Kobayashi, Yuki



School of Medicine, Department of Neuropsychiatry (Shinanomachi)


Project Assistant Professor (Non-tenured)/Project Research Associate (Non-tenured)/Project Instructor (Non-tenured)


Books 【 Display / hide

  • もう一歩上を目指す人のための集団認知行動療法治療者マニュアル

    中島, 美鈴, 藤澤, 大介, 松永, 美希, 大谷, 真, 金剛出版, 2021.06,  Page: 144p

    Scope: 強迫症を対象にした集団認知行動療法

  • Future interpersonal assistance: Psychological clinical practice in daily life

    Yuki Kobayashi, Fukumura Shuppan, 2017.07

    Scope: Obsessive-Compulsive Disorder

  • 家族と取り組む強迫性障害克服ワークブック : 大切な人を思いやり、症状に巻き込まれないために

    Landsman Kalen J, Rupertus Kathleen M, Pedrick Cherry, 堀越 勝, 蟹江 絢子, 新明 一星, 工藤 由佳, 小林 由季, 小平 雅基, 星和書店, 2017

Papers 【 Display / hide

  • Effect of Personality Traits on Sustained Remission Among Patients with Major Depression: A 12-Month Prospective Study

    Waka Nogami, Atsuo Nakagawa, Nariko Katayama, Yuka Kudo, Mizuki Amano, Sakae Ihara, Chika Kurata, Yuki Kobayashi, Yohei Sasaki, Natsumi Ishikawa, Yasunori Sato, Masaru Mimura

    Neuropsychiatric Disease and Treatment (Informa UK Limited)  Volume 18   2771 - 2781 2022.11

    Lead author, Corresponding author, Accepted

  • Associations of Autism Traits With Obsessive Compulsive Symptoms and Well-Being in Patients With Obsessive Compulsive Disorder: A Cross-Sectional Study

    Doi S., Kobayashi Y., Takebayashi Y., Mizokawa E., Nakagawa A., Mimura M., Horikoshi M.

    Frontiers in Psychology (Frontiers in Psychology)  12 2021.07

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    The aim of this study is to examine the association of autism traits with long-term obsessive compulsive disorder (OCD) symptoms and well-being levels in patient with OCD. Participants comprised 18 outpatients from a tertiary hospital and 100 adults who were registered in a large Japanese internet marketing research company and met OCD criteria by the Mini-International Neuropsychiatric Interview and were between the ages of 20 and 65 years. Clinical characteristics, autism trait assessed using the Autism Spectrum Quotient (AQ), OCD symptoms assessed using Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and well-being assessed using the Flourishing Scale were assessed. Multiple regression analyses showed that a greater total score of AQ, a greater subscale score “imagination” was associated with a greater score of Y-BOCS. Greater total score of AQ, a greater subscale score “social skill,” and “imagination” were associated with lower well-being score. Autism traits, especially lack of imagination, were associated with more severe OCD symptoms. Further, autism traits, especially social skill problems and lack of imagination, were associated with lower levels of well-being. Assessment of autism traits before treatment and a strategy designed for OCD patients with autism traits may be warranted.

  • Pseudo-continuous arterial spin labeling MRI study of patients with obsessive–compulsive disorder

    Ota M., Kanie A., Kobayashi Y., Nakajima A., Sato N., Horikoshi M.

    Psychiatry Research - Neuroimaging (Psychiatry Research - Neuroimaging)  303 2020.09

    ISSN  09254927

     View Summary

    © 2020 Elsevier B.V. Arterial spin labeling (ASL) magnetic resonance imaging is a novel technique that can measure regional cerebral blood flow (rCBF). Here we used pseudo-continuous ASL (pCASL) to examine the structural and functional imaging data in patients with obsessive-compulsive disorder (OCD). We estimated the gray matter volume imaging and pCASL imaging data by means of a voxel-by-voxel statistical analysis. We evaluated the differences of rCBF and gray matter volume between the OCD patients and healthy subjects. We detected a significant rCBF reduction in OCD patients in the right posterior cingulate extending to the lingual gyrus, thalamus, and hippocampus, and a significant increase in the left temporal gyrus and left frontal white matter region, compared with healthy subjects. We also observed a significant reduction in gray matter volume of OCD patients in the right hippocampus. We also estimated the correlation between the clinical severity of OCD and the rCBF and gray matter volumes, and found significant negative correlations between the severity of illness and the regional gray matter volume in the bilateral anterior cingulate corti. Our study demonstrated significant changes of rCBF in the cortico-striato-thalamo-cortical pathway around the hippocampus in OCD patients. These findings may help to elucidate the pathogenesis of OCD.

