Hamatani, Toshio

写真a

Affiliation

School of Medicine, Department of Obstetrics and Gynecology (Obstetrics) (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor

External Links

Career 【 Display / hide

  • 2005.07
    -
    Present

    2005(Jul.)- Instructor in Dept. Obstetrics and Gynecology. Keio University School of Medicine. 2004(Aug.)-2005(Jun.) Instructor in Dept. Obstetrics and Gynecology. Tokyo Women’s Medical Uni

Academic Background 【 Display / hide

  • 1992.03

    Keio University, Faculty of Medicine

    University, Graduated

Academic Degrees 【 Display / hide

  • M.D., Ph.D., Keio University, Dissertation, 2000.10

Licenses and Qualifications 【 Display / hide

  • 医籍登録, 1992.05

  • 日本産科婦人科学会 産婦人科専門医, 1997.10

  • 医学博士, 2000.10

  • 日本生殖医学会 生殖医療専門医, 2007.04

  • 人類遺伝学会 臨床遺伝専門医, 2014.12

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Research Areas 【 Display / hide

  • Life Science / Developmental biology (Developmental Biology)

  • Life Science / Genetics (Heredity/Genome Dynamics)

  • Life Science / Obstetrics and gynecology (Obstetrics and Gynecology)

 

Books 【 Display / hide

  • ARTラボ必携(柴原浩章編)

    宇津野宏樹, 浜谷敏生, 中外医学社, 2022.03

    Scope: 人工授精に用いる精液の凍結保存方法

  • 今日の治療指針64巻(2020年版)

    医学書院, 2022.01

    Scope: 多嚢胞性卵巣症候群

  • 【やさしくわかる 産科婦人科検査マスターブック】産科と婦人科 87巻Suppl.

    祝井麻希, 浜谷敏生, 2020.03

    Scope: (第3章) 生殖内分泌分野 頸管粘液検査・Huhnerテスト,  Contact page: 250-252

  • 治療薬Up-To-Dateポケット判 2020年版(監修:矢崎義雄,編集:松澤佑次,永井良三,伊藤貞嘉,松原和夫)

    浜谷敏生, メディカルレビュー社, 2020.01,  Page: 552-565

    Scope: 女性ホルモン剤/女性生殖器用薬

  • 治療法の再整理とアップデートのために 1361専門家による私の治療 2019-2020年度版

    上條慎太郎, 浜谷敏生, 日本医事新報, 2019.07

    Scope: 無月経・乳汁漏出症候群/PRL分泌過剰症,  Contact page: 4970:44-45

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Papers 【 Display / hide

  • Assisted reproductive technology in Japan: A summary report for 2018 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology

    Ishihara O., Jwa S.C., Kuwahara A., Katagiri Y., Kuwabara Y., Hamatani T., Harada M., Osuga Y.

    Reproductive Medicine and Biology (Reproductive Medicine and Biology)  20 ( 1 ) 3 - 12 2021.01

    ISSN  14455781

     View Summary

    Purpose: Since 2007, the Japan Society of Obstetrics and Gynecology (JSOG) has collected cycle-based data for assisted reproductive technology (ART) in an online registry. Here, we present the characteristics and treatment outcomes of ART cycles registered during 2018. Methods: The Japanese ART registry consists of cycle-specific information for all ART treatment cycles implemented at 621 participating facilities. We conducted descriptive analyses for such cycles registered for 2018. Results: In total, 454 893 treatment cycles and 56 979 neonates were reported in 2018: both increased from 2017. The mean maternal age was 38.0 years (standard deviation ± 4.7). Of 247 402 oocyte retrievals, 118 378 (47.8%) involved freeze-all-embryos cycles; fresh embryo transfer (ET) was performed in 50 463 cycles: a decreasing trend since 2015. A total of 199 914 frozen-thawed ET cycles were reported, resulting in 69 357 pregnancies and 49 360 neonates born. Single ET (SET) was performed in 82.2% of fresh transfers and 83.4% of frozen-thawed cycles, with singleton pregnancy/live birth rates of 97.2%/97.2% and 97.0%/97.2%, respectively. Conclusions: Total ART cycles and subsequent live births increased in 2018. SET was performed in over 80% of cases, and the mode of ET has shifted continuously from using fresh embryos to frozen-thawed ones compared with previous years.

