Papers - Eguchi, Yoko

The utility of simple questions to evaluate cognitive impairment

Daté Y., Sugiyama D., Tabuchi H., Saito N., Konishi M., Eguchi Y., Momota Y., Yoshizaki T., Mashima K., Mimura M., Nakahara J., Ito D.

PLoS ONE (PLoS ONE)  15 ( 5 )  2020.05

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© 2020 Daté et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Objectives As the population of patients with cognitive decline grows, physicians and caregivers need brief screening tools. Comprehensive neurocognitive batteries require special training and time for evaluation. We focused on accessibility and compared the diagnostic power of several easy questions. Design “Attended With” (AW) and “Head-Turning Sign” (HTS) factors and participants’ replies to following questions were recorded: “Do you feel that you have more difficulties in your daily life than you used to?”, [no consciousness (C-) or consciousness+ (C+)], “Could you tell me about your daily pleasures or pastimes?” [no pleasure (P-) or pleasure + (P+)], “What are notable current/recent news/topics?” [no news (N-) or news+ (N+)]. Setting This took place in our Memory Clinic between May 2016 and July 2019. Participants We enrolled 162 consecutive cases (44 cognitive normal (CN), 55 amnestic mild cognitive impairment (aMCI), and 48 Alzheimer’s disease (AD)). Measurements The sensitivity and specificity of each battery were calculated, and on account of those numbers, the population attributable risk percent % (PAR%) of (AW and HTS+), (C- and P-), (C- and N-), (P- and N-) as analysis of combination of questions, respectively, were calculated. Results AW had high sensitivity, 87.4, 95.8% (CN vs aMCI + AD, CN + aMCI vs AD) but the sensitivity of HTS was only 46.4, 57.7%, and HTS showed high specificity, 100.0, 71.8%. C- had high sensitivity, 80.6, 87.5%, whereas P- and N- had high specificity, both 83.9% in CN vs aMCI + AD, 88.1% and 75.9% in CN + aMCI vs AD, respectively. In combination analysis, the PAR% of (C- and N-) were as high as (AW and HTS+). Conclusions The combination of (C- and N-) is as powerful as (AW and HTS+) in screening AD. Our findings provide novel insights for screening utility of brief questions “Consciousness of Impairment” and “Recent News.”

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Sociopsychological characteristics of late nonagenarians in Japan: the protocol of the Arakawa 95+ study

Niimura H., Eguchi Y., Kida H., Suzuki K., Takayama M., Mimura M.

Psychogeriatrics (Psychogeriatrics)  20 ( 1 ) 50 - 58 2020.01

ISSN  13463500

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© 2019 Japanese Psychogeriatric Society Aim: The aim of this study was to examine sociopsychological characteristics of the oldest old in Japan. We conducted a baseline survey of a community-based cohort of persons aged 95 or older. Methods: Participants were aged 95+ years and resided in Arakawa Ward in Tokyo on 1 January 2016. We mailed a questionnaire to these individuals to assess their physical, mental, and social status. Subsequently, if respondents agreed, we conducted in-home interviews and examined their physical and cognitive function. Also, we mailed non-respondents a simplified version of full questionnaire. Additionally, we examined the basic registered data of the study population and the status of their Long-term Care Insurance. Data at baseline and 1-year follow-up were compared. Results: With regard to Long-term Care Insurance, 423 residents aged 95+ years (78.0%) were on long-term care level, 35 (6.5%) were on support level, and 84 (15.5%) did not require support. At the 1-year follow-up, 275 (50.7%) had the same care level, 107 (19.7%) required a greater level of care, and 131 had died (annual death rate: 24.2%). Compared to the simplified questionnaire group (n = 128) and the full questionnaire-only group (n = 14), a higher proportion of respondents who had completed the full questionnaire and had in-home interviews (n = 26) were men, lived only with a spouse, had higher activities of daily living, and reported more positive feelings and well-being. Conclusions: In the late nonagenarian population, the annual death rate was high, and care needs increased rapidly. However, some persons maintained the same care level or even showed improvement and successful ageing.