  • An Evaluation of Family-Based Treatment for OCD in Japan: A Pilot Randomized Controlled Trial

    Kobayashi Y., Kanie A., Nakagawa A., Takebayashi Y., Shinmei I., Nakayama N., Yamaguchi K., Nakayama C., Hirabayashi N., Mimura M., Horikoshi M.

    Frontiers in Psychiatry (Frontiers in Psychiatry)  10 2020.01

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    © Copyright © 2020 Kobayashi, Kanie, Nakagawa, Takebayashi, Shinmei, Nakayama, Yamaguchi, Nakayama, Hirabayashi, Mimura and Horikoshi. Objective: Although family involvement in the treatment of obsessive-compulsive disorder (OCD) produces a reduction in OCD symptoms and has significant effects on global functioning, few studies have focused on family intervention as part of OCD treatment in Japan. This study aims to examine the feasibility and efficacy of the family-based exposure and response prevention (FERP) program for adult patients with OCD and their family members. Design: Randomized controlled pilot study. Methods: A total of 18 outpatients aged 18–65 years with a primary diagnosis of OCD and one family member of each patient were randomized to an intervention group or a control group (1:1). The intervention group received the FERP program, which consisted of 16 weekly face-to-face cognitive behavioral therapy (CBT) sessions, including eight joint sessions with family members, in addition to treatment-as-usual (TAU). The control group received TAU alone. The primary outcome was the alleviation of OCD symptoms, as measured by changes in the total Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score from baseline to posttreatment. Analyses were provided on an intention-to-treat basis, and linear mixed models were used to test for significant group differences. Results: After 16 weeks, patients allocated to the FERP program showed improvement in OCD symptom severity, as measured by the total change score of the Y-BOCS (Hedges’ g = −1.58), as compared to the control group. Two patients (22.2%) in the FERP group reached remission, and five patients (55.6%) in the FERP group achieved treatment response. Clinical global improvement measured by the FAS-SR scores, K6 scores, and CGI-S scores was also observed (Hedges’ g = −1.35, −1.25, and −1.26, respectively) in the FERP group as compared to the control group. The dropout rate from the study was low (n = 2, 11.8%), and no adverse events were reported in the FERP group. Conclusion: Our results suggest that FERP may be an effective program for reducing patients’ OCD symptoms. Clinical Trial Registration: www.umin.ac.jp/ctr/, identifier UMIN000021763.

  • The Japanese version of the Family Accommodation Scale for Obsessive-Compulsive Disorder: Psychometric properties and clinical correlates

    Yuki Kobayashi, Hisato Matsunaga, Tomohiro Nakao, Yuka Kudo, Eisuke Sakakibara, Ayako Kanie, Noriko Nakayama, Issei Shinmei, Masaru Horikoshi


    Lead author, Corresponding author, Accepted,  ISSN  2211-3649

     View Summary

    Although a variety of obsessive-compulsive disorder (OCD)-related family pathologies, such as family accommodation, may exist in Japanese OCD patients, few studies on this topic have been conducted, and a validated assessment tool is not available in Japan. The Family Accommodation Scale (FAS) is the most widely used measure of accommodation behavior in OCD patients. The aims of this study were to develop a Japanese version of the FAS-Self-Rated Version (FAS-SR), to examine its reliability and validity, and to study the clinical correlates of family accommodation in OCD. We subsequently examined the psychometric properties of the Japanese version of the FAS-SR in a sample of 41 Japanese OCD patients and 41 relatives. The Japanese version of the FAS-SR demonstrated good internal consistency and test-retest reliability. It showed good convergent and divergent validity when concomitantly assessed with other measures, such as OCD symptom severity, functional impairment, family functioning, psychological distress, a variety of psychiatric symptoms and cognitive-reflection-impulsivity. Additionally, family psychopathology, especially somatization, obsessive-compulsive symptoms, depression, hostility and psychoticism, were significantly correlated with family accommodation in OCD. The Japanese version of the FAS-SR has acceptable psychometric properties for assessing family accommodation in Japanese patients with OCD in both research and clinical settings.