  • Infertility treatment hinders the careers of working women in Japan

    Ichikawa T., Ota I., Kuwabara Y., Tsushima R., Hamatani T., Hiraike O., Takeshita T., Osuga Y., Akira S.

    Journal of Obstetrics and Gynaecology Research (Journal of Obstetrics and Gynaecology Research)  46 ( 10 ) 1940 - 1950 2020.10

    ISSN  13418076

     View Summary

    Aim: Women undergoing infertility treatment often need to balance work and fertility treatment. Therefore, we evaluated the quality of life (QOL) and impact of infertility treatment on Japanese working women and their careers. Methods: We conducted an online questionnaire at 18 clinics in Japan. Responses were collected from 835 women, 713 of whom were working. The participants were divided into three groups based on treatment stage. Data were collected using the FertiQoL and an original questionnaire created by the authors. The Mann–Whitney U test and a multinomial logistic analysis were used. Results: Approximately 90% of the participants felt that treatment could hinder their work and 8% had quit their jobs. Low QOL was associated with sadness and despair due to infertility and mood disorders, disruptions to life and work, and the complicated medications and procedures involved in treatment. Social isolation and the effect of fertility treatment on daily life and work strongly hindered the careers of working women in the third stage of treatment (in vitro fertilization and intracytoplasmic sperm injection). Approximately 70% of the participants required support to subsidize treatment costs and sought shorter working hours and flextime systems. Only 55% informed their workplaces about the fertility treatment, but about 70% easily gained understanding by informing them. Conclusions: For many working women, infertility treatment posed barriers to their careers, which could explain the low QOL. Urgent introduction of a support system is necessary in Japan, and understanding and social acceptance of infertility appears to be important.

  • Assisted reproductive technology in Japan: A summary report for 2017 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology

    Ishihara O., Jwa S.C., Kuwahara A., Katagiri Y., Kuwabara Y., Hamatani T., Harada M., Ichikawa T.

    Reproductive Medicine and Biology (Reproductive Medicine and Biology)  19 ( 1 ) 3 - 12 2020.01

    ISSN  14455781

     View Summary

    Purpose: The Japan Society of Obstetrics and Gynecology (JSOG) has collected cycle-based assisted reproductive technology (ART) data in an online registry since 2007. Herein, we present the characteristics and treatment outcomes of ART cycles registered during 2017. Methods: We collected cycle-specific information for all ART cycles implemented at participating facilities and performed descriptive analysis. Results: In total, 448,210 treatment cycles and 56,617 neonates (1 in 16.7 neonates born in Japan) were reported in 2017, increased from 2016; the number of initiated fresh cycles decreased for the first time ever. The mean patient age was 38.0 years (standard deviation 4.6). A total 110,641 of 245,205 egg retrieval cycles (45.1%) were freeze-all cycles; fresh embryo transfer (ET) was performed in 55,720 cycles. A total 194,415 frozen-thawed ET cycles were reported, resulting in 66,881 pregnancies and 47,807 neonates born. Single ET (SET) was performed in 81.8% of fresh transfers and 83.4% of frozen cycles, with singleton pregnancy/live birth rates of 97.5%/97.3% and 96.7%/96.6%, respectively. Conclusions: Total ART cycles and subsequent live births increased continuously in 2017, whereas the number of initiated fresh cycles decreased. SET was performed in over 80% of cases, and ET shifted from using fresh embryos to frozen ones.

  • Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence

    Sasaki H., Hamatani T., Kamijo S., Iwai M., Kobanawa M., Ogawa S., Miyado K., Tanaka M.

    Frontiers in Endocrinology (Frontiers in Endocrinology)  10 2019.11

     View Summary

    Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in older women result in higher rates of miscarriage with aneuploidy. Age-related decline in fertility is strongly attributed to ovarian aging, diminished ovarian reserves, and decreased developmental competence of oocytes. In this review, we discuss the underlying mechanisms of age-related decline in oocyte quality, focusing on oxidative stress (OS) in oocytes. The primary cause is the accumulation of spontaneous damage to the mitochondria arising from increased reactive oxygen species (ROS) in oocytes, generated by the mitochondria themselves during daily biological metabolism. Mitochondrial dysfunction reduces ATP synthesis and influences the meiotic spindle assembly responsible for chromosomal segregation. Moreover, reproductively aged oocytes produce a decline in the fidelity of the protective mechanisms against ROS, namely the ROS-scavenging metabolism, repair of ROS-damaged DNA, and the proteasome and autophagy system for ROS-damaged proteins. Accordingly, increased ROS and increased vulnerability of oocytes to ROS lead to spindle instability, chromosomal abnormalities, telomere shortening, and reduced developmental competence of aged oocytes.

  • Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis

    Ogawa S., Yamada M., Nakamura A., Sugawara T., Nakamura A., Miyajima S., Harada Y., Ooka R., Okawa R., Miyauchi J., Tsumura H., Yoshimura Y., Miyado K., Akutsu H., Tanaka M., Umezawa A., Hamatani T.

    Stem Cell Reports (Stem Cell Reports)  12 ( 6 ) 1366 - 1379 2019.06

    ISSN  22136711

     View Summary

    © 2019 The Authors Zygotic genome activation (ZGA) begins after fertilization and is essential for establishing pluripotency and genome stability. However, it is unclear how ZGA genes prevent mitotic errors. Here we show that knockout of the ZGA gene Zscan5b, which encodes a SCAN domain with C2H2 zinc fingers, causes a high incidence of chromosomal abnormalities in embryonic stem cells (ESCs), and leads to the development of early-stage cancers. After irradiation, Zscan5b-deficient ESCs displayed significantly increased levels of γ-H2AX despite increased expression of the DNA repair genes Rad51l3 and Bard. Re-expression of Zscan5b reduced γ-H2AX content, implying a role for Zscan5b in DNA damage repair processes. A co-immunoprecipitation analysis showed that Zscan5b bound to the linker histone H1, suggesting that Zscan5b may protect chromosomal architecture. Our report demonstrates that the ZGA gene Zscan5b is involved in genomic integrity and acts to promote DNA damage repair and regulate chromatin dynamics during mitosis. In this article, Yamada and colleagues show that Zscan5b deficiency increases DNA stress, compromises chromosomal structure during mitosis, and leads to the development of early-stage cancers. Zscan5b deficiency may offer a murine model of human chromosomal breakage syndromes.

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Papers, etc., Registered in KOARA 【 Display / hide

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Reviews, Commentaries, etc. 【 Display / hide

  • 【受精と発生をめぐる話題】 着床前期胚発生における遺伝子発現調節機構

    浜谷敏生

    HORMONE FRONTIER IN GYNECOLOGY (メディカルレビュー社)  29 ( 1 )  2022.03

    Lead author, Last author, Corresponding author

  • 【最新知識の理解に役立つ 産婦人科医療の変遷と展望】生殖医療(ART)における調節卵巣刺激法

    浜谷敏生

    産婦人科の実際 70 ( 10 ) 1061 - 1067 2021.10

    Lead author, Last author, Corresponding author

  • 精子・卵子保存法の現在-「産む」選択肢をあきらめないために】配偶子保存の必要性と課題 化学療法・放射線療法の妊孕性への影響.

    HAMATANI TOSHIO

    臨床婦人科産科 72 ( 5 ) 410 - 416 2018.05

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

  • 【産婦人科外来パーフェクトガイド-いまのトレンドを逃さずチェック!】 疾患編 不妊・不育《人工授精》 提供精子を用いた人工授精(AID).

    HAMATANI TOSHIO

    臨床婦人科産科 72 ( 4 ) 163 - 166 2018.04

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

  • 産婦人科領域と炎症(青木大輔編著) 不妊治療における慢性炎症と着床不全

    HAMATANI TOSHIO

    別冊Bio Clinica: 慢性炎症と疾患 (北隆館)  6 ( 4 ) 78 - 83 2017.11

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

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Presentations 【 Display / hide

