津崎　盾哉 （ ツザキ　ジュンヤ ）

Tsuzaki, Junya

写真a

所属（所属キャンパス）

医学部 放射線科学教室（診断） （ 信濃町 ）

職名

助教（有期）

外部リンク
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  • VEGF-Positive Mass-Forming Intrahepatic Cholangiocarcinoma: New Subtype Based on Radiological and Molecular Pathological Analysis.

    Tsuzaki J, Kubota N, Soga S, Arai Y, Shibata T, Esaki M, Jinzaki M, Ojima H

    Hepatology research : the official journal of the Japan Society of Hepatology 2026年03月

    筆頭著者, 最終著者, 責任著者,  ISSN  1386-6346

    　概要を見る

    Aim: Among mass-forming (MF) type intrahepatic cholangiocarcinoma (ICC), approximately 20%–30% are hypervascular on imaging and are associated with improved prognosis. However, the molecular background based on gene expression of this entity remains unclear. Methods: We retrospectively analyzed 109 patients with MF-type ICC resected at the National Cancer Center Hospital, Japan. Preoperative dynamic computed tomography (CT) images were available for 48 cases. Based on the late-arterial-phase enhancement area (EA) and the relative enhancement ratio (RER), 17 were classified as hypervascular ICC (H-ICC, EA ≥ 50%), 21 as hypovascular ICC (h-ICC, EA < 50%, RER ≥ 1), and 10 as nonvascular ICC (N-ICC, EA < 50%, RER < 1). We compared group-wise arterial vessel density (AVD), then profiled angiogenesis genes to identify a suitable immunohistochemical marker. Results: The H-ICC group had a better prognosis than h-ICC (P = 0.024) and N-ICC (P = 0.002). H-ICC also had a higher AVD than other groups (P < 0.001). Among the angiogenesis-related genes, vascular endothelial growth factor A (VEGFA) exhibited the strongest correlation with EA (P = 0.012), and H-ICC exhibited higher VEGF positivity than other groups (P = 0.022). The survival and immunostaining profiles of h-ICC closely resembled those of N-ICC. ROC analysis revealed that a VEGF staining positivity of 70% was the optimal cut-off for identifying H-ICC. Conclusions: H-ICC is characterized by hyperenhancement occupying ≥ 50% of the tumor area on dynamic CT, high AVD, and elevated VEGFA expression. These findings support a distinct clinicopathological subset identifiable by LAP enhancement and VEGF immunostaining.

  • Free-breathing Three-dimensional MR Cholangiopancreatography Using Centric k-space Encoding Improved Gallbladder Visualization: A Prospective Study.

    Tsuzaki J, Nozaki T, Ito D, Habe T, Miyazaki S, Arai M, Hase M, Sakata H, Tsukada R, Yamada Y, Jinzaki M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine （日本磁気共鳴医学会）  advpub （ 0 ）  2026年02月

    筆頭著者, 最終著者, 責任著者,  ISSN  1347-3182

    　概要を見る

    <p>Purpose: MR cholangiopancreatography (MRCP) often suffers from signal loss because of concentrated bile. Gradient-and-spin-echo (GRASE) MRCP reduces this effect but is limited by breath-holding. We developed MRCP with centric order encoding (MRCP-CORE), a novel free-breathing sequence with shorter TE using centric k-space trajectory, T2 preparation, and velocity encoding, and evaluated its ability to visualize gallbladder.</p><p>Methods: In this prospective, single-center study, we enrolled 100 consecutive patients who underwent 3 MRCP sequences (MRCP-CORE, conventional MRCP, and GRASE MRCP) on a 3T system. Two blinded radiologists independently assessed the visibility of anatomical structures, artifacts, and overall image quality. SNR, contrast-to-noise ratio, and contrast ratio of the periductal tissue and gallbladder were measured. The Friedman test was used for comparisons; Jonckheere–Terpstra analysis tested the association between the gallbladder visibility and quantitative metrics.</p><p>Results: Ninety-nine patients (mean age, 68.5 ± 10.9 years; 52 men, 47 women) were evaluated. MRCP-CORE showed significantly higher SNR than conventional and GRASE MRCP (20.9 vs. 17.3 vs. 15.8; <i>P</i> < 0.001). Gallbladder visibility was significantly higher with MRCP-CORE than via conventional MRCP (<i>P</i> = 0.02) and comparable to that via GRASE MRCP (<i>P</i> = 1.00). No significant differences in artifact and overall image quality were observed among sequences. Trend analysis revealed gallbladder visibility was significantly influenced by bile concentration in conventional MRCP (<i>P</i> < 0.001), but not in MRCP-CORE (<i>P</i> = 0.12) or GRASE MRCP (<i>P</i> = 0.43).</p><p>Conclusion: MRCP-CORE enhanced gallbladder depiction compared with conventional MRCP, offering a robust free-breathing alternative to breath-hold GRASE MRCP.</p>

