慶應義塾研究者情報データベース

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• Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s disease

  Kobayashi N., Shinagawa S., Niimura H., Kida H., Nagata T., Tagai K., Shimada K., Oka N., Shikimoto R., Noda Y., Nakajima S., Mimura M., Shigeta M., Kondo K.

  Scientific Reports （Scientific Reports）  10 （ 1 ）  2020年12月

  　概要を見る

  © 2020, The Author(s). Early diagnosis of dementia including Alzheimer’s disease (AD) is an urgent medical and welfare issue. However, to date, no simple biometrics have been available. We reported that blood DNA methylation levels of the COASY gene, which encodes coenzyme A synthase, were increased in individuals with AD and amnestic mild cognitive impairment (aMCI). The present study sought to replicate these findings with larger numbers of samples. Another objective was to clarify whether COASY methylation is associated with neurodegeneration through a comparison of AD, AD with cardiovascular disease (CVD), and vascular dementia (VaD). We measured blood COASY methylation levels in normal controls (NCs) (n = 200), and individuals with aMCI (n = 22), AD (n = 151), and VaD (n = 21). Compared with NCs, they were significantly higher in individuals with aMCI and AD. Further, they were significantly higher in AD patients without cardiovascular diseases compared to AD patients with them. These findings suggest that COASY methylation levels may be related to neurodegeneration in AD.

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• Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD)

  Ninomiya T., Nakaji S., Maeda T., Yamada M., Mimura M., Nakashima K., Mori T., Takebayashi M., Ohara T., Hata J., Kokubo Y., Uchida K., Taki Y., Kumagai S., Yonemoto K., Yoshida H., Muto K., Momozawa Y., Akiyama M., Kubo M., Ikeda M., Kanba S., Kiyohara Y., Ninomiya T., Shibata M., Yoshida D., Hirakawa Y., Honda T., Chen S., Hirabayashi N., Furuta Y., Mihara A., Nakazawa T., Ohara T., Ihara K., Murashita K., Sawada K., Jung S., Terayama Y., Yonezawa H., Takahashi J., Akasaka H., Noguchi-Shinohara M., Iwasa K., Sakai K., Hayashi K., Niimura H., Shikimoto R., Kida H., Eguchi Y., Fukada Y., Kowa H., Wada K., Kishi M., Yoshida T., Shimizu H., Tachibana A., Ueno S.i., Ishikawa T., Fukuhara R., Koyama A., Hashimoto M., Esaki M., Takano Y., Inoue Y.

  Environmental Health and Preventive Medicine （Environmental Health and Preventive Medicine）  25 （ 1 ）  2020年12月

  ISSN  1342078X

  　概要を見る

  © 2020, The Author(s). Background: The burden of dementia is growing rapidly and has become a medical and social problem in Japan. Prospective cohort studies have been considered an effective methodology to clarify the risk factors and the etiology of dementia. We aimed to perform a large-scale dementia cohort study to elucidate environmental and genetic risk factors for dementia, as well as their interaction. Methods: The Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) is a multisite, population-based prospective cohort study of dementia, which was designed to enroll approximately 10,000 community-dwelling residents aged 65 years or older from 8 sites in Japan and to follow them up prospectively for at least 5 years. Baseline exposure data, including lifestyles, medical information, diets, physical activities, blood pressure, cognitive function, blood test, brain magnetic resonance imaging (MRI), and DNA samples, were collected with a pre-specified protocol and standardized measurement methods. The primary outcome was the development of dementia and its subtypes. The diagnosis of dementia was adjudicated by an endpoint adjudication committee using standard criteria and clinical information according to the Diagnostic and Statistical Manual of Mental Disorders, 3rd Revised Edition. For brain MRI, three-dimensional acquisition of T1-weighted images was performed. Individual participant data were pooled for data analyses. Results: The baseline survey was conducted from 2016 to 2018. The follow-up surveys are ongoing. A total of 11,410 individuals aged 65 years or older participated in the study. The mean age was 74.4 years, and 41.9% were male. The prevalence of dementia at baseline was 8.5% in overall participants. However, it was 16.4% among three sites where additional home visit and/or nursing home visit surveys were performed. Approximately two-thirds of dementia cases at baseline were Alzheimer’s disease. Conclusions: The prospective cohort data from the JPSC-AD will provide valuable insights regarding the risk factors and etiology of dementia as well as for the development of predictive models and diagnostic markers for the future onset of dementia. The findings of this study will improve our understanding of dementia and provide helpful information to establish effective preventive strategies for dementia in Japan.

