Details of a Researcher - Nishiyama, Takanori

Papers - Nishiyama, Takanori

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Characteristics of pure tone audiogram in patients with untreated sporadic vestibular schwannoma: Analysis of audiometric shape and interaural differences stratified by age and mode of onset.

Nobuyoshi Tsuzuki, Tsubasa Kitama, Koichiro Wasano, Takeshi Wakabayashi, Makoto Hosoya, Takanori Nishiyama, Hiroyuki Ozawa, Naoki Oishi

Auris, nasus, larynx (Auris Nasus Larynx) 51 ( 2 ) 347 - 355 2024.04

ISSN 03858146

OBJECTIVE: Asymmetric sensorineural hearing loss (ASHL) is the most common symptom of sporadic vestibular schwannoma (VS). However, there is still no universally accepted MRI protocol for diagnosing VS. This study identified the characteristics of pure tone audiogram (PTA) in patients with VS. METHODS: We conducted a retrospective chart review of patients diagnosed with sporadic unilateral VS. In the analysis, we focused on the shape and interaural differences of PTA, stratified by the mode of onset and patient age. RESULTS: In total, 390 patients met the inclusion criteria. The U-shaped audiogram showed the highest proportion in patients with the onset of sudden sensorineural hearing loss (SSNHL). In patients with SSNHL, U-shaped audiograms were younger than other audiograms, and 86.7 % of patients under 40 had U-shaped audiograms. Patients with VS were more likely to have interaural differences at higher frequencies than at lower frequencies. Patients with SSNHL had a significantly higher percentage of interaural differences at 500-4000 Hz than those with onset other than SSNHL (non-SSNHL patients). In addition, non-SSNHL patients had a significant trend toward a higher percentage of interaural differences at all frequencies with increasing age. CONCLUSION: MRI screening can be considered in patients with SSNHL with U-shaped audiograms under 40 years of age. In ASHL, not SSNHL, MRI screening can be considered for older patients with interaural differences at wider continuous frequencies. Patients with interaural differences at high frequencies had a higher priority than those with interaural differences at low frequencies as indications for MRI screening for VS.

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Prediction of Cochlear Implant Effectiveness With Surface-Based Morphometry.

Shujiro Minami, Masahiro Takahashi, Seiichi Shinden, Kyoko Shirai, Naoki Oishi, Hiroshi Nishimura, Masatsugu Masuda, Sawako Masuda, Takanori Nishiyama, Makoto Hosoya, Masafumi Ueno, Akinori Kashio, Hiroyuki Yamada, Tatsuo Matsunaga, Kimitaka Kaga, Ayumi Shintani, Kiyotaka Nemoto

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology (Otology and Neurotology) 45 ( 2 ) 114 - 120 2024.02

ISSN 15317129

OBJECTIVE: This study aimed to determine whether surface-based morphometry of preoperative whole-brain three-dimensional T1-weighted magnetic resonance imaging (MRI) images can predict the clinical outcomes of cochlear implantation. STUDY DESIGN: This was an observational, multicenter study using preoperative MRI data. SETTING: The study was conducted at tertiary care referral centers. PATIENTS: Sixty-four patients with severe to profound hearing loss (≥70 dB bilaterally), who were scheduled for cochlear implant (CI) surgery, were enrolled. The patients included 19 with congenital hearing loss and 45 with acquired hearing loss. INTERVENTIONS: Participants underwent CI surgery. Before surgery, high-resolution three-dimensional T1-weighted brain MRI was performed, and the images were analyzed using FreeSurfer. MAIN OUTCOME MEASURES: The primary outcome was monosyllable audibility under quiet conditions 6 months after surgery. Cortical thickness residuals within 34 regions of interest (ROIs) as per the Desikan-Killiany cortical atlas were calculated based on age and healthy-hearing control regression lines. RESULTS: Rank logistic regression analysis detected significant associations between CI effectiveness and five right hemisphere ROIs and five left hemisphere ROIs. Predictive modeling using the cortical thickness of the right entorhinal cortex and left medial orbitofrontal cortex revealed a significant correlation with speech discrimination ability. This correlation was higher in patients with acquired hearing loss than in those with congenital hearing loss. CONCLUSIONS: Preoperative surface-based morphometry could potentially predict CI outcomes and assist in patient selection and clinical decision making. However, further research with larger, more diverse samples is necessary to confirm these findings and determine their generalizability.

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Natural history of hearing and tumor growth in vestibular schwannoma in neurofibromatosis type 2-related schwannomatosis.

Takeshi Wakabayashi, Ryota Tamura, Kosuke Karatsu, Makoto Hosoya, Takanori Nishiyama, Yasuhiro Inoue, Kaoru Ogawa, Jin Kanzaki, Masahiro Toda, Hiroyuki Ozawa, Naoki Oishi

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (European Archives of Oto-Rhino-Laryngology) 2024

ISSN 09374477

OBJECTIVES: To determine the natural history of hearing loss and tumor volume in patients with untreated neurofibromatosis type 2 (NF2)-related schwannomatosis. Moreover, we statistically examined the factors affecting hearing prognosis. METHODS: This retrospective cohort study was conducted on 37 ears of 24 patients with NF2-related vestibular schwannomatosis followed up without treatment for more than 1 year. We obtained detailed chronological changes in the PTA and tumor volume in each case over time, and the rate of change per year was obtained. Multivariate analysis was also conducted to investigate factors associated with changes in hearing. RESULTS: The average follow-up period was approximately 9 years, and hearing deteriorated at an average rate of approximately 4 dB/year. The rate of maintaining effective hearing decreased from 30 ears (81%) at the first visit to 19 ears (51%) at the final follow-up. The average rate of change in tumor growth for volume was approximately 686.0 mm3/year. This study revealed that most patients with NF2 experienced deterioration in hearing acuity and tumor growth during the natural course. A correlation was observed between an increase in tumor volume and hearing loss (r = 0.686; p < 0.001). CONCLUSIONS: Although the hearing preservation rate in NF2 cases is poor with the current treatment methods, many cases exist in which hearing acuity deteriorates, even during the natural course. Patients with an increased tumor volume during the follow-up period were more likely to experience hearing deterioration. Trial registration number 20140242 (date of registration: 27 October 2014).

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A novel intraoperative continuous monitoring method combining dorsal cochlear nucleus action potentials monitoring with auditory nerve test system.

Makoto Hosoya, Yuriko Nagaoka, Takeshi Wakabayashi, Marie N Shimanuki, Takanori Nishiyama, Masafumi Ueno, Hiroyuki Ozawa, Naoki Oishi

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale (Journal of Otolaryngology - Head and Neck Surgery) 52 ( 1 ) 67 - 67 2023.12

ISSN 1916-0208

Highly accurate real-time cochlear nerve monitoring to preserve cochlear nerve function is essential for simultaneous cochlear implantation and ipsilateral vestibular schwannoma resection. In the present study, we developed a novel real-time monitoring system that combines dorsal cochlear nucleus action potential monitoring with intracochlear stimulating electrodes (Auditory Nerve Test System, ANTS). We used this system for a case with vestibular schwannoma resection via the translabyrinthine approach. The monitoring system developed in this study detected highly reliable evoked potentials from the cochlear nerve every two seconds continuously during tumor resection. Near-total tumor resection was achieved, and cochlear implantation was performed successfully after confirming the preservation of cochlear nerve function in a case. The patient's hearing was well compensated by cochlear implantation after surgery. Our novel method continuously achieved real-time monitoring of the cochlear nerve every two seconds during vestibular schwannoma resection. The usefulness of this monitoring system for simultaneous tumor resection and cochlear implantation was demonstrated in the present case. The system developed in this study is compatible with continuous facial nerve monitoring. This highly accurate and novel monitoring method will broaden the number of candidates for this type of surgery in the future.

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Development of cochlear spiral ligament fibrocytes of the common marmoset, a nonhuman model animal.

Makoto Hosoya, Kaho Iwabu, Tsubasa Kitama, Takanori Nishiyama, Naoki Oishi, Hideyuki Okano, Hiroyuki Ozawa

Scientific reports (Scientific Reports) 13 ( 1 ) 11789 - 11789 2023.12

Spiral ligament fibrocytes generate potassium gradients, which hair cells require to convert mechanical sound waves into electrical palsy. Together with the stria vascularis, they regulate endolymph electrolyte homeostasis. Developing spiral ligament fibrocytes and generating endocochlear potential with an appropriate endolymph ion composition are essential for hearing. Understanding spiral ligament fibrocyte development is useful for studying age-related and genetic hearing loss, as well as for regenerative therapy and cochlear immunology. Despite interspecies differences, most studies of cochlear development have been conducted in rodent models due to the difficulty of using human fetal samples. This study investigated the cochlear development of spiral ligament fibrocytes in a small New World monkey species, the common marmoset (Callithrix jacchus). We examined the developmental expression of specific genes in spiral ligament fibrocytes, including those essential for the generation of endolymphatic potential. Our results showed that this animal model of spiral ligament fibrocyte development is similar to that of humans and is a suitable alternative for the analysis of human cochlear development. The time course established in this study will be useful for studying the primate-specific developmental biology of the inner ear, which may lead to novel treatment strategies for human hearing loss.

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Effective cochlear implantation for idiopathic hypertrophic pachymeningitis with bilateral profound hearing loss: A case report.

Katsuyoshi Idei, Mitsuru Kitamura, Marie N Shimanuki, Makoto Hosoya, Nobuyoshi Tsuzuki, Natsuki Hasebe, Takanori Nishiyama, Hiroyuki Ozawa, Naoki Oishi

Medicine (Medicine (United States)) 102 ( 47 ) e36124 2023.11

ISSN 00257974

RATIONALE: Hypertrophic pachymeningitis (HP) is a local or diffuse fibrous thickness of the dura mater of the brain or spinal cord, caused by infection or connective tissue disease. Headache is the most common clinical symptom, followed by various cranial nerve disorders such as visual impairment, diplopia, and hearing loss. HP can be classified into secondary and idiopathic. Here, we report a case of bilateral progressive profound sensorineural hearing loss diagnosed in a patient with idiopathic HP, where a cochlear implant was effectively used. PATIENT CONCERNS: The patient was a 77-year-old woman. Hearing loss gradually progressed bilaterally, and magnetic resonance imaging showed a space-occupying lesion with a continuous contrast enhancement in the bilateral internal auditory canals, and diffused dural thickening from the middle to the posterior cranial fossa. DIAGNOSES: A trans-labyrinthine biopsy was conducted, and a definite diagnosis of idiopathic HP was made. Thickening of the dura mater in the bilateral internal auditory canals was thought to cause profound hearing loss. INTERVENTIONS AND OUTCOMES: A cochlear implant was implemented 4 months after biopsy, and a favorable hearing response was obtained postoperatively. LESSONS: This is the first report of a cochlear implant in a patient with idiopathic HP. Cochlear implantation was considered a good treatment for profound hearing loss due to idiopathic HP, which provides a reference for patients to receive timely and correct treatment.

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小児滲出性中耳炎に対する短期留置型鼓膜換気チューブの効果

利國桂太郎, 西山崇経, 羽生昇, 富永健裕, 石川直明, 若林毅, 中村伸太郎, 北村充, 大石直樹, 小澤宏之

日本耳鼻咽喉科頭頸部外科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 126 ( 11 ) 1229 - 1234 2023.11

ISSN 2436-5793

難治化リスクを伴わない小児滲出性中耳炎の初回鼓膜チューブ挿入術において,ガイドラインでは短期留置型チューブを第一選択として推奨している.今回,短期留置型鼓膜チューブ(D型)を用いて鼓膜チューブ挿入術を行った15歳未満の小児69例122耳を対象とし,再発率,穿孔残存率,感染率について,留置期間や中耳貯留液の性状,血清学的指標との関連について検討した.平均留置期間は15.7ヵ月で,再発率は13.1%,穿孔率は6.0%,感染率は7.4%であった.再発の有無での2群間比較を行うと,再発なし群で有意に留置期間が長かった.また,血清学的指標と中耳貯留液の性状,再発率の間に明らかな傾向は認めなかった.(著者抄録)

A Case of Vestibular Schwannoma with Deafness Showing Remarkable Hearing Recovery Following Hearing-Preserving Surgery.

Yusuke Sakaki, Makoto Hosoya, Takanori Nishiyama, Takeshi Wakabayashi, Marie N Shimanuki, Hiroyuki Ozawa, Naoki Oishi

The journal of international advanced otology (Journal of International Advanced Otology) 19 ( 5 ) 426 - 430 2023.09

ISSN 13087649

Surgery for vestibular schwannoma can be divided into hearing-preserving and nonhearing-preserving surgeries. Hearing-preserving surgery is usually not considered in patients with deafness due to vestibular schwannoma, because hearing is unlikely to improve, and surgery aims to maximize the tumor resection at the expense of hearing. We report an extremely rare case of a 46-year-old man with unilateral profound hearing loss due to a vestibular schwannoma with marked cystic degeneration in the left cistern, which significantly recovered to near-normal hearing levels after hearing-preserving surgery. Hearing loss gradually worsened, and preoperative pure-tone evaluation showed complete hearing loss in the left ear. However, the response to the distortion product otoacoustic emission was preserved, and hearing loss was considered to be retrocochlear. Tumor resection was performed using the retrolabyrinthine approach with continuous monitoring using dorsal cochlear nucleus action potential, auditory brainstem response, and facial nerve function muscle action potential. The cistern portion of the tumor was almost completely resected along with the wall. Postoperatively, the pure-tone threshold on the left side markedly improved. The present case clearly demonstrates the possibility of hearing recovery in patients with retrocochlear hearing loss. We should consider expanding the indications for hearing-preserving surgery.

