小澤　宏之 (オザワ　ヒロユキ)

Ozawa, Hiroyuki

写真a

所属（所属キャンパス）

医学部 耳鼻咽喉科学教室 （信濃町）

職名

教授

外部リンク
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学位 【 表示 ／ 非表示 】

  • 博士（医学）, 慶應義塾大学, 2010年01月

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免許・資格 【 表示 ／ 非表示 】

  • 耳鼻咽喉科専門医, 2003年09月

  • 日本癌治療医認定医機構　癌治療認定医, 2008年04月

  • 日本頭頸部外科学会　頭頸部がん専門医, 2010年10月

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研究分野 【 表示 ／ 非表示 】

  • ライフサイエンス / 腫瘍診断、治療学

  • ライフサイエンス / 耳鼻咽喉科学

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研究キーワード 【 表示 ／ 非表示 】

  • 甲状腺腫瘍

  • 頭蓋底腫瘍

  • 頭頸部癌

  • 頸動脈小体腫瘍

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研究テーマ 【 表示 ／ 非表示 】

  • 頸動脈小体腫瘍の発生、腫瘍進展の解明, 

    2014年
    -
    継続中

  • 頭頸部癌の転移メカニズムの解明, 

    2003年
    -
    継続中

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論文 【 表示 ／ 非表示 】

  • Cyclooxygenase‑2 expression is associated with chemoresistance through cancer stemness property in hypopharyngeal carcinoma

    Saito S., Ozawa H., Imanishi Y., Sekimizu M., Watanabe Y., Fumihiro I.T.O., Ikari Y., Nakahara N., Kameyama K., Ogawa K.

    Oncology Letters （Oncology Letters)  22 （ 1 ）  2021年07月

    ISSN  17921074

    　概要を見る

    Cyclooxygenase‑2 (COX‑2) is one of the two isoforms of COX, an enzyme that catalyzes the conversion of arachidonic acid to prostaglandins. COX‑2 is associated with the progression in various types of cancer, and its expres‑ sion has been associated with a poor prognosis in head and neck squamous cell carcinoma (HNSCC). Furthermore, COX‑2 expression has been associated with resistance to anticancer drugs. However, the precise mechanism of COX‑2 for chemoresistance in HNSCC has not been fully elucidated. The present study aimed to investigate the effect of COX‑2 on cancer stem cell (CSC) property and to reveal its effect on chemoresistance using in vitro and clinicopathological assays in HNSCC cells and tissues. The current study analyzed the immunohistochemical expression levels of COX‑2 and clinicopathological factors using matched samples of pretreatment biopsy and surgical specimens from patients with hypopharyngeal carcinoma who underwent tumor resec‑ tion with preoperative chemotherapy, including docetaxel. Additionally, the chemoresistance to docetaxel with or without a COX‑2 inhibitor (celecoxib) was examined in HNSCC cell lines by MTS assays. To evaluate the association of COX‑2 expression with stemness property, the expression levels of CSC‑associated genes after exposure to celecoxib were assessed by reverse transcription‑quantitative PCR. A sphere formation assay was also performed using ultra‑low attachment dishes and microscopic imaging. The immunohistochemical analysis of biopsy specimens revealed a negative association between COX‑2 expression in biopsy specimens and the pathological effect of induction chemotherapy in surgical specimens. The cell survival rate under exposure to docetaxel was decreased by the addition of celecoxib. COX‑2 inhibition led to downregulation of CSC‑associated gene expression and sphere formation. The present findings suggested that COX‑2 expression may be associated with chemoresistance through the cancer stemness property, and inhibition of COX‑2 may enhance chemo‑sensitivity in HNSCC. Therefore, COX‑2 may be an attractive target for the treatment of HNSCC.

  • Prognostic Value of the Lymphocyte-to-Monocyte Ratio in Patients with Parotid Gland Carcinoma

    Mikoshiba T., Ozawa H., Watanabe Y., Sekimizu M., Saito S., Yoshihama K., Nakamura S., Imanishi Y., Kameyama K., Ogawa K.

    Laryngoscope （Laryngoscope)  131 （ 3 ） E864 - E869 2021年03月

    ISSN  0023852X

    　概要を見る

    Objective: Previous studies have evaluated various markers as prognostic predictors in patients with many types of cancers. However, the influence of such factors on the outcomes of patients with parotid gland carcinoma (PGC) is unknown. This study investigated the roles of alternative markers in the prognoses of patients with PGC. Methods: Overall, 101 patients who underwent curative treatment for PGC were retrospectively evaluated, and their 5-year overall and disease-free survival rates were calculated. The prognostic values of clinical and pathologic factors were determined. Results: The 5-year overall and disease-free survival rates were 73.1% and 62.8%, respectively. Multivariate analysis revealed that a low lymphocyte-to-monocyte ratio (LMR), high T classification, high N classification, and perineural invasion were independent predictors of poor prognosis. Conclusions: Thus, we identified LMR as an independent prognostic factor for patients with PGC. Patients with low LMRs who are amenable to treatment may require adjuvant treatment to improve their prognoses. Level of Evidence: 4 Laryngoscope, 131:E864–E869, 2021.

  • Transoral Removal of Tumors of the Dorsal Aspect of the Soft Palate: A Technical Note

    Nakamura S., Ozawa H., Sekimizu M., Ikari Y., Nakahara N., Saito S., Yoshihama K., Nishiyama Y., Ogawa K.

