Yamagami, Jun

写真a

Affiliation

School of Medicine, Department of Dermatology (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor

External Links

Profile 【 Display / hide

  • Jun Yamagami is a dermatologist. His speciality includes autoimmune bullous diseases (e.g. pemphigus, pemphigoid), and pressure ulcer.

Career 【 Display / hide

  • 2000.07
    -
    2003.08

    静岡市立清水病院, 皮膚科, 医員

  • 2007.03
    -
    2010.03

    University of Pennsylvania, Department of Dermatology, Visiting scholar

  • 1998.04
    -
    Present

    Keio University School of Medicine, Department of Dermatology

Academic Background 【 Display / hide

  • 1992.04
    -
    1998.03

    Keno University, School of Medicine

    University, Graduated

Academic Degrees 【 Display / hide

  • 医学博士, 慶應義塾大学, Coursework, 2010.12

Matters concerning Career Achievements 【 Display / hide

  • 2016.10

    慶應義塾大学プレスリリース「ステロイド治療抵抗性の天疱瘡患者を対象とした抗CD20抗体(リツキシマブ)療法の医師主導治験を開始」

 

Research Areas 【 Display / hide

  • Dermatology

Research Keywords 【 Display / hide

  • 天疱瘡 類天疱瘡

Research Themes 【 Display / hide

  • 患者検体を用いた自己免疫性皮膚疾患発症機序の解明, 

    2012.07
    -
    Present

 

Books 【 Display / hide

  • 皮膚科のくすりの使い方

    山上淳, じほう, 2019.08

    Scope: 褥瘡,  Contact page: 173-177

  • 最新キーワードで読み解くALL About 皮膚科学

    山上淳, メディカルビュー社, 2019.06

    Scope: 天疱瘡/リツキシマブ,  Contact page: 96-97

  • 今日の治療指針2019

    山上淳, 医学書院, 2019.01

    Scope: 膿皮症,  Contact page: 1275-1277

  • WHAT’S NEW in 皮膚科学 2018-2019

    山上淳, メディカルレビュー社, 2018.04

    Scope: リツキシマブによる天疱瘡治療,  Contact page: 200-201

  • 今日の治療指針2018年版

    山上 淳, 医学書院, 2018.01

    Scope: 1236-1237

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Papers 【 Display / hide

  • Diagnosis and management of pemphigus: Recommendations of an international panel of experts

    Murrell DF, Pena S, Joly P, Marinovic B, Hashimoto T, Diaz LA, Sinha AA, Payne AS, Daneshpazhooh M, Eming R, Jonkman MF, Mimouni D, Borradori L, Kim SC, Yamagami J, Lehman JS, Saleh MA, Culton DA, Czernik A, Zone JJ, Fivenson D, Ujiie H, Wozniak K, Akman-Karakas A, Bernard P, Korman NJ, Caux F, Drenovska K, Prost-Squarcioni C, Vassileva S, Feldman RJ, Cardones AR, Bauer J, Ioannides D, Jedlickova H, Palisson F, Patsatsi A, Uzun S, Yayli S, Zillikens D, Amagai M, Hertl M, Schmidt E, Aoki V, Grando SA, Shimizu H, Baum S, Cianchini G, Feliciani C, Iranzo P, Mascaro JM, Jr., Kowalewski C, Hall R, Groves R, Harman KE, Marinkovich MP, Maverakis E, Werth VP

    J Am Acad Dermatol 82 ( 3 ) 575 - 585 e1 2020.03

    Joint Work, Accepted,  ISSN  0190-9622

  • Inter-rater reliability of the BIOCHIP indirect immunofluorescence dermatology mosaic in bullous pemphigoid and pemphigus patients

    Yang A., Xuan R., Melbourne W., Hashimoto T., Uzun S., Daneshpazhooh M., Yamagami J., Di Zenzo G., Mascaro J., Mahmoudi H., Patsatsi A., Drenovska K., Vassileva S., Murrell D.

