Details of a Researcher - Tsubota, Kazuo

Papers - Tsubota, Kazuo

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Serum free fatty acids levels not associated with normal tension glaucoma

Yuki Kenya, Kimura Itaru, Tsubota Kazuo

Clinical Ophthalmology 4 ( 1 ) 91 - 94 2010

ISSN 1177-5467

Purpose: To determine the free fatty acid levels in the sera of patients with normal-tension glaucoma and compare it with that of normal controls. Methods: Forty-four consecutive patients with newly diagnosed normal-tension glaucoma and forty-four age and gender matched controls were evaluated. The type and level of fatty acids in the sera were measured by gas chromatography (Model GC17A; Shimazu, Kyoto, Japan). Twenty-four fatty acids were identified from 12:0 to 24:1. The values were compared between the normal-tension glaucoma and control groups by Mann-Whitney U tests. Results: No statistically significant difference was found in the levels of any free fatty acids between the normal-tension glaucoma group and control group. Conclusion: No significant association was found in the serum free fatty acids levels including docosahexaenoic acid and eicosapentaenoic acid between normal-tension glaucoma patients and controls. © 2010 Yuki et al, publisher and licensee Dove Medical Press Ltd.

Topical tranilast for treatment of the early stage of mild dry eye associated with chronic GVHD

Ogawa Y., Dogru M., Uchino M., Tatematsu Y., Kamoi M., Yamamoto Y., Ogawa J., Ishida R., Kaido M., Hara S., Matsumoto Y., Kawakita T., Okamoto S., Tsubota K.

Bone Marrow Transplantation 45 ( 3 ) 565 - 569 2010

ISSN 0268-3369

Fibrosis and excessive extracellular matrix production are characteristic features of lacrimal gland chronic GVHD (cGVHD). Tranilast (n-3,4-anthoranilic acid), used for fibrotic skin disease, inhibits transforming growth factor-Β-induced matrix production. We conducted a non-randomized study comparing 8 patients (five men, three women; median age, 47 years) given topical tranilast with 10 patients (three men, seven women; median age, 37 years) receiving therapy with topical artificial tears, sodium hyaluronate and vitamin A for mild ocular cGVHD. The tranilast group instilled topical tranilast and artificial tears q.i.d., beginning the day of dry eye diagnosis. The ocular surface and tear dynamics of each patient were evaluated before hematopoietic stem cell transplant, at the onset of dry eye and after 3 months of treatment. At 3 months, the scores of the Rose Bengal test and Schirmer test with nasal stimulation had significantly improved in the tranilast group compared with that in the control group (P<0.05). Furthermore, although five control patients (50) developed severe dry eye within the treatment period, only one tranilast-treated patient (12.5) did; the rest still had mild dry eye (P<0.05). These results suggest the hypothesis that topical tranilast may effectively retard the progression of mild dry eye associated with cGVHD. © 2010 Macmillan Publishers Limited.

Access to Document (DOI)

Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users

Nakamura Shigeru, Kinoshita Shigeru, Yokoi Norihiko, Ogawa Yoko, Shibuya Michiko, Nakashima Hideo, Hisamura Ryuji, Imada Toshihiro, Imagawa Tomohiro, Uehara Masato, Shibuya Izumi, Dogru Murat, Ward Samantha, Tsubota Kazuo

PLoS ONE 5 ( 6 ) 2010

Background: Dry eye has shown a marked increase due to visual display terminal (VDT) use. It remains unclear whether reduced blinking while focusing can have a direct deleterious impact on the lacrimal gland function. To address this issue that potentially affects the life quality, we conducted a large-scale epidemiological study of VDT users and an animal study. Methodology/Principal Findings: Cross sectional survey carried out in Japan. A total of 1025 office workers who use VDT were enrolled. The association between VDT work duration and changes in tear film status, precorneal tear stability, lipid layer status and tear secretion were analyzed. For the animal model study, the rat VDT user model, placing rats onto a balance swing in combination with exposure to an evaporative environment was used to analyze lacrimal gland function. There was no positive relationship between VDT working duration and change in tear film stability and lipid layer status. The odds ratio for decrease in Schirmer score, index of tear secretion, were significantly increased with VDT working year (P = 0.012) and time (P = 0.005). The rat VDT user model, showed chronic reduction of tear secretion and was accompanied by an impairment of the lacrimal gland function and morphology. This dysfunction was recovered when rats were moved to resting conditions without the swing. Conclusions/Significance: These data suggest that lacrimal gland hypofunction is associated with VDT use and may be a critical mechanism for VDT-associated dry eye. We believe this to be the first mechanistic link to the pathogenesis of dry eye in office workers. © 2010 Nakamura et al.

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Inflammatory cells in brush cytology samples correlate with the severity of corneal lesions in atopic keratoconjunctivitis.

'Takano Y, Fukagawa K, Dogru M, Asano-Kato N, Tsubota K, Fujishima H.'

