Details of a Researcher - Iwata, Takashi

Papers - Iwata, Takashi

Division display 141 - 160 of about 223 ／ All the affair displays >>

堀場, 裕子, 平沢, 晃, 牧田, 和也, 松村, 聡子, 小川, 真里子, 岩田, 卓, 弟子丸, 亮太, 柳本, 茂久 and 青木, 大輔

Osteoporosis Japan 18 ( 3 ) 461 - 465 2010

ISSN 0919-6307

1979年〜2009年に大学病院産婦人科で44歳以下で両側卵巣摘出術を受けた51例(卵摘群)、健康維持外来受診中で、有経、自然閉経後卵巣摘出を含めた323例(対照群)を対象に2008年に開発したFRAXを用い、骨折リスクを算出し、閉経前両側卵巣摘出という因子がFRAXに与える影響について検討した。卵摘群では骨量正常が45例、骨量減少が6例、骨粗鬆症例は認めなかった。一方、対照群では骨量正常が238例、骨量減少が59例、骨粗鬆症が26例であった。卵摘群と対照群の骨密度を比較すると、卵摘群においてYAM値90%未満の例が31.8%に認められ、両群間に有意差を認めず、平均値の比較でも対照群と有意差を認めなかった。卵摘群における骨量減少6例は共に低BMIで、うち2例ではBMIが16以下であった。61歳例のFRAX値は9.7で他の5例に比べ高値であった。卵摘群における骨正常例ではL2-4YAMと大腿骨骨密度が骨量減少例と比べ有意に高値であった。

【妊孕能の可能性と限界を考える】子宮頸癌と生殖機能温存治療の実際

西尾, 浩, 藤井, 多久磨, 青海, 咲子, 仲村, 勝, 岩田, 卓 and 青木, 大輔

産婦人科の実際 59 ( 5 ) 777 - 782 2010

ISSN 0558-4728

【婦人科がんに関する最近の話題】広汎性子宮頸部摘出術後の妊孕能

仲村, 勝, 藤井, 多久磨, 西尾, 浩, 岩田, 卓, 高松, 潔 and 青木, 大輔

産科と婦人科 77 ( 9 ) 1089 - 1093 2010

ISSN 0386-9792

【妊娠を考慮した子宮頸部初期病変への対応】広汎性子宮頸部摘出術(radical trachelectomy)

仲村, 勝, 藤井, 多久磨, 西尾, 浩, 岩田, 卓 and 青木, 大輔

産科と婦人科 77 ( 4 ) 439 - 443 2010

ISSN 0386-9792

【知っておきたい婦人科がんのリスク】子宮頸がんリスクに関する環境因子

藤井, 多久磨, 岩田, 卓, 平尾, 薫丸, 齋藤, 深雪 and 青木, 大輔

産科と婦人科 77 ( 1 ) 45 - 48 2010

ISSN 0386-9792

【産婦人科診療　pros and cons】婦人科腫瘍　CIN局所療法の選択とその適応について

藤井, 多久磨, 西尾, 浩, 平尾, 薫丸, 岩田, 卓 and 青木, 大輔

産婦人科の実際 59 ( 3 ) 473 - 478 2010

ISSN 0558-4728

Abdominal radical trachelectomy as a fertility-sparing procedure in women with early-stage cervical cancer in a series of 61 women

Nishio, H., Fujii, T., Kameyama, K., Susumu, N., Nakamura, M., Iwata, T. and Aoki, D.

Gynecol Oncol 115 ( 1 ) 51 - 5 2009.10

ISSN 1095-6859

This retrospective study was conducted as a review of a series of women who had undergone abdominal radical trachelectomy and pelvic lymphadenectomy for early-stage cervical cancer.|We performed a retrospective review of patients who had undergone an abdominal radical trachelectomy. Data regarding tumor size and histology, surgical complications, recurrences, pregnancies and live births were collected and were presented as a percentage of the total number of cases.|A total of 61 women were followed up for a median of 27 months (range: one month--79 months). There were six recurrences (9.8%); none of the recurrences occurred in patients with a tumor diameter of <20 mm except in one case with adenocarcinoma. Twenty-nine women attempted to conceive; four of these women were successful. All four of these women had live births: two had preterm deliveries, and the remaining two had full-term deliveries. The cumulative pregnancy rate among the women who attempted to conceive was 13.8% (4/29).|Among selected women with early-stage cervical cancer, especially those with a tumor diameter of <20 mm, abdominal radical trachelectomy and pelvic lymphadenectomy is a fertility-sparing treatment option, even though the cumulative conception rate was not particularly high compared with that for women who had undergone a vaginal radical trachelectomy.