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Imaging of Temporal Bone Mass Lesions: A Pictorial Review.

Marie N Shimanuki, Takanori Nishiyama, Makoto Hosoya, Takeshi Wakabayashi, Hiroyuki Ozawa, Naoki Oishi

Diagnostics (Basel, Switzerland) (Diagnostics) 13 ( 16 ) 2023.08

ISSN 2075-4418

Tumoral lesions of the temporal bone include benign or malignant tumors and congenital or inflammatory lesions. Temporal bone lesions are difficult to approach. Therefore, making a preoperative diagnosis and considering whether the lesions require treatment are necessary; if they require treatment, then the type of treatment requires consideration. These tumors cannot be observed directly and must be diagnosed based on symptoms and imaging findings. However, the differentiation of temporal bone lesions is difficult because they are rare and large in variety. In this pictorial review, we divided temporal bone lesions by location such as along the facial nerve, along the internal jugular vein, around the endolymphatic sac, in the internal auditory canal/cerebellopontine angle, petrous apex, middle ear, and mastoid, focusing on the imaging findings of temporal bone lesions. Then, we created a diagnostic flowchart that suggested that the systematic separation of imaging findings is useful for differentiation. Although it is necessary to make comprehensive judgments based on the clinical symptoms, patient background, and imaging findings to diagnose temporal bone mass lesions, capturing imaging features can be a useful differentiation method.

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Transferability Based on Drug Structure Similarity in the Automatic Classification of Noncompliant Drug Use on Social Media: Natural Language Processing Approach.

Nishiyama T, Yada S, Wakamiya S, Hori S, Aramaki E

Journal of medical Internet research 25 e44870 2023.05

ISSN 1439-4456

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Apoptosis of type I spiral ganglion neuron cells in Otof-mutant mice

Tsuzuki N., Namba K., Saegusa C., Mutai H., Nishiyama T., Oishi N., Matsunaga T., Fujioka M., Ozawa H.

Neuroscience Letters (Neuroscience Letters) 803 137178 2023.04

ISSN 03043940

Otof, which encodes otoferlin, knockout mice are considered model mice for auditory neuropathy spectrum disorder, which is characterized by an absent auditory brainstem response (ABR) despite preserved distortion product otoacoustic emission (DPOAE). Although otoferlin-deficient mice lack neurotransmitter release at the inner hair cell (IHC) synapse, it remains unclear how the Otof mutation affects spiral ganglions. Thus, we used Otof-mutant mice carrying the Otoftm1a(KOMP)Wtsi allele (Otoftm1a) and analyzed spiral ganglion neurons (SGNs) in Otoftm1a/tm1a mice by immunolabeling type Ⅰ SGNs (SGN-Ⅰ) and type II SGNs (SGN-II). We also examined apoptotic cells in SGNs. Four-week-old Otoftm1a/tm1a mice had an absent ABR but normal DPOAEs. The number of SGNs was significantly lower in Otoftm1a/tm1a mice on postnatal day 7 (P7), P14, and P28 compared with that of wild-type mice. Moreover, significantly more apoptotic SGNs were observed in Otoftm1a/tm1a mice than in wild-type mice on P7, P14, and P28. SGN-IIs were not significantly reduced in Otoftm1a/tm1a mice on P7, P14, and P28. No apoptotic SGN-IIs were observed under our experimental conditions. In summary, Otoftm1a/tm1a mice showed a reduction in SGNs accompanied by apoptosis of SGN-Ⅰs even before the onset of hearing. We speculate that the reduction in SGNs with apoptosis is a secondary defect caused by a lack of otoferlin in IHCs. Appropriate glutamatergic synaptic inputs may be important for the survival of SGNs.

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Bell麻痺・Hunt症候群に対する経乳突顔面神経減荷術　手術による治療効果と聴力への影響

須田悟史, 都築伸佳, 大石直樹, 西山崇経, 細谷誠, 若林毅, 神崎晶, 小澤宏之

Otology Japan ((一社)日本耳科学会) 33 ( 1 ) 42 - 49 2023.02

ISSN 0917-2025

末梢性顔面神経麻痺に対する顔面神経減荷術は,その有効性について統一した見解は得られておらず,術後難聴の可能性も指摘されている.今回,当科で診療したBell麻痺・Hunt症候群のうち,ENoG値≦10%等の所見から重症例と診断され,治癒もしくは発症後6ヵ月以上経過観察可能であった48例(Bell麻痺:33例,Hunt症候群:15例)を対象として,経乳突顔面神経減荷術の治療成績および術後聴力閾値変化について検討した.治癒率について両疾患の手術群と保存加療群を比較し,Bell麻痺では有意差は見られなかったが[手術群(n=18):44.4%vs保存加療群(n=15):33.3%,p=0.52],Hunt症候群においては顔面神経減荷術の有効性が示唆された[手術群(n=9):66.7%vs保存加療群(n=6):0%,p=0.02].また術後は気導聴力で0.25,0.5,2,4,8kHz,骨導聴力では2,4kHzにおいて5～15dB程度の閾値上昇を来たす可能性が示された.本研究の限界として少数例の検討であることが挙げられ,今後の課題と考えている.(著者抄録)

Vestibular Schwannoma Surgery with Endoscope-Assisted Retrolabyrinthine Approach under Modified Reinforced Continuous Intraoperative Monitoring for Hearing Preservation: Experience of 33 Cases in a Single Center.

Makoto Hosoya, Takanori Nishiyama, Takeshi Wakabayashi, Marie N Shimanuki, Hidemi Miyazaki, Hiroyuki Ozawa, Naoki Oishi

Diagnostics (Basel, Switzerland) (Diagnostics) 13 ( 2 ) 2023.01

ISSN 2075-4418

Surgery for vestibular schwannoma includes various techniques such as the middle cranial fossa, suboccipital, translabyrinthine, and retrolabyrinthine approaches. The retrolabyrinthine approach does not impair the labyrinth and allows postoperative hearing preservation. Previously, we reported an endoscope-assisted retrolabyrinthine approach under reinforced continuous intraoperative monitoring for preservation of hearing and facial nerve function. However, the hearing preservation rate was relatively low in patients with long-wave V latency in the auditory brainstem response or poor otoacoustic emission response under this approach. Thus, the hearing preservation rate in such patients remains to be improved. To overcome this limitation, we modified the previous approach. In 26 of the 33 consecutive cases (79%) over the last three years, preservation of hearing equivalent to that before surgery or improved hearing was achieved. Postoperative deafness was observed in only two of the 33 cases (6%). According to previous reports, the rate of hearing preservation using the retrolabyrinthine approach is approximately 30-50%. Therefore, we have achieved a higher hearing preservation rate than that previously reported using the endoscopy-assisted retrolabyrinthine approach under reinforced continuous intraoperative monitoring. These improvements in our department are considered to be helpful for hearing preservation.

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Bilateral Deafness Due to Relapsing Polychondritis with Semicircular Canal Calcification Treated With Cochlear Implantation: A Case Report.

Kenichiro Arashi, Takanori Nishiyama, Makoto Hosoya, Nobuyoshi Tsuzuki, Takeshi Wakabayashi, Hiroyuki Ozawa, Naoki Oishi

Ear, nose, & throat journal (Ear, Nose and Throat Journal) 1455613231215173 - 1455613231215173 2023

ISSN 01455613

Relapsing polychondritis (RP) is a rare chronic inflammatory disease characterized by recurrent inflammation of cartilages throughout the body, with treatment-resistant dizziness and hearing loss in 40%-50% of patients with RP. Although rare, severe binaural hearing loss in RP is an indication for cochlear implantation (CI). Therefore, there are only a few reports on CI insertion in cases of RP. This report describes a 68-year-old woman who developed binaural hearing loss due to RP. She was treated with steroids and immunosuppressive drugs; however, her hearing did not improve significantly, and she relied on written communication for conversation. Subsequently, the patient underwent CI in the right ear. The patient showed improvement in speech perception; at 14 months postoperatively, she was able to speak with lipreading, and at 2 years postoperatively, she was able to speak without lipreading. Previous case reports on CI in patients with RP have shown varying degrees of postoperative hearing improvement. Our case demonstrates the effectiveness of CI in improving hearing and speech recognition in patients with RP having semicircular canal calcification. However, previous reports have shown that speech recognition declines 13 years after CI for RP. Therefore, continuous long-term follow-up is necessary.

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Intracochlear signal in FIESTA-C and hearings of patients with cerebellopontine angle schwannoma.

Mitsuru Kitamura, Naoki Oishi, Takanori Nishiyama, Makoto Hosoya, Natsuki Hasebe, Nobuyoshi Tsuzuki, Kaoru Ogawa

Acta oto-laryngologica (Acta Oto-Laryngologica) 143 ( 1 ) 19 - 23 2023

ISSN 00016489

BACKGROUND: Hearing loss in patients with cerebellopontine angle (CPA) schwannoma, is thought to be caused by the damage to the cochlea and the cochlear nerve. AIM: This study aimed to examine the relationships between the intracochlear signal in magnetic resonance imaging (MRI) and hearing in patients with CPA schwannoma. MATERIAL AND METHOD: In 79 patients with CPA schwannoma, we retrospectively examined the signal in the cochlea on the affected side was compared with that on the unaffected side to determine signal degradation in fast imaging reagents steady-state acquisition with cycle phases (FIESTA-C) MRI. For hearing evaluation, pure tone audiometry (PTA), speech audiometry, distortion product otoacoustic emissions (DPOAE), and auditory brainstem response (ABR) were used. For each parameter, we examined the differences between the groups with and without signal degradation. RESULTS: In the hearing test results, the I-wave latency of ABR was significantly longer in the group with signal degradation in FIESTA-C (1.84 ± 0.35 msec vs. 2.04 ± 0.37 msec, p = 0.048). There was no statistically significant difference in other tests. CONCLUSION: The MRI signal changes in the cochlear were related to the I-wave latency of ABR and reflected cochlear function. SIGNIFICANCE: We suggested the cochlear signal changes in CPA schwannoma patients related the hearing.

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Distribution of macrophages in the developing cochlea of the common marmoset, a primate model animal.

Makoto Hosoya, Tsubasa Kitama, Marie N Shimanuki, Takanori Nishiyama, Naoki Oishi, Hideyuki Okano, Hiroyuki Ozawa

Frontiers in immunology (Frontiers in Immunology) 14 1229414 - 1229414 2023

INTRODUCTION: Macrophages are essential immune cells in the cochlea that contribute to inflammation, tissue repair, and homeostasis. They also play an important role in local cochlear immunity. The developmental immigration and maturation of macrophages in the cochlea have been investigated and are considered essential for normal hearing acquisition. Most of our current knowledge regarding cochlear development is based on rodent models because of the ethical challenges of using human fetal samples for research. However, inter-species differences between rodents and humans have been reported. In this study, we used a primate animal model to investigate the distributions of macrophages in the developing cochlea. The common marmoset (Callithrix jacchus), a small monkey species that inhabits the New World, was used as the model. METHODS: We investigated the distribution of macrophages in the developing cochlea of the common marmoset by performing immunohistochemical analyses of cochlear tissue from common marmoset embryos at different development stages. RESULTS: We revealed detailed distribution changes in the macrophages of a primate animal model cochlea. This observation indicates that most of the changes in the general distribution of macrophages were well preserved between rodents and this primate. The distribution changes observed in the common marmoset were also compatible with observations in the human fetus; although, observations in the human fetus are limited. Our observations in this study also revealed several differences between common marmosets and rodents. CONCLUSION: The time course of immunological development and maturations established in this study will aid in the study of the primate-specific developmental biology of the inner ear. These observations may eventually lead to new therapeutic strategies for hearing loss in humans. In addition, understanding the immunological steady-state of the cochlea may help in the study of age- and genetic-induced hearing loss and in the design of regenerative therapies.

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Association between atherosclerosis, hearing recovery, and hearing in the healthy ear in idiopathic sudden sensorineural hearing loss: a retrospective chart analysis.

Nobuyoshi Tsuzuki, Koichiro Wasano, Naoki Oishi, Ko Hentona, Marie Shimanuki, Takanori Nishiyama, Yoshihiko Hiraga, Masafumi Ueno, Narihisa Suzuki, Seiichi Shinden, Kaoru Ogawa, Hiroyuki Ozawa

Scientific reports (Scientific Reports) 12 ( 1 ) 21571 - 21571 2022.12

Atherosclerosis is reported to be a risk factor for the severity of idiopathic sudden sensorineural hearing loss (ISSNHL). We evaluated the hypothesis that atherosclerosis affects the hearing thresholds of both the affected and healthy sides of ISSNHL patients. We conducted multivariate analyses on retrospectively collected data of patients with ISSNHL (N = 762) to evaluate the relationship between known factors linked to atherosclerosis and hearing thresholds on affected and healthy sides and whether these factors are prognostic for hearing recovery. Older ages, vertigo or dizziness, diabetes mellitus, and congestive heart failure were significantly related to higher hearing thresholds on the affected side. Older ages, male, and vascular disease were significantly related to higher hearing thresholds on the healthy side. Vertigo or dizziness, severe hearing loss and hearing loss at high frequencies on the affected side, higher hearing thresholds on the healthy side, regular anticoagulant medication, and delayed steroid treatment were significantly related to lack of recovery. Since several atherosclerosis-related factors are associated with higher hearing thresholds on both affected and healthy sides in ISSNHL and higher hearing thresholds on the healthy side predict poorer prognosis, diagnosis, and predicting prognosis of ISSNHL may benefit from rigorous evaluation of patients' cardiovascular comorbidities and hearing levels on both the healthy and affected sides.

