Details of a Researcher

Ogawa, Kaoru

写真a

Affiliation: School of Medicine （Mita）

Position: Professor Emeritus

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Academic Background 【 Display / hide 】

1975.04

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1981.08

Keio University, School of Medicine

University, Graduated

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Research Areas 【 Display / hide 】

Life Science / Otorhinolaryngology

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Research Keywords 【 Display / hide 】

Otology
Audiology
Skull Base Surgery

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Papers 【 Display / hide 】

Effects of tinnitus treatments on sleep disorders in patients with tinnitus

Wakabayashi Satoko, Saito Hideyuki, Oishi Naoki, Shinden Seiichi, Ogawa Kaoru

International Journal of Audiology 1 - 5 2017.09

ISSN 1499-2027

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Objective: To assess the effects of tinnitus treatments on sleep disorders in patients with tinnitus. Design: Subjects completed the Pittsburg Sleep Quality Index (PSQI), Tinnitus Handicap Inventory (THI), Self-rating Depression Scale (SDS), and State Trait Anxiety Inventory (STAI). The questionnaire results and the patients’ sex, age, time since the onset of tinnitus, and mean hearing level were examined, and differences between a sleep disorder group and a normal sleep group were examined. Patients completed the questionnaires again after initiating tinnitus treatments (counselling and use of sound generators), and the change in questionnaire scores at follow-up was evaluated. Study sample: Patients (N = 100) with tinnitus who visited Keio University Hospital and started treatment without medication between 2005 and 2008. Results: Sixty-six percent of the patients had sleep disorders. Compared with patients without sleep disorders, patients with sleep disorders had significantly higher SDS and STAI scores at the first visit. The mean PSQI scores showed significant improvement at follow-up. Conclusions: Sleep disorders in patients with tinnitus improved after tinnitus treatments. Complex interactions between depressive symptoms and anxiety may occur in these patients. The improvement in sleep disorders at follow-up was correlated with improvements in tinnitus severity and state anxiety.
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Clinical characteristics of patients with tinnitus evaluated with the Tinnitus Sample Case History Questionnaire in Japan

Kojima Takashi, Kanzaki Sho, Oishi Naoki, Ogawa Kaoru

PLoS ONE 12 （ 8 ） 2017.08

ISSN 1932-6203

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Background: The Tinnitus Sample Case History Questionnaire was determined as a standardized questionnaire for obtaining patient case histories and for characterizing patients into subgroups at the Tinnitus Research Initiative in 2006. In this study, we developed a Japanese version of this questionnaire for evaluating the clinical characteristics of patients with tinnitus. The Japanese version of the questionnaire will be available for evaluating treatments for tinnitus and for comparing data on tinnitus in research centers. Aims/Objectives: To evaluate the clinical characteristics of patients with tinnitus in Japan using a newly developed Japanese version of Tinnitus Sample Case History Questionnaire. Study design: This was a prospective study based on patient records. Setting: University hospitals, general hospitals, and clinics. Subjects and methods: We collected patient data using a Japanese translated version of the Tinnitus Sample Case History Questionnaire. In total, 584 patients who visited our institutions in Japan between August 2012 and March 2014 were included (280 males and 304 females; age 13–92 years; mean age, 60.8). We examined patients after dividing them into two groups according to the presence or absence of hyperacusis. The collected results were compared with those from the Tinnitus Research Initiative database. Results: Compared with the TRI database, there were significantly more elderly female patients and fewer patients with trauma-associated tinnitus. There was a statistically lower ratio of patients with hyperacusis. We found that patients with tinnitus in addition to hyperacusis had greater tinnitus severity and exhibited higher rates of various complications. Conclusion: The Japanese version of the Tinnitus Sample Case History Questionnaire developed in this study can be a useful tool for evaluating patients with tinnitus in Japan. The results of this multicenter study reflect the characteristics of patients with tinnitus who require medical care in Japan. Our data provides a preliminary basis for an international comparison of tinnitus epidemiology.
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Clinical outcomes of transoral videolaryngoscopic surgery for hypopharyngeal and supraglottic cancer