Access to Document (DOI)

Abdominal radical trachelectomy as a fertility-sparing procedure in women with early-stage cervical cancer in a series of 61 women

Nishio Hiroshi, Fujii Takuma, Kameyama Kaori, Susumu Nobuyuki, Nakamura Masaru, Iwata Takashi, Aoki Daisuke

Gynecologic Oncology 115 ( 1 ) 51 - 55 2009.10

ISSN 0090-8258

<p>Objective: This retrospective study was conducted as a review of a series of women who had undergone abdominal radical trachelectomy and pelvic lymphadenectomy for early-stage cervical cancer. Methods: We performed a retrospective review of patients who had undergone an abdominal radical trachelectomy. Data regarding tumor size and histology, surgical complications, recurrences, pregnancies and live births were collected and were presented as a percentage of the total number of cases. Results: A total of 61 women were followed up for a median of 27 months (range: one month - 79 months). There were six recurrences (9.8%); none of the recurrences occurred in patients with a tumor diameter of < 20 mm except in one case with adenocarcinoma. Twenty-nine women attempted to conceive; four of these women were successful. All four of these women had live births: two had preterm deliveries, and the remaining two had full-term deliveries. The cumulative pregnancy rate among the women who attempted to conceive was 13.8% (4/29). Conclusion: Among selected women with early-stage cervical cancer, especially those with a tumor diameter of < 20 mm, abdominal radical trachelectomy and pelvic lymphadenectomy is a fertility-sparing treatment option, even though the cumulative conception rate was not particularly high compared with that for women who had undergone a vaginal radical trachelectomy. © 2009 Elsevier Inc. All rights reserved.</p>

Access to Document (DOI)

当科更年期外来における更年期不定愁訴に対する漢方薬の使用状況について　8年前の調査結果との比較検討

牧田, 和也, 堀場, 裕子, 平沢, 晃, 岩田, 卓, 片岡, 史夫, 冨永, 英一郎, 堀口, 文, 青木, 大輔 and 吉村, 泰典

産婦人科漢方研究のあゆみ ( 26 ) 44 - 47 2009

ISSN 0913-865X

2006年1月〜2007年12月に更年期外来を3ヵ月以上継続通院した671例を抽出し、治療内容について外来カルテを中心に追跡調査し、2000年外来で行った同様調査結果と比較検討した。125例(18.6%)は特に継続的な薬物治療は行わず、血液検査や骨密度測定を定期的に施行している経過観察例、残り546例(81.4%)は継続的な薬物治療が行われていた。ホルモン補充療法(HRT)継続施行例は128例(19.1%)、漢方薬のみ使用例は54例(8.5%)であった。漢方薬の内訳は8年前の調査では桂枝茯苓丸の使用頻度が最も高く、加味逍遙散、牛車腎気丸、芍薬甘草湯の順であったが、今回調査でも使用頻度は桂枝茯苓丸が最も高く、以下加味逍遙散と共に慢性頭痛に対する呉茱萸湯、釣藤散使用例が急増していた。8年前調査では使用漢方薬の種類は10種類程度であったが今回調査では23種類に及んでいた。