    Laryngoscope （Laryngoscope)  2021年

    ISSN  0023852X

  • The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma

    Hirai H., Tada Y., Nakaguro M., Kawakita D., Sato Y., Shimura T., Tsukahara K., Kano S., Ozawa H., Okami K., Sato Y., Fushimi C., Shimizu A., Okamoto I., Takase S., Okada T., Sato H., Imanishi Y., Otsuka K., Watanabe Y., Sakai A., Ebisumoto K., Togashi T., Ueki Y., Ota H., Saigusa N., Takahashi H., Ando M., Urano M., Hanazawa T., Nagao T.

    Virchows Archiv （Virchows Archiv)  477 （ 2 ） 291 - 299 2020年08月

    ISSN  09456317

    　概要を見る

    Salivary duct carcinoma (SDC) is an aggressive, uncommon tumor histologically comparable to high-grade mammary ductal carcinoma. SDCs are usually androgen receptor (AR)–positive and often HER2-positive. Recently, therapies targeting these molecules for SDC have attracted attention. Lipid metabolism changes have been described in association with biological behavior in various cancers, although no such relationship has yet been reported for SDC. We therefore analyzed the clinicopathological relevance of the immunohistochemical expression of adipophilin (ADP) and fatty acid synthase (FASN), representative lipid metabolism–related proteins, in 147 SDCs. ADP and FASN were variably immunoreactive in most SDCs (both 99.3%), and the ADP and FASN expression was negatively correlated (P = 0.014). ADP-positive (≥ 5%) SDCs more frequently exhibited a prominent nuclear pleomorphism and high-Ki-67 labeling index than those ADP-negative (P = 0.013 and 0.011, respectively). In contrast, a high FASN score, calculated by the staining proportion and intensity, (≥ 120) was correlated with the high expression of AR and FOXA1 (P < 0.001 and = 0.003, respectively). The ADP and FASN expression differed significantly among the subtypes based on biomarker immunoprofiling, as assessed by the AR, HER2, and Ki-67 status (P = 0.017 and 0.003, respectively). A multivariate analysis showed that ADP-positive expression was associated with a shorter overall and progression-free survival (P = 0.018 and 0.003, respectively). ADP was associated with an aggressive histopathology and unfavorable prognosis, and FASN may biologically interact with the AR signaling pathway in SDC. ADP may, therefore, be a new prognostic indicator and therapeutic target in SDC.

  • Endoscopic endonasal removal of a pediatric paranasal ossifying fibroma using preoperative embolization

    Saito S., Ozawa H., Ikari Y., Nakahara N., Ito F., Sekimizu M., Kameyama K., Akiyama T., Toda M., Ogawa K.

    Otolaryngology Case Reports （Otolaryngology Case Reports)  14 2020年03月

    　概要を見る

    Background: Ossifying fibroma arising in the sinonasal tract is rare. Its treatment includes complete resection; however, this can be challenging to perform due to the well-vascularized nature of the fibroma. Some surgical techniques can control intraoperative hemorrhage; however, to date, no reports have assessed the use of preoperative embolization. Methods: We report a case of a child with ossifying fibroma arising from the ethmoid sinus, which was resected by endoscopic surgery using preoperative transarterial embolization. Conclusions: Embolization was effective in decreasing intraoperative hemorrhage. No complications related to the procedure or operation were encountered. Preoperative embolization should be considered for better control of the bleeding that occurs in ossifying fibromas, similar to that in other well-vascularized tumors.

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KOARA（リポジトリ）収録論文等 【 表示 ／ 非表示 】

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競争的研究費の研究課題 【 表示 ／ 非表示 】

  • 頭頸部癌における低酸素応答因子の免疫応答への影響の解析とその臨床応用

    2020年04月
    -
    2023年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 小澤 宏之, 基盤研究(C), 補助金,  研究代表者

  • 低酸素応答因子を標的とした頭頸部癌転移治療の開発

    2017年04月
    -
    2020年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 小澤　宏之, 基盤研究(C), 補助金,  研究代表者

  • 頭頸部癌における低酸素誘導因子発現の転移への影響とその臨床応用に関する研究

    2014年04月
    -
    2017年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 小澤　宏之, 基盤研究(C), 補助金,  研究代表者

    　研究概要を見る

    頭頸部癌症例のHIF1-α発現について検討を行った。早期舌癌25症例の免疫染色ではHIF1-αの核内発現と遅発性頸部転移との関係が示された。また経口的腫瘍切除の適応となった早期下咽頭癌症例においてリンパ節転移の有無とHIF1-α発現との間に相関を認めた。
    さらにHIF1-α阻害薬を用いて下流シグナルの変化をReal Time PCRで測定した。頭頸部癌細胞株にHIF1-α阻害薬を投与することにより、EMT関連遺伝子のなかではTWISTが、また癌幹細胞に関係するNANOGおよびOCT3/4遺伝子の発現が低下し、これらの遺伝子発現がHIF1-αにより制御され転移病巣形成に関与していることが示された。

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担当授業科目 【 表示 ／ 非表示 】

  • 耳鼻咽喉科学演習

    2023年度

  • 耳鼻咽喉科学実習

    2023年度

  • 耳鼻咽喉科学

    2023年度

  • 耳鼻咽喉科学講義

    2023年度

  • 耳鼻咽喉科学臨床実習

    2023年度

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担当経験のある授業科目 【 表示 ／ 非表示 】

  • 鼻副鼻腔腫瘍・前頭蓋底腫瘍・下垂体腫瘍

    慶應義塾

    2017年04月
    -
    2018年03月

  • 頭頸部癌の基礎と臨床

    慶應義塾

    2017年04月
    -
    2018年03月

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所属学協会 【 表示 ／ 非表示 】

  • 日本耳鼻咽喉科学会

    　

  • 日本頭頸部癌学会

    　

  • 日本頭頸部外科学会

    　

  • 日本頭蓋底外科学会

    　

  • 耳鼻咽喉科臨床学会

    　

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