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Development of the stria vascularis in the common marmoset, a primate model.

Makoto Hosoya, Tsubasa Kitama, Kaho Iwabu, Takanori Nishiyama, Naoki Oishi, Hideyuki Okano, Hiroyuki Ozawa

Scientific reports (Scientific Reports) 12 ( 1 ) 19811 - 19811 2022.12

Stria vascularis is a structure that generates potassium gradients in the cochlea, which is vital for hair cells to convert mechanical sound waves into electrical pulses. The precise development of the stria vascularis and subsequent generation of endocochlear potential are thus essential for hearing. Understanding the development of the stria vascularis is valuable for studying hearing loss caused by aging or genetics and designing regenerative therapy. Although inter-species differences have been reported between rodents and humans, most of our current knowledge regarding cochlear development has been obtained from rodent models because of the difficulty in using human fetal samples in this field of research. Therefore, we investigated the development of the cochlear stria vascularis in the common marmoset (Callithrix jacchus), a small monkey species native to the New World. Our study confirms that stria vascularis development in the common marmoset is similar to that in humans and is suitable for furthering our understanding of human cochlear development. The time course established in this report will aid in studying the primate-specific developmental biology of the inner ear, which could eventually lead to new treatment strategies for hearing loss in humans.

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Comparison of Cartilage Conduction Hearing Aid, Bone Anchored Hearing Aid, and ADHEAR: Case Series of 6 Patients with Conductive and Mixed Hearing Loss

Tsubasa Kitama, Takanori Nishiyama, Kaho Iwabu, Takeshi Wakabayashi, Marie N. Shimanuki, Makoto Hosoya, Naoki Oishi, Hiroyuki Ozawa

Applied Sciences (Switzerland) (Applied Sciences (Switzerland)) 12 ( 23 ) 2022.12

Cartilage conduction hearing aids (CC-HA), bone anchored hearing aids (Baha), and ADHEAR are good choices to improve hearing in patients who cannot use air conduction hearing aids because of aural atresia or continuous otorrhea. As there are many overlaps in the characteristics of these devices, we conducted a comparative trial of CC-HA, Baha, and ADHEAR. We provided patients with the opportunity to select their devices. The data of 6 patients who underwent comparative trials in our department between October 2021 and August 2022 were retrospectively examined. The gains of Baha and CC-HA outweighed those of ADHEAR. Regarding the sound localization test, there was no significant tendency for any of the hearing devices. Regarding the Glasgow Benefit Inventory, there was no clear tendency among the three devices in the quality of life evaluation. The most satisfactory model was the one subjectively chosen by the patient, regardless of the gain and score of the sound source localization test. Therefore, we believe that it is necessary to provide an opportunity for comparative trials and a consultation with each patient in the process of selecting a device.

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症例をどうみるか　内頸動静脈の露出を伴う先天性真珠腫症例に対する耳後部切開併用内視鏡下摘出術

西山崇経, 大石直樹, 若林毅, 北間翼, 細谷誠, 小澤宏之

JOHNS ((株)東京医学社) 38 ( 10 ) 1403 - 1406 2022.10

ISSN 0910-6820

症例は8歳男児で、5ヵ月ほど前より右耳漏が出現し、近医で耳処置を行った際に真珠腫上皮を認め、側頭骨CTで内頸動脈と頸静脈球の露出を伴う先天性真珠腫が疑われたため当科紹介受診となった。経過と画像所見より、内頸動脈と高位頸静脈球の露出を伴う前鼓室の先天性真珠腫の診断となった。内視鏡下経外耳道アプローチにて手術を行うこととし、術中所見では真珠腫の上方は耳管鼓室口下端、下方は前鼓室下端まで進展していた。真珠腫上皮を母膜の連続性を保ちながら剥離して適宜減量した。前下方の真珠腫上皮を摘出するために、骨性鼓膜輪前下方と外耳道入口部を必要に応じて削開し視野と操作野を作成した。最終的に内頸動脈壁が2ヶ所露出しており、母膜の連続性を保ちながら慎重に吸引管を用いて剥離・摘出した。術後はめまい、味覚障害、顔面神経麻痺を認めず、経過良好で術後2日目に退院となった。

外傷性アブミ骨陥入に対してアブミ骨摘出術後にアパセラムCを用いた伝音再建を行った1例

笠原健, 西山崇経, 中山梨絵, 小澤宏之

Otology Japan ((一社)日本耳科学会) 32 ( 3 ) 320 - 327 2022.09

ISSN 0917-2025

中耳外傷により耳小骨まで損傷が及ぶ例は多くなく、特にアブミ骨底板が卵円窓に陥入したという報告は外傷性耳小骨損傷の7.7%～19.0%と比較的少ない。今回、左耳かきによりアブミ骨が卵円窓へ陥入し外リンパ瘻を伴った症例を経験した。術前に55dBの混合性難聴を認め、激しいめまい症状を認めた。来院当日に手術加療を行い、術中はアブミ骨が卵円窓へ深く陥入し整復困難であったため摘出し、アパセラム耳小骨Cにて伝音再建を行った。術後めまいは速やかに改善し、聴力も徐々に改善した。アブミ骨の卵円窓への陥入が軽度な症例は、アブミ骨の整復のみで治療が可能という報告があるが、本症例のようにアブミ骨が深く卵円窓へ陥入している症例に関しては、アブミ骨摘出を伴う伝音再建術が必要となる。アブミ骨摘出を要する症例では術後聴力改善が得られない症例も少なくなく、術前から聴力予後が悪い可能性についての説明が重要であると考えられた。(著者抄録)

Intratemporal Facial Nerve Schwannomas: A Review of 45 Cases in A Single Center.

Tsubasa Kitama, Makoto Hosoya, Masaru Noguchi, Takanori Nishiyama, Takeshi Wakabayashi, Marie N Shimanuki, Masaki Yazawa, Yasuhiro Inoue, Jin Kanzaki, Kaoru Ogawa, Naoki Oishi

Diagnostics (Basel, Switzerland) (Diagnostics) 12 ( 8 ) 2022.08

ISSN 2075-4418

There are no established indications for facial nerve schwannoma treatment, including surgery, radiation and follow-up observation, and it is difficult to determine treatment policy uniformly. The treatment policy was examined from each treatment course. Data of patients with facial nerve schwannomas at our hospital from 1987 to 2018 were retrospectively examined. Their age, sex, clinical symptoms, tumor localization, treatment policies and outcomes were reviewed. In total, 22 patients underwent surgery and 1 patient underwent radiotherapy; 22 patients were followed up without treatment. After total resection, there were no tumor recurrences, and most patients had grade 3 or 4 postoperative facial paralysis. After subtotal resection, tumor regrowth was observed in four patients and reoperation was required in two patients. Facial nerve function was maintained in four patients and was decreased in two patients. During follow-up, six patients showed tumor growth. Only one patient had worsening facial nerve paralysis; four patients underwent facial nerve decompression owing to facial nerve paralysis during follow-up. If the tumor compresses the brain or it is prone to growth, surgery may be indicated, and when the preoperative facial nerve function is grade ≤3, consideration should be given to preserving facial nerve function and subtotal resection should be indicated. If the preoperative facial nerve function is grade ≥3, total resection with nerve grafting is an option to prevent regrowth. If there is no brain compression or tumor growth, the follow-up is a good indication, and decompression should be considered in facial nerve paralysis cases.

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A novel auricular prosthesis which incorporates a cartilage conduction hearing aid based on 3D data processing technique: a preclinical evaluation.

Takanori Nishiyama, Shintaro Hayashi, Naoki Oishi

ISSN 09374477

PURPOSE: To achieve the challenging goal of simultaneously improving aesthetics and auditory function in the treatment of microtia, we developed an auricular prosthesis incorporating a cartilage conduction hearing aid (APiCHA), which covers a cartilage conduction hearing aid (CC-HA). We evaluated the acoustic characteristics generated by the method of combining these two components using an artificial mastoid and investigated the possibility of clinical translation. METHODS: The first step in creating an APiCHA is to take molds of both the affected and normal auricles and invert the 3D data of the normal auricle to create data for the auricular prostheses. Grooves were then made inside the prosthetic data to fit the affected ear and a CC-HA, and the APiCHA was made of silicone. The acoustic characteristics were measured using an artificial mastoid, and the results were compared between CC-HA alone and with APiCHA. RESULTS: Compared with CC-HA alone, the gain was approximately 2 dB lower at high frequencies from 1 k Hz and higher, and approximately 2 dB higher at approximately 900 Hz when CC-HA was used with APiCHA. For the other frequencies, the acoustic characteristics were almost the same. CONCLUSION: The changes in acoustic characteristics caused by the combined use of APiCHA and CC-HA were minimal and did not pose a clinical problem. The combined use of APiCHA and CC-HA can be considered as a non-invasive and clinically applicable treatment option to achieve both aesthetic and auditory improvements for microtia.

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Understanding the Molecular Mechanism of Vestibular Schwannoma for Hearing Preservation Surgery: Otologists’ Perspective from Bedside to Bench

Makoto Hosoya, Takeshi Wakabayashi, Koichiro Wasano, Takanori Nishiyama, Nobuyoshi Tsuzuki, Naoki Oishi

Diagnostics (Diagnostics) 12 ( 5 ) 2022.05

ISSN 2075-4418

Vestibular schwannoma is a clinically benign schwannoma that arises from the vestibulocochlear nerve that causes sensorineural hearing loss. This tumor is clinically and oncologically regarded as a benign tumor as it does not metastasize or invade surrounding tissues. Despite being a benign tumor, its management is difficult and controversial due to the potential serious complications, such as irreversible sensorineural hearing loss, of current interventions. Therefore, preventing hearing loss due to the natural course of the disease and complications of surgery is a challenging issue for an otologist. Improvements have been reported recently in the treatment of vestibular schwannomas. These include advances in intraoperative monitoring systems for vestibular schwannoma surgery where the risk of hearing loss as a complication is decreased. Precise genomic analysis of the tumor would be helpful in determining the characteristics of the tumor for each patient, leading to a better hearing prognosis. These procedures are expected to help improve the treatment of vestibular schwannomas. This review summarizes recent advances in vestibular schwannoma management and treatment, especially in hearing preservation. In addition, recent advances in the understanding of the molecular mechanisms underlying vestibular schwannomas and how these advances can be applied in clinical practice are outlined and discussed, respectively. Moreover, the future directions from the bedside to the bench side are presented from the perspective of otologists.

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術後咽頭皮膚瘻に対するパウチ法を用いた管理の有用性

松居祐樹, 西山崇経, 今西順久, 重冨征爾, 佐藤陽一郎, 猪狩雄一, 五島可奈子, 笠原健, 小澤宏之

日本耳鼻咽喉科頭頸部外科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 125 ( 3 ) 271 - 278 2022.03

ISSN 2436-5793

縫合不全に伴う唾液漏出は頭頸部術後合併症の一つであり,救済処置として咽頭皮膚瘻を形成し二期的閉鎖を目指すことが多く,創部が安定し閉鎖術が行えるまでの期間は瘻孔からの唾液管理を要する.瘻孔に軟膏ガーゼを充填し,さらに上からガーゼで圧迫し,気管孔にカフ付きカニューレを留置する方法(以後,「従来法」)が一般的だが,度重なるガーゼと貼付テープの交換による疼痛や皮膚障害,カニューレ刺激による喀痰量増加,咳嗽誘発など患者負担が大きい.近年,患者負担軽減のためにさまざまな方法が報告されているが,咽頭皮膚瘻特有の構造的および性状的な問題点を解決できない例もあり,最適なパッキング方法とは言い難い.今回われわれは採尿バッグやストマパウチと粘土状皮膚保護剤を組み合わせた方法(以後,「パウチ法」)による管理を行った.パウチ法は粘土状皮膚保護剤による土手の成形と,パウチの面板の切り取り面積の調整により,瘻孔径を問わずさまざまな症例に柔軟に対応することができる汎用性の高い方法と考えられた.また,全例で交換頻度は3～4日毎,皮膚障害は軽度まで,カニューレは不要だった.パウチ法は従来法の欠点を補い,患者負担を軽減することができる方法だった.パウチ法の運用は,パウチ内に貯留する唾液管理は患者自身で対応可能であり,使用資材の取り扱いはストマ専従ナースとの協力が重要だった.(著者抄録)

Factors Influencing the Purchase Rate of Cartilage Conduction Hearing Aids

Tadashi Nishimura, Hiroshi Hosoi, Tomoko Sugiuchi, Nozomu Matsumoto, Takanori Nishiyama, Takano Kenichi, Satofumi Sugimoto, Hiroaki Yazama, Takeshi Sato, Masahiro Komori

Journal of the American Academy of Audiology (Georg Thieme Verlag KG) 33 ( 1 ) 14 - 22 2022.01

ISSN 10500545

Abstract

Background Innovated hearing aids (HAs), termed cartilage conduction hearing aids (CC-HAs), show good performance in patients with closed ears and continuous otorrhea. However, factors other than the ear condition that influence the purchase rate of CC-HAs remain unclear.

