SHIMANUKI Marie

写真a

Affiliation

School of Medicine, Otorhinolaryngology, Head and Neck Surgery (Shinanomachi)

Position

Instructor

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Papers 【 Display / hide 】

  • Intratemporal Facial Nerve Schwannomas: A Review of 45 Cases in A Single Center.

    Kitama T, Hosoya M, Noguchi M, Nishiyama T, Wakabayashi T, Shimanuki MN, Yazawa M, Inoue Y, Kanzaki J, Ogawa K, Oishi N

    Diagnostics (Basel, Switzerland) 12 ( 8 )  2022.07

  • Utility of computed tomography findings as a predictor of carotid artery invasion by metastatic lymph nodes in head and neck squamous cell carcinoma

    Mikoshiba T., Sakamoto K., Shinden S., Shimanuki M., Nakayama R., Okada T., Ozawa H.

    European Archives of Oto-Rhino-Laryngology (European Archives of Oto-Rhino-Laryngology)   2022

    ISSN  09374477

    　View Summary

    Purpose: Carotid artery invasion by metastatic lymph nodes in head and neck squamous cell carcinoma (HNSCC) is one of the diagnostic criteria for unresectable tumors. However, to date, the diagnostic criteria for carotid artery invasion have not been well documented. This study investigated the utility of computed tomography (CT) findings as a predictor of carotid artery invasion by metastatic lymph nodes in HNSCC. Methods: Twenty-eight patients who had metastatic lymph nodes of HNSCC attached to the carotid artery as seen on CT images before neck dissection from January 2011 to November 2017 were included. Five imaging parameters (angle of contact [AC], length of contact [LC], haziness of the carotid artery wall [HW], size of the lymph node, and involvement of the bifurcation of the carotid artery [IB]) were assessed using CT to predict carotid artery invasion. Furthermore, the utility of the combination of these five parameters was evaluated. Results: There were significant differences in AC, LC, and IB between patients with and without carotid artery invasion. There were significant differences in all combinations of the two image findings between patients with and without carotid artery invasion. In particular, the combinations of LC and HW, and LC and IB could clearly predict carotid artery invasion. Conclusion: AC, LC, and IB were useful predictors of carotid artery invasion of metastatic lymph nodes in HNSCC. This study is the first to report that IB is a useful predictor of carotid artery invasion in HNSCC.

  • Severe sudden sensorineural hearing loss related to risk of stroke and atherosclerosis

    Tsuzuki N., Wasano K., Oishi N., Hentona K., Shimanuki M., Nishiyama T., Hiraga Y., Shinden S., Ogawa K.

    Scientific Reports (Scientific Reports)  11 ( 1 ) 20204 2021.12

    　View Summary

    The cause of idiopathic sudden sensorineural hearing loss (idiopathic SSNHL)—diagnosed after excluding other causes of hearing loss, such as SSNHL associated with vestibular schwannoma (VS)—is unknown. The presumed pathogenesis of idiopathic SSNHL includes circulatory disorders (e.g., cochlear infarction). We tested the hypothesis that patients with SSNHL who are at high stroke risk will have a lower rate of VS compared to those with low stroke risk. The rationale is that the primary cause of SSNHL in patients with high stroke risk might be a circulatory disturbance. We conducted a retrospective study in six hospitals. Our sampling of SSNHL patients included those diagnosed with idiopathic SSNHL and VS-associated SSNHL. SSNHL patients who had a head MRI were stratified by severity of hearing loss and evaluated for differences in the detection rate of VS between the high-scoring CHADS2 (CHADS2-H-), an index of stroke risk, and low-scoring CHADS2 (CHADS2-L-) groups. We identified 916 patients who met the inclusion criteria. For severe hearing loss, the CHADS2-H group had a significantly lower rate of VS than the CHADS2-L group (OR 0 [95% CI 0.00–0.612]; P = 0.007). These results indirectly support the hypothesis that a primary cause of severe idiopathic SSNHL in those at high risk of stroke might be a circulatory disorder.

  • Early hearing improvement predicts the prognosis of idiopathic sudden sensorineural hearing loss

    Shimanuki M.N., Shinden S., Oishi N., Suzuki N., Iwabu K., Kitama T., Kida A., Sakamoto K., Ogawa K.

