIRO, Yamada Y, Kuribayashi S., Taylor and Francis, 2013年

    担当範囲: Computed Tomography Multispectral Imaging.

  • Advances in the Diagnosis of Coronary Atherosclerosis.

    JINZAKI MASAHIRO, Yamada M, Kuribayashi S., InTech, 2011年

    担当範囲: Image post-processing and interpretation.

  • Multislice CT 2003 BOOK

    陣崎 雅弘ほか, 産業開発機構株式会社, 2003年05月

    担当範囲: GE社製16スライスCT LightSpeed Ultra16の使用経験

論文 【 表示 / 非表示

  • Use of a digital phantom developed by QIBA for harmonizing SUVs obtained from the state-of-the-art SPECT/CT systems: a multicenter study.

    陣崎 雅弘

    EJNMMI Research (Springer)  7 ( 1 ) 53 2017年12月

    研究論文(学術雑誌), 共著

     概要を見る

    BACKGROUND:

    Although quantitative analysis using standardized uptake value (SUV) becomes realistic in clinical single-photon emission computed tomography/computed tomography (SPECT/CT) imaging, reconstruction parameter settings can deliver different quantitative results among different SPECT/CT systems. This study aims to propose a use of the digital reference object (DRO), which is a National Electrical Manufacturers Association (NEMA) phantom-like object developed by the Quantitative Imaging Biomarker Alliance (QIBA) fluorodeoxyglucose-positron emission tomography technical committee, for the purpose of harmonizing SUVs in Tc-99m SPECT/CT imaging.

    METHODS:

    The NEMA body phantom with determined Tc-99m concentration was scanned with the four state-of-the-art SPECT/CT systems. SPECT data were reconstructed using different numbers of the product of subset and iteration numbers (SI) and the width of 3D Gaussian filter (3DGF). The mean (SUVmean), maximal (SUVmax), and peak (SUVpeak) SUVs for six hot spheres (10, 13, 17, 22, 28, and 37 mm) were measured after converting SPECT count into SUV using Becquerel calibration factor. DRO smoothed by 3DGF with a FWHM of 17 mm (DRO17 mm) was generated, and the corresponding SUVs were measured. The reconstruction condition to yield the lowest root mean square error (RMSE) of SUVmeans for all the spheres between DRO17 mm and actual phantom images was determined as the harmonized condition for each SPECT/CT scanner. Then, inter-scanner variability in all quantitative metrics was measured before (i.e., according to the manufacturers' recommendation or the policies of their own departments) and after harmonization.

    RESULTS:

    RMSE was lowest in the following reconstruction conditions: SI of 100 and 3DGF of 13 mm for Brightview XCT, SI of 160 and 3DGF of 3 pixels for Discovery NM/CT, SI of 60 and 3DGF of 2 pixels for Infinia, and SI of 140 and 3DGF of 15 mm for Symbia. In pre-harmonized conditions, coefficient of variations (COVs) among the SPECT/CT systems were greater than 10% for all quantitative metrics in three of the spheres, SUVmax and SUVmean, in one of the spheres. In contrast, all metrics except SUVmax in the 17-mm sphere yielded less than 10% of COVs after harmonization.

    CONCLUSIONS:

    Our proposed method clearly reduced inter-scanner variability in SUVs. A digital phantom developed by QIBA would be useful for harmonizing SUVs in multicenter trials using SPECT/CT.

  • 18F-FDG-labeled red blood cell PET for blood-pool imaging: preclinical evaluation in rats.

    陣崎 雅弘

    EJNMMI research (springer)  7 ( 1 ) 19 2017年12月

    研究論文(学術雑誌), 共著

     概要を見る

    BACKGROUND:

    Red blood cells (RBCs) labeled with single-photon emitters have been clinically used for blood-pool imaging. Although some PET tracers have been introduced for blood-pool imaging, they have not yet been widely used. The present study investigated the feasibility of labeling RBCs with 18F-2-deoxy-2-fluoro-D-glucose (18F-FDG) for blood-pool imaging with PET. RBCs isolated from venous blood of rats were washed with glucose-free phosphate-buffered saline and labeled with 18F-FDG. To optimize labeling efficiency, the effects of glucose deprivation time and incubation (labeling) time with 18F-FDG were investigated. Post-labeling stability was assessed by calculating the release fraction of radioactivity and identifying the chemical forms of 18F in the released and intracellular components of 18F-FDG-labeled RBCs incubated in plasma. Just after intravenous injection of the optimized autologous 18F-FDG-labeled RBCs, dynamic PET scans were performed to evaluate in vivo imaging in normal rats and intraabdominal bleeding models (temporary and persistent bleeding).

    RESULTS:

    The optimal durations of glucose deprivation and incubation (labeling) with 18F-FDG were 60 and 30 min, respectively. As low as 10% of 18F was released as the form of 18F-FDG from 18F-FDG-labeled RBCs after a 60-min incubation. Dynamic PET images of normal rats showed strong persistence in the cardiovascular system for at least 120 min. In the intraabdominal bleeding models, 18F-FDG-labeled RBC PET visualized the extravascular blood clearly and revealed the dynamic changes of the extravascular radioactivity in the temporary and persistent bleeding.