Purpose To identify the factors that influence the purchase rate of CC-HAs.

Research Design A correlational study.

Study Sample A total of 249 patients were enrolled.

Data Collection and Analysis The patients' demographics, clinical characteristics, outcomes, and CC-HA transducer types were compared. The data were analyzed for six groups classified based on the ear condition.

Results In the unilateral closed-ear group, the purchase cases were significantly younger than the nonpurchase cases (p < 0.05). Regarding the outcomes in the bilateral closed-ear group, the purchase cases showed significantly better-aided thresholds at 0.25 and 0.5 kHz than the nonpurchase cases. No significant differences in the functional gains and speech recognition scores were found between purchase and nonpurchase cases in all six groups. Regarding the transducer type, the continued-use rate of the simple transducer type was significantly lower in the bilateral chronic continuous otorrhea, bilateral open, and unilateral open groups.

Conclusion In the closed ears, no remarkable negative factors were found. Transducer type had a significant influence on the continued-use rate in the nonclosed ears including the ears with chronic continuous otorrhea, although the purchase rate of CC-HAs in the bilateral chronic continuous otorrhea group was comparable to the closed ears.

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A rare case of external ear canal stenosis caused by COVID-19-related arterial thrombosis.

Makoto Hosoya, Ayumi Minami, Takanori Nishiyama, Nobuyoshi Tsuzuki, Takeshi Wakabayashi, Naoki Oishi

Ear, nose, & throat journal (Ear, Nose and Throat Journal) 1455613221097198 - 1455613221097198 2022

ISSN 01455613

Thrombosis is a characteristic symptom of coronavirus disease 2019 (COVID-19). Here, we present a case of external ear stenosis caused by arterial thrombosis after COVID-19 infection. To the best of our knowledge, this is the first report of external ear stenosis related to COVID-19. A 62-year-old man presented with left hearing loss. The patient had a history of hospitalization for COVID-19 treatment 11 months prior to visiting our hospital. He had been experiencing ear fullness and tinnitus after COVID-19 treatment. Physical examination revealed severe left external ear canal stenosis with a subcutaneous mass. Surgical removal of the subcutaneous mass was performed. Histopathological analysis revealed that a subcutaneous thrombosis caused the external ear canal stenosis. This case describes an unusual case of external ear canal stenosis after COVID-19. Clinical and pathological findings indicate that COVID-19 affected the external ear canal. In addition, histopathological results confirmed the formation of arterial thrombosis in the temporal bone region after COVID-19 treatment. This case shows the broad range of body sites that can be involved with thrombotic events with COVID including the subcutaneous tissue around the outer ear. This observation would be helpful in investigating or explaining the various otological symptoms of COVID-19.

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Cricotracheostomy in a patient with severe kyphosis: A case report.

Ken Kasahara, Takanori Nishiyama, Seiji Shigetomi, Yuichi Ikari, Yuki Matsui, Hiroyuki Ozawa

Ear, nose, & throat journal (Ear, Nose and Throat Journal) 1455613221077596 - 1455613221077596 2022

ISSN 01455613

Cricotracheostomy is a useful surgical procedure for opening the airway in cases where conventional tracheotomy is difficult. This is a safe and easy technique involving removal of the anterior portion of the cricoid cartilage. Herein, we report the case of a patient with difficulty in neck extension due to severe kyphosis, who underwent cricotracheostomy. A 65-year-old woman developed dyspnea and was transported to our hospital. SpO2 was 60% (room air) and endotracheal intubation was performed. She was managed on ventilator. However, weaning off the ventilator was difficult, and endotracheal intubation was prolonged. Subsequently, the patient was referred to us for a tracheostomy. The patient was unable to maintain the supine position due to severe kyphosis, and computed tomography revealed that the brachiocephalic artery was running just below the thyroid gland. Therefore, conventional tracheostomy was difficult to perform, and we performed cricotracheostomy instead. After the cricotracheostomy, there were no tracheal problems, such as tracheal stenosis and stomal hemorrhage. Cricotracheostomy can be performed in cases where multiple anatomical difficulties may be faced in the tracheostomy site, as in this case. Furthermore, cricotracheostomy is beneficial for long-term airway management because it causes fewer complications compared to conventional tracheotomy.

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Inner ear salivary gland choristoma extending to the middle ear with congenital profound hearing loss and facial palsy: a case report.

Yoshiharu Yamanobe, Naoki Oishi, Takanori Nishiyama, Makoto Hosoya, Kaoru Ogawa

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale (Journal of Otolaryngology - Head and Neck Surgery) 50 ( 1 ) 25 - 25 2021.12

ISSN 1916-0208

BACKGROUND: Salivary gland choristoma (SGCh) is a rare benign tumor reported in several unusual sites, such as the gastrointestinal tract, the optic nerve, and the internal auditory canal, but never reported in the inner ear. CASE PRESENTATION: An 8-year-old girl with a history of left profound congenital hearing loss presented to us with ipsilateral progressive severe facial nerve palsy (House-Brackmann Grade VI). The left tympanic membrane was swollen with a pulsatile tumor. Radiological investigations revealed a multilocular tumor in the inner ear extending into the middle ear and internal auditory canal (IAC). We performed a partial resection of the tumor by transmastoid approach to preserve the anatomical structure of the facial nerve. The tumor was pathologically diagnosed as SGCh. Two years after surgery, her facial function recovered to House-Brackmann Grade II and the residual tumor did not show regrowth on MRI. CONCLUSIONS: Although the natural course of this rare tumor is unknown, a partial resection is an acceptable treatment procedure when functional recovery of the facial nerve is anticipated.

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Severe sudden sensorineural hearing loss related to risk of stroke and atherosclerosis.

Nobuyoshi Tsuzuki, Koichiro Wasano, Naoki Oishi, Ko Hentona, Marie Shimanuki, Takanori Nishiyama, Yoshihiko Hiraga, Seiichi Shinden, Kaoru Ogawa

Scientific reports (Scientific Reports) 11 ( 1 ) 20204 - 20204 2021.12

The cause of idiopathic sudden sensorineural hearing loss (idiopathic SSNHL)-diagnosed after excluding other causes of hearing loss, such as SSNHL associated with vestibular schwannoma (VS)-is unknown. The presumed pathogenesis of idiopathic SSNHL includes circulatory disorders (e.g., cochlear infarction). We tested the hypothesis that patients with SSNHL who are at high stroke risk will have a lower rate of VS compared to those with low stroke risk. The rationale is that the primary cause of SSNHL in patients with high stroke risk might be a circulatory disturbance. We conducted a retrospective study in six hospitals. Our sampling of SSNHL patients included those diagnosed with idiopathic SSNHL and VS-associated SSNHL. SSNHL patients who had a head MRI were stratified by severity of hearing loss and evaluated for differences in the detection rate of VS between the high-scoring CHADS2 (CHADS2-H-), an index of stroke risk, and low-scoring CHADS2 (CHADS2-L-) groups. We identified 916 patients who met the inclusion criteria. For severe hearing loss, the CHADS2-H group had a significantly lower rate of VS than the CHADS2-L group (OR 0 [95% CI 0.00-0.612]; P = 0.007). These results indirectly support the hypothesis that a primary cause of severe idiopathic SSNHL in those at high risk of stroke might be a circulatory disorder.

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The Frequency Characteristic of Silicone Domes in Receiver in the Canal Hearing Aids.

Masafumi Ueno, Seiichi Shinden, Daisuke Suzuki, Noriomi Suzuki, Takanori Nishiyama, Naoki Oishi, Kaoru Ogawa

Journal of the American Academy of Audiology (Journal of the American Academy of Audiology) 32 ( 9 ) 556 - 561 2021.10

ISSN 10500545

BACKGROUND: There are several types of silicone domes in receiver in the canal hearing aids (RICs), which have different occlusion levels. However, the frequency characteristics of each type of silicone dome are unclear. PURPOSE: This study aimed to determine the frequency characteristics of three types of silicone domes (open domes, double-type power domes, and tulip domes) in RICs. RESEARCH DESIGN: This is an interventional study. STUDY SAMPLE: In total, 11 participants with a normal sense of hearing were prospectively enrolled. INTERVENTION: Participants were fitted with hearing aids, which were adjusted to similar settings, and only the silicone domes were changed. The acoustic gain of hearing aids was adjusted to 20 dB in the range of 250 Hz to 4 kHz using the 2-cc coupler. DATA COLLECTION AND ANALYSIS: We measured the real-ear aided gain (REAG) for each type of silicone dome. In each frequency, we statistically compared the REAG of each type of dome. Acoustic gain using the Open Fit coupler of each type of dome was also measured. RESULTS: The REAG was obtained with no leakage with open domes only at 2 kHz, and with tulip domes and double-type power domes in the range of 1 to 2 kHz. Double-type power domes obtained significantly higher REAG than tulip domes at 250 and 500 Hz. Under the Open Fit coupler, all types obtained higher acoustic gain than the REAG. CONCLUSION: This study provides the analysis of the frequency characteristics of silicone domes in RICs. The highest degree of occlusion was observed in double-type power domes, followed by tulip domes, and the lowest was observed in open domes.

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Three cases of otitis media caused by Mycobacterium abscessus subsp. abscessus: Importance of medical treatment and efficacy of surgery.

Yuri Nishiyama, Takanori Nishiyama, Sho Kanzaki, Naoki Oishi, Masato Fujioka, Hiroyuki Yamada, Chihiro Ebisuno, Mayumi Kaiho, Yoshifumi Uwamino, Hanako Fukano, Yoshihiko Hoshino, Naoki Hasegawa, Kaoru Ogawa

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (Journal of Infection and Chemotherapy) 27 ( 8 ) 1251 - 1257 2021.08

ISSN 1341321X

This study aimed to assess the clinical presentation, antibiotic therapy, surgery, and outcomes in patients with otitis media caused by Mycobacterium abscessus subsp. abscessus and discuss the efficacy of surgery. This is a retrospective case review of three patients diagnosed with otomastoiditis caused by M. abscessus subsp. abscessus. All patients had refractory otorrhea. One patient had granulation tissue in the tympanic membrane. They received medical treatment and underwent surgery. Otorrhea was resolved several months after the initiation of long-term multiantibiotic therapy in all cases. The timing of surgery varied among patients. Before initiating antibiotic therapy, mastoidectomy was performed to achieve definitive diagnosis in two patients, and wound dehiscence developed in these patients. Two patients underwent debridement after the initiation of multiantibiotic therapy. After antibiotic administration, tympanoplasty was performed to improve hearing in one patient. All patients achieved culture negativity after treatment, and no recurrences have been noted. From three cases, it is suggested that the mainstay of treatment for M. abscessus subsp. abscessus is long-term multiantibiotic therapy, and surgery itself may have little effect on achieving ear dryness. Thus, in most patients, drug therapy should be prioritized. Considering postoperative complications, surgery before achieving ear dryness should be avoided, except in emergency cases. In addition, if the diagnosis is not confirmed by repeated bacteriological tests, mastoidectomy should be performed to collect specimens. Tympanoplasty for hearing loss or eardrum perforation is recommended after discontinuation of medications.

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Who are good adult candidates for cartilage conduction hearing aids?

Takanori Nishiyama, Naoki Oishi, Kaoru Ogawa

ISSN 09374477

PURPOSE: Cartilage conduction hearing aids (CC-HAs) are novel hearing aids using the third hearing pathway of cartilage conduction. We assessed the efficacy of CC-HAs in adult hearing-loss patients who had various anatomical conditions of their ear canal(s) and determined who are good candidates for CC-HAs. METHODS: Patients (n = 37) were categorised into three groups of participants based on ear canal anatomy: (1) canal stenosis; (2) abnormal canal; (3) normal canal. After a 1-month free trial of normal usage, CC-HA-aided and unaided hearing thresholds (43 fitted ears) were determined using standard audiograms, after which participants could choose to purchase the device or not. Group and subgroup purchase rates were calculated along with the purchase reason (or not). Subgroup binary analysis of purchase rates was done according to hearing loss severity (< 70 dB and ≥ 70 dB) of unaided average air conduction (AC) hearing thresholds. RESULTS: CC-HA provided hearing improvements in all frequencies within each group. Overall, 60.47% of participants purchased a CC-HA after the trial. Over 70% participants with canal stenosis purchased CC-HAs, regardless of their AC hearing thresholds (severe vs. mild), and significantly more mild-loss participants in the abnormal canal group purchased their trial CC-HA compared to severe-loss participants (85.71% vs. 20%). CONCLUSION: Adult patients with ear canal stenosis or closure are the best candidates for CC-HAs, regardless of their hearing thresholds. Patients with more severe hearing loss accompanied by ear canal anomalies and patients with normal canal anatomy may not be good candidates.

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Efficacy of cartilage conduction hearing aids in children.