Br J Ophthalmol 88 ( 12 ) 1504-1505 2004.12

Research paper (scientific journal), Joint Work

INTACS before or after laser in situ keratomileusis: correction of thin corneas with moderately high myopia.

'Ito M, Arai H, Fukumoto T, Toda I, Tsubota K.'

J Refract Surg 20 ( 6 ) 818-822 2004.12

Research paper (scientific journal), Joint Work

Induction of epithelial progenitors in vitro from mouse embryonic stem cells and application for reconstruction of damaged cornea in mice.

'Homma R, Yoshikawa H, Takeno M, Kurokawa MS, Masuda C, Takada E, Tsubota K, Ueno S, Suzuki N.'

Invest Ophthalmol Vis Sci 45 ( 12 ) 4320-4326 2004.12

Research paper (scientific journal), Joint Work

Effect of preoperative tear function on early functional visual acuity after laser in situ keratomileusis.

'Tanaka M, Takano Y, Dogru M, Toda I, Asano-Kato N, Komai-Hori Y, Tsubota K.'

J Cataract Refract Surg 30 ( 11 ) 2311-2315 2004.11

Research paper (scientific journal), Joint Work

Dramatic healing of an allergic corneal ulcer persistent for 6 months by amniotic membrane patching in a patient with atopic keratoconjunctivitis: a case report.

Takano Y, Fukagawa K, Miyake-Kashima M, Tanaka M, Asano-Kato N, Dogru M, Tsubota K, Fujishima H.

Cornea 23 ( 7 ) 723-725 2004.10

Research paper (scientific journal), Joint Work

Lidocaine tape (Penles) reduces the pain of botulinum toxin injection for Meige syndrome.

'Onguchi T, Takano Y, Dogru M, Ono M, Tsubota K.'

Am J Ophthalmol 138 ( 4 ) 654-655 2004.10

Research paper (scientific journal), Joint Work

ドライアイ治療2004アップデート,角膜診療における患者さんの満足度アップ

坪田一男

ドライアイ研究会「角膜診療クオリティアップ1dayセミナー」 2004.09

Single Work

Ocular surface changes with applanation contact lens and coupling fluid use after argon laser photocoagulation in noninsulin-dependent diabetes mellitus.

Dogru M, Kaderli B, Gelisken O, Yucel A, Avci R, Goto E, Shimmura S, Shimazaki J, Tsubota K.

Am J Ophthalmol 138 ( 3 ) 381-388 2004.09

Research paper (scientific journal), Joint Work

Role of the endothelial pump in flap adhesion after laser in situ keratomileusis.

Bissen-Miyajima H, Nakamura K, Kaido M, Shimmura S, Tsubota K.

J Cataract Refract Surg 30 ( 9 ) 1989-1992 2004.09

Research paper (scientific journal), Joint Work

「アンチエイジング注目のEBM」

坪田一男

ＭCL抗加齢医学の実際2004−新しい医療を学ぶ２日間− 2004.09

Single Work

目から考えるアンチエイジング

坪田一男

日経プラスワンフォーラム 2004.09

Single Work

βブロッカー点眼と防腐剤が涙液・眼表面に及ぼす影響

'石岡みさき, 島崎潤, 八木幸子, 坪田一男'

臨床眼科(0370-5579) 58 ( 8 ) 1437-1440 2004.08

Research paper (scientific journal), Joint Work

Increased tear evaporation in a patient with ectrodactyly-ectodermal dysplasia-clefting syndrome.

Matsumoto Y, Dogru M, Goto E, Endo K, Tsubota K.

Jpn J Ophthalmol 48 ( 4 ) 372-375 2004.08

Research paper (scientific journal), Joint Work

Efficacy of core vitrectomy preceding triple corneal procedure.

Konomi K, Shimazaki J, Shimmura S, Akabane N, Goto E, Tsubota K.

Br J Ophthalmol 88 ( 8 ) 1023-1025 2004.08

Research paper (scientific journal), Joint Work

The relation of conjunctival and corneal findings in severe ocular allergies.

Tanaka M, Dogru M, Takano Y, Miyake-Kashima M, Asano-Kato N, Fukagawa K, Tsubota K, Fujishima H.

Cornea 23 ( 5 ) 464-467 2004.07

Research paper (scientific journal), Joint Work

Efficacy and safety of international donor sharing: a single-center, case-controlled study on corneal transplantation.

Shimazaki J, Shinozaki N, Shimmura S, Holland EJ, Tsubota K.

Transplantation 78 ( 2 ) 216-220 2004.07

Research paper (scientific journal), Joint Work

Therapeutic effect of cevimeline on dry eye in patients with Sjogren's syndrome: a randomized, double-blind clinical study.

Ono M, Takamura E, Shinozaki K, Tsumura T, Hamano T, Yagi Y, Tsubota K.

Am J Ophthalmol 138 ( 1 ) 39250 2004.07

Research paper (scientific journal), Joint Work

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