論文 - 小川　郁

小児心因性難聴の臨床像と治療結果

小川郁，神崎仁，井上泰宏，保谷則之，武井聡，志津木健，佐倉伸洋，浅野恭子，田副真美

Audiology Japan 42 （ 2 ） 131-136 1999年04月

研究論文（学術雑誌）, 共著

小児心因性難聴における心因の変化

浅野恭子，小川郁，井上泰宏，田副真美，神崎仁

Audiology Japan 42 （ 2 ） 94-99 1999年04月

研究論文（学術雑誌）, 共著

DPOAE位相情報の活用法

原田竜彦，井上泰宏，小川郁，神崎仁

Audiology Japan 42 （ 2 ） 94-99 1999年04月

研究論文（学術雑誌）, 共著

Aging does not alter phosphoinositide hydrolysis in the rat cochlear lateral wall

Ogawa Kaoru, Schacht Jochen

Auris Nasus Larynx 26 （ 1 ） 1 - 4 1999年01月

ISSN  0385-8146

　概要を見る

<p>We have previously reported that the inositol 1,4,5-trisphosphate (InsP₃) second messenger system is coupled to purinergic P2y receptors in the cochlear sensory epithelium and lateral wall. The tissues of the cochlear lateral wall (stria vascularis and spiral ligament) are responsible for maintaining the ionic composition of the cochlear endolymph. Both the endolymphatic potential and signal transduction processes are well known to be affected by aging. Furthermore, intracellular inositol concentrations decrease with age in the cochlear sensory epithelia. The present study compared the purinergic receptor-mediated release of inositol phosphates (InsPs) in the cochlear lateral wall of young (3 month-old) and aged (24 month-old) Fischer-344 rats. No differences were found in the incorporation of myo-[³H]inositol into phosphoinositide lipids. Likewise, the purinergic receptor-mediated release of InsPs remained unchanged. This suggests that the InsPs second messenger system in the cochlear lateral wall, in contrast to the sensory epithelium, may not be affected by aging.</p>

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Aging does not affect phosphoinositide hydrolysis in the cochlear lateral wall

Ogawa Kaoru, Schacht Johen

Auris Nasus Larynx 26 （ 1 ） 1-4 1999年01月

研究論文（学術雑誌）, 共著

広範な凝固壊死を伴った耳下腺多形性腺腫の1例

山内友江，亀山香織，草刈悟，阿部仁，内田光子，小川郁，向井萬起男，秦順一

日本臨床細胞学会誌 38 （ 1 ） 89-92 1999年01月

研究論文（学術雑誌）, 共著

広範な凝固壊死を伴った耳下腺多型腺腫の1例

山内友江，亀山香織，草刈悟，阿部仁，内田光子，小川郁，向井萬起男，秦順一

日本臨床細胞学会雑誌 38 （ 1 ） 89-92 1999年01月

研究論文（学術雑誌）, 共著

聾型突発性難聴の臨床像

保谷則之，小川郁，井上泰宏，斎藤秀行，原田竜彦，佐藤美奈子，神崎仁

Audiology Japan 41 （ 6 ） 765-769 1998年12月

研究論文（学術雑誌）, 共著

Quality of hearing preservation in acoustic neuroma surgery

Kanzaki Jin, Ogawa Kaoru, Inoue Yasuhiro, Shiobara Ryuzo, Toya Shigeo

The American Journal of Otology 19 （ 5 ） 644-648 1998年09月

研究論文（学術雑誌）, 共著

Quality of hearing preservation in acoustic neuroma surgery

Kanzaki Jin, Ogawa Kaoru, Inoue Yasuhiro, Shiobara Ryuzo, Toya Shigeo

American Journal of Otology 19 （ 5 ） 644 - 648 1998年09月

ISSN  0192-9763

　概要を見る

<p>Objective: This study aimed to investigate the factors affecting the quality of postoperative hearing in acoustic neuroma. Study Design: The study was designed as a retrospective case review. Setting: The study was performed at the Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan. Patients: The subjects were 94 patients with unilateral acoustic neuroma. Intervention: Hearing preservation surgery was performed in the subjects via the extended cranial fossa approach or the middle cranial fossa approach. Main Outcome Measures: The outcome measures included patient's age and gender, hearing level, speech discrimination score, tumor size, and surgical approach. The relationship between the qualities of preoperative and postoperative hearing and the long-term prognosis of preserved heating also was investigated. Results: In 94 subjects, there were 47 patients whose hearing was preserved (HP group) and 47 patients whose hearing was not preserved (non-HP group). Overall, hearing preservation rate was 50%. There were no significant differences in age, gender, and tumor size between the two groups. The heating preservation rate was significantly higher in patients with an intracanalicular tumor than that with a larger tumor. The better the preoperative quality of hearing was, the higher the postoperative one. Although the preserved hearing deteriorated after surgery in 4 patients, no significant hearing deterioration was observed in the other 43 patients. Conclusions: The results of this study indicated that the diagnosis for acoustic neuroma in the early stage with serviceable hearing is the most important to improve the quality of postoperative hearing.</p>