Imanishi Yorihisa, Ozawa Hiroyuki, Sakamoto Koji, Fujii Ryoichi, Shigetomi Seiji, Habu Noboru, Otsuka Kuninori, Sato Yoichiro, Watanabe Yoshihiro, Sekimizu Mariko, Ito Fumihiro, Tomita Toshiki, Ogawa Kaoru

BMC Cancer 17 （ 1 ） 2017.06

ISSN 1471-2407

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Background: Transoral videolaryngoscopic surgery (TOVS) was developed as a new distinct surgical procedure for hypopharyngeal cancer (HPC) and supraglottic cancer (SGC) staged at up to T3. However, long-term treatment outcomes of TOVS remain to be validated. Methods: Under a straight broad intraluminal view provided by combined use of a distending laryngoscope and a videolaryngoscope, we performed en bloc tumor resection via direct bimanual handling of the ready-made straight-form surgical instruments and devices. We retrospectively analyzed functional and oncologic outcomes of 72 patients with HPC (n = 58) or SGC (n = 14) whose minimum follow-up was 24 months or until death. Results: The cohort comprised nine patients of Tis, 23 of T1, 33 of T2, and 7 of T3. Among 36 patients (50%) who underwent neck dissection simultaneously, all but one were pathologically node-positive. Twelve patients underwent postoperative concurrent chemoradiation (CCRT) as adjuvant treatment, and another four patients underwent radiation or CCRT for second or later primary cancer. The endotracheal tube was removed in an operation room in all but two patients who underwent temporary tracheostomy. Pharyngeal fistula was formed transiently in two patients. The median time until patients resumed oral intake and could take a soft meal was 2 and 5 days, respectively. Eventually, 69 patients (96%) took normal meals. The 5-year cause-specific survival (CSS), overall survival (OS), larynx-preserved CSS, and loco-regional controlled CSS were 87.3%, 77.9%, 86.0%, and 88.0%, respectively. Multivariate analysis revealed N2-3 as an independent prognostic factor in both CSS (hazard ratio [HR] = 25.51, P = 0.008) and OS (HR = 4.90, P = 0.022), which indirectly reflected higher risk of delayed distant metastasis. Conclusions: Considering its sound functional and oncological outcomes with various practical advantages, TOVS can be a dependable, less invasive, and cost-effective surgical option of an organ-function preservation strategy for HPC and SGC.
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Characterization of slow-cycling cells in the mouse cochlear lateral wall

Li Yang, Watanabe Kotaro, Fujioka Masato, Ogawa Kaoru

PLoS ONE 12 （ 6 ） 2017.06

ISSN 1932-6203

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Cochlear spiral ligament fibrocytes (SLFs) play essential roles in the physiology of hearing including ion recycling and the generation of endocochlear potential. In adult animals, SLFs can repopulate after damages, yet little is known about the characteristics of proliferating cells that support SLFs’ self-renewal. Here we report in detail about the characteristics of cycling cells in the spiral ligament (SL). Fifteen P6 mice and six noise-exposed P28 mice were injected with 5-bromo-2′-deoxyuridine (BrdU) for 7 days and we chased BrdU retaining cells for as long as 60 days. Immunohistochemistry revealed that the BrdU positive IB4 (an endotherial marker) negative cells expressed an early SLF marker Pou3f4 but negative for cleaved-Caspase 3. Marker studies revealed that type 3 SLFs displayed significantly higher percentage of BrdU⁺ cells compared to other subtypes. Notably, the cells retained BrdU until P72, demonstrating they were dividing slowly. In the noise-damaged mice, in contrast to the loss of the other types, the number of type 3 SLFs did not altered and the BrdU incorporating- phosphorylated Histone H3 positive type 3 cells were increased from day 1 to 14 after noise exposure. Furthermore, the cells repopulating type 1 area, where the cells diminished profoundly after damage, were positive for the type 3 SLF markers. Collectively, in the latral wall of the cochlea, type 3 SLFs have the stem cell capacity and may contribute to the endogenous regeneration of lateral wall spiral ligament. Manipulating type 3 cells may be employed for potential regenerative therapies.
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Assessment of hyperacusis with a newly produced Japanese version of the Khalfa hyperacusis questionnaire