    CONCLUSIONS:

    RBCs can be effectively labeled with 18F-FDG and used for blood-pool imaging with PET in rats.

  • Incidental spade-shaped FDG uptake in the left ventricular apex suggests apical hypertrophic cardiomyopathy.

    Katagiri M, Nakahara T, Murata M, Ogata Y, Matsusaka Y, Iwabuchi Y, Yamada Y, Fukuda K, Jinzaki M.

    Annals of Nuclear Medicine (Springer)  31 ( 5 ) 399 - 406 2017年11月

    研究論文(学術雑誌), 共著

     概要を見る

    PURPOSE:

    Apical wall thickening with an "ace-of-spades" configuration is a unique sign of apical hypertrophic cardiomyopathy (AHCM). We investigated spade-shaped FDG uptake around the left ventricular apex (SSUA) incidentally found in routine oncological FDG PET.

    METHODS:

    Cases showing SSUA were selected based on retrospective review. The pattern or intensity of SSUA was compared with the results of electrocardiogram (ECG), echocardiography, and stress myocardial perfusion SPECT. The diagnosis of ACHM was based on the presence of giant negative T wave in ECG, thickness of spade-shaped hypertrophy in the apex in echocardiography, and increased tracer uptake in the apex in rest SPECT.

    RESULTS:

    Among the 34 patients in 36 PET scans showing SSUA, SSUA was weak in 17 and intense in 17. There were isolated SSUA (n = 29) and SSUA with diffuse or other focal left ventricular uptake (n = 5). Three patients with the latter uptake pattern turned out to have coexistence of AHCM and asymmetric septal hypertrophy. Of the 16 SSUA-positive patients who underwent echocardiography, 13 (81%) were diagnosed as AHCM and the remaining 3 were regarded as borderline AHCM (apical wall thickness, 14-15 mm). There were 16 patients with SSUA who also underwent PET scans after the study period among which 11 (69%) had persistent SSUA in the follow-up PET. In the remaining 5, follow-up PET scans showed diffuse left ventricular uptake and SSUA was barely visible. The intensity of SSUA was significantly or marginally associated with giant negative T wave (p < 0.01), apical asynergy (p = 0.08), and impaired coronary flow reserve (p < 0.05). There were no other factors correlated with the pattern or intensity of SSUA.

    CONCLUSION:

    SSUA incidentally found in oncological FDG PET appeared to be associated with AHCM, especially in ischemic conditions. The moderate repeatability of SSUA was probably due to obscurity by physiological uptake.

  • Ra-223 SPECT for semi-quantitative analysis in comparison with Tc-99m HMDP SPECT: phantom study and initial clinical experience.

    Owaki Y1,2, Nakahara T3, Kosaka T4, Fukada J1, Kumabe A1, Ichimura A, Murakami M, Nakajima K, Fukushi M, Inoue K, Oya M, Jinzaki M.

    EJNMMI Research (Springer)  7 ( 1 ) 81 2017年10月

    研究論文(学術雑誌), 共著

     概要を見る

    BACKGROUND:
    Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to be more accurate than planar imaging in terms of lesion-based analysis. The aims of this study were to assess the feasibility and clinical usefulness of Ra-223 SPECT. The energy spectrum of Ra-223 and SPECT images of a cylindrical phantom with a hot rod were obtained to determine the collimator candidates and energy window settings suitable for clinical Ra-223 SPECT (basic study A). Another phantom with a tube-shaped chamber and two spheres simulating bowel activity and metastatic lesions in the lumbar spine was scanned with medium-energy general-purpose (MEGP) and high-energy general-purpose (HEGP) collimators (basic study B). Ten patients with CRPC underwent SPECT imaging 2 h after Ra-223 injection successively with MEGP and HEGP collimators in random order for 30 min each. Lesion detectability and semi-quantitative analyses of bone metastasis (i.e. lesion-to-background ratio (LBR)) were performed compared to Tc-99m HMDP SPECT.
    RESULTS:
    Basic study A revealed that an 84-keV photopeak ± 20% using the HEGP collimator offers better SPECT image quality than the other imaging conditions. Basic study B showed that uptake in one of the spheres was overestimated by overlapped activity of the tube-shaped chamber in planar imaging whereas the spheres had similar counts and significantly higher sphere-to-background ratio in SPECT. On both planar and SPECT images, HEGP gave higher image contrast than MEGP (p < 0.01). In the clinical study, Ra-223 SPECT at 84 keV ± 20% depicted more lesions with the HEGP than with the MEGP collimator (51 vs 36, p = 0.013). There was a positive correlation between LBR in Tc-99m SPECT and in Ra-223 SPECT (r = 0.67 with the MEGP and 0.69 with the HEGP collimator, p < 0.01). LBRs were significantly higher with the HEGP than with the MEGP collimator (p < 0.01).
    CONCLUSIONS:
    We recommended the use of the HEGP collimator at 84 keV ± 20% for Ra-223 SPECT imaging. Lesion-based semi-quantitative analysis in the human study revealed a good correlation between Ra-223 and Tc-99m HMDP SPECT in the early phase (2-3 h post injection).