Takanori Nishiyama, Naoki Oishi, Kaoru Ogawa

International journal of pediatric otorhinolaryngology (International Journal of Pediatric Otorhinolaryngology) 142 110628 - 110628 2021.03

ISSN 01655876

OBJECTIVES: Cartilage conduction hearing aids (CC-HAs) are novel hearing aids that use the third hearing pathway of cartilage conduction. We assessed the efficacy of CC-HAs and the hearing effects and safety of additional tape compression over the transducer in children with hearing loss. METHODS: The patients (n = 42) underwent a one-month free trial of CC-HAs. Forty of them were patients with auditory canal atresia or stenosis. CC-HA-aided and unaided hearing thresholds (48 fitted ears) were determined using standard audiograms, after which participants could choose to purchase the device or not. We calculated the purchase rates and compared the patient characteristics between the purchase and non-purchase groups along with the purchase reason (or not). We applied additional tape compression over the CC-HA transducer and assessed the hearing effects and side effects. RESULTS: CC-HA led to hearing improvements at all frequencies. Overall, 72.92% of participants purchased a CC-HA after the trial. By applying additional tape compression over the CC-HA transducer, the stability and hearing gains were improved mainly at low frequencies, and no side effects such as dermatitis were observed. CONCLUSIONS: CC-HAs are efficacious in producing hearing improvements in children, especially in patients with atresia or canal stenosis who cannot use air conduction hearing aids. Furthermore, we found that the additional tape compression over the transducer was an easy and a safe method for improving the hearing effects and stability of the CC-HA.

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外耳道癌症例22耳の検討

鈴木成尚, 大石直樹, 小澤宏之, 神崎晶, 藤岡正人, 西山崇経, 野口勝, 細谷誠, 関水真理子, 斎藤真, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 124 ( 3 ) 197 - 204 2021.03

ISSN 0030-6622

外耳道癌の確立した治療法はないが、切除可能例では手術が優先される。当院ではT1〜T3症例に手術、T4症例に化学放射線療法(CCRT)を選択してきた。側頭骨外側切除術は伝音難聴が必発のため聴覚機能が犠牲になるとされてきたが、術後補聴による聴覚の再獲得に取り組んでいる。当科での短期成績の検討を行った。2012年1月〜2018年6月に初回治療を行った外耳道癌21例22耳を対象とした。改訂Pittsburgh分類にてT1が4耳、T2が9耳、T3が6耳、T4が3耳だった。17耳に手術、5耳にCCRTか重粒子線治療を施行した。側頭骨外側切除術を施行したT3例6耳中3耳で断端陽性となったが、T1・T2例ではすべて陰性だった。2年生存率はT1が100%、T2が88.9%、T3が83.3%、T4が100%だった。聴器合併症は側頭骨外側切除術例では伝音難聴のみだったが、放射線治療例では骨導低下、外耳道狭窄、難治性耳漏などを認めた。術後に軟骨伝導補聴器を試聴した5例中4例で常時装用となった。術前CTで腫瘍が鼓膜をわずかに越えるのみ、造影MRIで外耳道前方の軟部組織の境界が明瞭な症例では切除断端は陰性であり、側頭骨外側切除術の良い適応であった。そのほかのT3・T4症例ではCCRTが第一選択と考えられた。放射線の難治性合併症を考慮すると、側頭骨外側切除術後に補聴を行う治療では聴覚を有効活用できた。(著者抄録)

Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice.

Takanori Nishiyama, Masato Fujioka, Chika Saegusa, Naoki Oishi, Tatsuhiko Harada, Makoto Hosoya, Hideyuki Saya, Kaoru Ogawa

Biochemical and biophysical research communications (Biochemical and Biophysical Research Communications) 534 921 - 926 2021.01

ISSN 0006291X

Mammalian auditory hair cells are not spontaneously replaced. Their number and coordinated polarization are fairly well-maintained and both these factors might be essential for the cochlear amplifier. Cell cycle regulation has critical roles in regulating appropriate cell size and cell number. However, little is known about the physiological roles of the Hippo pathway, which is one of the most important signaling cascades that regulates cell growth, differentiation, and regenerative capacity in the cochlear sensory epithelium. Herein, we investigated the in vivo role of the large tumor suppressor 1 (LATS1), an essential kinase in the Hippo/yes-associated protein pathway, in the cochlea using the LATS1 knockout mice. LATS1 was expressed in hair cells and supporting cells. It was strongly expressed on the surface of the cuticular plate of the organ of Corti. We found that LATS1 knockout caused congenital hearing loss due to the irregular orientation and slightly reduced number of hair cells, whereas the number of supporting cells remained unchanged. On the surface of the hair cells, the kinocilium and stereocilia were dispersed during and after morphogenesis. However, the expression of the receptor-independent polarity regulators, such as Par3 or Gαi, was not affected. We concluded that LATS1 has an indispensable role in the maturation of mammalian auditory hair cells, but not in the development of the supporting cells, and thus, has a role in the hearing acquisition.

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Management of tinnitus in patients with vestibular schwannoma who underwent surgical resection.

Mitsuru Kitamura, Naoki Oishi, Noriomi Suzuki, Takashi Kojima, Takanori Nishiyama, Masuru Noguchi, Makoto Hosoya, Kaoru Ogawa

ISSN 09374477

PURPOSE: To evaluate tinnitus and its management in patients with vestibular schwannoma (VS) who underwent surgery, we investigate the effect of surgical approach or residual hearing on tinnitus severity and the effects of intervention for tinnitus including educational counseling, sound therapy using hearing aids (HAs), and medication (selective serotonin reuptake inhibitors, and SSRIs). METHODS: Seventy-one subjects of VS patients who underwent surgery were included. Their tinnitus severity was evaluated using the Japanese version of the Tinnitus Handicap Inventory (THI). The relationships between postoperative THI scores and surgery types or residual hearing levels were examined. We also examined longitudinal changes in THI scores and the efficacy of the intervention. RESULTS: Surgery approach, hearing preservation or hearing loss surgery, and residual hearing levels were not significantly related to the postoperative tinnitus severity. In 71 cases, 45 cases did not require any management for tinnitus. On the contrary, 26 patients had at least one episode of tinnitus distress (THI score was greater than or equal to 18). Educational counseling alone was found to be effective in 17 cases out of the 26 cases, and the remaining 9 cases required more intervention than educational counseling alone. We selected sound therapy with HA for 7 cases and administration of SSRI for 2 cases, which was found to be highly effective in 8 cases. CONCLUSION: Based on the present study, we consider that appropriate management may be possible for tinnitus in the majority of VS patients who underwent surgery.

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Cartilage Conduction Hearing Aid Fitting in Clinical Practice.

Tadashi Nishimura, Hiroshi Hosoi, Tomoko Sugiuchi, Nozomu Matsumoto, Takanori Nishiyama, Takano Kenichi, Satofumi Sugimoto, Hiroaki Yazama, Takeshi Sato, Masahiro Komori

Journal of the American Academy of Audiology (Journal of the American Academy of Audiology) 32 ( 6 ) 386 - 392 2021

ISSN 10500545

BACKGROUND: Cartilage conduction hearing aids (CCHAs) were newly devised and spread fast in Japan since their launch in 2017. However, little knowledge is available for this new device. PURPOSE: The aim of this study was to establish the knowledge of CCHAs and suggest their indication. RESEARCH DESIGN: Correlational study. STUDY SAMPLE: A total 256 patients were registered. DATA COLLECTION AND ANALYSIS: The fitting of CCHAs was surveyed in nine institutions. The outcomes were assessed by audiometric tests. The patients were classified into seven groups, depending on the ear conditions. The clinical characteristics, assessment results, and purchase rates were compared among the groups. The assessment results of CCHAs were also compared with those of previously used hearing aids. RESULTS: Most patients who used CCHAs were classified into the bilateral closed (aural atresia or severe stenosis) ear (n = 65) or unilateral closed ear (n = 124) groups. The patients in these groups achieved good benefits that resulted in a high purchase rate. The bilateral continuous otorrhea group also supported a high purchase rate, although the benefits of CCHAs were not always excellent. In contrast, the purchase rate was poor in the patients who could use air conduction hearing aids (ACHAs) without absolute problems. As for using a CCHA as a contralateral routing of signals hearing aid, the benefits depended on the patients. CONCLUSIONS: CCHAs are considered as a great option not only to the patients with closed ears but also to those who had difficulties in ACHAs usage.

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A Retrospective Analysis of 22 Cases with Carcinomas of the External Auditory Canal

Narihisa Suzuki, Naoki Oishi, Hiroyuki Ozawa, Sho Kanzaki, Masato Fujioka, Takanori Nishiyama, Masaru Noguchi, Makoto Hosoya, Mariko Sekimizu, Shin Saito, Kaoru Ogawa

Journal of Otolaryngology of Japan (Journal of Otolaryngology of Japan) 124 ( 3 ) 197 - 204 2021

ISSN 00306622

Carcinoma of the external auditory canal is a rare tumor, accounting for about 1% of all head and neck cancers. Although no treatment method has been established yet, surgical treatment is the primary treatment method in cases where resection is possible. At our institution, we adopt surgical treatment, mainly lateral temporal bone resection （LTBR）, for cases with T1―T3 disease, and chemoradiation therapy（CCRT）for cases with T4 disease, as the treatment of first choice. We have adopted cartilage conduction hearing aids（CC―HAs）in some cases following LTBR. We examined the short―term outcomes, at two years, in the patients treated at our department. This study was a retrospective case review of 22 ears with carcinoma of the external auditory canal in 21 patients who underwent initial treatment at our institution between January 2012 and June 2018. The observation period was 2 to 81 months（median 26 months）. The tumors were analyzed using the modified Pittsburgh tumor staging system. The tumor T stage was T1 in four ears, T2 in nine ears, T3 in six ears, and T4 in three ears. CCRT was performed in three ears with T4 disease and one ear with T2 disease, heavy ion radiotherapy was performed in one ear with T2 disease, and surgery（LTBR in 16 ears and partial external auditory meatus resection in one ear）was performed for all the other cases. The surgical margin after LTBR was positive in three out of six cases with T3 disease and negative in all of the cases with T1 and T2 disease. The positive surgical margin was mainly found in the medial wall of the tympanic cavity or cartilaginous portion of the external acoustic meatus. The overall 2―year survival rate was 87.4%; the rate was 100% in the T1 cases, 87.5% in the T2 cases, 75.0% in the T3 cases, and 100% in the T4 cases. Four out of five patients who tried CC―HAs continued to use them after the LTBR. The indication for LTBR should be carefully judged in cases with T3 disease. The appropriate indication for LTBR in cases with T3 disease are: 1）a small amount of soft tissue shadow beyond the tympanum in the preoperative CT, and/ or 2）a clear boundary between the tumor and the soft tissue around the external acoustic meatus in the preoperative enhanced MRI. In cases with T3 disease not fulfilling these criteria, CCRT should be selected as the treatment of first choice. However, considering the side effects after CCRT, including sensorineural hearing loss and persistent otorrhea in some cases, LTBR with postoperative CC―HAs is one of the optimal treatment options that would allow the remaining hearing ability to be utilized.

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Validation and multidimensional analysis of the japanese penn acoustic neuroma quality-of-life scale.

Takanori Nishiyama, Naoki Oishi, Takashi Kojima, Kento Kasuya, Masaru Noguchi, Toru Ishikawa, Makoto Hosoya, Kaoru Ogawa

The Laryngoscope (Laryngoscope) 130 ( 12 ) 2885 - 2890 2020.12

ISSN 0023852X

OBJECTIVES: In the management of vestibular schwannoma (VS), patient-perceived outcomes should be given as much attention as physician-reported objective outcomes. Concomitant symptoms can be annoying for sufferers, lowering quality of life (QoL). However, it is difficult to determine the degree to which these symptoms lower QoL using only objective measures. The Penn Acoustic Neuroma Quality of Life Scale (PANQOL) is a validated disease-specific questionnaire commonly used to assess QoL in VS patients. It was developed and published in English. In this study, we translated the PANQOL questionnaire into Japanese and validated its reliability and utility. We also evaluated patient factors that could influence PANQOL scores. STUDY DESIGN: Cross-sectional study. METHODS: Seventy-two VS patients monitored conservatively were included in this study. They were assessed using the Japanese versions of PANQOL (PANQOL-J) and questionnaires about specific symptoms related to VS. The PANQOL questionnaire was translated into Japanese according to the accepted standards. The reliability and utility of the PANQOL-J questionnaire, as well as the relationship with VS-specific symptoms, were statistically analyzed. RESULTS: The mean total score was 78.7. Almost all of its domains had good internal consistency. Most PANQOL-J domains were related to those of the Short Form-36, with the exception of facial dysfunction domain. Scores of all PANQOL-J domains were comparable to scores of other questionnaires related to the VS-specific symptoms. Our analyses indicated tinnitus or facial palsy might affect the PANQOL-J total score. CONCLUSIONS: We confirmed the validity of the Japanese version of PANQOL questionnaire and its reliability and utility in the management of VS symptoms concerning facial function. LEVEL OF EVIDENCE: 4 Laryngoscope, 2020.

