御子柴　卓弥 （ミコシバ　タクヤ）

Mikoshiba, Takuya

写真a

所属（所属キャンパス）

医学部 耳鼻咽喉科・頭頸部外科学教室 （信濃町）

職名

助教（有期）
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  • Ectopic adrenocorticotropic hormone syndrome in patients with olfactory neuroblastoma.

    Mikoshiba T, Sekimizu M, Saito S, Nakamura S, Nagai R, Kawaida M, Kurihara I, Kobayashi S, Ozawa H

    Endocrine-related cancer 2024年07月

    ISSN  1351-0088

  • Utility and optimal management of planned drug holidays during lenvatinib treatment in patients with unresectable differentiated thyroid cancer: a real-world multi-center study

    Mikoshiba T., Sekimizu M., Kono T., Nagai R., Kawasaki T., Sato Y., Ito F., Nakahara N., Shigetomi S., Ozawa H.

    Endocrine （Endocrine）  2024年

    ISSN  1355008X

    　概要を見る

    Purpose: Lenvatinib achieves favorable therapeutic outcomes for patients with radioactive iodine therapy refractory differentiated thyroid cancer (DTC); however, its use is associated with a high incidence of adverse events. To avoid severe adverse events, planned drug holidays (PDH) have been proposed. This study aimed to evaluate treatment effects, identify prognostic factors, and investigate the usefulness of PDH in patients with unresectable DTC who received lenvatinib across the multi-institutions. Methods: Fifty-one patients with unresectable DTC treated with lenvatinib were evaluated retrospectively. Overall survival (OS) and progression-free survival (PFS) were calculated, and prognostic factors were assessed. OS, PFS, and time to treatment failure (TTF) were compared between patients with and without PDH. Lenvatinib administration schedule was evaluated in PDH. Results: The 3-year OS and PFS rate were 53.5% and 42.1%, respectively. Multivariate analysis revealed that presence of maximum size of lung metastasis ≥10 mm was independent prognostic factor for poorer OS and PFS, and histology other than papillary thyroid carcinoma was the independent prognostic factor for poorer PFS. Twenty-five patients (49%) treated with PDH. There were significant differences in OS, PFS, and TTF between patients with and without PDH. Various schedules were used in PDH. Eight (32%) patients required switch to the different administration schedule. Conclusion: Our results suggest that PDHs may extend OS, PFS, and TTF. In patients with PDH, various schedules used for lenvatinib administration highlight the difficulty in determining a uniform administration schedule. Therefore, it is crucial to consider the optimal lenvatinib administration schedule on a case-by-case basis.

  • Molecular basis of carotid body tumor and associated clinical features in Japan identified by genomic, immunohistochemical, and clinical analyses

    Yoshihama K., Mutai H., Sekimizu M., Ito F., Saito S., Nakamura S., Mikoshiba T., Nagai R., Takebayashi A., Miya F., Kosaki K., Ozawa H., Matsunaga T.

    Clinical Genetics （Clinical Genetics）  103 （ 4 ） 466 - 471 2023年04月

    ISSN  00099163

    　概要を見る

    Carotid body tumor (CBT) is classified as a paraganglioma (PGL). Here, we report the genetic background, protein expression pattern, and clinical findings of 30 Japanese CBT cases. Germline pathogenic or likely pathogenic (P/LP) variants of genes encoding succinate dehydrogenase subunits (SDHs) were detected in 15 of 30 cases (50%). The SDHB variants were the most frequently detected, followed by SDHA and SDHD variants. One case with SDHAF2 variant was bilateral CBT, and other two multiple PGL cases were not detected P/LP variants. The three cases with germline variants that could be tested did not have somatic P/LP variants of the same genes. Immunohistochemical analysis showed negative SDHB signals in CBT tissues in five cases with germline P/LP variants of SDHB, SDHD, or SDHA. In addition, SDHB signals in CBT tissues were negative in four of nine cases without germline P/LP variants of SDHs. These findings suggest the involvement of unidentified molecular mechanisms affecting SDHs.

  • Carotid body tumor with neck metastasis due to germline SDHB variant: a case report and literature review.

    Mikoshiba T, Yoshihama K, Ito F, Sekimizu M, Nakamura S, Nagai R, Akiyama T, Matsubara K, Obara H, Ozawa H

    International cancer conference journal 11 （ 1 ） 6 - 11 2022年01月

  • Utility of computed tomography findings as a predictor of carotid artery invasion by metastatic lymph nodes in head and neck squamous cell carcinoma

    Mikoshiba T., Sakamoto K., Shinden S., Shimanuki M., Nakayama R., Okada T., Ozawa H.

    European Archives of Oto-Rhino-Laryngology （European Archives of Oto-Rhino-Laryngology）  279 （ 9 ） 4561 - 4568 2022年

    ISSN  09374477

    　概要を見る

    Purpose: Carotid artery invasion by metastatic lymph nodes in head and neck squamous cell carcinoma (HNSCC) is one of the diagnostic criteria for unresectable tumors. However, to date, the diagnostic criteria for carotid artery invasion have not been well documented. This study investigated the utility of computed tomography (CT) findings as a predictor of carotid artery invasion by metastatic lymph nodes in HNSCC. Methods: Twenty-eight patients who had metastatic lymph nodes of HNSCC attached to the carotid artery as seen on CT images before neck dissection from January 2011 to November 2017 were included. Five imaging parameters (angle of contact [AC], length of contact [LC], haziness of the carotid artery wall [HW], size of the lymph node, and involvement of the bifurcation of the carotid artery [IB]) were assessed using CT to predict carotid artery invasion. Furthermore, the utility of the combination of these five parameters was evaluated. Results: There were significant differences in AC, LC, and IB between patients with and without carotid artery invasion. There were significant differences in all combinations of the two image findings between patients with and without carotid artery invasion. In particular, the combinations of LC and HW, and LC and IB could clearly predict carotid artery invasion. Conclusion: AC, LC, and IB were useful predictors of carotid artery invasion of metastatic lymph nodes in HNSCC. This study is the first to report that IB is a useful predictor of carotid artery invasion in HNSCC.

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