Papers - Tanaka, Kenji

Effect of intracerebral 6-nitronoradrenaline, an endogenous catechol-O-methyltransferase (COMT) inhibitor, on striatal dopamine metaolism in anesthetized rats

Huotari M, Passlin M, Nordberg HL, Forsberg M, Kotisaari S, Tuomisto L, Shintani Futoshi, Tanaka Kenji, F Reenila I, Laitinen K, Mannisto PT

Journal of Neuroscience Methods 109 ( 1 ) 47-52 2001.08

Research paper (scientific journal), Joint Work

Elevated serum levels of interleukin-18 in schizophrenia

Shintani Futoshi, Tanaka Kenji, Fujii Yasuo, Yagi Gohei, Asai Masahiro

Psychiatry and Clinical Neuroscience 54 ( 6 ) S5-55 2000.12

Research paper (scientific journal), Joint Work

Switching Neuroleptics polypharmacy into monopharmacy in Chronic schizophrenic patients

Watanabe Koichiro, Tanaka Kenji, Arai Tatsuyoshi, Hosogane Nana, Oda Kenichi, Tsunoda Kenichi, Uchida Hiroyuki, Inagaki Ataru, Yagi Gouhei

International Clinical Psychopharmacology 15 ( 6 ) 374 2000.11

Research paper (scientific journal), Joint Work

Serum interleukin-18 levels are elevated in schizophrenia

Tanaka Kenji F., Shintani Futoshi, Fujii Yasuo, Yagi Gohei, Asai Masahiro

Psychiatry Research 96 ( 1 ) 75 - 80 2000.09

ISSN  0165-1781

　View Summary

<p>Interleukin-18 (IL-18) is a recently discovered proinflammatory cytokine which plays a pivotal role in T helper 1 (Th1) responses. IL-18 is produced by macrophage-like cells, and inappropriate IL-18 production has been known to be involved in immunological disturbances. Schizophrenia is a common disease whose pathogenesis is still unclear; however, an activation of the inflammatory response system, including the Th1 cytokine response, may be related to the pathophysiology of schizophrenia. We measured the serum IL-18 levels of 66 schizophrenics and age- and sex-matched control subjects by using an ELISA assay. We found significantly increased serum IL-18 levels in the schizophrenic patients (P = 0.0002). This finding supports the hypothesis that immune activation is involved in the pathophysiology of schizophrenia. (C) 2000 Elsevier Science Ireland Ltd.</p>

• Access to Document (DOI)

Serum interleukin-18 levels are elevated in schizophrenia

Tanaka Kenji, Shintani Futoshi, Fujii Yasuo, Yagi Gohei, Asai Masahiro

Psychiatry Research 96 ( 1 ) 75-80 2000.09

Research paper (scientific journal), Joint Work

脳内インターロイキン―1受容体アンタゴニストによるストレス反応の調節機構の解明

Shintani Futoshi，Tanaka Kenji，Wakita Tetsuya，Yagi Gouhei，Asai Masahiro

精神薬研究年報 32   30-32 2000.03

Research paper (scientific journal), Joint Work

精神分裂病の慢性重症例に対する抗精神病薬療法と血中モノアミン代謝産物の変動

Yagi Gouhei, Tanaka Kenji

臨床薬理 31 ( 1 ) 47-48 2000.01

Research paper (scientific journal), Joint Work

Awakenings（めざめ現象）と非定型抗精神病薬への切り替え

Tanaka Kenji, Fujii Yasuo

臨床精神薬理 2 ( 8 ) 859-866 1999.08

Research paper (scientific journal), Joint Work