Banno, Koji

写真a

Affiliation

School of Medicine, Department of Obstetrics and Gynecology (Gynecology) （Shinanomachi）

Position

Associate Professor

E-mail Address

E-mail address

External Links
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Career 【 Display / hide 】

  • 1992.05
    -
    1993.05

    慶應義塾大学病院研修医

  • 1995.07
    -
    1996.03

    慶應義塾大学助手(医学部産婦人科学）

  • 1996.04
    -
    2000.03

    癌研究会癌研究所細胞生物部研究生

  • 2001.06
    -
    2005.03

    慶應義塾大学助手（医学部産婦人科学）

  • 2005.04
    -
    2007.03

    慶應義塾大学助手（医学部産婦人科学・外来医長）

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Academic Background 【 Display / hide 】

  • 1992

    Keio University, Faculty of Medicine

    University, Graduated

  • 2000

    Keio University, Graduate School, Division of Medicine, 婦人科腫瘍学・細胞生物学

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（医学）, Keio University, Coursework

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Licenses and Qualifications 【 Display / hide 】

  • 日本臨床細胞学会　指導医

  • 日本婦人科腫瘍学会　専門医

  • がん治療暫定教育医

  • がん治療認定医

  • 日本婦人科腫瘍学会指導医

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Research Areas 【 Display / hide 】

  • Human genetics

  • Obstetrics and gynecology

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Research Keywords 【 Display / hide 】

  • エピジェネテイクス

  • 子宮体癌

  • 子宮内膜

  • 子宮移植

  • 家族性腫瘍

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Books 【 Display / hide 】

  • Nonhuman Primate Research in Uterus Transplantation.

    Kisu I, Banno K, Matoba Y, Aoki D. , Splinger, 2020.01

    Scope: Nonhuman Primate Research in Uterus Transplantation.,  Contact page： 57-67

  • Cell Biology of the Ovary, Stem Cells, Development, Cancer, and Clinical Aspects

    Kobayashi Y, Nomura H, Kataoka F, Tominaga E, Banno K, Aoki D, USA: Springer, 2018.05

    Scope: Clinical Management of Epithelial Ovarian Cancer.

  • 実践　臨床生殖免疫学

    BANNO KOUJI, 中外医学社, 2018.05

    Scope: 子宮移植

  • 臨床医とための最新産科婦人科

    BANNO KOUJI, 先端医療技術研究所, 2017.08

    Scope: 子宮移植の現状と展望.

  • 慶應義塾大学病院の医師100人と学ぶ病気の予習帳

    BANNO KOUJI, 講談社, 2015.12

    Scope: 子宮筋腫

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Papers 【 Display / hide 】

  • Cowden syndrome complicated by schizophrenia: A first clinical report.

    Kobayashi Y, Takeda T, Kunitomi H, Ueki A, Misu K, Kowashi A, Takahashi T, Anko M, Watanabe K, Uchida T, Tominaga E, Banno K, Kosaki K, Aoki D.

    Europian Journal of Medical Genetics （European Journal of Medical Genetics)  63 （ 8 ）  2020.08

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  17697212

    　View Summary

    © 2020 Elsevier Masson SAS Patients with Cowden syndrome exhibit mucocutaneous lesions, hamartomatous polyposis of the gastrointestinal tract, and macrocephaly, often complicated by malignant tumors, such as breast, thyroid, and uterine cancers. Autism spectrum and epilepsy have been known as neuropsychiatric symptoms associated with Cowden syndrome; however, to the best of our knowledge, there is no report on cases complicated by schizophrenia. Here, we report a first case of Cowden syndrome complicated by schizophrenia. A 49-year-old Japanese woman started experiencing auditory hallucinations in her teens. She had left breast cancer at the age of 34 years, and right breast cancer at the age of 37 years, all of which were surgically treated. She was also being treated by oral medications for Hashimoto's disease. On consulting her previous doctor for abnormal uterine bleeding that lasted for a year, she was diagnosed with endometrial cancer. However, immediately before surgery, her auditory hallucinations and paranoid delusions became severe, and she was referred to our hospital for detailed examination and treatment. No abnormalities were found on head MRI, and she was diagnosed with schizophrenia on the basis of neuropsychiatric examination findings. After her psychiatric symptoms were controlled by 2 mg of risperidone, she underwent surgery for endometrial cancer. Although there was no apparent family history, physical findings including macrocephaly and papillomatous skin lesions together with her past medical history of multiple malignant tumors suggested Cowden syndrome. Postoperatively, genetic testing revealed a pathogenic variant c.655C > T; p. Gln219* (NM_000314.4) in PTEN, leading to the confirmation of the diagnosis of Cowden syndrome.