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栄養指標と予後口腔扁平上皮癌根治手術例における栄養・炎症・免疫複合指標の予後推定能の網羅的検討

松居祐樹, 今西順久, 重冨征爾, 佐藤陽一郎, 猪狩雄一, 西山崇経, 五島可奈子, 笠原健

日本癌治療学会学術集会抄録集 ((一社)日本癌治療学会) 58回 WS4 - 2 2020.10

聴神経腫瘍術後「非有効聴力」残存耳に対する補聴器装用効果が得られた一例

長谷部夏希, 大石直樹, 西山崇経, 北村充, 都築伸佳, 細谷誠, 藤岡正人, 神崎晶, 宮崎日出海, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 63 ( 5 ) 468 - 468 2020.09

ISSN 0303-8106

高齢者の聴覚と暮らし方と健康に関する学術調査(第3報) 老人性難聴に関連する遺伝子多型の探索

野口勝, 藤岡正人, 忰田かおり, 北村充, 堀明美, 薬師丸令子, 西山崇経, 石川徹, 細谷誠, 鈴木成尚, 長谷部夏希, 岡本康秀, 大石直樹, 神崎晶, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 63 ( 5 ) 376 - 376 2020.09

ISSN 0303-8106

高齢者の聴覚と暮らし方と健康に関する学術調査(第3報) 85-89歳の聴力分布

忰田かおり, 藤岡正人, 野口勝, 堀明美, 薬師丸令子, 西山崇経, 石川徹, 鈴木成尚, 細谷誠, 北村充, 長谷部夏希, 岡本康秀, 大石直樹, 神崎晶, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 63 ( 5 ) 375 - 375 2020.09

ISSN 0303-8106

口腔扁平上皮癌における炎症・栄養・免疫複合指標の予後推定能の検討

松居祐樹, 今西順久, 五島可奈子, 西山崇経, 佐藤陽一郎, 重冨征爾, 栗林徹, 舟越和人

頭頸部癌 ((一社)日本頭頸部癌学会) 46 ( 2 ) 175 - 175 2020.07

ISSN 1349-5747

外側側頭骨切除後の熱源としてDRESS症候群が疑われた一例

松居祐樹, 西山崇経, 五島可奈子, 佐藤陽一郎, 今西順久

神奈川医学会雑誌 (神奈川県医師会) 47 ( 2 ) 209 - 210 2020.07

ISSN 0285-0680

Low-dose rapamycin-induced autophagy in cochlear outer sulcus cells.

Chika Saegusa, Makoto Hosoya, Takanori Nishiyama, Tsubasa Saeki, Chisato Fujimoto, Hideyuki Okano, Masato Fujioka, Kaoru Ogawa

Laryngoscope investigative otolaryngology 5 ( 3 ) 520 - 528 2020.06

Objectives: Autophagy is an intracellular housekeeping process that degrades cytoplasmic organelles, damaged molecules, and abnormal proteins or pathogens and is essential for normal hearing. Recent studies revealed the essential roles of autophagy in hearing and balance. The aim of this study was to evaluate the activation state of rapamycin-induced autophagy in cochlear outer sulcus cells (OSCs). Methods: We used autophagy reporter transgenic mice expressing the green fluorescent protein-microtubule-associated protein light chain 3 (GFP-LC3) fusion protein and counted GFP-LC3 puncta in cochlear OSCs to evaluate the activation state of autophagy after oral administration of rapamycin. Results: We observed basal level GFP-LC3 expression and an increase in the number of GFP-LC3 puncta in cochlear OSCs by oral administration of rapamycin. This increase was detected when the daily rapamycin intake was as low as 0.025 mg/kg, and it was dose dependent. The increased number of puncta was more at the basal turn than the apical turn. Conclusion: Oral intake of low-dose rapamycin activates autophagy in cochlear OSCs. Level of evidence: NA.

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刺激音の症例別最適化による聴神経腫瘍手術時の聴覚モニタリング改善の試み

細谷誠, 大石直樹, 野口勝, 西山崇経, 鈴木成尚, 長谷部夏希, 北村充, 藤岡正人, 神崎晶, 小川郁

日本耳科学会総会・学術講演会抄録集 ((一社)日本耳科学会) 29回 449 - 449 2019.10

新しいHeads up Surgery外視鏡耳科手術の長所と短所は何か? 顕微鏡と比較、脳外科医の評価と比較

神崎晶, 西山崇経, 細谷誠, 野口勝, 鈴木成尚, 大石直樹, 藤岡正人, 小川郁

日本耳科学会総会・学術講演会抄録集 ((一社)日本耳科学会) 29回 239 - 239 2019.10

当科におけるアパタイト人工耳小骨を用いた内視鏡下アブミ骨手術症例の検討

細谷誠, 藤岡正人, 鈴木成尚, 西山崇経, 野口勝, 長谷部夏希, 北村充, 神崎晶, 大石直樹, 小川郁

日本耳科学会総会・学術講演会抄録集 ((一社)日本耳科学会) 29回 461 - 461 2019.10

当科での経外耳道的内視鏡下耳科手術(TEES)により施行した鼓室形成術1型(inlay法)症例の検討

北村充, 藤岡正人, 神崎晶, 細谷誠, 長谷部夏希, 西山崇経, 野口勝, 鈴木成尚, 大石直樹, 小川郁

日本耳科学会総会・学術講演会抄録集 ((一社)日本耳科学会) 29回 387 - 387 2019.10

小児症例における軟骨伝導補聴器試聴者の臨床的検討

西山崇経, 大石直樹, 神崎晶, 藤岡正人, 鈴木成尚, 野口勝, 細谷誠, 北村充, 長谷部夏希, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 62 ( 5 ) 395 - 395 2019.10

ISSN 0303-8106

神経線維腫症2型を呈する日本人症例におけるNF2遺伝子変異と臨床像の関係

野口勝, 藤岡正人, 大石直樹, 奈良清光, 務台英樹, 長谷部夏希, 松崎佐栄子, 西山崇経, 鈴木成尚, 細谷誠, 神崎晶, 松永達雄, 小川郁

日本耳科学会総会・学術講演会抄録集 ((一社)日本耳科学会) 29回 445 - 445 2019.10

高齢者の聴覚と暮らし方と健康に関する学術調査(第2報) 老人性難聴のリスクファクターの探索

忰田かおり, 藤岡正人, 北村充, 堀明美, 薬師丸令子, 野口勝, 粕谷健人, 西山崇経, 石川徹, 細谷誠, 鈴木成尚, 長谷部夏希, 岡本康秀, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 62 ( 5 ) 568 - 568 2019.10

ISSN 0303-8106

高齢者の聴覚と暮らし方と健康に関する学術調査(第2報) GWASによる老人性難聴関連遺伝子多型の探索

野口勝, 藤岡正人, 忰田かおり, 北村充, 堀明美, 薬師丸令子, 粕谷健人, 西山崇経, 石川徹, 細谷誠, 鈴木成尚, 長谷部夏希, 岡本康秀, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 62 ( 5 ) 435 - 435 2019.10

ISSN 0303-8106

自宅連日検査によるPendred症候群の臨床像の探索と解析

山野邉義晴, 藤岡正人, 忰田かおり, 細谷誠, 長谷部夏希, 鈴木成尚, 西山崇経, 野口勝, 勝沼紗矢香, 鈴木法臣, 南修司郎, 神崎晶, 大石直樹, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 62 ( 5 ) 418 - 418 2019.10

ISSN 0303-8106

聴神経腫瘍の臨床聴力温存率向上を目指した取り組み

大石直樹, 細谷誠, 鈴木成尚, 北村充, 長谷部夏希, 野口勝, 西山崇経, 藤岡正人, 神崎晶, 宮崎日出海, 小川郁

日本耳科学会総会・学術講演会抄録集 ((一社)日本耳科学会) 29回 448 - 448 2019.10

Preoperative electrophysiological analysis predicts preservation of hearing and facial nerve function following vestibular schwannoma surgery with continuous intraoperative neural monitoring: Clinical outcomes of 22 cases.

Makoto Hosoya, Naoki Oishi, Takanori Nishiyama, Masaru Noguchi, Kento Kasuya, Noriomi Suzuki, Hidemi Miyazaki, Kaoru Ogawa

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 44 ( 5 ) 875 - 880 2019.09

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聴神経腫瘍診療の未来聴神経腫瘍診療における「早期発見、早期治療」小・中型腫瘍に対する聴力温存手術の役割

大石直樹, 細谷誠, 野口勝, 西山崇経, 鈴木成尚, 粕谷健人, 鈴木法臣, 宮崎日出海, 小川郁

Otology Japan ((一社)日本耳科学会) 29 ( 3 ) 211 - 214 2019.09

ISSN 0917-2025

MRIの普及に伴い、より小・中型の聴神経腫瘍が診断される機会が増えてきている。「早期発見」によって、聴神経腫瘍における疾患予後である「腫瘍の大きさが制御され、より良好な機能が温存される」症例の増加が期待される。疾患の自然経過を踏まえたうえで、「早期治療」をすべき症例を選別することが重要である。当科では、聴力温存・経側頭骨手術である後迷路法に近年取り組み、精度の高い術中持続神経モニタリングを併用し約4年間で施行した聴神経腫瘍手術は68例であり、その6割で後迷路法を施行した。後向きの検討から、術前ABR/DPOAEの結果により、より高い確率で聴力温存を果たし得る症例を選別できることが判明した。現在当科では、将来に聴力を喪失するあるいは腫瘍が増大する可能性が高いと判断される症例に対し、小腫瘍あるいは聴力が比較的良好な段階で聴力温存手術を施行する治療プロトコールを採用し、聴力温存率の向上に取り組んでいる。(著者抄録)

聴覚過敏症状の自覚的表現についての検討

西山崇経, 新田清一, 鈴木大介, 坂本耕二, 齋藤真, 野口勝, 大石直樹, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 62 ( 3 ) 235 - 239 2019.06

ISSN 0303-8106

聴覚過敏は、日常的な音に対して過敏性や不快感を示す状態で、外界からの音によらない耳鳴や、自分の声のみが強く聞こえる自声強聴とは異なった病態を表すと考えられている。しかし、過敏症状には「響く」、「大きく(強く)聞こえる」など多彩な表現が存在するにもかかわらず、各表現を分類して意義を検討している報告はない。そこで、過敏症状を訴えた168名を対象に、過敏症状の自覚的表現と疾患との関連や、これらの表現の臨床的意義について検討した。疾患の内訳は、約3分の2が急性感音難聴で、次いで加齢性難聴であり、聴力検査上異常を認めない症例も1割程度含まれていた。「響く」が最も多く、「響く」か否かを問診することは過敏症状のスクリーニングに役立ち、「割れる」や「二重に聞こえる」は感音難聴の存在を疑い、「大きく(強く)聞こえる」は極めて軽微な内耳障害や、聴覚中枢を含めた病態の関与を考える必要がある表現と考えられた。(著者抄録)

遺伝性難聴Pendred症候群/DFNB4の難聴・めまいに対する新規療法の医師主導治験

藤岡正人, 細谷誠, 西山崇経, 野口勝, 鈴木成尚, 矢部はる奈, 吉浜圭祐, 松永達雄, 宇佐美真一, 小川郁

小児耳鼻咽喉科 (日本小児耳鼻咽喉科学会) 40 ( 2 ) 123 - 123 2019.05

ISSN 0919-5858

3 hands surgeryでの経外耳道的内視鏡下耳科手術(TEES)

藤岡正人, 小澤宏之, 野口勝, 西山崇経, 細谷誠, 鈴木成尚, 神崎晶, 大石直樹, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 122 ( 4 ) 617 - 617 2019.04

ISSN 0030-6622

当院の神経線維腫症2型症例におけるNF2遺伝子の分子遺伝学的検討

野口勝, 藤岡正人, 大石直樹, 吉浜圭祐, 松永達雄, 務台英樹, 奈良清光, 西山崇経, 鈴木成尚, 細谷誠, 松崎佐栄子, 神崎晶, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科学会) 122 ( 4 ) 705 - 705 2019.04

Accepted, ISSN 0030-6622

当院における難聴遺伝外来の現況とこころみ

細谷誠, 藤岡正人, 野口勝, 吉浜圭祐, 西山崇経, 鈴木成尚, 大石直樹, 神崎晶, 松永達雄, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科学会) 122 ( 4 ) 622 - 622 2019.04

ISSN 0030-6622

当院における外耳道癌症例の検討

鈴木成尚, 大石直樹, 小澤宏之, 神崎晶, 藤岡正人, 西山崇経, 野口勝, 細谷誠, 関水真理子, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 122 ( 4 ) 596 - 596 2019.04

ISSN 0030-6622

小児滲出性中耳炎における血液学的炎症指標を用いた予後関連因子の検討

西山崇経, 大石直樹, 利國桂太郎, 羽生昇, 神崎晶, 藤岡正人, 野口勝, 鈴木成尚, 細谷誠, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 122 ( 4 ) 607 - 607 2019.04

ISSN 0030-6622

側頭骨内顔面神経鞘腫42例の臨床像

大石直樹, 野口勝, 井上泰宏, 神崎晶, 藤岡正人, 西山崇経, 鈴木成尚, 細谷誠, 平賀良彦, 原田竜彦, 神崎仁, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 122 ( 4 ) 640 - 640 2019.04

ISSN 0030-6622

自宅連日検査によるペンドレッド症候群の聴力変化の記録とその解析検討

山野邉義晴, 藤岡正人, 西山崇経, 野口勝, 鈴木成尚, 細谷誠, 矢部はる奈, 吉浜圭祐, 勝沼紗矢香, 鈴木法臣, 野口佳裕, 川島慶之, 藤川太郎, 神崎晶, 大石直樹, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 122 ( 4 ) 622 - 622 2019.04

ISSN 0030-6622

【ビギナーのための耳鳴・聴覚過敏診療】診断の進め方聴覚過敏

西山崇経, 新田清一

JOHNS ((株)東京医学社) 35 ( 1 ) 23 - 26 2019.01

ISSN 0910-6820

Severity of Tinnitus Distress Negatively Impacts Quality of Life in Patients With Vestibular Schwannoma and Mimics Primary Tinnitus.

