Kobayashi, Yuki

写真a

Affiliation

School of Medicine, Department of Neuropsychiatry (Shinanomachi)

Position

Project Assistant Professor (Non-tenured)/Project Research Associate (Non-tenured)/Project Instructor (Non-tenured)
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Books 【 Display / hide 】

  • もう一歩上を目指す人のための集団認知行動療法治療者マニュアル

    中島, 美鈴, 藤澤, 大介, 松永, 美希, 大谷, 真, 金剛出版, 2021.06,  Page： 144p

    Scope: 強迫症を対象にした集団認知行動療法

  • Future interpersonal assistance: Psychological clinical practice in daily life

    Yuki Kobayashi, Fukumura Shuppan, 2017.07

    Scope: Obsessive-Compulsive Disorder

  • 家族と取り組む強迫性障害克服ワークブック : 大切な人を思いやり、症状に巻き込まれないために

    Landsman Kalen J, Rupertus Kathleen M, Pedrick Cherry, 堀越 勝, 蟹江 絢子, 新明 一星, 工藤 由佳, 小林 由季, 小平 雅基, 星和書店, 2017

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Papers 【 Display / hide 】

  • An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis.

    Divya Ramakrishnan, Luis C Farhat, Edoardo F Q Vattimo, Jessica L S Levine, Jessica A Johnson, Bekir B Artukoglu, Angeli Landeros-Weisenberger, Abraham Zangen, Antoine Pelissolo, Carlos A de B Pereira, Christian Rück, Daniel L C Costa, David Mataix-Cols, David Shannahoff-Khalsa, David F Tolin, Elham Zarean, Elisabeth Meyer, Emily R Hawken, Eric A Storch, Erik Andersson, Euripedes C Miguel, Giuseppe Maina, James F Leckman, Jerome Sarris, John S March, Juliana B Diniz, Kenneth Kobak, Luc Mallet, Nienke C C Vulink, Revital Amiaz, Rodrigo Yacubian Fernandes, Roseli G Shavitt, Sabine Wilhelm, Shahrokh Golshan, Sophie Tezenas du Montcel, Stefano Erzegovesi, Upasana Baruah, William M Greenberg, Yuki Kobayashi, Michael H Bloch

    Journal of psychiatric research 173   387 - 397 2024.03

    Lead author, Corresponding author

    　View Summary

    INTRODUCTION: Expert consensus operationalized treatment response and remission in obsessive-compulsive disorder (OCD) as a Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) reduction ≥35% and score ≤12 with ≤2 on Clinical Global Impressions Improvement (CGI-I) and Severity (CGI-S) scales, respectively. However, there has been scant empirical evidence supporting these definitions. METHODS: We conducted a systematic review and an individual participant data meta-analysis of randomized-controlled trials (RCTs) in adults with OCD to determine optimal Y-BOCS thresholds for response and remission. We estimated pooled sensitivity/specificity for each percent reduction threshold (response) or posttreatment score (remission) to determine response and remission defined by a CGI-I and CGI-S ≤ 2, respectively. RESULTS: Individual participant data from 25 of 94 eligible RCTs (1235 participants) were included. The optimal threshold for response was ≥30% Y-BOCS reduction and for remission was ≤15 posttreatment Y-BOCS. However, differences in sensitivity and specificity between the optimal and nearby thresholds for response and remission were small with some uncertainty demonstrated by the confidence ellipses. CONCLUSION: While the empirically derived Y-BOCS thresholds in our meta-analysis differ from expert consensus, given the predominance of data from more recent trials of OCD, which involved more refractory participants and novel treatment modalities as opposed to first-line therapies, we recommend the continued use of the consensus definitions.

