中村　善雄 (ナカムラ　ヨシオ)

Nakamura, Yoshio

写真a

所属（所属キャンパス）

医学部 皮膚科学教室 （信濃町）

職名

専任講師

特記事項

Nakamura
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経歴 【 表示 ／ 非表示 】

  • 2006年04月
    -
    2008年03月

    東京厚生年金病院

  • 2008年04月
    -
    2009年06月

    慶応義塾大学医学部皮膚科

  • 2009年07月
    -
    2011年10月

    荻窪病院皮膚科

  • 2011年10月
    -
    2014年06月

    慶応義塾大学医学部皮膚科

  • 2014年07月
    -
    2016年06月

    国立がん研究センター中央病院

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学歴 【 表示 ／ 非表示 】

  • 2000年04月
    -
    2006年03月

    金沢大学, 医学部, 医学科

    大学, 卒業

  • 2014年04月
    -
    2018年03月

    慶應義塾大学, 医学研究科, 医療科学系

    大学院, 単位取得退学

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学位 【 表示 ／ 非表示 】

  • 博士(医学), 慶應義塾大学, 課程, 2019年01月

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免許・資格 【 表示 ／ 非表示 】

  • 医師免許, 2006年04月

  • 日本皮膚科学会認定皮膚科専門医, 2011年10月

  • 日本がん治療認定医機構認定がん治療認定医, 2014年04月

  • 日本皮膚科学会認定皮膚悪性腫瘍指導専門医, 2017年04月

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研究分野 【 表示 ／ 非表示 】

  • ライフサイエンス / 皮膚科学

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研究キーワード 【 表示 ／ 非表示 】

  • 皮膚がん

  • 腫瘍外科

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  • Outcomes in extramammary Paget's disease patients with brain metastasis: a retrospective analysis.

    Fusumae T, Fukuda K, Hirai I, Nakamura Y, Tanese K, Iwata T, Funakoshi T

    Journal of the American Academy of Dermatology 2020年05月

    ISSN  0190-9622

  • Weekly docetaxel monotherapy for metastatic extramammary Paget’s disease: Retrospective single-institute analysis

    Nakamura Y., Tanese K., Hirai I., Fukuda K., Kawakami Y., Amagai M., Funakoshi T.

    Journal of Dermatology （Journal of Dermatology)  47 （ 4 ） 418 - 422 2020年04月

    ISSN  03852407

    　概要を見る

    © 2020 Japanese Dermatological Association Monthly docetaxel (DTX) monotherapy is the first-line regimen that is preferably used for metastatic extramammary Paget’s disease (EMPD). However, the high-dose DTX regimen frequently causes severe hematological adverse events (AE). To overcome such safety concerns, a weekly low-dose DTX monotherapy has been proposed for use in the treatment of various cancer types. In this study, we aimed to evaluate the feasibility and efficacy of weekly DTX (25 mg/m2) monotherapy for metastatic EMPD by retrospectively analyzing the clinical courses of 14 patients treated with this regimen. Weekly DTX monotherapy was well tolerated and all patients completed the treatment schedule without treatment withdrawal, dose reduction or treatment-related death. While five cases (35.7%) experienced hematological AE, their severity was mild. The response rate was 35.7% (5/14 cases), which included five partial responses. The mean progression-free survival (PFS) and overall survival were 7.1 (95% confidence interval [CI], 5.1–9.1) and 26.4 months (95% CI, 16.7–36.1), respectively. Furthermore, the median PFS was 7.3 months (95% CI, 4.5–10.0) in patients aged 65 years and younger and 7.1 months (95% CI, 4.4–9.9) in patients older than 65 years. These results suggest that weekly DTX monotherapy may be a useful regimen that has a high treatment continuation rate with low levels of hematological toxicity, regardless of the patient’s age for metastatic EMPD.

  • Metastatic cutaneous squamous cell carcinoma in liver successfully treated with partial hepatectomy and adjuvant irinotecan chemotherapy

    Asahina Y., Nakamura Y., Tanese K., Hirai I., Fukuda K., Amagai M., Funakoshi T.

    In Vivo （In Vivo)  34 （ 2 ） 825 - 828 2020年

    ISSN  0258851X

    　概要を見る

    © 2020 International Institute of Anticancer Research. All rights reserved. Background: The management of distant metastatic cutaneous squamous cell carcinoma (cSCC) relies mainly on chemotherapies and radiotherapy. Management of patients with cSCC with surgically resectable distant metastatic lesions is not clear. Case Report: A 59-year-old male had 4×10 cmsized cSCC on the perianal skin with inguinal lymph node metastasis. Surgical resection was performed followed by radiation and adjuvant carboplatin and farmorubicin combination therapy. Six months later, 25 mm-sized solitary metastatic nodule arose on the liver. Base on his favorable overall condition fulfilling the criteria of tumor resectability for the treatment of tumors in liver and having good performance status, laparoscopic partial hepatectomy and six courses of adjuvant irinotecan therapy were performed. The surgical margin was negative and the patient has maintained complete remission for over 3 years. Conclusion: The clinical course of the present case suggests that surgical approaches should also be considered as candidate additional therapy for resectable distant metastatic cSCC.

