奥田 茂男 (オクダ シゲオ)

Okuda, Shigeo

写真a

所属(所属キャンパス)

医学部 放射線科学教室(診断) (信濃町)

職名

准教授

メールアドレス

メールアドレス

外部リンク

その他の所属・職名 【 表示 / 非表示

  • 医学部, 准教授

経歴 【 表示 / 非表示

  • 2008年04月
    -
    2015年08月

    慶應義塾大学医学部, 放射線科学教室(診断), 学部内講師

  • 2015年09月
    -
    継続中

    慶應義塾大学医学部, 放射線科学教室(診断), 准教授

学位 【 表示 / 非表示

  • 医学博士, 慶應義塾, 論文

 

研究分野 【 表示 / 非表示

  • 放射線科学 (Radiation Science)

研究キーワード 【 表示 / 非表示

  • 核磁気共鳴

  • 画像診断学

 

著書 【 表示 / 非表示

  • 循環器急性期診療

    伊藤大樹、松本直也、奥田 茂男, メディカル・サイエンス・インターナショナル, 2015年06月

    担当範囲: 5章 画像検査

  • 冠動脈疾患の非観血的イメージング

    奥田 茂男、谷本 伸弘、栗林 幸夫, 中山書店、東京, 2006年07月

    担当範囲: 92-98

論文 【 表示 / 非表示

  • Usefulness of <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography for predicting the prognosis and treatment response of neoadjuvant therapy for pancreatic ductal adenocarcinoma

    Yokose T., Kitago M., Matsusaka Y., Masugi Y., Shinoda M., Yagi H., Abe Y., Oshima G., Hori S., Endo Y., Toyama K., Iwabuchi Y., Takemura R., Ishii R., Nakahara T., Okuda S., Jinzaki M., Kitagawa Y.

    Cancer Medicine (Cancer Medicine)  9 ( 12 ) 4059 - 4068 2020年06月

     概要を見る

    © 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. Background: The Response Evaluation Criteria in Solid Tumors (RECIST) for computed tomography (CT) is preoperatively used to evaluate therapeutic effects. However, it does not reflect the pathological treatment response (PTR) of pancreatic ductal adenocarcinoma (PDAC). The Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) for positron emission tomography (PET)/CT is effective in other cancers. This study aimed to confirm the usefulness of PERCIST and the prognostic utility of PET/CT for PDAC. Methods: Forty-two consecutive patients with PDAC who underwent neoadjuvant therapy (NAT) and pancreatectomy at our institution between 2014 and 2018 were retrospectively analyzed. We evaluated the treatment response and prognostic significance of PET/CT parameters and other clinicopathological factors. Results: Twenty-two patients who underwent PET/CT both before and after NAT with the same protocol were included. RECIST revealed stable disease and partial response in 20 and 2 cases, respectively. PERCIST revealed stable metabolic disease, partial metabolic response, and complete metabolic response in 8, 9, and 5 cases, respectively. The PTR was G3, G2, and G1 in 8, 12, and 2 cases, respectively. For comparing the concordance rates between PTR and each parameter, PERCIST (72.7% [16/22]) was significantly superior to RECIST (36.4% [8/22]) (P =.017). The area under the curve survival values of PET/CT parameters were 0.777 for metabolic tumor volume (MTV), 0.500 for maximum standardized uptake value, 0.554 for peak standardized uptake value corrected for lean body mass, and 0.634 for total lesion glycolysis. A 50% cut-off value for the MTV reduction rate yielded the largest difference in survival between responders and nonresponders. On multivariate analysis, MTV reduction rates < 50% were independent predictors for relapse-free survival (hazard ratio [HR], 3.92; P =.044) and overall survival (HR, 14.08; P =.023). Conclusions: PERCIST was more accurate in determining NAT’s therapeutic effects for PDAC than RECIST. MTV reduction rates were independent prognostic factors for PDAC.

  • Quantification of intratumoral collagen and elastin fibers within hepatocellular carcinoma tissues finds correlations with clinico-patho-radiological features

    Maehara J., Masugi Y., Abe T., Tsujikawa H., Kurebayashi Y., Ueno A., Ojima H., Okuda S., Jinzaki M., Shinoda M., Kitagawa Y., Oda Y., Honda H., Sakamoto M.