  • Bone SPECT/CT Localizes Increased Bone Metabolism and Subsequent Bone Resorption in Reflex Sympathetic Dystrophy.

    Narimatsu H, Nakahara T, Kodama S, Hisazumi H, Tominaga S, Ohkuma K, Jinzaki M.

    Clinical Nuclear Medicine (Wolters Kluwer Health)  42 ( 10 ) 784 - 786 2017年10月

    研究論文(学術雑誌), 共著

     概要を見る

    A 64-year-old man with lung cancer with a history of revascularization of the occluded right femoral artery underwent bone scintigraphy, which showed intense uptake in the distal side of the right leg. The additional SPECT/CT clarified that the uptake was predominantly increased in the epiphyses of the right ankle and foot with possible osteopenia. One month later, follow-up SPECT/CT showed the manifestation of periosteal resorption in the hypermetabolic sites with slight decrease in bone metabolism. Radiological correlation between bone metabolism and subsequent bone resorption in addition to clinical symptoms in this patient suggested the diagnosis of reflex sympathetic dystrophy.

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

研究発表 【 表示 / 非表示

  • 心臓・冠動脈CTの現状

    陣崎 雅弘

    第68回日本循環器学会総会・学術集会 (東京) , 2004年03月, その他

  • Imaging of renal masses for diagnosis and management

    陣崎 雅弘

    2004 STANFORD RADIOLOGY POSTGRADUATE COURSES (Maui, Hawaii) , 2004年03月, 口頭(招待・特別)

  • マルチスライスCTの臨床応用

    陣崎 雅弘

    河田町放射線学術講演会 (東京) , 2004年02月, その他

  • 泌尿器領域の画像診断

    陣崎 雅弘

    第23回日本画像医学会 (東京) , 2004年02月, その他

  • マルチスライスCTによる冠動脈プラークの診断

    陣崎 雅弘

    第4回動脈硬化教育フォーラム (東京) , 2004年02月, その他

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競争的資金等の研究課題 【 表示 / 非表示

  • 立位の単純CT画像を用いた人体の解剖学的構造の定量化~臥位撮影との比較~

    2017年04月
    -
    2020年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 陣崎 雅弘, 基盤研究(B), 補助金,  代表

  • 4次元CTによる動態評価の基礎的検討と臨床応用

    2014年04月
    -
    2017年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 陣崎 雅弘, 基盤研究(C), 補助金,  代表

     研究概要を見る

    基礎検討では、4次元CTで計測した流速は超音波の流速値と比例関係にあり、CTで流速計測が可能になることを示した。
    次に臨床応用を4つの領域で検討した。鼻咽頭機能評価では、閉鎖不全腔を定量評価できることから重症度判定が正確で、従来のX線検査及び侵襲のある喉頭鏡を置換できる可能性があることを示せた。ステントグラフト後のendoleak評価では、従来のCTと比べ4次元CTは診断能が向上し、多くの症例で血管造影を置換できることを示せた。更に、排尿中に4次元CTを撮影すると排尿機能を評価でき、排尿障害患者の様々な尿路閉塞の原因を特定できることを示した。整形領域では、関節運動の定量評価ができることを示した。

受賞 【 表示 / 非表示

  • 慶應医学三四会北島賞

    2013年06月, 泌尿器画像診断アルゴリズムの構築

  • 第72回日本医学放射線学会 教育展示優秀賞

    2013年06月, 腎血管筋脂肪腫の新しい分類

  • 第72回日本医学放射線学会 Cypos Gold Medal

    2013年04月, 高分解能 CT による冠動脈の狭窄度診断精度の向上

  • 第25回日本腹部放射線学会 打田賞 

    2012年06月, 腎転座型腎癌の画像所見

  • 日獨医報 Best Paper Award

    2009年04月, CT・MRI時代における非血管特殊造影検査の意義:泌尿器・生殖器 -経静脈性尿路造影-

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担当授業科目 【 表示 / 非表示

  • 放射線医学演習

    2019年度

  • 放射線医学実習

    2019年度

  • 放射線医学

    2019年度

  • 放射線医学講義

    2019年度

  • 放射線医学特論

    2019年度

担当経験のある授業科目 【 表示 / 非表示

  • 放射線医学臨床実習 X線、CT,MR

    慶應義塾, 2015年度, 通年, 専門科目, 演習, 専任, 8人

  • 循環器診断学 X線

    慶應義塾, 2015年度, 秋学期, 専門科目, 講義

  • 放射線医学基礎講義 画像総論

    慶應義塾, 2015年度, 秋学期, 専門科目, 講義

教育活動及び特記事項 【 表示 / 非表示

  • MDCTの基本 パワーテキスト

    2010年

    , 教科書・教材の開発

     内容を見る

    メディカルサイエンスインターナショナル2010