  • 更年期症状を契機に診断された甲状腺機能亢進症の2例.

    平田 桃、横田まぐみ、谷本彗子、仲村 勝、山上 亘、森定 徹、片岡史夫、岩田 卓、阪埜浩司、田中 守、青木大輔.

    東京産科婦人科学会誌 69 （ 3 ） 575 - 580 2020.07

    Research paper (scientific journal), Joint Work, Accepted

  • Upregulation of cyclase-associated actin cytoskeleton regulatory protein 2 in epithelial ovarian cancer correlates with aggressive histologic types and worse outcomes.

    Adachi M, Masugi Y, Yamazaki K, Emoto K, Kobayashi Y, Tominaga E, Banno K, Aoki D, Sakamoto M.

    Japanese Journal of Clinical Oncology （Japanese Journal of Clinical Oncology)  50 （ 6 ） 643 - 652 2020.07

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  03682811

    　View Summary

    © 2020 The Author(s). Objective: Cyclase-associated actin cytoskeleton regulatory protein 2 (CAP2) regulates actin dynamics to control cell cycles and cell migration. CAP2 overexpression contributes to cancer progression in several tumor types; however, the role of CAP2 expression in ovarian cancer remains unclear. This study aimed to clarify the significance of CAP2 expression in epithelial ovarian tumor. Methods: We evaluated CAP2 expression in ovarian cancer cell lines using quantitative real-time polymerase chain reaction, western blotting and immunocytochemistry and examined the effect of CAP2 silencing in migration and proliferation assays. CAP2 immunohistochemistry was conducted using tissue specimens from 432 ovarian carcinoma patients; a further 55 borderline and benign 65 lesions were analyzed. CAP2 expression levels were defined as low, intermediate or high, for correlation analysis with clinicopathological factors. Results: CAP2 expression was significantly higher in cell lines from Type II ovarian cancer than in those in Type I, and knockdown of CAP2 showed decreased migration and proliferation. Higher levels of CAP2 expression in human tissues were associated with Type II histology, residual lesion, lymph node metastasis, ascites cytology and higher clinical stage. High CAP2 expression levels were observed in 26 (23.4%) of 111 Type II ovarian cancers and in 16 (5.0%) of 321 Type I cancers but not in any borderline or benign lesions. Multivariate analyses showed that CAP2 expression in ovarian cancer is an independent prognostic factor for recurrence-free survival (P = 0.019). Conclusion: CAP2 expression is upregulated in aggressive histologic types of epithelial ovarian cancer and serves as a novel prognostic biomarker for patient survival.

  • Hysteroscopic Photodynamic diagnosis Using 5-aminolwvulinic acid: A High Sensitivity Diagnostic Method For Uterine Endometrial Malignant Disease.

    Matoba Y, Banno K, Kisu I , Kobayashi Y, Tsuji K, Nagai S, Yamagami W, Nakamura M, Tominaga E, Kawaida M, Aoki D.

    Journal of Minimal Invasive Gynecology  27 （ 5 ） 1087 - 1094 2020.07

    Research paper (scientific journal), Accepted

  • Evaluation of safety and diagnostic performance for flexible hysteroscopy in 1591 outpatient cases.

    Kobayashi Y, Tsuji K, Nakamura K, Nagai S, Takahashi T, Kobayashi A, Anko M, Hirano T, Watanabe K, Matoba Y, Kunitomi H, Adachi M, Yamagami W, Tominaga E, Banno K, Aoki D.

    Japanese Journal of Clinical Oncology  2020.06

    Research paper (scientific journal), Joint Work, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • メタボローム解析による閉経期日本人女性の代謝プロファイリング

    渡辺慶子、飯田美穗、小林佑介、富永英一郎、阪埜浩司、武林　享、田中　守、青木大輔

    第72回日本産科婦人科学会学術講演会 (東京都千代田区　東京フォーラム) , 2020.04, Other

  • Application of photodynamic diagnosis using 5-aminolevulinic acid to hysteroscopic examination

    Matoba Y, Banno K, Kisu I, Kobayashi Y, Tsuji K, Nagai S, Yamagami W, Nakamura M, Tominaga E, Tanaka M, Aoki D

    第72回日本産科婦人科学会学術講演会 (東京都千代田区　東京フォーラム) , 2020.04, Poster (general)

  • First pregnancy after uterus transplantation assuming the procurement of uterus from a deceased donor in non-human primates

    Kisu I,Banno K, Matoba Y, Adachi M,.Matsuda K, Nakamura K, Nogami Y, Tanaka M, Aoki D