    Hepatology Research (Hepatology Research)  50 ( 5 ) 607 - 619 2020年05月

    ISSN  13866346

     概要を見る

    © 2019 The Japan Society of Hepatology Aim: Emerging evidence suggests a promising role for tumor stromal factors in characterizing patients with various types of malignancies, including hepatocellular carcinoma (HCC). We quantified the amount of collagen and elastin fibers in HCC samples with the aim of clarifying the clinico-patho-radiological significance of fiber deposition in HCC. Methods: We computed the amount of collagen and elastin fibers using digital image analysis of whole-slide images of Elastica van Gieson-stained tissues from 156 surgically resected HCCs. Furthermore, we assessed the correlations between the fiber content of HCC samples and clinical, pathological, and radiological features, including immunohistochemistry-based molecular subtypes and immunosubtypes. Results: The intratumoral area ratio of collagen in HCC tissues (median 3.4%, range 0.1–22.2%) was more than threefold that of elastin (median 0.9%, range 0.1–9.0%); there was a strong positive correlation between the amounts of collagen and elastin. Higher levels of combined collagen and elastin were significantly associated with the confluent multinodular macroscopic tumor type, the absence of a fibrous capsule, intratumoral steatosis, scirrhous tumor stroma, dense inflammatory-cell infiltrates, and the biliary/stem cell markers-positive HCC subtype. The associations of higher collagen levels with radiological findings, including heterogeneous enhancement and persistent enhancement on dynamic computed tomography, were significant. In contrast, the associations of radiological findings with elastin fibers were not significant. Intratumoral fibrous stroma in HCC comprised septum-like and perisinusoidal fibrosis; these two forms represented distinct distribution patterns of fibers and fibroblasts. Conclusion: Quantitative analysis suggested that stromal fiber-rich HCCs likely represent a distinct clinico-patho-radiological entity.

  • Comparison of silent navigator waveform generation methods

    Iwadate Y., Nozaki A., Nunokawa Y., Okuda S., Kabasawa H., Jinzaki M.

    Magnetic Resonance in Medical Sciences (Magnetic Resonance in Medical Sciences)  19 ( 2 ) 154 - 158 2020年

    ISSN  13473182

     概要を見る

    © 2019 Japanese Society for Magnetic Resonance in Medicine. The silent navigator technique utilizes a non-selective excitation and an appropriate respiratory waveform generation method is necessary for an accurate motion detection. We compared three methods for silent navigator waveform generation. The profile generation method with coil selection (prof-selection) resulted in a high cross correlation with bellows signals and a large respiration amplitude. The prof-selection method should be used for silent navigator waveform generation.

  • A case of pancreatic hamartoma with characteristic radiological findings: radiological-pathological correlation

    Toyama K., Matsusaka Y., Okuda S., Miura E., Kubota N., Masugi Y., Kitago M., Hori S., Yokose T., Shinoda M., Sakamoto M., Jinzaki M.

    Abdominal Radiology (Abdominal Radiology)  45 ( 7 ) 2244 - 2248 2020年

    ISSN  2366004X

     概要を見る

    © 2020, Springer Science+Business Media, LLC, part of Springer Nature. Pancreatic hamartoma is a rare benign tumor. Its preoperative diagnosis is challenging. We present a case of pancreatic hamartoma whose radiological-pathological correlation was evaluated in detail. A 53-year-old man was referred to our institution for diagnosis and treatment. Contrast-enhanced computed tomography (CT) and magnetic resonance image revealed a 3.5 cm long tumor arising from the head of the pancreas with cystic and solid components, the latter of which was gradually and inhomogeneously enhanced in the delayed phase. Fluorodeoxyglucose (FDG) positron emission tomography/CT revealed slight FDG uptake in the solid component. Histologically, a number of pancreatic lobule-like structures, which were mainly composed of aggregates of small ducts embedded in concentric fibrous stroma with no apparent islets or peripheral nerves, were observed in the solid component, whereas multiple dilated ducts were seen in the cystic region. The solid component also contained a narrow area of edematous fibrous stroma with low vessel density, which corresponded with the unenhanced part in the inhomogeneously enhanced solid component. There was no remarkable cytological atypia throughout the mass. A pathological diagnosis of pancreatic hamartoma was made. The radiological findings agree well with the pathological findings. When a pancreatic tumor is of the solid type, preoperatively diagnosing it as pancreatic hamartoma is not possible. However, when a pancreatic tumor with cystic and solid components is inhomogeneously enhanced in contrast-enhanced studies, a diagnosis of pancreatic hamartoma can be considered.

  • Clinical utility of the Vesical Imaging-Reporting and Data System for muscle-invasive bladder cancer between radiologists and urologists based on multiparametric MRI including 3D FSE T2-weighted acquisitions

    Arita Y., Shigeta K., Akita H., Suzuki T., Kufukihara R., Kwee T.C., Ishii R., Mikami S., Okuda S., Kikuchi E., Oya M., Jinzaki M.

