Hosoya, Makoto



School of Medicine, Otorhinolaryngology, Head and Neck Surgery (Shinanomachi)


Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

External Links

Academic Degrees 【 Display / hide

  • 医学博士, 慶應義塾大学, Coursework, 2017.03


Research Areas 【 Display / hide

  • Life Science / Otorhinolaryngology


Papers 【 Display / hide

  • Low-dose rapamycin-induced autophagy in cochlear outer sulcus cells

    Saegusa Chika, Hosoya Makoto, Nishiyama Takanori, Saeki Tsubasa, Fujimoto Chisato, Okano Hideyuki, Fujioka Masato, Ogawa Kaoru


    ISSN  2378-8038

  • A phase I/IIa double blind single institute trial of low dose sirolimus for Pendred syndrome/DFNB4

    Fujioka M., Akiyama T., Hosoya M., Kikuchi K., Fujiki Y., Saito Y., Yoshihama K., Ozawa H., Tsukada K., Nishio S.Y., Usami S.I., Matsunaga T., Hasegawa T., Sato Y., Ogawa K.

    Medicine (Medicine)  99 ( 19 ) e19763 2020.05

    ISSN  0025-7974

     View Summary

    INTRODUCTION: Pendred syndrome (PDS)/DFNB 4 is a disorder with fluctuating and progressive hearing loss, vertigo, and thyroid goiter. We identified pathophysiology of a neurodegenerative disorder in PDS patient derived cochlear cells that were induced via induced pluripotent stem cells and found sirolimus, an mTOR inhibitor, as an inhibitor of cell death with the minimum effective concentration less than 1/10 of the approved dose for other diseases. Given that there is no rational standard therapy for PDS, we planned a study to examine effects of low dose oral administration of sirolimus for the fluctuating and progressive hearing loss, and the balance disorder of PDS by daily monitor of their audio-vestibular symptoms. METHODS AND ANALYSIS: This is a phase I/IIa double blind parallel-group single institute trial in patient with PDS/DFNB4. Sixteen of outpatients with fluctuating hearing diagnosed as PDS in SLC26A4 genetic testing aged in between 7 and 50 years old at the time of consent are given either placebo or sirolimus tablet (NPC-12T). In NPC-12T placebo arm, placebo will be given for 36 weeks; in active substance arm, placebo will be given for 12 weeks and the NPC-12T for 24 weeks. Primary endpoints are safety and tolerability. The number of occurrences and types of adverse events and of side effects will be sorted by clinical symptoms and by abnormal change of clinical test results. A 2-sided 95% confidence interval of the incidence rate by respective dosing arms will be calculated using the Clopper-Pearson method. Clinical effects on audio-vestibular tests performed daily and precise physiological test at each visit will also be examined as secondary and expiratory endpoints. TRIAL REGISTRATION NUMBER: JMA-IIA00361; Pre-results.

  • A case report of Gorham-Stout disease diagnosed during the course of recurrent meningitis and cholesteatoma

    Hosoya M., Oishi N., Nishiyama J., Ogawa K.

    Journal of Otolaryngology - Head and Neck Surgery (Journal of Otolaryngology - Head and Neck Surgery)  49 ( 1 ) 18 2020.04

    ISSN  1916-0216

     View Summary

    © 2020 The Author(s). Background: Gorham-Stout disease is a rare bone disorder. Here, we present a case of Gorham-Stout disease diagnosed during follow-up of a patient with cholesteatoma; the disease affected the temporal bone and other sites of the skull. To the best of our knowledge, this is the first report of Gorham-Stout disease diagnosed with recurrent cerebrospinal leakage after surgery to treat cholesteatoma. Case presentation: A 25-year-old male patient re-presented to our department for the first time in 7 years with otorrhea in the right ear and recurrent meningitis. The patient had a history of multiple surgeries for cholesteatoma and suffered from recurrent cerebrospinal fluid leakage, which initially was thought to be caused by recurrence of cholesteatoma. Therefore, skull base reconstruction was planned. However, the underlying cause was identified eventually as defects in the temporal bone caused by massive osteolysis due to Gorham-Stout disease. Skull base reconstruction was abandoned because the osteolysis was considered to be progressive. Conservative treatment with infectious control was implemented as an alternative. Conclusion: This case describes unusual temporal bone osteolysis after cholesteatoma surgery and the importance of considering the possibility of multiple concurrent diseases in such individuals. The distinguishing features of this case are the fact that the temporal bone had disappeared, and deconstruction was complicated by infection and inflammation caused by cholesteatoma, surgical invasion, and Gorham-Stout disease. Appropriate diagnosis saved the patient from ineffective multiple surgeries for cerebrospinal fluid leakage or cholesteatoma, and improved his quality of life.

