Shiba, Daisuke

写真a

Affiliation

School of Medicine, Department of Ophthalmology (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor
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Career 【 Display / hide 】

  • 2000.05
    -
    2002.04

    慶應義塾大学病院, 眼科臨床研修医

  • 2002.05
    -
    2003.08

    国立成育医療センター, 第二専門診療部レジデント（眼科）

  • 2003.09
    -
    2004.06

    静岡赤十字病院, 医師

  • 2004.07
    -
    2006.06

    大阪厚生年金病院, フェロー

  • 2006.07
    -
    Present

    慶應義塾大学医学部眼科, 助教

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Academic Background 【 Display / hide 】

  • 　

    Keio University, 医学部

    University

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Research Areas 【 Display / hide 】

  • Life Science / Ophthalmology

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Research Keywords 【 Display / hide 】

  • 緑内障

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Papers 【 Display / hide 】

  • Association between glaucoma severity and driving cessation in subjects with primary open-angle glaucoma

    Takahashi A., Yuki K., Awano-Tanabe S., Ono T., Shiba D., Tsubota K.

    BMC Ophthalmology (BMC Ophthalmology)  18 ( 1 )  2018.05

    　View Summary

    © 2018 The Author(s). Background: The aim of this study, which included a baseline cross-sectional study and a 3-year follow-up prospective study, was to investigate the association between glaucomatous visual field damage and driving cessation in subjects with primary open-angle glaucoma (POAG). Methods: A total of 211 POAG subjects divided into 3 groups according to POAG severity (mild, moderate, or severe) in the better eye were enrolled along with 148 control subjects; subjects were asked about changes in their driving status. In the 3-year follow-up study, 185 of the POAG subjects and 80 of the controls annually reported their driving status. Adjusted odds ratios and 95% confidence intervals for the prevalence and incidence of driving cessation were estimated with a multiple logistic regression model. Results: In the original cross-sectional study, 11/148 (7%) members of the control group reported having given up driving over the previous 5 years; the corresponding figures for the mild POAG, moderate POAG, and severe POAG groups were 9/173 (5%), 0/22 (0%), and 5/16 (31%), respectively (p = 0.001, Fisher's exact test), with severe POAG found to be associated with driving cessation after adjustment for age, gender, systemic hypertension, and diabetes mellitus (odds ratio 11.52 [95% CI 2.87-46.35], ref. control, p = 0.001). In the follow-up study, the proportions of subjects who ceased driving were 1/80 (1.3%) in the control group, 8/152 (5.3%) in the mild POAG group, 5/22 (22.7%) in the moderate POAG group, and 2/11 (18.2%) in the severe POAG group (p = 0.001, Fisher's exact test). Moderate POAG and severe POAG in the better eye were found to be associated with driving cessation after adjustment for age, gender, systemic hypertension, and diabetes mellitus (moderate POAG in the better eye: odds ratio 37.7 [95% CI 3.7-383.8], ref. control, p = 0.002, and severe POAG in the better eye: odds ratio 52.8 [95% CI 3.5-797.0], ref. control, p = 0.004). Conclusion: Moderate and Severe POAG in the better eye is associated with driving cessation.

  • Factors associated with developing a fear of falling in subjects with primary open-angle glaucoma

    Adachi S., Yuki K., Awano-Tanabe S., Ono T., Shiba D., Murata H., Asaoka R., Tsubota K.

    BMC Ophthalmology (BMC Ophthalmology)  18 ( 1 )  2018.02

    　View Summary

    © 2018 The Author(s). Background: To investigate the relationship between clinical risk factors, including visual field (VF) defects and visual acuity, and a fear of falling, among patients with primary open-angle glaucoma (POAG). Methods: All participants answered the following question at a baseline ophthalmic examination: Are you afraid of falling? The same question was then answered every 12 months for 3 years. A binocular integrated visual field was calculated by merging a patient's monocular Humphrey field analyzer VFs, using the 'best sensitivity' method. The means of total deviation values in the whole, superior peripheral, superior central, inferior central, and inferior peripheral VFs were calculated. The relationship between these mean VF measurements, and various clinical factors, against patients' baseline fear of falling and future fear of falling was analyzed using multiple logistic regression. Results: Among 392 POAG subjects, 342 patients (87.2%) responded to the fear of falling question at least twice in the 3 years study period. The optimal regression model for patients' baseline fear of falling included age, gender, mean of total deviation values in the inferior peripheral VF and number of previous falls. The optimal regression equation for future fear of falling included age, gender, mean of total deviation values in the inferior peripheral VF and number of previous falls. Conclusion: Defects in the inferior peripheral VF area are significantly related to the development of a fear of falling.

  • The efficacy of transcorneal electrical stimulation for the treatment of primary open-angle glaucoma: A pilot study

    Ota Y., Ozeki N., Yuki K., Shiba D., Kimura I., Tsunoda K., Shinoda K., Ohde H., Tsubota K.

    Keio Journal of Medicine (Keio Journal of Medicine)  67 ( 3 ) 45 - 53 2018

    ISSN  00229717

    　View Summary

    © 2017 by The Keio Journal of Medicine. The aim of this study was to evaluate the effects of transcorneal electrical stimulation in subjects with primary open-angle glaucoma. Five eyes of four male subjects with primary open-angle glaucoma (average age: 52.25 ± 14.68 years) were enrolled. The subjects underwent transcorneal electrical stimulation every 3 months according to the following procedure. A Dawson-Trick-Litzkow electrode was placed on the cornea, and biphasic electric current pulses (10 ms, 20 Hz) were delivered using a stimulator (BPG-1, BAK Electronics) and a stimulus isolation unit (BSI-2). A current that evoked a phosphene that the subject perceived in the whole visual area was delivered continuously for 30 min. Humphrey visual field testing was performed after every third transcorneal electrical stimulation treatment. Changes in mean deviation (MD) values were evaluated with a linear regression model. Transcorneal electrical stimulation was performed 18.2 ± 9.4 times over a period of 49.8 ± 23.0 months. The average pretranscorneal electrical stimulation intraocular pressure, best corrected visual acuity, and MD values were 11.8 ± 1.79 mmHg, 0.14 ± 0.19 (logMAR) and −17.28 ± 6.24 dB, respectively. No significant differences were observed in intraocular pressure before and after transcorneal electrical stimulation. However, there was a significant positive linear relationship between changes in MD values and the number of transcorneal electrical stimulation treatments (R2 = 0.176, P = 0.005, Spearman correlation R = 0.294, P = 0.008). Transcorneal electrical stimulation treatment may improve glaucomatous visual field defects in subjects with primary open-angle glaucoma. Large-scale studies are necessary to confirm these preliminary findings.

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Presentations 【 Display / hide 】

  • 慶大眼科における高齢者のぶどう膜炎の統計的検討

    Shiba Daisuke, Hashizume Kouhei, Takahashi Keiko, Andou Yasutaka, Muraki Yasuhide, Suzuki Saburousuke

    [Domestic presentation]  日本臨床眼科学会, 

    2002.10
    , 

    Oral presentation (general)

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Courses Taught 【 Display / hide 】

  • LECTURE SERIES, OPHTHALMOLOGY

    2025

  • LECTURE SERIES, OPHTHALMOLOGY

    2024

  • LECTURE SERIES, OPHTHALMOLOGY

    2023

  • LECTURE SERIES, OPHTHALMOLOGY

    2022

  • LECTURE SERIES, OPHTHALMOLOGY

    2021

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Courses Previously Taught 【 Display / hide 】

  • 緑内障、小児眼科

    Keio University

    2015.04
    -
    2016.03

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