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Increasing light physical activity helps to maintain cognitive function among the community-dwelling oldest old population: a cross-sectional study using actigraph from the Arakawa 85+ study

Suzuki K., Niimura H., Kida H., Eguchi Y., Kitashima C., Takayama M., Mimura M.

Geriatrics and Gerontology International (Geriatrics and Gerontology International)   2020

ISSN  14441586

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© 2020 Japan Geriatrics Society Aim: To investigate the influence of replacing sedentary time with physical activity on cognitive function using an isotemporal substitution model in a population of community-dwelling oldest old. Methods: This cross-sectional study included residents of the Arakawa ward, Tokyo, who were part of a prospective cohort from the Arakawa 85+ study. We measured physical activity in 136 participants using a triaxial actigraph. Cognitive function was measured using the Addenbrooke's Cognitive Examination-III and participants were divided into a “cognitive decline group” (Addenbrooke's Cognitive Examination-III ≤88) and “cognitive maintain group” (Addenbrooke's Cognitive Examination-III ≥89). Physical activity was divided into three categories: sedentary behavior (≤1.5 metabolic equivalents), light physical activity (>1.5 to <3.0 metabolic equivalents), and moderate-to-vigorous physical activity (≥3 metabolic equivalents). Using an isotemporal substitution approach, we applied multiple logistic regression analysis to demonstrate the association between cognitive function and replacing 30 min/day of sedentary behavior with an equal period of light physical activity. Covariates included age, education and the Center for Epidemiologic Studies Depression Scale. Results: Our findings showed that in men, replacing 30 min of sedentary behavior per day with light physical activity was associated with a 1.47-fold increase in the odds of maintaining cognitive function. An association between physical activity and cognitive function was not observed in female participants. Conclusions: Our results indicate that substituting sedentary behavior with light physical activity could be helpful in maintaining cognitive function in community-dwelling oldest old men. These results highlight the importance of behavioral changes to promote cognition. Geriatr Gerontol Int ••; ••: ••–•• Geriatr Gerontol Int 2020; ••: ••–••.

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Large-Scale Dialog Corpus Towards Automatic Mental Disease Diagnosis

Sakishita M., Kishimoto T., Takinami A., Eguchi Y., Kano Y.

Studies in Computational Intelligence (Studies in Computational Intelligence)  843   111 - 118 2020

ISSN  1860949X

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© Springer Nature Switzerland AG 2020. Recently, the number of people who are diagnosed as mental diseases is increasing. Efficient and objective diagnosis is important to start medical treatments in earlier stages. However, mental disease diagnosis is difficult to quantify criteria, because it is performed through conversations with patients, not by physical surveys. We aim to automate mental disease diagnosis in order to resolve these issues. We recorded conversations between psychologists and subjects to build our diagnosis speech corpus. Our subjects include healthy persons, people with mental diseases of depression, bipolar disorder, schizophrenia, anxiety and dementia. All of our subjects are diagnosed by doctors of psychiatry. Then we made accurate transcription manually, adding utterance time stamps, linguistic and non-linguistic annotations. Using our corpus, we performed feature analysis to find characteristics for each disease. We also tried automatic mental disease diagnosis by machine learning, while the number of sample data is few because we were still in our pilot study phase. We will increase the number of subjects in future.

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Subiculum volumes associated with memory function in the oldest-old individuals aged 95 years and older

Eguchi Y., Noda Y., Nakajima S., Tsugawa S., Kida H., Plitman E., Graff-Guerrero A., Chakravarty M., Takayama M., Arai Y., Matsuda H., Mimura M., Niimura H.

Geriatrics and Gerontology International (Geriatrics and Gerontology International)  19 ( 4 ) 347 - 351 2019.04