  • A rare case of bifurcated chorda tympani

    Kasahara K., Hosoya M., Oishi N., Ogawa K.

    Journal of International Advanced Otology (Journal of International Advanced Otology)  16 ( 1 ) 141 - 144 2020.04

    ISSN  13087649

     View Summary

    © 2020, AVES. All rights reserved. Preservation of the chorda tympani is important in middle ear surgery to prevent dysgeusia postoperatively. However, determining the exact course of the chorda tympani before surgery is not always possible, especially in cases with accompanying malformations. In this report, we pre-sented an extremely rare case of bifurcation of the chorda tympani in a 15-year-old male patient. We performed tympanoplasty for a middle ear malformation with conductive hearing loss. During the operation, we noticed and carefully preserved the bifurcated chorda tympani. The patient did not develop dysgeusia postoperatively. Appropriate handling and understanding of the anomalous chorda tympani preserved the patient’s sense of taste and hence quality of life.

  • A new training method for velopharyngeal dysfunction: Self-inhalation for hypernasality

    Kobayashi R., Tsunoda K., Takazawa M., Ueha R., Hosoya M., Fujimaki Y., Nito T., Yamasoba T.

    Auris Nasus Larynx (Auris Nasus Larynx)  47 ( 2 ) 250 - 253 2020.04

    ISSN  03858146

     View Summary

    © 2019 Elsevier B.V. Objective: There are various methods to treat velopharyngeal dysfunction including surgery and rehabilitation therapy. Even if a rehabilitation program is effective, the evaluation of its efficacy remains subjective. In this paper, we propose a new method of rehabilitation training for velopharyngeal dysfunction focusing on the objective peak inspiratory flow (PIF) rate. Methods: Four patients, who were diagnosed with velopharyngeal dysfunction without cleft palate at ENT clinic of the National Hospital Organization, Tokyo Medical Center, participated in this study. All patients underwent our original rehabilitation program for velopharyngeal dysfunction, a method using the In-Check Dial, Turbohaler model. As a self-training rehabilitation program, we asked them to inhale forcefully 10 times daily at home using the In-Check Dial to increase the value of PIF rate for 3 months. We measured the patients’ PIF rates with the In-Check Dial at the ENT clinic at the initial visit and after the 3-month training. Results: The PIF rates of the four patients without nasal clips were higher than the rates with nasal clips at the initial visit. After the training, PIF rate without a nasal clip of all patients increased than the rate at the initial visit, which represented significant difference (P < 0.05). Also, after 3 months, PIF rate without a nasal clip was higher or equal than the rates with a nasal clip at the initial visit except one case. Naso-pharyngo-laryngeal fiberscopy did not detect salivary pooling around larynx and mirror fogging test did not show nasal escape in the three of four patients after 3 months of training. All reported improvement in dysphagia and dysarthria. Conclusion: This new method can be used not only to evaluate velopharyngeal function but also as an effective self-training treatment.

display all >>

Reviews, Commentaries, etc. 【 Display / hide

  • 【フローチャートと検査一覧で ひと目でわかる耳鼻咽喉科診療】耳科編 耳鳴・聴覚過敏 急性耳鳴,慢性耳鳴,無難聴性耳鳴,心因性疾患

    細谷 誠, 神崎 晶

    耳鼻咽喉科・頭頸部外科 ((株)医学書院)  92 ( 5 ) 053 - 058 2020.04

    ISSN  0914-3491

     View Summary

    <文献概要>ここを押さえておこう ●耳鳴・聴覚過敏の診断には問診が重要である.●耳鼻咽喉科疾患以外の基礎疾患および精神疾患の除外が必要.●慢性耳鳴・聴覚過敏に対しては,Tinnitus Retraining Therapyを検討する.