Oishi Naoki, Yamada Hiroyuki, Kanzaki Sho, Kurita Akihiro, Takiguchi Yoichiro, Yuge Isamu, Asama Yoji, Masuda Masatsugu, Ogawa Kaoru

Acta Oto-Laryngologica 1 - 5 2017.04

ISSN 0001-6489

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Objectives: The purpose of this study was to determine the validity and reliability of a Japanese version of the Khalfa hyperacusis questionnaire (KHQ) and proposed a threshold KHQ score for classifying hyperacusis. Methods: In total, 112 patients with hyperacusis (group A) and 103 patients without hyperacusis (group B). The patients in group A were further classified into the following subgroups: subjects with hyperacusis as their chief complaint (n = 26, group A1) and subjects with hyperacusis accompanied by chief complaints of tinnitus and/or hearing loss (n = 86, group A2). Results: The average total questionnaire score for patients in group A was 11.8 ± 9.7, which was statistically significantly higher than that of patients in group B, 5.7 ± 4.8. Cronbach’s coefficients for internal consistency were high for the total score (0.92). The average total scores for groups A1 and A2 were 18.1 ± 11.1 and 9.9 ± 8.4, respectively, and the difference between the groups was statistically significant. Conclusions: We developed a Japanese version of the KHQ. It showed high reliability and validity; suggesting its usefulness in clinical practice. We propose that a total KHQ score of 16 is an appropriate cutoff for classifying hyperacusis
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Papers, etc., Registered in KOARA 【 Display / hide 】

Development of novel therapeutics for autoimmune inner ear disorder by using new transgenic mouse model

Ogawa, Kaoru

科学研究費補助金研究成果報告書 2020
Multifunctional gene delivery system for rAAV-mediated gene transfer using hydrogel microparticles

Ogawa, Kaoru

学事振興資金研究成果実績報告書（慶應義塾大学) 2019
Modeling inner ear cilliopathy using patient derived iPS cells

Ogawa, Kaoru

科学研究費補助金研究成果報告書 2019
AR-navigated transcanal endoscopic inner ear sugery

Ogawa, Kaoru

科学研究費補助金研究成果報告書 2019
Regenerative medicine for hypothyroidism with thyroid follicular cells derived from human iPS cells

Ogawa, Kaoru

科学研究費補助金研究成果報告書 2019

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Presentations 【 Display / hide 】

シンポジウム「耳音響放射」

Ogawa Kaoru

第103回日本耳鼻咽喉科学会総会,

2003.05
,
Other
両側難聴，顔面神経麻痺，めまいをきたした慢性肥厚性硬膜炎の一例

Watabe takahisa, Kanzaki shou, Masuda masatsugu, Takiguhi youichirou, Inoue yasuhiro, Satou minako, Ogawa kaoru

第155回日本耳鼻咽喉科学会東京地方部会,

2003.03
,
Oral presentation (general)
特別講演「感音難聴の診断と耳音響放射」

Ogawa Kaoru

平成15年度山梨県地方部会研修会,

2003.03
,
Other
めまいを伴う急性感音難聴として発症した脳幹海綿状血管腫の一症例

Asama Youji, Gotou Fumiyuki, Araki Yasutomo, Kunihiro Takanobu, Ogawa Kaoru

第155回日本耳鼻咽喉科学東京都地方部会,

2003.03
,
Oral presentation (general)
Shy Drager症候群による睡眠時呼吸障害の一例

Yabe Haruna, Shiotani Akihiro, Araki Kouji, Ikeda Asako, Moro Kazuhisa, Fukuda Hiroyuki, Ogawa Kaoru, Takahashi Saeko, Asano Kouichirou, Yamaguchi Kazuhiro

第155回日本耳鼻咽喉科学会東京都地方部会,

2003.03
,
Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

急性感音難聴のPresicion Medicineに向けたコンパニオン診断開発

2020.07

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2022.03

MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Principal investigator
Development of novel therapeutics for autoimmune inner ear disorder by using new transgenic mouse model

2018.04

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2021.03

MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator
AR-navigated transcanal endoscopic inner ear sugery

2017.06

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2019.03

MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory) , Principal investigator
Immunobiology in the cochlea: an analyses with a novel autoimmune transgenic mouse

2015.04

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2018.03

MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator