澤田 将史 (サワダ マサフミ)

Sawada, Masafumi

写真a

所属(所属キャンパス)

医学部 放射線科学教室(治療) (信濃町)

職名

助教(有期)

 

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  • Dosimetric study of whole-brain irradiation with high-energy photon beams for dose reduction to the scalp

    Sawada M., Kunieda E., Akiba T., Kabuki S., Nagao R., Fukuzawa T., Matsumoto Y., Shigematsu N.

    British Journal of Radiology (British Journal of Radiology)  93 ( 1114 )  2020年10月

    ISSN  00071285

     概要を見る

    Objective: To evaluate the efficiency of high-energy photons for mitigating alopecia due to whole-brain irradiation (WBRT). Methods: Planning CT data from 10 patients who received WBRT were collected. We prepared 4 WBRT plans that used 6 or 15 MV photon beams, with or without use of a field-in-field (FiF) technique, and compared outcomes using a treatment planning system. The primary outcome was dose parameters to the scalp, including the mean dose, maximum dose, and dose received to 50% scalp (D50%). Secondary outcomes were minimum dose to the brain surface. Results: Using FiF, the mean doses were 24.4-26.0 and 22.4-24.1 Gy, and the maximum doses were 30.5-32.1 and 28.5-30.8 Gy for 6 and 15 MV photon beams, respectively. Without FiF, the mean doses were 24.6-26.9 and 22.6-24.5 Gy, and the maximum doses were 30.8-34.6 and 28.6-32.4 Gy for 6 and 15 MV photon beams. The 15 MV plan resulted in a lower scalp dose for each dose parameter (p < 0.001). Using FiF, the minimum doses to the brain surface for the 6 and 15 MV plans were 28.9 ± 0.440 and 29.0 ± 0.557 Gy, respectively (p = 0.70). Without FiF, the minimum doses to the brain surface for the 6 and 15 MV plans were 28.9 ± 0.456 and 29.0 ± 0.529, respectively (p = 0.66). Conclusion: Compared with the 6 MV plan, the 15 MV plan achieved a lower scalp dose without impairing the brain surface dose. Advances in knowledge: High-energy photon WBRT may mitigate alopecia of patients who receiving WBRT.

競争的研究費の研究課題 【 表示 / 非表示

  • マイトファジーを標的にした膵がん放射線増感方法の新規開発

    2020年04月
    -
    2022年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 澤田 将史, 若手研究, 補助金,  研究代表者