  • 【難聴を治す-2020年版】感音難聴とiPS創薬

    藤岡 正人, 細谷 誠

    JOHNS ((株)東京医学社)  36 ( 1 ) 101 - 104 2020.01

    ISSN  0910-6820

  • ヒトiPS細胞を用いた内耳疾患研究および治療法開発

    細谷 誠, 藤岡 正人

    日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科学会)  122 ( 12 ) 1508 - 1515 2019.12

    ISSN  0030-6622

     View Summary


  • Correction: ClinGen expert clinical validity curation of 164 hearing loss gene–disease pairs (Genetics in Medicine, (2019), 21, 10, (2239-2247), 10.1038/s41436-019-0487-0)

    DiStefano M.T., Hemphill S.E., Oza A.M., Siegert R.K., Grant A.R., Hughes M.Y., Cushman B.J., Azaiez H., Booth K.T., Chapin A., Duzkale H., Matsunaga T., Shen J., Zhang W., Kenna M., Schimmenti L.A., Tekin M., Rehm H.L., Tayoun A.N.A., Amr S.S., Abdelhak S., Alexander J., Avraham K., Bhatia N., Bai D., Boczek N., Brownstein Z., Burt R., Bylstra Y., del Castillo I., Choi B.Y., Downie L., Friedman T., Giersch A., Goh J., Greinwald J., Griffith A.J., Hernandez A., Holt J., Hosoya M., Ying L.J., Jain K., Kim U.K., Kremer H., Krantz I., Leal S., Lewis M., Liu X.Z., Low W., Lu Y., Luo M., Masmoudi S., Ming T.Y., Moreno-Pelayo M.A., Morín M., Morton C., Murray J., Mutai H., Nara K., Pandya A., Pei-Rong S.K., Smith R.J.H., Jamuar S.S., Suer F.E., Usami S.I., Van Camp G., Yamazawa K., Yuan H.J., Black-Zeigelbein E., Zhang K.

    Genetics in Medicine (Genetics in Medicine)  21 ( 10 )  2019.10

    ISSN  10983600

     View Summary

    © 2019, American College of Medical Genetics and Genomics. In the original version of this Article, the address for affiliation 8, Division of Hearing and Balance Research, National Hospital Organization Tokyo Medical Center, Tokyo, Japan, was incorrectly given as Laboratory of Auditory Disorders and Division of Hearing and Balance Research, Tokyo, Japan. Furthermore, the address for affiliation 9, Medical Genetics Center, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan, was incorrectly given as Medical Genetics Center, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan. They have now been corrected in both the PDF and HTML versions of the Article.

  • 高齢者の聴覚と暮らし方と健康に関する学術調査(第2報) 老人性難聴のリスクファクターの探索

    忰田 かおり, 藤岡 正人, 北村 充, 堀 明美, 薬師丸 令子, 野口 勝, 粕谷 健人, 西山 崇経, 石川 徹, 細谷 誠, 鈴木 成尚, 長谷部 夏希, 岡本 康秀, 小川 郁

    Audiology Japan ((一社)日本聴覚医学会)  62 ( 5 ) 568 - 568 2019.10

    ISSN  0303-8106

display all >>

Research Projects of Competitive Funds, etc. 【 Display / hide

  • 進化動物学的知見からの発生時間軸の種差を応用した聴覚器発生の高時間分解解析


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Principal investigator

  • コモンマーモセットを用いた内耳研究プラットフォームの創生


    Keio University, Grant-in-Aid for Scientific Research (B), No Setting

     View Summary


  • Binaural brain mechanism of bilateral cochlear implants with auditory neuropathy


    独立行政法人国立病院機構(東京医療センター臨床研究センター), Grant-in-Aid for Scientific Research (C), No Setting

     View Summary

    1996年に新しい聴覚障害として研究代表者の加我がAuditory Nerve Disease (AND)、米国のStarrがAuditory Neuropathy (AN)としてそれぞれ発表したが、現在では同一の新しい聴覚障害として世界的に認知されている。また2008年には本疾患の先天性障害について米国のNorthernらがANSDとして提案した。現在、ANSDの効果的な治療の主たる方法は両側人工内耳手術である。しかし、ANSDはsynaptopathyとneuropathyの少なくとも2タイプがあり、両耳聴が中枢聴覚で成立しているか全く不明で、単耳聴と両耳聴成立の有無を明らかにすることで病態生理についての解明に取り組み、ANSDの小児と成人患者の聴覚・言語認知能力の解明に貢献する。

  • 多層オミックスとiPS技術,霊長類モデルを駆使した加齢性難聴への挑戦


    Keio University, Challenging Research (Pioneering), No Setting

     View Summary


  • Development of novel therapeutics for the cochlear hearing impairments by using hiPSCs and common marmoset models


    Keio University, Grant-in-Aid for Scientific Research (A), No Setting

display all >>


Courses Taught 【 Display / hide