ISSN  14441586

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© 2019 Japan Geriatrics Society Aim: Few cohort studies targeting the oldest-old individuals have been carried out. The subiculum in the hippocampus is thought to be related to memory function, and atrophy of this structure might result in the conversion from amnestic mild cognitive impairment to Alzheimer's disease. Thus, we sought to examine the relationship between subiculum volumes and memory function in individuals aged ≥95 years, using a novel cognitive examination called the Addenbrooke's Cognitive Examination III (ACE-III) and an advanced magnetic resonance imaging analytical method, Multiple Automatically Generated Templates Brain Segmentation Algorithm (MAGeTbrain), to measure hippocampal subfield volumes. Methods: A part of the cohort data of the Arakawa 95+ study for the oldest-old aged ≥95 years was used. A total of 10 individuals completed all of the examinations. The MAGeT brain was applied to estimate the subfield volumes of the hippocampus. Correlation analyses and multiple regression analyses were carried out to examine a relationship among ACE-III memory scores and the subfield volumes in the hippocampus, including the subiculum. Results: There was a significant relationship between ACE-III memory scores and subdivision volumes. Regression analyses showed that subiculum volumes were associated with ACE-III memory scores in the oldest-old individuals (β = 0.721, P = 0.019; F 1, 8 = 8.67, adjusted R 2 = 0.46). Conclusions: The subiculum might play a pivotal role in memory function in the oldest-old individuals aged ≥95 years. The present finding warrants further research including larger sample sizes. Geriatr Gerontol Int 2019; 19: 347–351.

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Remote neuropsychological assessment of elderly Japanese population using the Alzheimer’s Disease Assessment Scale: A validation study

Yoshida K., Yamaoka Y., Eguchi Y., Sato D., Iiboshi K., Kishimoto M., Mimura M., Kishimoto T.

Journal of Telemedicine and Telecare (Journal of Telemedicine and Telecare)   2019

ISSN  1357633X

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© The Author(s) 2019. Introduction: Studies have demonstrated the high agreement of several remote neuropsychological tests using video teleconferencing (VTC) with face-to-face (FTF) tests. However, the reliability of the remotely administered Alzheimer’s Disease Assessment Scale cognitive subscale (ADAS-cog), one of the most commonly used neuropsychological tests to detect cognitive decline, has not been substantially elucidated, particularly in Japanese populations. Therefore, this study aimed to evaluate the reliability of the remotely administered ADAS-cog compared with FTF-administered ADAS-cog among elderly Japanese participants. Methods: Participants aged ≥60 years with and without cognitive impairment, i.e. those with mild cognitive impairment (MCI), those with dementia and healthy controls (HCs), were assessed with the ADAS-cog using VTC and FTF testing at an interval of >2 weeks and <3 months. The assessment order (VTC or FTF) was randomized by participants. Participants’ scores were compared among the entire sample, as well as subgroups, using intra-class correlation coefficients (ICCs) in a mixed-effects model. Results: A total of 73 participants were included in the study (36 men; age, 76.3 ± 7.6 years). The ICC for the ADAS-cog total score was high in the entire sample (0.86), whereas ICCs were moderate to high for the subgroups (MCI: 0.63, dementia: 0.80 and HC: 0.74). Discussion: The results indicate that a VTC-administered ADAS-cog could be an alternative for an FTF-administered ADAS-cog, although further replication studies with larger sample sizes and a wider range of cognitive functionalities are warranted.

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Decision-making based on social conventional rules by elderly people

Hidetsugu Komeda, Eguchi Yoko, Takashi Kusumi, Yuka Kato, Jin Narumoto, Masaru Mimura

Frontiers in Psychology (Frontiers in Psychology)  9 ( AUG )  2018.08

Research paper (scientific journal), Joint Work, Accepted

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© 2018 Komeda, Eguchi, Kusumi, Kato, Narumoto and Mimura. Information used by older adults engaging in a social decision making task of judging a protagonist as a good or a bad person was investigated. Older (n = 100, 50 women, mean age = 63.6 years) and younger (n = 100, 50 women, mean age = 25.7 years) adults participated in a web-based survey. In Experiment 1, we assessed participants' rapid decision-making processes when making good or bad judgments after reading consecutive sentences without reviewing previously read sentences. The percentages of good judgments were analyzed. In Experiment 2, two protagonists engaging in a deliberate decision-making process were presented, and participants were asked to judge better and worse protagonists. The percentages of behavior-based judgments were analyzed. Results of Experiment 1 indicated that older adults judged protagonists as "good" more often than younger adults. Especially, older adults judged protagonists with good behavior as being "good." In Experiment 2, older adults made behavior-based judgments more than younger people. Additionally, older and younger adults used information on personalities of protagonists for making judgments in situations with bad outcomes, or incongruent. Moreover, multiple regression analysis suggested that people with more general trust engaged more, whereas people with more caution engaged less in making behavior-based judgments.