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• Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants

  Ichikawa N., Lisi G., Yahata N., Okada G., Takamura M., Hashimoto R.i., Yamada T., Yamada M., Suhara T., Moriguchi S., Mimura M., Yoshihara Y., Takahashi H., Kasai K., Kato N., Yamawaki S., Seymour B., Kawato M., Morimoto J., Okamoto Y.

  Scientific Reports （Scientific Reports）  10 （ 1 ）  2020年12月

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  © 2020, The Author(s). The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically important functional connections (FCs), and explore their association to treatments. Resting state fMRI data of 130 individuals (65 melancholic major depressive disorder (MDD) patients, 65 healthy controls) were included to build a melancholic MDD classifier, and 10 FCs were selected by our sparse machine learning algorithm. This biomarker generalized to a drug-free independent cohort of melancholic MDD, and did not generalize to other MDD subtypes or other psychiatric disorders. Moreover, we found that antidepressants had a heterogeneous effect on the identified FCs of 25 melancholic MDDs. In particular, it did impact the FC between left dorsolateral prefrontal cortex (DLPFC)/inferior frontal gyrus (IFG) and posterior cingulate cortex (PCC)/precuneus, ranked as the second ‘most important’ FC based on the biomarker weights, whilst other eight FCs were normalized. Given that left DLPFC has been proposed as an explicit target of depression treatments, this suggest that the limited efficacy of antidepressants might be compensated by combining therapies with targeted treatment as an optimized approach in the future.

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• Optimal robot for intervention for individuals with autism spectrum disorders

  Kumazaki H., Muramatsu T., Yoshikawa Y., Matsumoto Y., Ishiguro H., Kikuchi M., Sumiyoshi T., Mimura M.

  Psychiatry and Clinical Neurosciences （Psychiatry and Clinical Neurosciences）  74 （ 11 ） 581 - 586 2020年11月

  ISSN  13231316

  　概要を見る

  © 2020 The Authors. Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology With recent rapid advances in technology, human-like robots have begun functioning in a variety of ways. As increasing anecdotal evidence suggests, robots may offer many unique opportunities for helping individuals with autism spectrum disorders (ASD). Individuals with ASD often achieve a higher degree of task engagement through the interaction with robots than through interactions with human trainees. The type and form of robots to be used for individuals with ASD have been meticulously considered. Simple robots and animal robots are acceptable because of their simplicity and the ease of interesting and engaging interactions. Android robots have the benefit of the potential of generalization into daily life to some extent. Considering the affinity between robots and users is important to draw out the potential capabilities of robotic intervention to the fullest extent. In the robotic condition, factors such as the appearance, biological motion, clothes, hairstyle, and disposition are important. Many factors of a user, such as age, sex, and IQ, may also affect the affinity of individuals with ASD toward a robot. The potential end-users of this technology may be unaware or unconvinced of the potential roles of robots in ASD interventions. If trainers have extensive experience in using robots, they can identify many potential roles of robots based on their experience. To date, only a few studies have been conducted in the field of robotics for providing assistance to individuals with ASD, and future studies are needed to realize an optimal robot for this purpose.

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• Lower mortality from suicidal trauma among patients with a psychiatric diagnosis upon admission: Nationwide japanese retrospective cohort study

  Ishida T., Kuwahara Y., Shibahashi K., Okura Y., Sugiyama K., Hamabe Y., Mimura M., Suzuki T., Uchida H.