  • Serum cytokeratin 19 fragment 21-1 and carcinoembryonic antigen combination assay as a biomarker of tumour progression and treatment response in extramammary Paget disease

    Nakamura Y., Tanese K., Hirai I., Amagai M., Kawakami Y., Funakoshi T.

    British Journal of Dermatology （British Journal of Dermatology)  181 （ 3 ） 535 - 543 2019年09月

    ISSN  00070963

    　概要を見る

    © 2019 British Association of Dermatologists Background: Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma affecting the genitals and axillary regions. As metastasis of these tumours is itself rare, solid disease management strategies have not been established. Serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment 21-1 (CYFRA 21-1) levels have been identified as candidate biomarkers for tumour progression in EMPD. Objectives: To determine the accuracy of and the correlation between these markers in patients with EMPD. Methods: Serum CEA and CYFRA 21-1 levels were examined in 30 patients with EMPD treated at Keio University Hospital, and compared against clinical information. Both assays were performed at the time of diagnosis, during the postoperative observation period, and following systemic treatment in those with confirmed metastasis. Serum levels were then correlated with tumour progression status and treatment responses. Results: Normal levels for both assays were observed in all 11 patients with primary localized disease (100%). In patients with metastatic disease the CEA positivity rate was 79% (15 of 19 patients), with a rate of 63% (12 of 19 patients) for CYFRA 21-1. Changes in CEA and CYFRA 21-1 levels were statistically independent; however, using a combined view, elevated levels of either marker improved the positivity rate to 95% (18 of 19 patients). Use of both markers also correlated well with treatment responses. Conclusions: The combination of CEA and CYFRA 21-1 is useful for predicting metastasis and treatment response in patients with EMPD, especially in those who only have elevation of a single marker. What's already known about this topic?. Serum levels of carcinoembryonic antigen (CEA) and cytokine 19 fragment 21-1 (CYFRA 21-1) have been shown to be elevated in patients with extramammary Paget disease (EMPD). Elevation of serum CEA levels is associated with tumour progression of EMPD. A single small study reported that serum CYFRA 21-1 levels are elevated in patients with EMPD with lymph node metastasis. What does this study add?. Serum CEA and CYFRA 21-1 were present in 79% and 63% of 19 cases of metastatic EMPD, respectively. Elevations of CEA and CYFRA 21-1 were statistically independent. CEA and CYFRA 21-1 combination assays were positive in 95% of cases of metastatic EMPD. What is the translational message?. Combination assays with CEA and CYFRA 21-1 are useful for monitoring treatment response in patients with metastatic EMPD, particularly in those with elevation of either marker.

  • Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease

    Hirai I., Tanese K., Nakamura Y., Ishii M., Kawakami Y., Funakoshi T.

    Oncologist （Oncologist)  24 （ 6 ） e394 - e396 2019年06月

    ISSN  10837159

    　概要を見る

    © AlphaMed Press 2019 Extramammary Paget's disease (EMPD) is a rare cutaneous adenocarcinoma that clinicopathologically resembles breast cancer. The prognosis of metastatic EMPD is poor. Although several chemotherapies have been tried, the effects are temporary; better drugs and combinations are required. In the present study, we retrospectively analyze the efficacy and safety of combination of cisplatin, epirubicin, and paclitaxel in five metastatic EMPD cases. The efficacy was better than that for previously reported regimens: 80% partial responses, including two patients who were refractory to taxane- and/or platinum-based regimens. In terms of safety, four patients who were able to continue treatment exhibited acceptable tolerability. This is the first regimen to combine taxane and anthracycline. When treating breast cancer, anthracycline is regarded as the key cytotoxic agent, and anthracycline in combination with taxane constitutes a key chemotherapeutic regimen. Given our results, we speculate both drugs are critical chemotherapeutic agents for the treatment of metastatic EMPD.

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研究発表 【 表示 ／ 非表示 】

  • Analysis Of The Appropriate Margin Of Pigmented Bcc: A Single Institute Retrospective Study In Japan

    中村 善雄

    World congress on cancers of the skin (Sydney) , 

    2018年08月

  • Retrospective Study Of Chemotherapy Using Carboplatin And Epirubicin For Advanced Epithelial Malignancy Of The Skin. World congress on cancers of the skin

    中村 善雄

    World congress on cancers of the skin (Sydney) , 

    2018年08月

  • Pretreatment prognostic factors and early markers for outcome in advanced melanoma treated with nivolumab

    中村 善雄

    ESMO 2016 congress (Copenhagen) , 

    2016年10月
    , 

    ESMO

  • Outcomes of local treatment for malignant melanoma brain metastases: a single institution retrospective study

    中村 善雄

    European Cancer Congress (Vienna) , 

    2015年09月

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競争的研究費の研究課題 【 表示 ／ 非表示 】

  • 組織透明化法による乳房外パジェット病の立体構造の解析

    2021年04月
    -
    2023年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 中村 善雄, 若手研究, 補助金,  研究代表者

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