    第72回日本産科婦人科学会学術講演会 (東京都千代田区　東京フォーラム) , 2020.04, Poster (general)

  • A case of shoulder dystocia of a giant infant successfully deliverd by various delivery techniques

    Sovanara H, Stothy P, Kanal K, Banno K, Matsuoka A, Haruyama R, Fujita N

    第72回日本産科婦人科学会学術講演会 (東京都千代田区　東京フォーラム) , 2020.04, Poster (general)

  • Prognostic significance of PD-L1 expression in carbon-iron radiotherapy for cervical adenocarcinoma

    Iijima M, Okonogi N, Banno K, Tsuji K, Kobayashi Y, Tominaga E, Hasagawa S, Tanaka M, Aoki D.

    第72回日本産科婦人科学会学術講演会 (東京都千代田区　東京フォーラム) , 2020.04, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • エピゲノム異常を標的とした子宮内膜癌の新たな診断・治療法の探索

    2016.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 阪埜　浩司, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • ラットにおける半導体レーザー手術装置に関する基礎的研究

    2009.12
    -
    Present

    Commissioned ｒesearch

  • 子宮内膜症に関する創薬標的の探索および疾患モデルの構築

    2009.10
    -
    Present

    Joint research

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Awards 【 Display / hide 】

  • 平成25年度 日本医師会医学研究奨励賞

    BANNO KOUJI, 2013.11

  • 平成24年度　日本産科婦人科学会学術奨励賞

    BANNO KOUJI, 2012.12, 子宮体癌におけるジェネティクスとエピジェネティクス 〜子宮内膜の発癌とDNAミスマッチ修復遺伝子異常との関連を中心に〜

  • 平成23年度　医学部Best Teacher Award

    BANNO KOUJI, 2012.07

    Type of Award： Keio commendation etc.

  • 平成22年度　医学部Best Teacher Award

    BANNO KOUJI, 2011.06

    Type of Award： Keio commendation etc.

  • 平成21年度　医学部 Best Teacher Award

    BANNO KOUJI, 2010.03

    Type of Award： Keio commendation etc.

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Courses Taught 【 Display / hide 】

  • LECTURE SERIES, GYNECOLOGY

    2020

  • LECTURE SERIES, GYNECOLOGY

    2019

  • 大学院修士講義

    2019, Major subject, Lecture, Within own ｆaculty

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Courses Previously Taught 【 Display / hide 】

  • 婦人科 臨床実習

    Keio University, 2015, Full academic year, Major subject, Seminar, Lecturer outside of Keio, 5h, 100people

  • 大学院特別講義 臨床腫瘍学

    Keio University, 2015, Full academic year, Major subject, Lecture, Within own ｆaculty, 30people

    家族性腫瘍

  • 婦人科学

    Keio University, 2015, Spring Semester, Major subject, Lecture, Within own ｆaculty, 100people

  • 婦人科学 臨床実習

    Keio University, 2014, Full academic year, Major subject, Laboratory work/practical work/exercise, Within own ｆaculty

  • 大学院講義 臨床腫瘍学

    Keio University, 2014, Full academic year, Other, Lecture, Within own ｆaculty

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Educational Activities and Special Notes 【 Display / hide 】

  • 大学院特別講義 臨床腫瘍学

    2015.11
    -
    Present

    , Special Affairs

  • 婦人科学

    2015.09
    -
    Present

    , Special Affairs

  • 婦人科臨床実習

    2015.05
    -
    2015.12

    , Special Affairs

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Social Activities 【 Display / hide 】

  • 日本子宮移植研究会

    2014.03
    -
    Present

  • 日本学術会議

    2007.01
    -
    2008.04

  • 女性の健康基金

    2005
    -
    2006
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Memberships in Academic Societies 【 Display / hide 】

  • 日本家族性腫瘍学会, 

    2009.01
    -
    Present

  • 日本医師会総合政策研究機構, 

    2007.01
    -
    2008.09

  • 日本癌治療学会, 

    2002
    -
    Present

  • 日本婦人科腫瘍学会, 

    2002
    -
    Present

  • 日本臨床細胞学会, 

    2002
    -
    Present

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Committee Experiences 【 Display / hide 】

  • 2014.03
    -
    Present

    Director, 日本子宮移植研究会

  • 2009.01
    -
    Present

    Board of Councillors, 日本家族性腫瘍学会

  • 2009.01
    -
    2016.10

    編集委員, 日本家族性腫瘍学会

  • 2007.01
    -
    2008.09

    客員研究員, 日本医師会総合政策研究機構

  • 2007.01
    -
    2008.04

    上席学術調査員, 日本学術会議

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