明日の診療に役立つ画像診断・内耳道病変

小川郁

耳鼻と臨床 44 （ 5 ） 740-742 1998年05月

研究論文（学術雑誌）, 単著

高齢者の耳鳴

小川郁

耳鼻咽喉科・頭頚部外科 70 （ 5 ） 27-31 1998年04月

研究論文（学術雑誌）, 単著

New system for linear accelerator radiosurgery with a gantry-mounted video camera

Kunieda Etsuo, Kitamura Masayuki, Kawaguchi Osamu, Ohira Takayuki, Ogawa Kouichi, Ando Yutaka, Nakamura Kayoko, Kubo Atsushi

Int J Radiat Oncol Biol Phys 40 （ 3 ） 739-746 1998年03月

研究論文（学術雑誌）, 共著

Hearing in the MRL/lpr mouse as a possible model of immune-mediated sensorineural hearing loss

Inoue Y., Kanzaki J., Ogawa K., Hashiguchi K., Masuda M.

European Archives of Oto-Rhino-Laryngology 255 （ 5 ） 240 - 243 1998年

ISSN  0937-4477

　概要を見る

<p>In order to clarify the possible mechanism of hearing loss in immune-mediated sensorineural hearing loss, basic research needed includes animal model studies. In the present investigation, we examined hearing thresholds and cochlear histologies of the MRL/lpr mouse which is now well-known as a model for pathology consistent with systemic lupus erythematosis (SLE). Present findings demonstrated that there were no statistically significant differences in auditory brainstem response (ABR) thresholds between 4- to 6-week-old 'young' and 20- to 25-week-old 'old' MRL mice. These differences were not sex-dependent. Under light microscopy, there were no abnormal morphological findings in the cochleas of either young or old MRL mice. With immunohistochemistry, mouse IgG was detected around the capillary walls in the stria vascularis in both young and old MRL mice. Serum IgG level of the MRL mice significantly decreased after predonisolone (PSL) administration. However, expression of mouse IgG in the stria vascularis was not observed in the MRL mice after PSL administration. From these results, we speculate that the hearing of the MRL mouse does not always deteriorate, and the deposition of mouse IgG on the capillary wall in the stria vascularis is not a sufficient factor to induce hearing loss. At this point, we conclude that the MRL mouse should not be considered a useful model for immune-mediated sensorineural hearing loss.</p>

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Hearing preservation surgery in acoustic neuroma patients with normal hearing

Kanzaki J, Ogawa K, Inoue Y, Shiobara R

Skull Base Surgery 7   109-113 1998年

研究論文（学術雑誌）, 共著

Quality of hearing preservation in acoustic neuroma surgery

Kanzaki J, Ogawa K, Inoue Y, Shiobara R

The American Journal of Otology 19   644-648 1998年

研究論文（学術雑誌）, 共著

Hearing of MRL/lpr mouse: Is it used as a model of immune-mediated sensorinoural hearing loss ?

Inoue Yasuhiro, Kanzaki Jin, Ogawa Kaoru, Hashiguchi Kazuhiro, Masuda Masazumi, Saito Hideyuki, Harada Tatsuhiko

European Archives of Otorhinolaryngology 255   240-243 1998年

研究論文（学術雑誌）, 共著

Hearing preservation surgery in acoustic neuroma patients with normal hearing

Kanzaki Jin, Ogawa Koru, Inoue Yasuhiro, Shiobara Ryuzo

Skull Base Surg 7   109-113 1998年

研究論文（学術雑誌）, 共著

Photo-induced cochlear ischemia of guinea pig

Saito Hideyuki, Ogawa Kaoru, Inoue Yasuhiro, Harada Tatsuhiko, Hoya Noriyuki, Kanzaki Jin

Proc Sendai Symposium 7   67-69 1997年12月

研究論文（学術雑誌）, 共著

DPPOAE latency measuremant using inverse FFT

Harada Tatsuhiko, Inoue Yasuhiro, Ogawa Kaoru, Saito Hideyuki, Hoya Noriyuki, Kanzaki Jin

Proc Sendai Symposium 7   113-114 1997年12月

研究論文（学術雑誌）, 共著