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高齢者の詐欺被害を防ぐしなやかな地域連携モデルの研究開発

Eguchi Yoko

秋田県立大学ウェブジャーナルA（地域貢献部門）  ( 5 ) 64 - 72 2018.03

Research paper (scientific journal), Joint Work

Relationships between socio‐clinico‐demographic factors and global cognitive function in the oldest old living in the Tokyo Metropolitan area: Reanalysis of the Tokyo Oldest Old Survey on Total Health (TOOTH)

Eguchi Yoko,Tasato K, Nakajima S, Noda Y, Tsugawa S, Shinagawa S, Niimura H, Hirose N, Arai Y, Mimura M

International journal of geriatric psychiatry (Wiley)  33 ( 7 ) 926 - 933 2018.03

Research paper (scientific journal), Joint Work, Accepted,  ISSN  08856230

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Copyright © 2018 John Wiley & Sons, Ltd. Background: Despite a steady increase in life expectancy, a few studies have investigated cross-sectional correlates and longitudinal predictors of cognitive function, a core domain of the successful aging, among socio-clinico-demographic factors in the oldest-old exclusively. Objectives: The aims of this study were to examine socio-clinico-demographic characteristics associated with global cognition and its changes in the oldest-old. Methods: We reanalyzed a dataset of cognitively preserved community-dwelling subjects aged 85 years and older in the Tokyo Oldest Old Survey on Total Health, a 6-year longitudinal observational study. This study consisted of (1) baseline cross-sectional analyses examining correlates of global cognition (n = 248) among socio-clinico-demographic factors and (2) longitudinal analyses examining baseline predictors for changes of global cognition in 3-year follow-up (n = 195). The Mini-Mental State Examination was used as a screening test to assess global cognition. Results: At baseline, higher weights were related to higher cognitive function in the oldest-old. The baseline predictors of global cognitive decline in 3-year follow-up were higher global cognition, shorter education period, and lower sociocultural activities and lower instrumental activity of daily living, in this order. Conclusions: The present study suggests that it is crucial to attain higher education during early life and avoid leanness or obesity, participate in sociocultural cognitive activities during late life, and maintain instrumental activity of daily living to preserve optimal cognitive function in the oldest-old, which will facilitate developing prevention strategies for cognitive decline and promoting successful aging in this increasing population.

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Preparing for a paradigm shift in aging populations: listen to the oldest old

Hiroko Komatsu, Kaori Yagasaki, Hisashi Kida, Eguchi Yoko, Hidehito Niimura

International journal of qualitative studies on health and well-being (International Journal of Qualitative Studies on Health and Well-being)  13 ( 1 ) 1511768 2018

Research paper (scientific journal), Joint Work, Accepted,  ISSN  17482623

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© 2018, © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Purpose: Current healthcare systems are not suitable for serving future societies in which the oldest old are commonplace. The objective of this study was to understand what the oldest old care most about in their daily lives. Methods: Semi-structured in-depth interviews and thematic analysis were used. Face-to-face interviews were conducted in 17 elderly residents (≥ 95 years) of Arakawa-ku, Tokyo, Japan from July to November 2017. Results: Three themes emerged from the interview responses: “unshakable beliefs and social ties,” “natural acceptance,” and “my day-to-day life with precious moments.” The oldest old strongly believe in diligence and compassion and maintain strong relationships with people around them. Despite their small social networks, they are concerned about future society. They accept their selves and their lives, including their impending deaths. Despite their functional decline, they control their lives by making very small decisions. They live on a moment-to-moment basis, cherishing simple events. Conclusion: Maintaining autonomy through making small decisions and enjoying small pleasures are important to the oldest old. Understanding the needs of the oldest old is the first step towards developing optimal geriatric care for an aging population.