  • Incidence and Clinical Course of Lower-Limb Lymphedema after Intranodal n-Butyl-2-Cyanoacrylate Embolization for Postoperative Lymphorrhea.

    Tsukada J, Inoue M, Tamura M, Torikai H, Yoshikawa H, Miyabayashi M, Tsuzaki J, Kogo T, Furukawa Y, Ogawa R, Yamamoto Y, Suzuki Y, Ito N, Nakatsuka S, Jinzaki M

    Journal of vascular and interventional radiology : JVIR 37 （ 4 ） 108541 2026年01月

    筆頭著者, 最終著者, 責任著者,  ISSN  1051-0443

    　概要を見る

    Purpose: To evaluate the incidence and clinical course of lower-limb lymphedema following intranodal n-butyl-2-cyanoacrylate (nBCA) embolization of the inguinal lymph nodes for postoperative lymphorrhea. Materials and Methods: This retrospective study included 26 patients (24 men and 2 women; age, 69.5 years) who underwent intranodal nBCA embolization for postoperative lymphorrhea between 2017 and 2023. Under ultrasound (US) guidance, inguinal lymph nodes were punctured, and embolization was performed with nBCA and ethiodized oil at a 2:1 ratio (ethiodized oil:nBCA). The primary approach was to embolize through the initially accessed lymph node when the efferent channel and leakage site were visualized. Clinical success was defined as improvement of lymphorrhea-related symptoms with catheter removal or ≥80% drainage reduction within 21 days. Lower-limb lymphedema was defined as new-onset or worsening of existing edema in 60 days after embolization and categorized as reversible or persistent. Results: Clinical success was achieved in 24 of 26 patients (92.3%), with a median time to resolution of 6 days (range, 2–21 days). Lower-limb lymphedema worsened in 6 patients (23.1%), including 4 reversible and 2 persistent cases. No new-onset lymphedema occurred; all represented exacerbation of pre-existing edema. Both persistent cases involved patients with prior pelvic lymph node dissection. No procedure-related deaths or major complications occurred. Conclusion: Inguinal intranodal nBCA embolization effectively controls postoperative lymphorrhea but may worsen pre-existing lower-limb lymphedema, particularly in patients with prior pelvic lymph node dissection. To minimize nontarget embolization of lower-extremity drainage pathways, lymphatic embolization should be performed as selectively and as close to the leakage site as possible.

  • Efficacy of three-dimensional fast spin echo t2-weighted magnetic resonance imaging (cube) for evaluating the longitudinal spread of perihilar cholangiocarcinoma after endoscopic biliary stenting: a diagnostic study.

    Sonoda K, Abe Y, Yokoyama Y, Tsuzaki J, Okuda S, Ueno A, Takemura R, Kitago M, Hasegawa Y, Hori S, Tanaka M, Nakano Y, Okita H, Jinzaki M, Kitagawa Y

    International journal of surgery (London, England) 112 （ 1 ） 325 - 332 2025年09月

    筆頭著者, 最終著者, 責任著者,  ISSN  1743-9191

  • Pearls and pitfalls in imaging of axial spondyloarthritis for rheumatologists

    Nozaki T., Tsujioka Y., Sugimoto H., Yamada Y., Yamada M., Yokoyama Y., Fujishiro H., Nimura A., Tsuzaki J., Hase M., Okada M., Kaneko Y., Jinzaki M.