  • Effect of Personality Traits on Sustained Remission Among Patients with Major Depression: A 12-Month Prospective Study

    Waka Nogami, Atsuo Nakagawa, Nariko Katayama, Yuka Kudo, Mizuki Amano, Sakae Ihara, Chika Kurata, Yuki Kobayashi, Yohei Sasaki, Natsumi Ishikawa, Yasunori Sato, Masaru Mimura

    Neuropsychiatric Disease and Treatment (Informa UK Limited)  Volume 18   2771 - 2781 2022.11

    Lead author, Corresponding author, Accepted

  • Associations of Autism Traits With Obsessive Compulsive Symptoms and Well-Being in Patients With Obsessive Compulsive Disorder: A Cross-Sectional Study

    Satomi Doi, Yuki Kobayashi, Yoshitake Takebayashi, Eriko Mizokawa, Atsuo Nakagawa, Masaru Mimura, Masaru Horikoshi

    Frontiers in Psychology (Frontiers Media SA)  12   697717 - 697717 2021.07

    Accepted

    　View Summary

    The aim of this study is to examine the association of autism traits with long-term obsessive compulsive disorder (OCD) symptoms and well-being levels in patient with OCD. Participants comprised 18 outpatients from a tertiary hospital and 100 adults who were registered in a large Japanese internet marketing research company and met OCD criteria by the Mini-International Neuropsychiatric Interview and were between the ages of 20 and 65 years. Clinical characteristics, autism trait assessed using the Autism Spectrum Quotient (AQ), OCD symptoms assessed using Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and well-being assessed using the Flourishing Scale were assessed. Multiple regression analyses showed that a greater total score of AQ, a greater subscale score “imagination” was associated with a greater score of Y-BOCS. Greater total score of AQ, a greater subscale score “social skill,” and “imagination” were associated with lower well-being score. Autism traits, especially lack of imagination, were associated with more severe OCD symptoms. Further, autism traits, especially social skill problems and lack of imagination, were associated with lower levels of well-being. Assessment of autism traits before treatment and a strategy designed for OCD patients with autism traits may be warranted.

  • Pseudo-continuous arterial spin labeling MRI study of patients with obsessive-compulsive disorder.

    Miho Ota, Ayako Kanie, Yuki Kobayashi, Aiichiro Nakajima, Noriko Sato, Masaru Horikoshi

    Psychiatry research. Neuroimaging (Psychiatry Research - Neuroimaging)  303   111124 - 111124 2020.09

    Accepted,  ISSN  09254927

    　View Summary

    Arterial spin labeling (ASL) magnetic resonance imaging is a novel technique that can measure regional cerebral blood flow (rCBF). Here we used pseudo-continuous ASL (pCASL) to examine the structural and functional imaging data in patients with obsessive-compulsive disorder (OCD). We estimated the gray matter volume imaging and pCASL imaging data by means of a voxel-by-voxel statistical analysis. We evaluated the differences of rCBF and gray matter volume between the OCD patients and healthy subjects. We detected a significant rCBF reduction in OCD patients in the right posterior cingulate extending to the lingual gyrus, thalamus, and hippocampus, and a significant increase in the left temporal gyrus and left frontal white matter region, compared with healthy subjects. We also observed a significant reduction in gray matter volume of OCD patients in the right hippocampus. We also estimated the correlation between the clinical severity of OCD and the rCBF and gray matter volumes, and found significant negative correlations between the severity of illness and the regional gray matter volume in the bilateral anterior cingulate corti. Our study demonstrated significant changes of rCBF in the cortico-striato-thalamo-cortical pathway around the hippocampus in OCD patients. These findings may help to elucidate the pathogenesis of OCD.

  • An Evaluation of Family-Based Treatment for OCD in Japan: A Pilot Randomized Controlled Trial.

    Yuki Kobayashi, Ayako Kanie, Atsuo Nakagawa, Yoshitake Takebayashi, Issei Shinmei, Noriko Nakayama, Keiko Yamaguchi, Chiaki Nakayama, Naotsugu Hirabayashi, Masaru Mimura, Masaru Horikoshi