  • 提供精子を用いた人工授精の動向と課題

    浜谷敏生

    第12回岡山大学大学院保健学研究科公開セミナー「様々な家族のカタチ2:LGBTと家族形成」 (WEB開催) , 

    2021.06

  • ランションセミナー「~ART保険適応化とガイドライン策定に向けて~ EBMに基づいた卵巣刺激法の考察」

    浜谷敏生

    第62回日本卵子学会学術集会, 

    2021.05

  • 「婦人科内分泌学の概説」,シンポジウム12「リウマチ学における女性医学-next stageに向けて-」

    浜谷敏生

    第65回日本リウマチ学会学術集会 (神戸ポートピアホテル,神戸国際会議場・展示場) , 

    2021.04

  • 教育講演5「ART における調節卵巣刺激update」

    浜谷敏生

    第65回日本生殖医学会学術講演会 (WEB開催) , 

    2020.12

  • [シンポジウム6 種々な家族形成のかたち] 提供精子を用いた人工授精の現況と課題

    浜谷敏生

    第64回日本生殖医学会学術講演会 (兵庫県・神戸国際会議場) , 

    2019.11

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 胚および子宮内膜由来の細胞外分泌顆粒に着目した着床不全の病態解明と新規治療法開発

    2021.04
    -
    2025.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • 生殖とエクソソーム:卵成熟、受精、胚発生、着床におけるクロストーク機構の解明

    2016.04
    -
    2020.03

    Grant-in-Aid for Scientific Research, Research grant, Principal investigator

  • 卵子の老化および生殖細胞、卵巣の凍結保存に関する研究 分担課題:成熟卵胞内エクソソームの加齢変化

    2016.04
    -
    2019.03

    Japan Agency for Medical Research and Development (AMED), Health and Labour Sciences Research Grants, Research grant, Coinvestigator(s)

  • 卵子加齢の分子特性解明と新しいバイオマーカー開発の橋渡し研究

    2014.04
    -
    2017.03

    Grant-in-Aid for Scientific Research, Research grant, Coinvestigator(s)

  • 着床前期胚における「ゲノムの若返り」機構の解明

    2013.04
    -
    2016.03

    Grant-in-Aid for Scientific Research, Research grant, Principal investigator

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Awards 【 Display / hide

  • 第47回日本哺乳動物卵子学会 学術奨励賞 基礎部門

    HAMATANI TOSHIO, 2006.05, 日本哺乳動物卵子学会, マウス着床遅延モデルを用いた胚性着床因子の網羅的検討

    Type of Award: Award from Japanese society, conference, symposium, etc.

  • 三四会奨励賞

    HAMATANI TOSHIO, 2005.11, 慶應義塾大学医学部三四会, 着床前期胚の遺伝子発現プロファイリングとその動態解析

    Type of Award: Keio commendation etc.

  • Excellent Oral Presentation Award (The 57th Annual Congress of Japan Society of Obstetrics and Gynecology, Apr. 4, 2005)

    HAMATANI TOSHIO, 2005.04, Dynamics of global gene expression changes during mouse preimplantation development

    Type of Award: Award from Japanese society, conference, symposium, etc.

  • Shock Award (NIA Post-Doctoral Retreat Talk Winner, Sep. 17, 2003)

    HAMATANI TOSHIO, 2003.09, Aging in Oocytes

    Type of Award: Other

  • Serono Foundation Laureates - Reproductive Endocrinology Fellowship 2002(Feb.)-2004(Jan.)

    HAMATANI TOSHIO, 2001.07, Developmental Mechanism of Preimplantation Embryo in Mouse Using NIA 15K cDNA microarray

    Type of Award: Award from publisher, newspaper, foundation, etc.

 

Courses Taught 【 Display / hide

  • MEDICAL PROFESSIONALISM 6

    2022

  • LECTURE SERIES, OBSTETRICS

    2022

  • ADVANCED MEDICAL TECHNOLOGIES

    2022

  • MEDICAL PROFESSIONALISM 6

    2021

  • LECTURE SERIES, OBSTETRICS

    2021

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Memberships in Academic Societies 【 Display / hide

  • Associate Editor of "Human Reproduction Update", 

    2010
    -
    2013
  • Editorial board member of "Scientific Reports", 

    2015
    -
    2016
  • 日本生殖医学会 代議員, 

    2010
    -
    Present
  • 日本内分泌学会

     
  • 日本産科婦人科学会・東京産科婦人科学会・専門医制度委員会 (副委員長2013-), 

    2011
    -
    2015

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Committee Experiences 【 Display / hide

  • 2009.01
    -
    Present

    Associate editor, Human Reproduction Update