Takashi Kojima, Naoki Oishi, Takanori Nishiyama, Kaoru Ogawa

Frontiers in neurology 10 389 - 389 2019

Objective: Quality of life (QoL) and subjective symptoms are predominantly used to evaluate treatment outcome of patients with vestibular schwannoma (VS). However, for patients undergoing conservative treatment-the most frequently used intervention-the association between QoL and subjective symptoms is unclear. Moreover, it is unknown whether VS-related tinnitus could be associated with the audiological and psychological status of the patient. Our overall aim is to provide objective evidence of this association to better guide treatment of VS. Methods: In a prospective study, we analyzed factors that influence VS-related tinnitus and QoL in 72 patients receiving conservative management of unilateral sporadic VS. This was done through questionnaires that assessed QoL, anxiety, depression, and audiological examinations. We used the SF-36 Short Form to assess QoL; the Tinnitus Handicap Inventory, Dizziness Handicap Inventory, Facial Clinimetric Evaluation Scale, Visual Analog Scale for hearing impairment to assess symptoms subjectively; and pure tone audiometry, the speech discrimination for hearing measurements. For psychological status, we used the Hospital Anxiety and Depression Scale. For analyses, we used Pearson correlation analysis and multiple regression between variables and QoL. Results: Correlation and regression analyses revealed that the severity of tinnitus distress had the largest negative impact on QoL in all domains of SF-36. The severity of tinnitus was significantly associated with subjective hearing impairment and the degree of depression and anxiety. Hearing thresholds had no statistical association with severity of tinnitus. Conclusions: To our knowledge, this is the first study to investigate VS-related tinnitus with respect to both patients' hearing status and psychological condition. Our results suggest that tinnitus distress strongly affects VS patients' QoL and that its characteristics are similar to primary tinnitus. An intervention for VS-related tinnitus, therefore, should assess to what extent tinnitus bothers patients, and it should reduce any unpleasant emotions that may exacerbate symptoms. This approach should improve their QoL.

Access to Document (DOI)

Intraoperative Facial Nerve Monitoring Revealed the Origin of Rapidly Progressing Schwannoma in the Cerebellopontine Angle: A Case of Large Intermediate Nerve Schwannoma.

Hosoya M, Oishi N, Noguchi M, Kasuya K, Nishiyama T, Ishikawa T, Kasahara K, Miyazaki H, Ogawa K

The journal of international advanced otology (Journal of International Advanced Otology) 14 ( 3 ) 488 - 492 2018.12

Accepted, ISSN 13087649

Schwannoma arising from the intermediate nerve is very rare, with only a few cases reported in the literature. Here, we report a rare case of a rapidly growing schwannoma that originated from the intermediate nerve in a 17-year-old woman. We performed tumor resection using the translabyrinthine approach with continuous intraoperative monitoring, in which the facial nerve root was used to evoke muscle action potential. The monitoring revealed the tumor origin and enabled complete surgical resection with the preservation of facial nerve motor function. The facial nerve root evoked muscle action potential-based continuous monitoring revealed the origin of the rare intermediate nerve schwannoma. Appropriate surgery using this monitoring system could spare facial nerve function even in this rare case and retain the patient's quality of life.

Access to Document (DOI)

【内視鏡下耳科手術】当科での経外耳道的内視鏡下耳科手術における工夫 3 hands techniqueを中心に

藤岡正人, 小澤宏之, 野口勝, 粕谷健人, 石川徹, 猪狩雄一, 西山崇経, 細谷誠, 神崎晶, 大石直樹, 小川郁

Otology Japan ((一社)日本耳科学会) 28 ( 5 ) 659 - 662 2018.12

ISSN 0917-2025

光学機器の進歩と各種器具の上市を背景に、昨今急速に普及している経外耳道的内視鏡下耳科手術(TEES)は、その近接した広い視野角による死角の減少と微細で鮮明な映像情報とを利点とする反面、片手操作ゆえの不便さが常に伴う。一方、鼻科領域で標準術式となっている内視鏡下鼻副鼻腔手術は経鼻内視鏡頭蓋底手術(EESBS)へと発展を見せており、EESBSでは二人の術者による"4 hands surgery"が一般的である。当科ではEESBSの手法をTEESに導入し、助手が内視鏡を持ち視野を作る、"3 hands surgery"によるTEESを積極的に行っている。術者が両手操作で作業を行うことができ、かつ内視鏡が術野の変化に合わせて迅速に移動できるため、出血をコントロールしながら、近接した死角の少ない視野を確保することが可能である。一方で、TEESでは鼻副鼻腔以上に狭いスペースで手術が展開されるため、スコーパーの臨機応変、迅速かつ的確な内視鏡操作により、視野とワーキングスペースを同時に確保することがEESBS以上に厳しく要求される。内視鏡操作と術操作を異なる術者が行うと、術者の遠近感の把握感覚が異なるため、EESBS同様、特殊な手技として修練を経験することが望ましい。術者とスコーパーが相補的な手技を同時に行うチームワークが手術の円滑な進行には不可欠であり、EESBSの手術教育を基盤とした手技習得と、cadaver dissectionによる十分なトレーニングが肝要と私達は考えている。(著者抄録)

耳鼻咽喉科医主導の補聴器診療

西山崇経

耳鼻咽喉科臨床 (耳鼻咽喉科臨床学会) 111 ( 10 ) 724 - 725 2018.10

ISSN 0032-6313

Cadaverを用いた内視鏡下耳科手術(TEES)のトレーニング

藤岡正人, 神崎晶, 大石直樹, 小澤宏之, 西山崇経, 野口勝, 鈴木成尚, 細谷誠, 小川郁

Otology Japan ((一社)日本耳科学会) 28 ( 4 ) 452 - 452 2018.09

ISSN 0917-2025

日本語版PANQOL質問紙を用いた聴神経腫瘍患者術後QOLの検討

西山崇経, 大石直樹, 野口勝, 細谷誠, 鈴木成尚, 神崎晶, 藤岡正人, 小川郁

Otology Japan ((一社)日本耳科学会) 28 ( 4 ) 387 - 387 2018.09

ISSN 0917-2025

後迷路法による聴神経腫瘍手術における術後聴力予測因子の検討

細谷誠, 大石直樹, 粕谷健人, 野口勝, 西山崇経, 石川徹, 鈴木成尚, 藤岡正人, 神崎晶, 宮崎日出海, 小川郁

Otology Japan ((一社)日本耳科学会) 28 ( 4 ) 386 - 386 2018.09

ISSN 0917-2025

当科における耳鳴認知行動療法グループ指導の導入

中野瑛理佳, 神埼晶, 片岡ちなつ, 田副真美, 粕谷健人, 西山崇経, 石川徹, 野口勝, 鈴木成尚, 藤岡正人, 大石直樹, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 61 ( 5 ) 339 - 339 2018.09

ISSN 0303-8106

コモンマーモセット蝸牛におけるミトコンドリアの観察

鈴木成尚, 佐伯翼, 藤岡正人, 細谷誠, 三枝智香, 神崎晶, 大石直樹, 西山崇経, 野口勝, 小川郁

Otology Japan ((一社)日本耳科学会) 28 ( 4 ) 429 - 429 2018.09

ISSN 0917-2025

Tinnitus Sample Case History QuestionnairesとTHIを組み合わせた重症度別の耳鳴患者の臨床像

鈴木成尚, 小島敬史, 神崎晶, 大石直樹, 藤岡正人, 西山崇経, 野口勝, 細谷誠, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 61 ( 5 ) 328 - 328 2018.09

ISSN 0303-8106

Mycobacterium abscessus subsp.abscessusによる中耳炎における手術時期についての考察

北村友理, 西山崇経, 神崎晶, 大石直樹, 藤岡正人, 山田浩之, 粕谷健人, 石川徹, 野口勝, 細谷誠, 戎野ちひろ, 角田真弓, 小川郁

Otology Japan ((一社)日本耳科学会) 28 ( 4 ) 312 - 312 2018.09

ISSN 0917-2025

Hippo経路構成因子のLats1キナーゼ欠損がマウス内耳に与える影響の解析

西山崇経, 藤岡正人, 大石直樹, 細谷誠, 神崎晶, 鈴木成尚, 野口勝, 小川郁

Otology Japan ((一社)日本耳科学会) 28 ( 4 ) 361 - 361 2018.09

ISSN 0917-2025

耳鳴に対する補聴器による音響療法の長期経過

大石直樹, 稲垣洋三, 野口勝, 西山崇経, 鈴木成尚, 細谷誠, 藤岡正人, 神崎晶, 新田清一, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 61 ( 5 ) 338 - 338 2018.09

ISSN 0303-8106

高齢者の聴覚と暮らし方と健康に関する学術調査(第1報) 老人性難聴のリスクファクターの探索

忰田かおり, 藤岡正人, 堀明美, 薬師丸令子, 粕谷健人, 野口勝, 西山崇経, 石川徹, 細谷誠, 鈴木成尚, 大石直樹, 神崎晶, 今西順久, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 61 ( 5 ) 302 - 302 2018.09

ISSN 0303-8106

超高齢社会における聴覚医学の課題と使命高齢者の聴覚と暮らし方と健康に関する学術調査(第1報) 老人性難聴関連遺伝子多型の探索

野口勝, 藤岡正人, 粕谷健人, 西山崇経, 石川徹, 細谷誠, 鈴木成尚, 堀明美, 忰田かおり, 薬師丸令子, 大石直樹, 神崎晶, 今西順久, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 61 ( 5 ) 317 - 317 2018.09

ISSN 0303-8106

聴神経腫瘍症例における難聴急性増悪時のステロイドの治療効果

野口勝, 大石直樹, 西山崇経, 細谷誠, 鈴木成尚, 藤岡正人, 神崎晶, 小川郁

Otology Japan ((一社)日本耳科学会) 28 ( 4 ) 388 - 388 2018.09

ISSN 0917-2025

PANQOL日本語版を用いた聴神経腫瘍wait and scan患者のQOL評価

西山崇経, 大石直樹, 小島敬史, 粕谷健人, 神崎晶, 藤岡正人, 野口勝, 石川徹, 細谷誠, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 121 ( 4 ) 585 - 585 2018.04

ISSN 0030-6622

当科での経外耳道的内視鏡下耳科手術(TEES)

藤岡正人, 神崎晶, 小澤宏之, 大石直樹, 粕谷健人, 野口勝, 西山崇経, 石川徹, 細谷誠, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 121 ( 4 ) 570 - 570 2018.04

ISSN 0030-6622

側頭骨炎症性腫瘤性病変に対する治療方針

粕谷健人, 大石直樹, 神崎晶, 藤岡正人, 西山崇経, 野口勝, 石川徹, 細谷誠, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 121 ( 4 ) 529 - 529 2018.04

ISSN 0030-6622

聴神経腫瘍wait and scan患者に対する手術適応の検討

野口勝, 大石直樹, 粕谷健人, 西山崇経, 細谷誠, 石川徹, 藤岡正人, 神崎晶, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 121 ( 4 ) 586 - 586 2018.04

ISSN 0030-6622

聴覚過敏を主訴とした感覚過敏症患者の臨床的特徴について(第2報)

神崎晶, 粕谷健人, 石川徹, 西山崇経, 野口勝, 細谷誠, 大石直樹, 藤岡正人, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 121 ( 4 ) 584 - 584 2018.04

ISSN 0030-6622

聴神経腫瘍手術における顔面神経根誘発筋活動電位を用いた術中持続顔面神経モニタリングの有用性の検討

細谷誠, 大石直樹, 粕谷健人, 野口勝, 西山崇経, 石川徹, 藤岡正人, 神崎晶, 宮崎日出海, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 121 ( 4 ) 585 - 585 2018.04

ISSN 0030-6622

聴神経腫瘍に対する後迷路法術中持続神経モニタリングを併用した手術手技の工夫

大石直樹, 宮崎日出海, 野口勝, 西山崇経, 細谷誠, 粕谷健人, 石川徹, 藤岡正人, 神崎晶, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 121 ( 4 ) 586 - 586 2018.04

ISSN 0030-6622

外科的切除を選択した側頭骨炎症性偽腫瘍の1例

粕谷健人, 大石直樹, 神崎晶, 藤岡正人, 西山崇経, 野口勝, 石川徹, 細谷誠, 小川郁

Otology Japan ((一社)日本耳科学会) 27 ( 4 ) 662 - 662 2017.10

ISSN 0917-2025

残存聴力のない難治性中耳内耳疾患に対してSubtotal petrosectomyに準ずる手術加療を行なった9症例の検討

西山崇経, 大石直樹, 平賀良彦, 粕谷健人, 神崎晶, 藤岡正人, 石川徹, 野口勝, 細谷誠, 小川郁

Otology Japan ((一社)日本耳科学会) 27 ( 4 ) 469 - 469 2017.10

ISSN 0917-2025

慢性めまいを呈した2例の外リンパ瘻症例

石川徹, 神崎晶, 大石直樹, 藤岡正人, 粕谷健人, 西山崇経, 野口勝, 細谷誠, 松田帆, 池園哲郎, 小川郁

Otology Japan ((一社)日本耳科学会) 27 ( 4 ) 499 - 499 2017.10

ISSN 0917-2025

当科での経外耳道的内視鏡下耳科手術における工夫 3 hands techniqueを中心に

藤岡正人, 小澤宏之, 神崎晶, 大石直樹, 粕谷健人, 野口勝, 西山崇経, 石川徹, 細谷誠, 小川郁

Otology Japan ((一社)日本耳科学会) 27 ( 4 ) 276 - 276 2017.10

ISSN 0917-2025

聴神経腫瘍に対する後迷路法手術適応とアプローチの工夫

大石直樹, 宮崎日出海, 粕谷健人, 野口勝, 西山崇経, 石川徹, 細谷誠, 藤岡正人, 神崎晶, 小川郁

Otology Japan ((一社)日本耳科学会) 27 ( 4 ) 289 - 289 2017.10

ISSN 0917-2025

顔面神経鞘腫に対して全摘術を行った4症例とその適応の検討

野口勝, 大石直樹, 粕谷健人, 西山崇経, 石川徹, 細谷誠, 神崎晶, 藤岡正人, 小川郁

Otology Japan ((一社)日本耳科学会) 27 ( 4 ) 471 - 471 2017.10

ISSN 0917-2025

修正Khalfa Hyperacusis Questionnaire日本語版の提案

石川徹, 大石直樹, 神崎晶, 山田浩之, 藤岡正人, 粕谷健人, 西山崇経, 野口勝, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 60 ( 5 ) 399 - 399 2017.09