    European Radiology (European Radiology)  2020年

    ISSN  09387994

     概要を見る

    © 2020, European Society of Radiology. Objectives: To investigate the clinical utility of the Vesical Imaging-Reporting and Data System (VI-RADS) by comparing its diagnostic performance for muscle-invasive bladder cancer (MIBC) between radiologists and urologists based on multiparametric MRI, including three-dimensional (3D) fast spin-echo (FSE) T2-weighted acquisitions. Methods: This study included 66 treatment-naïve patients (60 men, 6 women; mean age 74.0 years) with pathologically proven bladder cancer who underwent multiparametric MRI, including 3D FSE T2-weighted imaging, before transurethral bladder tumour resection between January 2010 and November 2018. The MRI scans were categorised according to the five-point VI-RADS score by four independent readers (two board-certified radiologists and board-certified urologists each), blinded to the histopathological findings. The VI-RADS scores were compared with the postoperative histopathological diagnosis. Interobserver agreement was assessed using weighted kappa coefficients. ROC analysis and generalised estimating equations were used to evaluate the diagnostic performance. Results: Forty-nine (74.2%) and 17 (25.8%) tumours were confirmed to be non-MIBC and MIBC, respectively, based on pathological examination. The interobserver agreement was good-to-excellent between all pairs of readers (range, 0.73–0.91). The urologists’ sensitivity/specificity values for DCE-MRI VI-RADS scores were significantly lower than those of radiologists. No significant differences were observed for the overall VI-RADS score. The AUC for the overall VI-RADS score was 0.94, 0.92, 0.89, and 0.87 for radiologists 1 and 2 and urologists 1 and 2, respectively. Conclusions: The VI-RADS score, based on multiparametric MRI including 3D FSE T2-weighted acquisitions, can be useful for radiologists and urologists to determine the bladder cancer muscle invasion status preoperatively. Key Points: • VI-RADS (using multiparametric MRI including 3D FSE T2-weighted acquisitions) achieves good to excellent interobserver agreement and has similar diagnostic performance for detecting muscle invasion by both radiologists and urologists. • The diagnostic performance of the overall VI-RADS score is high for both radiologists and urologists, particularly due to the dominant effect of diffusion-weighted imaging on the overall VI-RADS score. • The sensitivity and specificity values of the T2WI VI-RADS scores for four readers in our study (using 3D FSE T2-weighted acquisitions) were similar (with slightly higher specificity values) to previously published results (using 2D FSE T2-weighted acquisitions).

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

総説・解説等 【 表示 / 非表示

  • MRIを用いた右室機能評価を知る

    奥田茂男、山田祥岳、陣崎雅弘

    循環器ジャーナル (医学書院)  67 ( 3 )  2020年07月

    総説・解説(学術雑誌), 共著

研究発表 【 表示 / 非表示

  • 大動脈ステントグラフトが 4D Flow に及ぼす影響:基礎的検討

    藤代力也、布川嘉信、渡部敏男、奥田茂男、井上政則、藤原広和、陣崎雅弘、野崎敦

    日本磁気共鳴医学会大会 (熊本) , 2019年10月, ポスター(一般), 磁気共鳴医学会

  • KatARCを用いた心臓2D cine画像の検討

    小川隼人、布川嘉信、渡部敏男、松本俊亮、奥田茂男、陣崎雅弘、野崎敦

    日本磁気共鳴医学会大会 (熊本) , 2019年10月, ポスター(一般), 磁気共鳴医学会

  • 1年間の進歩を丸ごとレビュー Artificial Intelligence

    奥田茂男

    SCMR Japan WG, 2019年08月, 口頭(招待・特別)

  • 各領域の進歩2 心臓

    奥田茂男

    SAMI, 2019年07月, 口頭(招待・特別)

  • Cine, 4D Flow における kt の利用

    奥田茂男

    AIMS Cardiac Imaging 2019, 2019年05月, 口頭(招待・特別)

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競争的資金等の研究課題 【 表示 / 非表示

  • 低速血流にも対応する 4D flow 法による血流評価

    2018年04月
    -
    2021年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 奥田 茂男, 基盤研究(C), 補助金,  代表

  • 大動脈および肺動脈の低侵襲治療における 4D flow MRI を用いた血流評価

    2015年04月
    -
    2019年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 奥田 茂男, 基盤研究(C), 補助金,  代表

 

担当授業科目 【 表示 / 非表示

  • 放射線医学講義

    2020年度

  • 内科学(消化器)講義

    2020年度

  • 内科学(循環器)講義

    2020年度

  • 臨床実習入門

    2020年度

  • 診断学実習

    2020年度

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担当経験のある授業科目 【 表示 / 非表示

  • 消化器内科系統講義 肝胆画像診断

    慶應義塾, 2015年度, 通年, 専門科目, 講義, 専任, 100人

    肝臓、胆嚢、画像診断

  • 放射線診断学系統講義

    慶應義塾, 2015年度, 通年, 専門科目, 講義, 専任, 100人

    MR基礎

  • 放射線診断学

    慶應義塾, 2015年度, 通年, 専門科目, 演習, 専任, 1時間

    消化管造影、心大血管画像診断