    Modern Rheumatology 35 （ 4 ） 612 - 625 2025年07月

    ISSN  14397595

    　概要を見る

    This review provides key insights into sacroiliitis imaging, covering anatomy, imaging techniques, and interpretation. It focuses on normal physiological changes in young to middle-aged women, children, and the elderly that can resemble sacroiliitis. We emphasize the importance of distinguishing between active and structural lesions, as highlighted in the recent ASAS-SPARTAN standardized magnetic resonance imaging protocol. Physicians should be aware that bone marrow oedema signals on magnetic resonance imaging, a hallmark of active inflammation in axial spondyloarthritis, can also be observed in young to middle-aged women, especially postpartum, even without spondyloarthritis. Paediatric sacroiliac joints may show changes mimicking inflammation due to ongoing bone growth. Furthermore, degenerative changes in the sacroiliac joint are common with advancing age and can be mistaken for sacroiliitis or interpreted as structural changes. The presence of accessory sacroiliac joints, prone to degeneration, further complicates diagnosis. Accurate interpretation requires considering these normal variations to avoid misdiagnosing spondyloarthritis. Collaboration between clinicians and radiologists is crucial, especially when encountering atypical or clinically inconsistent findings. Japan College of Rheumatology 2025. Published by Oxford University Press.

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  • 腹部MRIでみる高速化撮像法の使い方

    津崎 盾哉

    断層映像研究会雑誌 （断層映像研究会）  52 （ 1 ） 11 - 11 2025年11月

    ISSN  0914-8663

  • 門脈圧亢進関連疾患に対するIVR治療の未来予想図　受け継ぎ、つながり、広げる、門脈関連IVR　当施設での経験から

    田村 全, 吉川 裕紀, 小川 遼, 竹下 諒, 塚田 実郎, 津崎 盾哉, 古川 裕二, 古後 斗冴, 山本 洋輔, 山崎 裕哉, 小泉 淳, 中塚 誠之, 陣崎 雅弘

    日本門脈圧亢進症学会雑誌 （(一社)日本門脈圧亢進症学会）  31 （ 3 ） 111 - 111 2025年08月

    ISSN  1344-8447

  • 特集 腹部の最新画像情報2025 胆管内乳頭状腫瘍:原発性硬化性胆管炎の経過中に肝破裂と腹膜播種を起こした1例

    屋代 香絵, 山田 祥岳, 津崎 盾哉, 池田 織人, 新妻 雄介, 山田 実加, 城谷 良太, 真杉 洋平, 上野 彰久, 田中 真之, 平田 賢郎, 陣崎 雅弘

    臨床放射線 （金原出版）  70 （ 4 ） 559 - 566 2025年07月

    ISSN  0009-9252

  • リウマチ専門医のための体軸性脊椎関節炎の画像におけるパールとピットフォール(Pearls and pitfalls in imaging of axial spondyloarthritis for rheumatologists)

    Nozaki Taiki, Tsujioka Yuko, Sugimoto Hideharu, Yamada Yoshitake, Yamada Minoru, Yokoyama Youichi, Fujishiro Hitomi, Nimura Akimoto, Tsuzaki Junya, Hase Manabu, Okada Masato, Kaneko Yuko, Jinzaki Masahiro

    Modern Rheumatology （Oxford University Press）  35 （ 4 ） 612 - 625 2025年07月

    ISSN  1439-7595

  • CT- and Ultrasound-Guided Drainage Using Drainaway: A Single-Center Experience of 51 Cases(タイトル和訳中)

    Yamamoto Yosuke, Tsukada Jitsuro, Tamura Masashi, Yokotsuka Shinnosuke, Onishi Masaki, Togawa Koji, Ogawa Ryo, Furukawa Yuji, Kogo Togo, Tsuzaki Junya, Yoshikawa Hiroki, Miyabayashi Mamina, Maeshima Katsuya, Jinzaki Masahiro, Nakatsuka Seishi

    日本インターベンショナルラジオロジー学会雑誌 （(一社)日本インターベンショナルラジオロジー学会）  40 （ Suppl. ） 235 - 235 2025年05月

    ISSN  1340-4520

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