    Journal of the European Academy of Dermatology and Venereology (Journal of the European Academy of Dermatology and Venereology)  33 ( 12 ) 2327 - 2333 2019.12

    Joint Work, Accepted,  ISSN  09269959

     View Summary

    © 2019 European Academy of Dermatology and Venereology Background: The BIOCHIP (Dermatology Mosaic 7; EUROIMMUN, Lubeck, Germany) is a novel multiplex indirect immunofluorescence (IIF) technique used in the serological diagnosis of bullous pemphigoid (BP) and pemphigus. Objective: To validate the accuracy and inter-rater reliability (IRR) of the BIOCHIP in the diagnosis of BP, pemphigus foliaceus (PF) and pemphigus vulgaris (PV). Methods: Sera from patients with BP (n = 38), PF (n = 8), PV (n = 23), control patients (n = 64) and healthy control volunteers (n = 39) were tested. Sera were collected and analysed during the course of the disease at 1–5 different time points. The BIOCHIP was performed for all patients, digital images were captured of each incubated field, and the images were shared with 10 dermatologists experienced in reading IF from around the world to report. There were 312 BIOCHIP slides consisting of 1872 photos in total. All patients were de-identified. Fleiss Kappa was used to estimate the IRR. Results: Fleiss Kappa was computed for each category (Oesophagus, Oesophagus immunofluorescence pattern, Salt-Split Skin (SSS), SSS immunofluorescence location, BP180, BP230, Dsg 1 and Ds3). The inter-rater agreement between the 10 raters varied between fair and moderate for all categories. Those that demonstrated fair concordance included monkey oesophagus (k = 0.257, P < 0.0001), oesophagus pattern (k = 0.357, P < 0.0001), Dsg1 (k = 0.390, P < 0.0001) and BP230 (k = 0.281, P < 0.0001). Moderate agreement was demonstrated for SSS (k = 0.416, P < 0.0001), SSS immunofluorescence location (k = 0.505, P < 0.0001), Dsg3 (k = 0.437, P < 0.0001) and BP180 (k = 0.559, P < 0.0001). Conclusion: The BIOCHIP mosaic-based immunofluorescence test is a simple, time and effort saving test that can aid in the diagnosis and screening of BP, PV and PF. However, the level of agreement was relatively low. The authors found the most common causes to be variable levels of training, indicating the presence of a learning curve in the interpretation of the results and ambiguous staining patterns leading to incongruent results.

  • Japanese guidelines for the management of pemphigoid (including epidermolysis bullosa acquisita)

    Ujiie H, Iwata H, Yamagami J, Nakama T, Aoyama Y, Ikeda S, Ishii N, Iwatsuki K, Kurosawa M, Sawamura D, Tanikawa A, Tsuruta D, Nishie W, Fujimoto W, Amagai M, Shimizu H, Committee for Guidelines for the Management of Pemphigoid, Diseases

    J Dermatol 46 ( 12 ) 1102 - 1135 2019.12

    Joint Work, Accepted,  ISSN  0385-2407

  • Generalized eruptive histiocytoma developing into xanthoma disseminatum with central diabetes insipidus

    Kobayashi K, Kurihara Y, Yamagami J, Ito J, Shima H, Shimada H, Ichimura C, Ishiko A, Amagai M, Ouchi T

    J Dermatol 46 ( 8 ) e281 - e283 2019.08

    Joint Work, Accepted,  ISSN  0385-2407

  • Autoimmunity and immunological tolerance in autoimmune bullous diseases

    Takahashi H., Iriki H., Mukai M., Kamata A., Nomura H., Yamagami J., Amagai M.

    International immunology (International immunology)  31 ( 7 ) 431 - 437 2019.07

     View Summary

    © The Japanese Society for Immunology. 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Autoimmune diseases are devastating conditions in which the immune system is directed against the host, leading to life-threatening destruction of organs. Although autoantigens are ill-defined in most autoimmune diseases, this is not the case in the skin. Autoimmune bullous diseases have been extensively studied with detailed characterization of autoantigens, the epitopes that are targeted, and the mechanisms of action that mediate autoimmune tissue destruction. Pemphigus is an autoimmune bullous disease caused by circulating IgG that targets two desmosomal proteins, desmoglein 1 and 3, which are crucial for cell-cell adhesion of keratinocytes. Binding of auto-antibodies to desmogleins impairs keratinocyte adhesion, leading to severe blistering disease. Mouse models that recapitulate the human disease have been instrumental in elucidating the detailed pathophysiology. Taking advantage of the fact that desmogleins are specifically targeted in pemphigus, studying humoral and cellular autoimmunity against these autoantigens provides us with an opportunity to understand not only the effector mechanisms of B and T cells in mediating pathology but also how autoreactive lymphocytes are regulated during development in the thymus and post-development in the periphery. This review introduces pemphigus and its subtypes as prototypic autoimmune diseases from which recent basic and translational developments should provide insight into how autoimmunity develops.