【婦人科的基礎疾患を合併する妊娠・分娩の対応とその問題点】子宮頸癌合併妊娠

岩田, 卓, 西尾, 浩, 藤井, 多久磨 and 青木, 大輔

産婦人科の実際 58 ( 7 ) 999 - 1004 2009

ISSN 0558-4728

【産婦人科手術療法マニュアル】婦人科手術　悪性　子宮頸部円錐切除術

岩田, 卓, 藤井, 多久磨, 塚崎, 克己 and 青木, 大輔

産科と婦人科 76 ( Suppl. ) 217 - 223 2009

ISSN 0386-9792

卵巣腫瘍で腹腔鏡下手術を施行し、境界悪性腫瘍と診断された症例の術前MRI評価について

西尾, 浩, 藤井, 多久磨, 奥田, 茂男, 亀山, 香織, 大野, 暁子, 仲村, 勝, 岩田, 卓 and 青木, 大輔

日本産科婦人科内視鏡学会雑誌 25 ( 1 ) 246 - 251 2009

ISSN 1884-9938

良性卵巣腫瘍の術前診断で腹腔鏡下卵巣腫瘍摘出術および付属器切除術を施行し、術後病理検査で境界悪性腫瘍と診断された15例を対象に、術前MRI所見を後方視的に検討した。その結果、術前MRIで境界悪性腫瘍を含めた悪性腫瘍の可能性を示唆する所見を認めた症例は6例(40%)で、腫瘍内の一部に造影効果を認める充実部分が存在する(4例)、もしくは20cm以上の腫瘍径(2例)などの所見があった。その他の9例では悪性腫瘍を示唆する所見は指摘できなかった。また、術後に粘液性境界悪性腫瘍と診断された10例のうち8例(80%)は単房性腫瘍であり、そのうち6例(60%)はT1強調画像、T2強調画像ともに高信号を呈する内膜症性嚢胞と診断されていた。術後の臨床経過については、いずれの症例においても観察期間(平均36ヵ月)に再発所見を認めていない。

【QOLを考慮した婦人科がん治療】【妊孕能温存】　広汎性子宮頸部摘出術の適応と限界

西尾, 浩, 藤井, 多久磨, 仲村, 勝, 岩田, 卓 and 青木, 大輔

臨床婦人科産科 63 ( 12 ) 1495 - 1499 2009

ISSN 0386-9865

【子宮疾患・子宮内膜症の臨床　基礎・臨床研究のアップデート】腫瘍性疾患　頸部腫瘍　子宮頸上皮内癌

塚崎, 克己, 岩田, 卓, 藤井, 多久磨 and 青木, 大輔

日本臨床 67 ( 増刊5 子宮疾患・子宮内膜症の臨床 ) 200 - 205 2009

ISSN 0047-1852

産婦人科領域における最新の手術広汎性子宮頸部摘出術の適応と今後の課題

藤井, 多久磨, 西尾, 浩, 仲村, 勝, 岩田, 卓, 青木, 大輔 and 吉村, 泰典

日本産科婦人科学会東京地方部会会誌 58 ( 3 ) 295 - 296 2009

ISSN 0288-5751

広汎性子宮頸部摘出術は子宮頸部早期浸潤癌に対し、最近注目を集めている手術法である。この術式は安全性の確認が行われている段階で、長期予後は明らかとなっていない。我々の施設で施行された症例検討では腫瘍径が小さい扁平上皮癌では比較的安全と考えられる。一方、腫瘍径が大きいものや腺癌ではリスクが低くないことから注意を要する。この手術を施行するには患者への十分な情報提供が必要なことから、当面は限られた施設で適応規準を整備して施行することが手術を受ける患者にとって一番のメリットであると考えている。(著者抄録)

Ancillary testing of liquid-based cytology specimens for identification of patients at high risk of cervical cancer

Fujii, T., Saito, M., Iwata, T., Hirao, N., Nishio, H., Ohno, A., Tsukazaki, K., Mukai, M., Kameyama, K. and Aoki, D.

Virchows Arch 453 ( 6 ) 545 - 55 2008.12

ISSN 0945-6317

Integration of human papillomavirus DNAs into the host genome is crucial to the development of cervical cancer. Overexpression of the P16 protein has been reported in cervical intraepithelial neoplasia (CIN) as well as cervical cancer. Such molecular biomarkers have been utilized for ancillary testing of liquid-based cytology specimens; however, their clinical application remains controversial. To detect CIN 2 or more advanced lesions, 153 liquid-based cytology (LBC) specimens were investigated to determine the physical status of the human papillomavirus (HPV) DNA by in situ hybridization (ISH) and to detect overexpression of the P16 protein by immunocytochemistry combined with HPV genotyping by polymerase chain reaction. The combination of ISH, P16 immunocytochemistry, and LBC showed high sensitivity (89.3%) as well as high specificity (92.6%). We confirmed the usefulness of P16 immunocytochemistry combined with ISH and HPV genotyping as ancillary molecular-biological tests of LBC specimens for identifying patients at high risk of cervical cancer.