  Psychiatry Research （Psychiatry Research）  293 2020年11月

  ISSN  01651781

  　概要を見る

  © 2020 Suicide and self-harm are major public health issues. Few studies have compared mortality from suicidal trauma between patients with and without contact with psychiatric services. This study aimed to compare the in-hospital mortality of suicidal trauma between patients with and without a psychiatric diagnosis upon hospital admission. Data on 15- to 90-year-old patients with suicidal trauma between 2004 and 2015 was extracted from the Japan Trauma Data Bank. In-hospital mortality were compared between patients with and without a psychiatric diagnosis. A total of 9,803 patients were included. The median age was 42 years (interquartile range: 29–59), and 5,010 patients (51.1%) were male. The most frequent method of injury was falling from a height (53.4%), followed by stabbing (32.3%) and burns (6.2%). In total, 4,878 patients (49.8%) had a psychiatric diagnosis upon admission. The proportion of patients with a psychiatric diagnosis was significantly lower among males, teenagers, and older people. In-hospital mortality was significantly lower among patients with a psychiatric diagnosis than those without (10.9%vs18.7%). Contact with psychiatric services might be protective among people with suicidal trauma. However, the proportion of psychiatric service use was generally low. These findings show the importance of delivering appropriate psychiatric services to high-risk patients.

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KOARA（リポジトリ）収録論文等 【 表示 ／ 非表示 】

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• 治療抵抗性統合失調症における興奮抑制バランスの破綻 : TMS-EEG/MRS研究

  三村, 將

  科学研究費補助金研究成果報告書 2021年

• 自律神経システムの予測処理機能と精神疾患症状との関係性の探索的解明

  三村, 將

  科学研究費補助金研究成果報告書 2021年

• 高次脳機能障害に対する視覚ツールを用いた認知行動療法の検証

  三村, 將

  科学研究費補助金研究成果報告書 2021年

• 母と娘の脳は似ている? : うつ病における女性優位な世代間効果の生物学的基盤の検出

  三村, 將

  科学研究費補助金研究成果報告書 2020年

• グルタミン酸機能障害仮説に基く1H-MRSによる治療抵抗性統合失調症の病態の解明

  三村, 將

  科学研究費補助金研究成果報告書 2018年

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• Publisher Correction: Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants (Scientific Reports, (2020), 10, 1, (3542), 10.1038/s41598-020-60527-z)

  Ichikawa N., Lisi G., Yahata N., Okada G., Takamura M., Hashimoto R.i., Yamada T., Yamada M., Suhara T., Moriguchi S., Mimura M., Yoshihara Y., Takahashi H., Kasai K., Kato N., Yamawaki S., Seymour B., Kawato M., Morimoto J., Okamoto Y.

  Scientific Reports （Scientific Reports）  10 （ 1 ）  2020年12月

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  © 2020, The Author(s). The original version of this Article contained errors. In the original PDF version, the published date was omitted and now reads: “Published: 26 February 2020”. In addition, there were typographical errors in the Methods section, under the subheading “Experimental protocol and data acquisition”, where: “In the scan room with dimmed lights, participants were not required to keep looking at a cross mark in the center of the monitor screen, think of anything in particular, and not to sleep.” now reads: “In the scan room with dimmed lights, participants were required to keep looking at a cross mark in the center of the monitor screen, think of nothing in particular, and not to sleep.” In Table 2 where the ‘Contribution’ value for ID #7 was incorrect, the value “\” now reads “0.263”. In the Results section under the subheading “Effect of treatment with antidepressants”, where BDI and HAMD values were reversed, “(Mean(SD): BDI Pre = 19.1 (5.63), BDI Post = 11.3 (5.41), paired t-test results on BDI: p = 7.29 × 10−7; and HAMD Pre = 31.3 (7.48), HAMD Post = 18.7 (12.2), paired t-test results on HAMD: p = 7.26 × 10−7).” now reads: “(Mean(SD): BDI Pre = 31.3 (7.48), BDI Post = 18.7 (12.2), paired t-test results on BDI: p = 7.26 × 10−7; and HAMD Pre = 19.1 (5.63), HAMD Post = 11.3 (5.41), paired t-test results on HAMD: p = 7.29 × 10−7).” In the Supplementary Information file, there were missing values in Table S1c under the “Time 2 (6-8w)” column and on the “Severity of symptoms (BDI-II) “and “Observer-rated depression scale (HAMD-17)” rows. These values now read “18.7 (12.2)” and “11.3 (5.4)” respectively. These errors have now been corrected in the PDF and HTML versions of the Article, and in the accompanying Supplementary Information file.