    Frontiers in psychiatry (Frontiers in Psychiatry)  10   932 - 932 2020.01

    Accepted

    　View Summary

    Objective: Although family involvement in the treatment of obsessive-compulsive disorder (OCD) produces a reduction in OCD symptoms and has significant effects on global functioning, few studies have focused on family intervention as part of OCD treatment in Japan. This study aims to examine the feasibility and efficacy of the family-based exposure and response prevention (FERP) program for adult patients with OCD and their family members. Design: Randomized controlled pilot study. Methods: A total of 18 outpatients aged 18-65 years with a primary diagnosis of OCD and one family member of each patient were randomized to an intervention group or a control group (1:1). The intervention group received the FERP program, which consisted of 16 weekly face-to-face cognitive behavioral therapy (CBT) sessions, including eight joint sessions with family members, in addition to treatment-as-usual (TAU). The control group received TAU alone. The primary outcome was the alleviation of OCD symptoms, as measured by changes in the total Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score from baseline to posttreatment. Analyses were provided on an intention-to-treat basis, and linear mixed models were used to test for significant group differences. Results: After 16 weeks, patients allocated to the FERP program showed improvement in OCD symptom severity, as measured by the total change score of the Y-BOCS (Hedges' g = -1.58), as compared to the control group. Two patients (22.2%) in the FERP group reached remission, and five patients (55.6%) in the FERP group achieved treatment response. Clinical global improvement measured by the FAS-SR scores, K6 scores, and CGI-S scores was also observed (Hedges' g = -1.35, -1.25, and -1.26, respectively) in the FERP group as compared to the control group. The dropout rate from the study was low (n = 2, 11.8%), and no adverse events were reported in the FERP group. Conclusion: Our results suggest that FERP may be an effective program for reducing patients' OCD symptoms. Clinical Trial Registration: www.umin.ac.jp/ctr/, identifier UMIN000021763.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • うつ病の認知行動療法における未来に対する否定的な認知と反芻思考との関連

    天野 瑞紀, 中川 敦夫, 片山 奈理子, 小林 由季, 小澤 満玲, 梅田 聡, 寺澤 悠理, 田渕 肇, 菊地 俊暁, 三村 將

    日本認知療法・認知行動療法学会プログラム・抄録集 (日本認知療法・認知行動療法学会)  23回   260 - 260 2023.11

  • 認知行動療法による反芻思考に関連する時間的に推移する脳機能ネットワーク変化

    片山 奈理子, 品川 和志, 平野 仁一, 中川 敦夫, 小林 由季, 神谷 慶, 田島 美幸, 寺澤 悠理, 梅田 聡, 菊地 俊暁, 三村 將

    日本認知療法・認知行動療法学会プログラム・抄録集 (日本認知療法・認知行動療法学会)  23回   248 - 248 2023.11

  • Column_Family Accommodation in OCD

    Yuki Kobayashi

    Seishinka Resident 4 ( 1 ) 11 - 11 2023.02

  • うつ病の非薬物療法

    清水恒三朗, 田島美幸, 小林由季, 菊地俊暁, 三村將

    臨床と研究 99 ( 5 ) 17 - 22 2022.05

  • エビデンスの秘密と嘘

    小林由季, 中川敦夫

    こころの科学 2020年9月 ( 213 ) 63 - 67 2020.09

    Lead author

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Presentations 【 Display / hide 】

  • 集団認知行動療法のプログラムの作成と有用性の検証

    小林由季, 田島美幸, 清水恒三朗, 腰みさき, 田村法子, 原祐子, 野田祥子, 藤澤大介, 菊地俊暁

    第22回日本認知療法・認知行動療法学会, 

    2022.11
    , 

    Poster presentation

  • 認知行動療法における多職種連携マニュアルの開発

    田島美幸, 小林由季, 清水恒三朗, 岡田佳詠, 大嶋信雄, 前田初代, 丹野義彦, 中川敦夫, 藤澤大介, 菊地俊暁

    第22回日本認知療法・認知行動療法学会, 

    2022.11
    , 

    Poster presentation

  • 認知行動療法における現状とその課題～厚生労働省認知行動療法研修事業アンケート結果より～

    小林由季, 中川敦夫, 田島美幸, 満田大, 大野裕, 三村將

    第22回日本認知療法・認知行動療法学会, 

    2022.11
    , 

    Poster presentation

  • Reliability and validity of the Japanese version of Family Accommodation Scale for OCD-Patient Version (FAS-PV)