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Reviews, Commentaries, etc. 【 Display / hide

  • Column_Family Accommodation in OCD

    Yuki Kobayashi

    Seishinka Resident 4 ( 1 ) 11 - 11 2023.02

  • うつ病の非薬物療法

    清水恒三朗, 田島美幸, 小林由季, 菊地俊暁, 三村將

    臨床と研究 99 ( 5 ) 17 - 22 2022.05

  • エビデンスの秘密と嘘

    小林由季, 中川敦夫

    こころの科学 2020年9月 ( 213 ) 63 - 67 2020.09

    Lead author

  • A new type of exposure and response prevention : ERP based on inhibitory learning theory and acceptance commitment therapy

    堀越 勝, 小林 由季

    精神科治療学 (星和書店)  32 ( 4 ) 477 - 483 2017.04

    ISSN  0912-1862

     View Summary

    強迫症(obsessive-compulsive disorder:OCD)に対する有効な治療法として、薬物療法以外に曝露反応妨害法(exposure and response prevention:ERP)が挙げられる。従来のERPのベースとなる理論が感情処理理論であったのに対して、新しいタイプのERPとして、制止学習理論に基づいたERPと、アクセプタンスに基づいたERPが提唱されている。本稿では、それぞれのERPの理論的背景やERPの実践について紹介する。OCD患者の病理・病態における多様性を考えれば、標準的なERPを基本として持ちながらも、制止学習理論やアクセプタンスに基づいたERPなどを症例に応じて柔軟に活用する必要がある。そのような取り組みが治療効果や再発予防に寄与すると考えられ、OCDに対する新たな治療法の展開が期待される。(著者抄録)

  • Family program for Obsessive-Compulsive Disorder: A Pilot Study

    Kobayashi Y, Iijima S, Kanie A, Shinemi I, Nakayama N, Horikoshi M

    Report of Research Support, The Mental Health Okamoto Memorial Foundation ((公財)メンタルヘルス岡本記念財団)  28 ( 28 ) 61 - 65 2017.03

    Lead author,  ISSN  0916-9156

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Presentations 【 Display / hide

  • 集団認知行動療法のプログラムの作成と有用性の検証

    小林由季, 田島美幸, 清水恒三朗, 腰みさき, 田村法子, 原祐子, 野田祥子, 藤澤大介, 菊地俊暁



    Poster presentation

  • 認知行動療法における多職種連携マニュアルの開発

    田島美幸, 小林由季, 清水恒三朗, 岡田佳詠, 大嶋信雄, 前田初代, 丹野義彦, 中川敦夫, 藤澤大介, 菊地俊暁



    Poster presentation

  • 認知行動療法における現状とその課題~厚生労働省認知行動療法研修事業アンケート結果より~

    小林由季, 中川敦夫, 田島美幸, 満田大, 大野裕, 三村將



    Poster presentation

  • Reliability and validity of the Japanese version of Family Accommodation Scale for OCD-Patient Version (FAS-PV)

    Kobayashi, Y, Horikoshi, M

    The Association of Japanese Clinical Psychology, 30th annual conference, 


    Poster presentation

  • 強迫症患者における強迫症状とマインドフルネスとの関連

    小林由季, 中川敦夫, 竹林由武, 土井理美, 溝川絵里子, 堀越勝



    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 強迫性障害の巻き込みに関する尺度日本語版の信頼性と妥当性の検討


    日本心理臨床学会, 研究助成, Principal investigator

  • 強迫症に対する予後改善パッケージプログラムの開発と効果検証


    日本学術振興会, 科学研究費助成事業, 基盤研究(C), No Setting

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  • 強迫性障害の予後改善プログラムの開発および有効性の検討


    日本学術振興会, 科学研究費助成事業 基盤C, Principal investigator

  • 強迫性障害に対する家族の巻き込まれに関する実態調査


    国立精神・神経医療研究センター, 若手臨床研究グループ活動奨励研究費, Principal investigator

  • 強迫性障害に対する家族プログラムの開発


    メンタルヘルス岡本記念財団, 研究助成, Principal investigator