    European Archives of Oto-Rhino-Laryngology (European Archives of Oto-Rhino-Laryngology)  278 ( 11 ) 4251 - 4258 2021.11

    ISSN  09374477

    　View Summary

    Purpose: To determine pre- and post-treatment factors that are useful for predicting the prognosis of hearing improvement in idiopathic sudden sensorineural hearing loss (ISSHL). Methods: This retrospective study included 332 patients with ISSHL. Patients received intravenous steroid treatment (prednisolone sodium succinate; 120 mg/day followed by dose tapering). Complete recovery of hearing levels was defined as a final pure-tone audiometry of ≤ 20 dB HL or the same level as the contralateral ear. Patients’ age; sex; side of hearing loss; initial hearing level; days from onset to treatment; presence of vertigo, diabetes, and hypertension; and hearing improvement on days 3–4 and 6–7 after treatment initiation were analyzed as potential prognostic factors. Results: Overall, 109 patients (32%) had complete recovery. Results of the multivariate logistic regression model identified age (odds ratio [OR] = 0.974), initial hearing level (OR = 0.949), vertigo (OR = 0.409), and hearing improvement on days 6–7 after treatment initiation (OR = 1.11) as significant independent predictors of complete recovery. Age ≥ 60 years, initial hearing level ≥ 72.5 dB HL, and vertigo contributed to poor prognosis. Patients without these three factors and a hearing improvement of ≥ 10 dB HL on days 6–7 post-treatment had a complete recovery rate of 80%. Only 1.5% of the patients with 2–3 of these factors and a hearing improvement of < 10 dB HL on days 6–7 after treatment initiation achieved complete recovery. Conclusion: Age, initial hearing level, vertigo, and hearing improvement on days 6–7 after treatment initiation were independent predictors of hearing recovery in ISSHL.

  • Labyrinthine destruction caused by inflammatory pseudotumor of the temporal bone: A report of three cases and review of the literature

    Imamura K., Hosoya M., Kasuya K., Shimanuki M.N., Shinden S., Ogawa K., Oishi N.

    Laryngoscope Investigative Otolaryngology (Laryngoscope Investigative Otolaryngology)  6 ( 4 ) 857 - 865 2021.08

    　View Summary

    Background: Inflammatory pseudotumors (IPTs) are rare, idiopathic, and inflammatory lesions that are histopathologically benign. Here, we present three cases of labyrinthine destruction caused by an IPT. Methods: The first patient was a 74-year-old male with a mass lesion extending from the inner ear to the external ear canal. The second patient was a 62-year-old female with a foliated polycystic lesion in the petrous bone on the dorsal side of the left internal auditory canal. The third patient was a 68-year-old female with a mass extending from the inner ear to the middle ear, destroying the semicircular canal and cochlea. Results: In two cases, we performed surgical resection successfully with no recurrence. In the other case, the lesion showed shrinkage after chemotherapy for colorectal cancer incidentally found during the examination process. Conclusion: Surgical technique and indication for IPT should be based on the location and function of the lesion. In addition, there is room to consider pharmacotherapy as a treatment option for IPT of the temporal bone. Level of Evidence: 4.

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 一般市中病院における慢性耳鳴患者95例に対する補聴器による音響療法の治療成績

    島貫 茉莉江, 山田 浩之, 今村 香菜子, 和泉 光倫, 太田 久裕, 本間 大和, 大石 直樹, 小澤 宏之

    Audiology Japan ((一社)日本聴覚医学会)  64 ( 5 ) 375 - 375 2021.09

    ISSN  0303-8106

  • 突発性難聴の予後予測因子の検討　治癒の予測について

    島貫 茉莉江, 新田 清一, 北間 翼, 喜田 有未来, 坂本 耕二, 大石 直樹, 小川 郁

    日本耳科学会総会・学術講演会抄録集 ((一社)日本耳科学会)  29回   247 - 247 2019.10

  • 人工内耳装用例における補聴器装用の意義

    島貫 茉莉江, 新田 清一, 岡田 峻史, 喜田 有未来, 坂本 耕二

    日本耳鼻咽喉科学会会報 ((一社)日本耳鼻咽喉科頭頸部外科学会)  122 ( 4 ) 613 - 613 2019.04

    ISSN  0030-6622

  • 高度感音難聴患者の聴覚活用に関する検討　語音明瞭度と補聴器/人工内耳の選択について

    島貫 茉莉江, 新田 清一, 坂本 耕二, 御子柴 卓弥, 岡田 峻史, 大石 直樹, 小川 郁

    Otology Japan ((一社)日本耳科学会)  28 ( 4 ) 609 - 609 2018.09

    ISSN  0917-2025

  • 頭頸部癌におけるシスプラチンによる急性腎障害の予測因子についての検討

    島貫 茉莉江, 今西 順久, 井口 聖名, 佐藤 えみり, 佐藤 陽一郎, 栗林 徹, 舟越 和人, 黒岩 信子

    頭頸部癌 ((一社)日本頭頸部癌学会)  44 ( 2 ) 149 - 149 2018.05

    ISSN  1349-5747

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • マウスと小型霊長類コモンマーモセットにおける内耳幹細胞能についての比較検討

    2023.04
    -
    2026.03

    基盤研究(C), Principal investigator

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