Access to Document (DOI)

Ancillary testing of liquid-based cytology specimens for identification of patients at high risk of cervical cancer

Fujii Takuma, Saito Miyuki, Iwata Takashi, Hirao Nobumaru, Nishio Hiroshi, Ohno Akiko, Tsukazaki Katsumi, Mukai Makio, Kameyama Kaori, Aoki Daisuke

Virchows Archiv 453 ( 6 ) 545 - 555 2008.12

ISSN 0945-6317

<p>Integration of human papillomavirus DNAs into the host genome is crucial to the development of cervical cancer. Overexpression of the P16 protein has been reported in cervical intraepithelial neoplasia (CIN) as well as cervical cancer. Such molecular biomarkers have been utilized for ancillary testing of liquid-based cytology specimens; however, their clinical application remains controversial. To detect CIN 2 or more advanced lesions, 153 liquid-based cytology (LBC) specimens were investigated to determine the physical status of the human papillomavirus (HPV) DNA by in situ hybridization (ISH) and to detect overexpression of the P16 protein by immunocytochemistry combined with HPV genotyping by polymerase chain reaction. The combination of ISH, P16 immunocytochemistry, and LBC showed high sensitivity (89.3%) as well as high specificity (92.6%). We confirmed the usefulness of P16 immunocytochemistry combined with ISH and HPV genotyping as ancillary molecular-biological tests of LBC specimens for identifying patients at high risk of cervical cancer. © 2008 Springer-Verlag.</p>

Access to Document (DOI)

子宮体がん術後患者における骨密度の特徴に関する検討

平沢, 晃, 牧田, 和也, 堀場, 裕子, 弟子丸, 亮太, 柳本, 茂久, 野村, 弘行, 片岡, 史夫, 岩田, 卓, 冨永, 英一郎, 阪埜, 浩司, 進, 伸幸, 堀口, 文 and 青木, 大輔

Osteoporosis Japan 16 ( 3 ) 429 - 431 2008

ISSN 0919-6307

産婦人科で初回治療として両側卵巣摘出術を伴う手術療法を施行した子宮体癌(体癌群)132例、健康維持外来を受診した非担癌自然閉経症例(対照群)224例、計356例を対象に、子宮体癌術後患者における骨代謝の特徴について自然閉経例と比較検討した。体癌群においては骨粗鬆症/骨量減少と診断できた症例は132例中35例(27%)で、対照群では224例中90例(40%)で、体癌群では骨量正常例が有意に多かった。また卵巣摘出時の閉経の有無によって骨粗鬆症/骨量減少の発生頻度に有意差を認めなかった。検討結果から、子宮体癌例は卵巣摘出を施行しているにも拘わらず、骨粗鬆症/骨量減少の高危険群とはいいがたいことが判明した。しかし、近年、若年発症例が増加していることから長期的フォローアップが必要と思われた。

Dendritic cell based personalized immunotherapy based on cancer antigen research

Kawakami, Y., Fujita, T., Kudo, C., Sakurai, T., Udagawa, M., Yaguchi, T., Hasegawa, G., Hayashi, E., Ueda, Y., Iwata, T., Wang, Q., Okada, S., Tsukamoto, N., Matsuzaki, Y. and Sumimoto, H.

Front Biosci 13 1952 - 8 2008

ISSN 1093-9946

Human tumor antigens were identified using various immunological and genetic methods, and immune responses to the identified antigens were evaluated in cancer patients. Autologous tumor specific unique antigens derived from genetic alterations in cancer cells were isolated from patients with favorable prognosis after immunotherapy, indicating that they are attractive targets for immunotherapy. Immunogenicity of shared antigens was found to differ among patients due to antigen expression in cancer cells and patients' immunoreactivity. These observations suggest that personalization may be applied for cancer immunotherapy. We therefore developed intratumoral DC administration protocols that are able to induce immune responses to both unique and shared tumor antigens expressed in each individual cancer. By combining cryoablative tumor pretreatment and TLR stimulated DC, the anti-tumor effect of the intratumoral DC administration was significantly augmented in a murine tumor model. This improved protocol enhanced systemic induction of anti-tumor CD8+ CTL, and was able to regress relatively large remote untreated tumors. In clinical trials, systemic immune induction was observed by intratumoral DC administration following cryoablative tumor treatment, although anti-tumor effects are relatively weak, indicating that additional interventions are required for more effective immunotherapy.

【妊娠中に発見された悪性腫瘍の取り扱い】子宮頸癌I a期に対する円錐切除術

西尾, 浩, 藤井, 多久磨, 仲村, 勝, 村上, 功, 岩田, 卓, 大野, 暁子, 塚崎, 克己 and 青木, 大輔

産婦人科の実際 57 ( 4 ) 633 - 637 2008

ISSN 0558-4728

　 Previous page - Next page 　