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Papers, etc., Registered in KOARA 【 Display / hide

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Reviews, Commentaries, etc. 【 Display / hide

  • 食道良性腫瘍および腫瘍様病変の診断 天疱瘡

    中村理恵子, 大森泰, 松田諭, 眞柳修平, 入野誠之, 和田則仁, 川久保博文, 山上淳, 天谷雅行, 北川雄光

    胃と腸 55 ( 3 ) 301 - 303 2020.03

    Joint Work,  ISSN  0536-2180

  • せまる天疱瘡治療の新時代

    山上淳

    西日本皮膚科 82 ( 1 ) 5 - 9 2020.02

    Single Work,  ISSN  0386-9784

  • 天疱瘡,類天疱瘡による口腔・咽喉頭粘膜病変

    松本伸晴, 矢部はる奈, 山上淳

    耳鼻咽喉科・頭頸部外科 92 ( 2 ) 132 - 135 2020.02

    Joint Work,  ISSN  0914-3491

  • 薬剤によって誘発される自己免疫性水疱症

    山上淳

    MB Derma 292   38 - 44 2020.02

    Single Work,  ISSN  1343-0831

  • 天疱瘡

    山上淳, 天谷雅行

    新薬と臨牀 69 ( 1 ) 54 - 57 2020.01

    Joint Work,  ISSN  0559-8672

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Presentations 【 Display / hide

  • 造影CTで活動性出血の所見なく、血腫除去時に判明したdeep dissecting hemtomaの1例

    小川夕貴, 伏間江貴之, 舩越建, 加藤達也, 岡部圭介, 小林秀, 天谷雅行, 山上淳

    第889回日本皮膚科学会東京地方会(城西地区) (東京) , 2020.02

  • 水疱性類天疱瘡患者の BPDAI スコアと重症度インプレッションによる予後予測の試み

    白木沙由理, 栗原佑一, 江上将平, 天谷雅行, 氏家英之, 山上淳

    第41回水疱症研究会 (愛媛) , 2020.01

  • 治療現場に即した天疱瘡・類天疱瘡に対するIVIGの使いかた

    山上淳

    第41回水疱症研究会 (愛媛) , 2020.01

  • 高齢女性の左前胸部に生じたMammary-type myofibroblastomaの1例

    早川道太郎, 八代聖, 中村善雄, 種瀬啓士, 天谷雅行, 亀山香織, 山上淳

    第887回日本皮膚科学会東京地方会(城西地区) (東京) , 2019.12

  • IL-27 is crucial in anti-desmoglein 3 autoantibody production in pemphigus vulgaris mouse model

    Kamata A, Takahashi H, Yoshida H, Yamagami J, Amagai M

    48th Annual Meeting of the Japanese Society for Immunology (Hamamatsu, Japan) , 2019.12

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Elucidating pathophysiology of pemphigus by single cell analysis of auto-reactive B cells

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 山上 淳, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • [慶應義塾・学事振興資金(個人研究A)] 単一細胞解析による天疱瘡の自己反応性B細胞レパトアの解明

    2016.04
    -
    2017.03

    Keio Gijuku Academic Development Funds, 山上淳

  • [基盤研究 C] 16K11734 デスモグレインを標的とした選択的な口腔癌および口腔扁平苔癬治療モデルの開発

    2016
    -
    2018

    Grant-in-Aid for Scientific Research, 河野通良

  • [慶應義塾・学事振興資金(個人研究B)] 天疱瘡の水疱形成機序からみた新たな治療標的の開発

    2015.04
    -
    2016.03

    Keio Gijuku Academic Development Funds, 山上淳

  • [慶應義塾・学事振興資金(個人研究A)] 天疱瘡発症機序におけるデスモグレイン前駆体特異的B細胞の意義の解明

    2013.04
    -
    2014.03

    Keio Gijuku Academic Development Funds, 山上淳

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Awards 【 Display / hide

  • JSID Fellowship Shiseido Award

    2014, 一般社団法人日本研究皮膚科学会(JSID), 天疱瘡における自己反応性B細胞の活性化機構の解明

 

Courses Taught 【 Display / hide

  • LECTURE SERIES, DERMATOLOGY

    2020

  • LECTURE SERIES, DERMATOLOGY

    2019

Courses Previously Taught 【 Display / hide

  • Dermatology

    Keio University, 2017

  • 皮膚科学

    学校法人慶應義塾大学, 2018

  • 皮膚科学講義「水疱症・膿疱症」2017/11/27

    Keio University, 2017

  • 皮膚科学講義「膿疱症」「物理化学的皮膚障害・光線性皮膚疾患」2015/11/18

    Keio University, 2015

  • 慶應義塾大学 研修医ランチョンセミナー「症例提示とレクチャー」2014/09/18

    Keio University, 2014

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Memberships in Academic Societies 【 Display / hide

  • 日本皮膚科学会