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• Quality of life changes in response to yoga therapy in patients with schizophrenia: Reanalysis of Three randomized controlled trials

  Ikai-Tani S., Tani H., Kamiyama S., Mimura M., Uchida H.

  Asian Journal of Psychiatry （Asian Journal of Psychiatry）  54 2020年12月

  ISSN  18762018

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• Comparison of various items of the quality of life in Alzheimer's disease scale (QOL-AD) in patients with mild or moderate stages of dementia: a cross-sectional study

  Shikimoto R., Nakaaki S., Sato J., Sato H., Mimura M.

  Psychogeriatrics （Psychogeriatrics）  20 （ 6 ） 926 - 928 2020年11月

  ISSN  13463500

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• Correction: Factors associated with successful antipsychotic dose reduction in schizophrenia: a systematic review of prospective clinical trials and meta-analysis of randomized controlled trials (Neuropsychopharmacology, (2020), 45, 5, (887-901), 10.1038/s41386-019-0573-7)

  Tani H., Takasu S., Uchida H., Suzuki T., Mimura M., Takeuchi H.

  Neuropsychopharmacology （Neuropsychopharmacology）  45 （ 5 ）  2020年04月

  ISSN  0893133X

  　概要を見る

  © 2020, The Author(s), under exclusive licence to American College of Neuropsychopharmacology. In the original version of this Article, the DOI doi.org/10.1016/j. schres.2019.09.013 was incorrectly listed for reference 9. It should instead be listed for reference 10. This has been corrected in both the PDF and HTML versions of the Article.

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• Effectiveness of brexpiprazole in the treatment in a patient with Huntington's disease

  Mimura Y., Funayama M., Oi H., Takata T., Takeuchi H., Mimura M.

  Psychiatry and Clinical Neurosciences （Psychiatry and Clinical Neurosciences）  74 （ 4 ） 278 - 279 2020年04月

  ISSN  13231316

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競争的研究費の研究課題 【 表示 ／ 非表示 】

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• 高次脳機能障害に対する視覚ツールを用いた認知行動療法の検証

  2019年04月

  -

  2022年03月

  文部科学省・日本学術振興会, 科学研究費助成事業, 三村　將, 基盤研究（Ｃ）, 補助金,  研究代表者

• ドライブレコーダと脳画像による高齢者の実車運転不安全行動に関する特性の検討

  2014年04月

  -

  2017年03月

  文部科学省・日本学術振興会, 科学研究費助成事業, 三村　将, 基盤研究(C), 補助金,  研究代表者

  　研究概要を見る

  軽度認知障害や高次脳機能障害をもつ高齢ドライバーの自動車運転安全性について、神経心理学的検査、有効視野検査、簡易ドライビングシミュレータ、運転適性スクリーニング検査日本語版とともに、教習所内の実車行動に対する教習指導員の他覚的評価と、そのドライブレコーダー画像を見た作業療法士の事後評価、さらに実車前後の対象者自身の自己評価とを比較検討した。その結果、教習指導員による評価と作業療法士による事後評価とは高い関連性を示した。一方、実車成績が低い対象者は実車前の自己評価が相対的に高く、事後は評価が低下した。本研究を通じて、運転に関する自己評価が適切な運転行動に寄与していることが明らかとなった。

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• 精神医学講義

  2025年度

• 精神医学講義

  2024年度

• 精神医学特論Ⅳ

  2023年度

• 精神医学講義

  2023年度

• 漢方医学

  2023年度

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