    Kobayashi, Y, Horikoshi, M

    The Association of Japanese Clinical Psychology, 30th annual conference, 

    2020.11
    , 

    Poster presentation

  • 強迫症患者における強迫症状とマインドフルネスとの関連

    小林由季, 中川敦夫, 竹林由武, 土井理美, 溝川絵里子, 堀越勝

    第20回日本認知療法・認知行動療法学会, 

    2020.11
    , 

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 強迫性障害の巻き込みに関する尺度日本語版の信頼性と妥当性の検討

    2019.04
    -
    2020.03

    日本心理臨床学会, 研究助成, Principal investigator

  • 強迫症に対する予後改善パッケージプログラムの開発と効果検証

    2017.04
    -
    2023.03

    日本学術振興会, 科学研究費助成事業, 基盤研究(C), No Setting

    　View Summary

    強迫症は長期予後が不良であることが多く、寛解に至った強迫症患者の約半数が再発を経験しており、再発率の高さが指摘されている。予後不良要因として、強迫症状やうつ症状の重篤性、家族機能の不全、社会機能の低さなどがあげられている。さらに、治療後に残存する軽度の強迫症状が強迫症患者のQOL低下を維持し、強迫症の再発リスクとなる可能性があると報告されている。このような背景を踏まえ、本研究の目的は、強迫症の予後改善パッケージプログラムを開発し、その有効性を検討することである。
    研究初年度には強迫症に対する薬物療法以外の治療を終えた患者を対象に、強迫症の長期予後に関する実態調査を実施した。2018年度は実態調査の結果について統計解析を行い、その結果を基に、残遺症状別の介入候補として、1．行動活性化、2．心理学的ウェルビーイング、3．マインドフルネス、4．家族への巻き込みへの対応、を検討した。さらにこれまでの臨床経験も踏まえて、各介入の組み合わせや介入の順番、実施回数などについて議論を重ね、その妥当性について検討した。2019年度は、臨床現場における本プログラムの実施可能性について検討し、2020年度には強迫症における強迫症状とマインドフルネスとの関連について学会発表を行い、2021年度には強迫症における自閉症傾向とウェルビーイングとの関連について論文発表を行った。
    強迫症患者に対する予後調査、及び予後改善を目的とした介入パッケージプログラムは国内ではほぼ皆無である。本研究は、強迫症患者だけでなく、強迫症患者の家族機能を高めることも期待され、臨床的にも社会的にも意義があると考える。

  • A randomized controlled trial of Family based ERP Program (FERP) for obsessive compulsive disorder

    2015.04
    -
    2019.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Kanie Ayako, Kobayashi Yuki, Takebayashi Yoshitake, Nakayama Noriko, Kontani Keiko, Shinmei Issei, Yamaguchi Keiko, Nakayama Chiaki, Mizokawa Eriko, Tairako Yukino, Hirabayashi Naotsugu, Horikoshi Masaru, Nakagawa Atsuo, Grant-in-Aid for Young Scientists (B), No Setting

    　View Summary

    The aim of this study was to examine the safety and efficacy of the family-based Exposure Response Prevention program for Obsessive-Compulsive Disorder (OCD) patients and their family members. Study participants were randomly assigned to the treatment as usual group and the program implementation group. Total 18 patients and 18 family members were enrolled this study. The patients assigned to the program implementation group received total 12 to 16 sessions, whereas their family members received the family program consisting of 8 sessions. The results showed a significant reduction in OCD symptoms and depression symptom in patients, and depression symptom in their family members after the program implementation. Additionally, the frequency of family accommodation in OCD symptoms was decreased. Two patients dropped out during the study and no serious side effects or adverse events were reported, suggesting the safety and efficacy of the program.

  • 強迫性障害に対する家族の巻き込まれに関する実態調査

    2014
    -
    2016

    国立精神・神経医療研究センター, 若手臨床研究グループ活動奨励研究費, Principal investigator

  • 強迫性障害に対する家族プログラムの開発

    2014
    -
    2016

    メンタルヘルス岡本記念財団, 研究助成, Principal investigator

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