論文 - 大家　基嗣

The benefit of laparoscopic partial nephrectomy in high body mass index patients

Kaneko Gou, Miyajima Akira, Kikuchi Eiji, Nakagawa Ken, Oya Mototsugu

Japanese Journal of Clinical Oncology 42 （ 7 ） 619 - 624 2012年07月

ISSN  0368-2811

　概要を見る

<p>Objective: The aims of the present study were to evaluate the effect of body mass index on the surgical outcomes of open partial nephrectomy and laparoscopic partial nephrectomy, and to analyze whether higher body mass index patients may derive greater benefit from laparoscopic partial nephrectomy. Methods: We reviewed 110 patients who underwent open partial nephrectomy and 47 patients who underwent laparoscopic partial nephrectomy at our institution. We analyzed the data to determine what kind of factor would be associated with prolonged operative time, increased estimated blood loss and prolonged ischemic time, and compared the result of open partial nephrectomy with that of laparoscopic partial nephrectomy. Results: A statistically significant correlation was observed between body mass index and operative time or estimated blood loss in open partial nephrectomy. Multivariate analysis also demonstrated that body mass index was an independent predictor for prolonged operative time and higher estimated blood loss in open partial nephrectomy, but not in laparoscopic partial nephrectomy. In the normal body mass index group (body mass index &lt; 25.0 kg/m. ²), although mean operative time in the laparoscopic partial nephrectomy group was significantly longer than that in the open partial nephrectomy group, the difference was relatively small. In the high body mass index group (body mass index ≥ 25.0 kg/m. ²), the mean operative time of the two groups was not statistically different. The estimated blood loss of open partial nephrectomy was significantly higher than that of laparoscopic partial nephrectomy in both groups. In both operative procedures, tumor size was an independent predictor for prolonged ischemic time in multivariate analysis. Conclusions: Body mass index was an independent predictor for prolonged operative time and higher estimated blood loss in open partial nephrectomy but not in laparoscopic partial nephrectomy. Laparoscopic partial nephrectomy was less influenced by body mass index and had a greater benefit, especially in high body mass index patients.</p>

• Access to Document (DOI)

The Benefit of Laparoscopic Partial Nephrectomy in High Body Mass Index Patients

Kaneko Gou, Miyajima Akira, Kikuchi Eiji, Nakagawa Ken, Oya Mototsugu

JAPANESE JOURNAL OF CLINICAL ONCOLOGY 42 （ 7 ） 619 - 624 2012年07月

研究論文（学術雑誌）, 共著,  ISSN  0368-2811

• Access to Document (DOI)

IJU this issue

Oya Mototsugu

International Journal of Urology 19 （ 7 ） 593 2012年07月

ISSN  0919-8172

• Access to Document (DOI)

A case of spinal and bulbar muscular atrophy with high-stage and high-gleason score prostate cancer responded to maximal androgen blockade therapy

Kosaka Takeo, Miyajima Akira, Kikuchi Eiji, Takahashi Shinichi, Suzuki Norihiro, Oya Mototsugu

Journal of Andrology 33 （ 4 ） 563 - 565 2012年07月

ISSN  0196-3635

　概要を見る

<p>Spinal and bulbar muscular atrophy is a hereditary motor neuron disease caused by the expansion of CAG triplets in the androgen receptor. Because the length of CAG repeat is inversely related with androgen receptor function, patients with a longer CAG repeat are expected to have a lower incidence of prostate cancer. Here, we report an extremely rare case of highstage prostate cancer in a patient with spinal and bulbar muscular atrophy, which responded to maximal androgen blockade therapy.</p>

• Access to Document (DOI)

Testosterone and 5 alpha-reductase

Maeda Takahiro, Kikuchi Eiji, Oya Mototsugu

Japanese Journal of Clinical Urology 66 （ 7 ） 495 - 502 2012年06月

ISSN  0385-2393

Tracing the conversion process from primordial germ cells to pluripotent stem cells in mice

Nagamatsu Go, Kosaka Takeo, Saito Shigeru, Takubo Keiyo, Akiyama Hideo, Sudo Tetsuo, Horimoto Katsuhisa, Oya Mototsugu, Suda Toshio

Biology of Reproduction 86 （ 6 ）  2012年06月

ISSN  0006-3363

　概要を見る

<p>To understand mechanisms underlying acquisition of pluripotency, it is critical to identify cells that can be converted to pluripotent stem cells. For this purpose, we focused on unipotent primordial germ cells (PGCs), which can be reprogrammed into pluripotent embryonic germ (EG) cells under defined conditions. Treatment of PGCs with combinations of signaling inhibitors, including inhibitors of MAP2K (MEK), GSK3B (GSK-3beta), and TGFB (TGFbeta) type 1 receptors, induced cells to enter a pluripotent state at a high frequency (12.1%) by Day 10 of culture. When we employed fluorescence-activated cell sorting to monitor conversion of candidate cells to a pluripotent state, we observed a cell cycle shift to S phase, indicating enrichment of pluripotent cells, during the early phase of EG formation. Transcriptome analysis revealed that PGCs retained expression of some pluripotent stem cell-associated genes, such as Pou5f1 and Sox2, during EG cell formation. On the other hand, PGCs lost their germ lineage characteristics and acquired expression of pluripotent stem cell markers, such as Klf4 and Eras. The overall gene expression profiles revealed by this system provide novel insight into how pluripotency is acquired in germcommitted cells.</p>

• Access to Document (DOI)

Patterns of interstitial lung disease during everolimus treatment in patients with metastatic renal cell carcinoma

Mizuno Ryuichi, Asano Koichiro, Mikami Shuji, Nagata Hirohiko, Kaneko Gou, Oya Mototsugu

Japanese Journal of Clinical Oncology 42 （ 5 ） 442 - 446 2012年05月

ISSN  0368-2811

　概要を見る

<p>Objective: To elucidate the patterns of interstitial lung disease during everolimus treatment in patients with metastatic renal cell carcinoma, we reviewed seven cases of everolimus-induced interstitial lung disease. Methods: Seven patients with metastatic renal cell carcinoma, which continued to progress despite treatment with sunitinib or sorafenib, developed interstitial lung disease after treatment with everolimus. Results: Chest X-ray demonstrated diffuse infiltrates in lung fields, and chest computed tomography showed bilateral reticular and ground-glass opacities. Serum levels of lactate dehydrogenase (7/7), C-reactive protein (6/7), pulmonary surfactant associated protein D (1/7) and Krebs von den Lungen 6 (5/7) were elevated. The bronchoalveolar lavage fluid obtained from four patients with Grade 3 interstitial lung disease showed lymphocytosis. The transbronchial lung biopsy specimens showed interstitial lymphocytic infiltration and septal thickening of alveolar walls. In two cases with mild interstitial lung disease, the everolimus therapy was successfully continued. In four cases with Grade 3 interstitial lung disease, the drug was discontinued and steroid therapy was initiated. Pulmonary symptoms and radiological abnormalities resolved within 2 months. Conclusions: Serum Krebs von den Lungen 6 was elevated compared with baseline in all cases with interstitial lung disease. Some patients who developed mild interstitial lung disease during everolimus treatment could continue to receive the treatment. Even when severe interstitial lung disease developed, withdrawal of the drug and short-term use of high-dose steroids resulted in rapid recovery. Prompt recognition of interstitial lung disease exacerbation as well as exclusion of progressive disease or infection is of primary importance.</p>

• Access to Document (DOI)

Patterns of Interstitial Lung Disease During Everolimus Treatment in Patients with Metastatic Renal Cell Carcinoma

Mizuno Ryuichi, Asano Koichiro, Mikami Shuji, Nagata Hirohiko, Kaneko Gou, Oya Mototsugu

JAPANESE JOURNAL OF CLINICAL ONCOLOGY 42 （ 5 ） 442 - 446 2012年05月

研究論文（学術雑誌）, 共著,  ISSN  0368-2811

• Access to Document (DOI)

Lymphorrhea and lymphocele

Shinoda Kazunobu, Oya Mototsugu

Japanese Journal of Clinical Urology 66 （ 4 ） 151 - 155 2012年04月

ISSN  0385-2393

Urethroplasty for hypospadias

Asanuma Hiroshi, Oya Mototsugu

Japanese Journal of Clinical Urology 66 （ 4 ） 404 - 410 2012年04月

ISSN  0385-2393

Extrapancreatic solid pseudopapillary tumor

Miyazaki Yasumasa, Miyajima Akira, Maeda Takahiro, Yuge Kazuyuki, Hasegawa Masanori, Kosaka Takeo, Kikuchi Eiji, Kameyama Kaori, Jinzaki Masahiro, Nakagawa Ken, Oya Mototsugu

International Journal of Clinical Oncology 17 （ 2 ） 165 - 168 2012年04月

ISSN  1341-9625

　概要を見る

<p>A 22-year-old woman complained of abdominal discomfort. Ultrasonography, computed tomography, and an endocrinologic work-up revealed a 7-cm nonfunctional tumor at the left adrenal lesion. A transumbilical laparo-endoscopic single-site adrenalectomy was successfully completed in 166 min. The postoperative period was uneventful. The pathologic examination confirmed the solid pseudopapillary tumor occurred in the retroperito-neum. There are only five previous reports of extrapan-creatic solid pseudopapillary tumors. In this case, the tumor was separated from the pancreas and no ectopic pancreas was histologically observed. To the best of our knowledge, this case is the first report of a solid pseudopapillary tumor of the retroperitoneum.</p>

• Access to Document (DOI)

Three cases of granulocyte colony-stimulating factor-producing urinary upper tract carcinomas

Shirakawa Hiroshi, Kikuchi Eiji, Mikami Shuji, Fukamachi Shigeru, Miyazaki Yasumasa, Tanaka Nobuyuki, Miyajima Akira, Oya Mototsugu

SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY 46 （ 2 ） 136 - 141 2012年04月

研究論文（学術雑誌）, 共著,  ISSN  0036-5599

• Access to Document (DOI)

PREDICTION AND CLINICAL IMPLICATION OF SEED MIGRATION AFTER BRACHYTHERAPY WITH I-125 FREE SEEDS IN PATIENTS WITH LOCALIZED PROSTATE CANCER

Nakashima Jun, Sugawara Akitomo, Nagata Hirohiko, Mizuno Ryuichi, Shigematsu Naoyuki, Oya Mototsugu, Tachibana Masaaki

JOURNAL OF UROLOGY 187 （ 4 ） E455 - E456 2012年04月

研究論文（学術雑誌）, 共著,  ISSN  0022-5347

REGULATION OF MCP-1 EXPRESSION THROUGH ANGIOTENSIN II TYPE 1 RECEPTOR IN CASTRATION-RESISTANT PROSTATE CANCER

Shirotake Suguru, Miyajima Akira, Kosaka Takeo, Tanaka Nobuyuki, Kikuchi Eiji, Oya Mototsugu

JOURNAL OF UROLOGY 187 （ 4 ） E394 - E394 2012年04月

研究論文（学術雑誌）, 共著,  ISSN  0022-5347

Extrapancreatic solid pseudopapillary tumor: case report and review of the literature

Miyazaki Yasumasa, Miyajima Akira, Maeda Takahiro, Yuge Kazuyuki, Hasegawa Masanori, Kosaka Takeo, Kikuchi Eiji, Kameyama Kaori, Jinzaki Masahiro, Nakagawa Ken, Oya Mototsugu

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 17 （ 2 ） 165 - 168 2012年04月

研究論文（学術雑誌）, 共著,  ISSN  1341-9625

• Access to Document (DOI)

PI3K/AKT DUAL INHIBITOR RESTORES DOCETAXEL SENSITIVITY IN CASTRATION RESISTANT PROSTATE CANCER

Yasumizu Yota, Miyajima Akira, Kosaka Takeo, Shirotake Suguru, Kikuchi Eiji, Oya Mototsugu

JOURNAL OF UROLOGY 187 （ 4 ） E394 - E395 2012年04月

研究論文（学術雑誌）, 共著,  ISSN  0022-5347

PREOPERATIVE GRADING OF HYDRONEPHROSIS CAN IMPROVE THE ACCURACY OF WORSE PATHOLOGICAL PREDICTION IN PATIENTS WITH UPPER TRACT UROTHELIAL CARCINOMA TREATED SURGICALLY

Ito Yujiro, Kikuchi Eiji, Tanaka Nobuyuki, Akita Hirotaka, Jinzaki Masahiro, Mikami Shuji, Miyajima Akira, Nakagawa Ken, Kuribayashi Sachio, Oya Mototsugu

JOURNAL OF UROLOGY 187 （ 4 ） E884 - E884 2012年04月

研究論文（学術雑誌）, 共著,  ISSN  0022-5347

Prognostic Role of KiSS-1 and Possibility of Therapeutic Modality of Metastin, the Final Peptide of the KiSS-1 Gene, in Urothelial Carcinoma

Takeda Toshikazu, Kikuchi Eiji, Mikami Shuji, Suzuki Eriko, Matsumoto Kazuhiro, Miyajima Akira, Okada Yasunori, Oya Mototsugu

MOLECULAR CANCER THERAPEUTICS 11 （ 4 ） 853 - 863 2012年04月

研究論文（学術雑誌）, 共著,  ISSN  1535-7163

• Access to Document (DOI)

NOVEL NF-KAPPAB INHIBITOR DHMEQ: THE NEW STRATEGY FOR ACQUIRED CHEMO-RESISTANT BLADDER CANCER

Ito Yujiro, Kikuchi Eiji, Tanaka Nobuyuki, Shirakawa Hiroshi, Miyajima Akira, Horiguchi Yutaka, Nakashima Jun, Nakagawa Ken, Umezawa Kazuo, Oya Mototsugu

JOURNAL OF UROLOGY 187 （ 4 ） E227 - E228 2012年04月

研究論文（学術雑誌）, 共著,  ISSN  0022-5347

COLOR DOPPLER SONOGRAPHIC EVALUATION OF URETERIC JET ANGLE IN DETECTING HIGH GRADE VESICOURETERAL REFLUX IN CHILDREN

Asanuma Hiroshi, Satoh Hiroyuki, Matsui Zenichi, Mizuno Ryuichi, Masuda Aya, Kono Hidaka, Shinoda Kazunobu, Kikuchi Eiji, Nagata Hirohiko, Miyajima Akira, Nakagawa Ken, Oya Mototsugu

JOURNAL OF UROLOGY 187 （ 4 ） E248 - E248 2012年04月

研究論文（学術雑誌）, 共著,  ISSN  0022-5347