ISSN 0303-8106

当科における耳鳴認知行動療法グループ指導の導入(第一報)

粕谷健人, 神崎晶, 大石直樹, 藤岡正人, 西山崇経, 野口勝, 石川徹, 細谷誠, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 60 ( 5 ) 400 - 400 2017.09

ISSN 0303-8106

細胞周期調節経路の破綻に伴う内耳への影響 ∽Lats1キナーゼ欠損マウスの解析

西山崇経, 藤岡正人, 大石直樹, 細谷誠, 原田竜彦, 神崎晶, 粕谷健人, 石川徹, 野口勝, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 60 ( 5 ) 283 - 283 2017.09

ISSN 0303-8106

補聴器治療を行った耳鳴患者におけるTinnitus Functional Indexによる治療効果評価

野口勝, 大石直樹, 鈴木法臣, 神崎晶, 藤岡正人, 粕谷健人, 西山崇経, 石川徹, 細谷誠, 小川郁

Audiology Japan ((一社)日本聴覚医学会) 60 ( 5 ) 405 - 405 2017.09

ISSN 0303-8106

Hippo経路におけるLats1キナーゼ欠損による内耳機能・構造的影響の解析

西山崇経, 藤岡正人, 大石直樹, 細谷誠, 原田竜彦, 鈴木法臣, 松崎佐栄子, 國仲慎治, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 119 ( 4 ) 614 - 614 2016.04

ISSN 0030-6622

急性感音難聴後の聴覚過敏症状に対し発症後早期から補聴器による聴覚リハビリテーションを行った2例

西山崇経, 新田清一, 鈴木大介, 坂本耕二, 石川徹, 藤田紘子, 上野真史, 太田真未, 小川郁

AUDIOLOGY JAPAN (日本聴覚医学会) 58 ( 5 ) 455 - 456 2015

ISSN 0303-8106

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一側性難聴耳の補聴器適合検査における遮音方法の検討 : 音場検査における遮音方法について

西山崇経, 新田清一, 鈴木大介, 岡崎宏, 坂本耕二, 南修司郎, 齋藤真, 野口勝, 中村伸太郎, 太田真未, 小川郁

Audiology Japan (Japan Audiological Society) 56 ( 5 ) 437 - 438 2013.09

ISSN 0303-8106

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人工内耳装用者の語音聴取と自覚的改善度・満足度の検討

岡崎宏, 新田清一, 鈴木大介, 西山崇経, 坂本耕二, 齋藤真, 野口勝, 中村伸太郎, 上野恵, 太田真未, 小川郁

Audiology Japan (Japan Audiological Society) 56 ( 5 ) 543 - 544 2013.09

ISSN 0303-8106

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一側性難聴耳の補聴器適合検査における遮音方法の検討〜裸耳と装用閾値の実例検証

南修司郎, 鈴木大介, 岡崎宏, 西山崇経, 齋藤真, 野口勝, 太田真未, 小川郁, 新田清一

Audiology Japan (Japan Audiological Society) 56 ( 5 ) 439 - 440 2013.09

ISSN 0303-8106

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突発性難聴の難聴残存症例における耳鳴と聴覚過敏の経時的変化

中村伸太郎, 新田清一, 西山崇経, 鈴木大介, 岡崎宏, 坂本耕二, 齋藤真, 野口勝, 上野恵, 太田真未, 小川郁

Audiology Japan (Japan Audiological Society) 56 ( 5 ) 657 - 658 2013.09

ISSN 0303-8106

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両耳/片耳装用の比較試聴の有用性に関する検討

鈴木大介, 新田清一, 岡崎宏, 坂本耕二, 甲能武幸, 西山崇経, 中村伸太郎, 上野恵, 小川郁

言語聴覚研究 ((一社)日本言語聴覚士協会) 10 ( 3 ) 195 - 195 2013.09

ISSN 1349-5828

サルベージ手術後に下顎骨壊死をきたした中咽頭癌の一例

中村伸太郎, 坂本耕二, 甲能武幸, 西山崇経, 新田清一

頭頸部癌 ((一社)日本頭頸部癌学会) 39 ( 2 ) 229 - 229 2013.05

ISSN 1349-5747

甲状腺癌リンパ節転移診断における穿刺物中サイログロブリン濃度測定に抗甲状腺抗体が及ぼす影響

坂本耕二, 甲能武幸, 西山崇経, 中村伸太郎, 新田清一

頭頸部癌 ((一社)日本頭頸部癌学会) 39 ( 2 ) 157 - 157 2013.05

ISSN 1349-5747

耳下腺腫瘍手術における大耳介神経温存の効果に関する検討

甲能武幸, 坂本耕二, 西山崇経, 中村伸太郎, 新田清一

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 116 ( 4 ) 416 - 416 2013.04

ISSN 0030-6622

Usefulness and Pitfalls of Thyroglobulin Measurement of Fine Needle Aspirates (FNA-Tg) for Detection of Neck Lymph Node Metastasis with Differentiated Thyroid Carcinoma

Sakamoto K., Nakamura S., Nishiyama T., Kono T., Shinden S.

The Journal of the Japan Broncho-esophagological Society (The Japan Broncho-esophagological Society) 64 ( 2 ) 152 - 152 2013

ISSN 0029-0645

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オープンフィッティングにおいて起こりうる問題とその対処法の検討 : 他機関における補聴器購入者の調整経験をもとに

上野恵, 鈴木大介, 岡崎宏, 坂本耕二, 甲能武幸, 西山崇経, 中村伸太郎, 新田清一

Audiology Japan (Japan Audiological Society) 55 ( 5 ) 519 - 520 2012.09

ISSN 0303-8106

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一側性難聴患者に対する補聴器装用の試み

鈴木大介, 新田清一, 岡崎宏, 坂本耕二, 甲能武幸, 西山崇経, 中村伸太郎, 上野恵, 小川郁

Audiology Japan (Japan Audiological Society) 55 ( 5 ) 543 - 544 2012.09

ISSN 0303-8106

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一側性難聴に伴う耳鳴に対する補聴器による音響療法

新田清一, 鈴木大介, 岡崎宏, 坂本耕二, 甲能武幸, 西山崇経, 上野恵, 小川郁

Audiology Japan (Japan Audiological Society) 55 ( 5 ) 513 - 514 2012.09

ISSN 0303-8106

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補聴器の初期調整時の装用時間と音に対する慣れの検討

岡崎宏, 新田清一, 鈴木大介, 坂本耕二, 甲能武幸, 西山崇経, 中村伸太郎, 上野恵, 小川郁

Audiology Japan (Japan Audiological Society) 55 ( 5 ) 421 - 422 2012.09

ISSN 0303-8106

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補聴器装用者の満足度に関わる要因の検討 : 簡便な質問紙を用いた検討

西山崇経, 新田清一, 鈴木大介, 岡崎宏, 坂本耕二, 甲能武幸, 中村伸太郎, 上野恵, 小川郁

Audiology Japan (Japan Audiological Society) 55 ( 5 ) 527 - 528 2012.09

ISSN 0303-8106

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正中法によるENoGを使った末梢性顔面神経麻痺の予後予測

西山崇経, 新田清一, 坂本耕二, 山田浩之, 甲能武幸, 小川郁

Otology Japan ((一社)日本耳科学会) 22 ( 4 ) 649 - 649 2012.09

ISSN 0917-2025

軟素材外耳道再建型鼓室形成術における外耳道拡大術について

新田清一, 坂本耕二, 甲能武幸, 西山崇経, 中村伸太郎, 小川郁

Otology Japan ((一社)日本耳科学会) 22 ( 4 ) 537 - 537 2012.09

ISSN 0917-2025

当院で施行した放射線療法症例のQOL調査

坂本耕二, 新田清一, 伊藤文展, 甲能武幸, 西山崇経, 荒川和清, 柴山千秋

頭頸部癌 ((一社)日本頭頸部癌学会) 38 ( 2 ) 189 - 189 2012.05

ISSN 1349-5747

頭頸部癌放射線療法に伴う有害事象の重症化に関わる栄養学的指標の検討

甲能武幸, 坂本耕二, 伊藤文展, 西山崇経, 新田清一, 柴山千秋, 荒川和清

頭頸部癌 ((一社)日本頭頸部癌学会) 38 ( 2 ) 211 - 211 2012.05

ISSN 1349-5747

当科における大唾液腺腫瘍手術症例の検討

伊藤文展, 新田清一, 坂本耕二, 甲能武幸, 西山崇経

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 115 ( 4 ) 502 - 502 2012.04

ISSN 0030-6622

甲状腺癌リンパ節転移診断における穿刺物中サイログロブリン濃度測定の有用性

坂本耕二, 新田清一, 伊藤文展, 甲能武幸, 西山崇経, 稲垣洋三

日本気管食道科学会会報 ((NPO)日本気管食道科学会) 63 ( 2 ) s46 - s46 2012.04

ISSN 0029-0645

甲状腺悪性腫瘍の頸部リンパ節転移に対するPET/CT検査の有用性について

甲能武幸, 坂本耕二, 伊藤文展, 西山崇経, 新田清一

日本気管食道科学会会報 ((NPO)日本気管食道科学会) 63 ( 2 ) s47 - s47 2012.04

ISSN 0029-0645

当科における補聴器装用患者の検討軽度難聴患者を中心に

新田清一, 鈴木大介, 岡崎宏, 坂本耕二, 伊藤文展, 甲能武幸, 西山崇経, 小川郁

日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会) 115 ( 4 ) 493 - 493 2012.04

ISSN 0030-6622

早期喉頭癌治療後の音声に関する検討

甲能武幸, 齋藤康一郎, 矢部はるな, 新田清一, 坂本耕二, 伊藤文展, 西山崇経

音声言語医学 (日本音声言語医学会) 53 ( 1 ) 46 - 46 2012.01

ISSN 0030-2813

補聴器装用患者の語音聴取に関する検討聴力レベル、聴力型との関係について

上野恵, 鈴木大介, 岡崎宏, 坂本耕二, 伊藤文展, 甲能武幸, 西山崇経, 新田清一

音声言語医学 (日本音声言語医学会) 53 ( 1 ) 68 - 68 2012.01

ISSN 0030-2813

補聴器装用患者の語音聴取に関する検討補聴器装用の効果について

鈴木大介, 新田清一, 上野恵, 岡崎宏, 坂本耕二, 伊藤文展, 甲能武幸, 西山崇経

音声言語医学 (日本音声言語医学会) 53 ( 1 ) 68 - 69 2012.01

ISSN 0030-2813

軟素材外耳道再建を行った鼓室形成術後の鼓膜陥凹と真珠腫再形成について

新田清一, 坂本耕二, 伊藤文展, 甲能武幸, 西山崇経, 小川郁

Otology Japan ((一社)日本耳科学会) 21 ( 4 ) 517 - 517 2011.10

ISSN 0917-2025

オープンフィッティングにおける耳栓の特徴に関する検討

上野恵, 鈴木大介, 岡崎宏, 坂本耕二, 伊藤文展, 甲能武幸, 西山崇経, 新田清一

Audiology Japan (Japan Audiological Society) 54 ( 5 ) 473 - 474 2011.09

ISSN 0303-8106

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乳幼児の聴力評価に関する検討 : BOA・CORとASSRの閾値差を中心に

岡崎宏, 新田清一, 鈴木大介, 坂本耕二, 伊藤文展, 甲能武幸, 西山崇経, 上野恵

Audiology Japan (Japan Audiological Society) 54 ( 5 ) 639 - 640 2011.09

ISSN 0303-8106

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オープンフィッティングにおける耳栓の適応に関する検討

鈴木大介, 新田清一, 上野恵, 岡崎宏, 坂本耕二, 伊藤文展, 甲能武幸, 西山崇経

Audiology Japan (Japan Audiological Society) 54 ( 5 ) 475 - 476 2011.09

ISSN 0303-8106

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難聴を主訴に受診した補聴器装用患者の耳鳴に関する検討

新田清一, 鈴木大介, 岡崎宏, 坂本耕二, 伊藤文展, 甲能武幸, 西山崇経, 上野恵, 小川郁

Audiology Japan (Japan Audiological Society) 54 ( 5 ) 309 - 310 2011.09

ISSN 0303-8106

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難聴患者の心理状態・生活障害に関する検討 : 聴力レベルとの関係について

西山崇経, 新田清一, 鈴木大介, 岡崎宏, 上野恵, 坂本耕二, 伊藤文展, 甲能武幸

Audiology Japan (Japan Audiological Society) 54 ( 5 ) 497 - 498 2011.09

ISSN 0303-8106

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