Papers - Hosoya, Makoto

Engraftment of Human Pluripotent Stem Cell-derived Progenitors in the Inner Ear of Prenatal Mice

Takeda, Hiroki, Hosoya, Makoto, Fujioka, Masato, Saegusa, Chika, Saeki, Tsubasa, Miwa, Toru, Okano, Hideyuki, Minoda, Ryosei

SCIENTIFIC REPORTS (Scientific Reports)  8 ( 1 ) 871 - 874 2018.01

Research paper (scientific journal),  ISSN  2045-2322

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© 2018 The Author(s). There is, at present, no curative treatment for genetic hearing loss. We have previously reported that transuterine gene transfer of wild type CONNEXIN30 (CX30) genes into otocysts in CX30-deleted mice could restore hearing. Cell transplantation therapy might be another therapeutic option, although it is still unknown whether stem cell-derived progenitor cells could migrate into mouse otocysts. Here, we show successful cell transplantation of progenitors of outer sulcus cell-like cells derived from human-derived induced pluripotent stem cells into mouse otocysts on embryonic day 11.5. The delivered cells engrafted more frequently in the non-sensory region in the inner ear of CX30-deleted mice than in wild type mice and survived for up to 1 week after transplantation. Some of the engrafted cells expressed CX30 proteins in the non-sensory region. This is the first report that demonstrates successful engraftment of exogenous cells in prenatal developing otocysts in mice. Future studies using this mouse otocystic injection model in vivo will provide further clues for developing treatment modalities for congenital hearing loss in humans.

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Tympanoplasty for chondrodysplasia punctata: Case report

Hosoya, Makoto, Kanzaki, Sho, Wakabayashi, Satoko, Ogawa, Kaoru

AURIS NASUS LARYNX 44 ( 5 ) 616 - 619 2017.10

Research paper (scientific journal),  ISSN  0385-8146

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Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss

Hosoya, Makoto, Fujioka, Masato, Sone, Takefumi, Okamoto, Satoshi, Akamatsu, Wado, Ukai, Hideki, Ueda, Hiroki R., Ogawa, Kaoru, Matsunaga, Tatsuo, Okano, Hideyuki

CELL REPORTS 18 ( 1 ) 68 - 81 2017.01

Research paper (scientific journal),  ISSN  2211-1247

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Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness: An exploratory study

Koganemaru, Satoko, Goto, Fumiyuki, Arai, Miki, Toshikuni, Keitaro, Hosoya, Makoto, Wakabayashi, Takeshi, Yamamoto, Nobuko, Minami, Shujiro, Ikeda, Satoshi, Ikoma, Katsunori, Mima, Tatsuya

BRAIN STIMULATION 10 ( 3 ) 576 - 578 2017.01

Research paper (scientific journal),  ISSN  1935-861X

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Overlapping expression of anion exchangers in the cochlea of a non-human primate suggests functional compensation

Hosoya, Makoto, Fujioka, Masato, Kobayashi, Reona, Okano, Hideyuki, Ogawa, Kaoru

NEUROSCIENCE RESEARCH 110   1 - 10 2016.09

Research paper (scientific journal),  ISSN  0168-0102

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Expression pattern of wolframin, the WFS1 (Wolfram syndrome-1 gene) product, in common marmoset (Callithrix jacchus) cochlea

Suzuki, Noriomi, Hosoya, Makoto, Oishi, Naoki, Okano, Hideyuki, Fujioka, Masato, Ogawa, Kaoru

NEUROREPORT 27 ( 11 ) 833 - 836 2016.08

Research paper (scientific journal),  ISSN  0959-4965

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Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea

Hosoya, Makoto, Fujioka, Masato, Ogawa, Kaoru, Okano, Hideyuki

SCIENTIFIC REPORTS 6   833 - 836 2016.02

Research paper (scientific journal),  ISSN  2045-2322

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Distinct Expression Pattern of a Deafness Gene, KIAA1199, in a Primate Cochlea

Hosoya, Makoto, Fujioka, Masato, Okano, Hideyuki, Ogawa, Kaoru

BIOMED RESEARCH INTERNATIONAL    1 - 10 2016

Research paper (scientific journal),  ISSN  2314-6133

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Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma

Mizutari, Kunio, Fujioka, Masato, Hosoya, Makoto, Bramhall, Naomi, Okano, Hirotaka James, Okano, Hideyuki, Edge, Albert S. B.

NEURON 77 ( 1 ) 58 - 69 2013.01

Research paper (scientific journal),  ISSN  0896-6273

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Expression and Function of Sox21 During Mouse Cochlea Development

Hosoya, Makoto, Fujioka, Masato, Matsuda, Satoru, Ohba, Hiroyuki, Shibata, Shinsuke, Nakagawa, Fumiko, Watabe, Takahisa, Wakabayashi, Ken-ichiro, Saga, Yumiko, Ogawa, Kaoru, Okano, Hirotaka James, Okano, Hideyuki

NEUROCHEMICAL RESEARCH 36 ( 7 ) 1261 - 1269 2011.07

Research paper (scientific journal),  ISSN  0364-3190

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