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詐欺被害防止のための取り組みの変遷と心理学の貢献可能性―米国における詐欺研究との比較を通して―対人心理学研究

Eguchi Yoko

対人社会心理学研究  ( 18 ) 179 - 188 2018

Joint Work

テレビ会議システムを用いた時計描画検査の信頼性

飯干 紀代子, 岸本 泰士郎, 江口 洋子, 加藤 佑佳, 松岡 照之, 成本 迅, 三村 將

高次脳機能研究 37 ( 2 ) 220 - 227 2017

Research paper (scientific journal), Joint Work, Accepted

95歳以上の超高齢者のメンタルヘルス疫学研究

新村 秀人, 三村 將, 高山 緑, 江口 洋子, 喜田 恒

大和証券ヘルス財団研究業績集 40   40 - 45 2017

Research paper (scientific journal), Joint Work

高齢者に対するビデオ会議システムを用いた改訂長谷川式簡易知能評価スケールの信頼性試験

Eguchi Yoko

日本遠隔医療学会雑誌 12 ( 2 ) 145 - 148 2016.10

Research paper (scientific journal), Joint Work

有名人の顔が含まれる社会的出来事写真を用いた遠隔記憶検査作成の試み

Eguchi Yoko

認知リハビリテーション 21 ( 1 ) 5 - 20 2016.10

Research paper (scientific journal), Joint Work, Accepted

現実的な思考が困難なために就職活動が妨げられている頭部外傷の1例

Eguchi Yoko

認知リハビリテーション 20 ( 1 ) 41 - 50 2015

Research paper (scientific journal), Joint Work, Accepted

Quantitative Analysis of Amyloid Deposition in Alzheimer Disease Using PET and the Radiotracer C-11-AZD2184

Ito, Hiroshi, Shimada, Hitoshi, Shinotoh, Hitoshi, Takano, Harumasa, Sasaki, Takeshi, Nogami, Tsuyoshi, Suzuki, Masayuki, Nagashima, Tomohisa, Takahata, Keisuke, Seki, Chie, Kodaka, Fumitoshi, Eguchi, Yoko, Fujiwara, Hironobu, Kimura, Yasuyuki, Hirano, Shigeki, Ikoma, Yoko, Higuchi, Makoto, Kawamura, Kazunori, Fukumura, Toshimitsu, Boo, Eva Lindstrom, Farde, Lars, Suhara, Tetsuya

JOURNAL OF NUCLEAR MEDICINE 55 ( 6 ) 932 - 938 2014.06

Research paper (scientific journal), Joint Work,  ISSN  0161-5505

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In vivo tau PET imaging using [11C]PBB3 in Alzheimer's disease and non-Alzheimer's disease tauopathies

Suhara, Tetsuya, Shimada, Hitoshi, Shinotoh, Hitoshi, Hirano, Shigeki, Eguchi, Yoko, Takahata, Keisuke, Kimura, Yasuyuki, Yamada, Makiko, Ito, Hiroshi, Higuchi, Makoto

JOURNAL OF NUCLEAR MEDICINE 55   72 - 78 2014.05

Research paper (scientific journal), Joint Work,  ISSN  0161-5505

Apathy correlates with prefrontal amyloid B deposition in Alzheimer's disease

Mori, Takaaki, Shimada, Hitoshi, Shinotoh, Hitoshi, Hirano, Shigeki, Eguchi, Yoko, Yamada, Makiko, Fukuhara, Ryuji, Tanimukai, Satoshi, Zhang, Ming-Rong, Kuwabara, Satoshi, Ueno, Shu-ichi, Suhara, Tetsuya

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 85 ( 4 ) 449 - 455 2014.04

Research paper (scientific journal), Joint Work,  ISSN  0022-3050

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Imaging of amyloid deposition in human brain using positron emission tomography and [F-18]FACT: comparison with [C-11] PIB

Ito, Hiroshi, Shinotoh, Hitoshi, Shimada, Hitoshi, Miyoshi, Michie, Yanai, Kazuhiko, Okamura, Nobuyuki, Takano, Harumasa, Takahashi, Hidehiko, Arakawa, Ryosuke, Kodaka, Fumitoshi, Ono, Maiko, Eguchi, Yoko, Higuchi, Makoto, Fukumura, Toshimitsu, Suhara, Tetsuya

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 41 ( 4 ) 745 - 754 2014.04

Research paper (scientific journal), Joint Work,  ISSN  1619-7070

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