Nogami, Yuya

写真a

Affiliation

School of Medicine, Department of Obstetrics and Gynecology (Gynecology) ( Shinanomachi )

Position

Assistant Professor/Senior Assistant Professor
Scopus Paper Info  
Paper Count: 36 Citation Count: 756 h-index: 16

Click to view the Scopus page. The data was downloaded from Scopus API in August 23, 2026, via http://api.elsevier.com and http://www.scopus.com .

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Career 【 Display / hide 】

  • 2012.04
    -
    2016.09

    Keio University School of Medicine, Department of Obstetrics and Gynecology

  • 2016.10
    -
    2020.03

    Tokyo Medical Center, Obstetrics and Gynecology

  • 2020.04
    -
    2025.12

    Keio University School of Medicine, Department of Obstetrics and Gynecology

  • 2026.01
    -
    Present

    Keio University School of Medicine, Department of Obstetrics and Gynecology

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Academic Background 【 Display / hide 】

  • 2001.04
    -
    2007.03

    Keio University, School of Medicine

    University, Graduated, Master's course

  • 2013.04
    -
    2016.03

    Keio University, School of Medicine

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（医学）, Keio University, Coursework, 2016.03

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Papers 【 Display / hide 】

  • Fallopian tube nontuberculous mycobacterial infection caused by Mycobacterium abscessus mimicking fallopian tube carcinoma: A case report

    Fukunaga C., Kiyokawa S., Nakamura K., Kaneko Y., Kanazawa T., Manabe Y., Nogami Y., Uno S., Uwamino Y., Namkoong H., Yagi F., Muramoto H., Ueno A., Sekine S., Masuda K., Yamagami W.

    Case Reports in Women S Health 51 2026.09

    　View Summary

    Fallopian tube carcinoma is frequently detected at an advanced stage, and its imaging findings and tumor marker profiles are often indistinguishable from those of ovarian or peritoneal carcinoma. Nontuberculous mycobacteria (NTM) are environmental acid-fast bacilli with increasing clinical significance in both immunocompromised and immunocompetent individuals. Infection of gynecologic organs is extremely rare. This report describes a case of fallopian tube NTM infection caused by Mycobacterium abscessus that mimicked fallopian tube carcinoma. An 87-year-old woman underwent fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) during routine surveillance, which revealed focal FDG uptake in the right adnexal region. Serum CA125 was elevated, and magnetic resonance imaging demonstrated findings suspicious for fallopian tube carcinoma. Primary debulking surgery was performed. Intraoperative frozen-section examination of the right adnexa revealed necrotizing granulomas without evidence of malignancy, raising suspicion of mycobacterial infection. Fresh specimens were submitted for microbiological evaluation. Culture identified Mycobacterium abscessus, establishing the diagnosis of fallopian tube NTM infection. The patient was asymptomatic and had no abscess formation. Complete surgical resection was achieved, and no antimicrobial therapy was administered. The patient remained recurrence-free at 1-year follow-up. This case highlights the difficulty of differentiating infectious granulomatous disease from malignancy based on imaging findings alone. Intraoperative frozen-section examination played a crucial role in prompting microbiological investigation and establishing the correct diagnosis.

  • Primary Uterine NUT Carcinoma: A Case Report and Literature Review

    Shiraishi T., Kisu I., Kaneko N., Fukuda T., Watanabe J., Hayashi R., Ueno A., Emoto K., Nakamura K., Nogami Y., Tsuji K., Masuda K., Yamagami W.

    Clinics and Practice 16 ( 1 )  2026.01

    　View Summary

    Background: Nuclear protein in testis (NUT) carcinoma is a rare, aggressive, and poorly differentiated epithelial malignancy characterized by the rearrangement of NUTM1 (NUT midline carcinoma family member 1) on 15q14. It primarily originates along the midline structures, including the head, neck, thorax, and mediastinum. Although NUT carcinoma of the pelvic gynecological organs is exceedingly rare, reported cases have been limited to primary or metastatic ovarian tumors. Here, we present the first documented case of primary uterine NUT carcinoma. Case presentation: A 53-year-old postmenopausal woman presented with abnormal uterine bleeding and a uterine mass. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. The initial postoperative histopathological evaluation suggested undifferentiated endometrial sarcoma; however, subsequent immunohistochemical (IHC) analysis and fluorescence in situ hybridization revealed NUTM1 rearrangement, confirming the diagnosis of NUT carcinoma. The patient experienced tumor recurrence six months postoperatively and succumbed to the disease nine months later. Discussion: The pathological diagnosis was challenging; the presence of abrupt squamous differentiation prompted further IHC analysis, leading to the definitive diagnosis. Primary uterine NUT carcinoma may be misdiagnosed as other undifferentiated uterine tumors due to its rarity and histological overlap. Conclusions: Given the diagnostic challenges, NUT IHC staining and molecular testing for NUTM1 rearrangement should be considered in undifferentiated uterine tumors with ambiguous histopathological features.

  • LCN2-mediated ferroptosis resistance in tissue homeostasis and early-stage tumorigenesis of the fallopian tube epithelium

    Imaeda K., Tamura T., Nagai S., Sugihara E., Yamasaki J., Otsuki Y., Nakamura K., Takeda T., Nakamura K., Nogami Y., Tsuji K., Chiyoda T., Kisu I., Kobayashi Y., Banno K., Yamaguchi R., Sakurada K., Saya H., Aoki D., Ahmed A.A., Nagano O., Masuda K., Yamagami W.

    Iscience 28 ( 6 )  2025.06

    　View Summary

    While the fallopian tube epithelium (FTE) is known to be composed of various differentiated cells such as secretory and ciliated cells, the upstream regulatory mechanisms of cell differentiation that are essential for tissue homeostasis remain under investigation. In this study, we established human FTE organoids and identified quiescent cells within the early organoid formation by observing cellular proliferation heterogeneity. We also analyzed two single-cell transcriptomic data to trace the differentiation trajectory in human FTE, and found that the gene LCN2 serves as a marker gene of early stage of the trajectory. Genetically manipulated FTE organoids indicated that LCN2 inhibits ferroptosis and promotes cell survival under oxidative stress. In addition, the FTE organoids introduced p53 dysfunction, the common genetic characteristics of high-grade serous carcinoma, showed upregulated LCN2 expression and enhanced ferroptosis resistance. This study provides insights into the LCN2-mediated protective mechanism of human FTE quiescent cells and its potential role in tumorigenesis.

  • Safe Implementation of Robotic Surgery for Gynecologic Diseases at a Tertiary Center: Retrospective Analysis of 149 Cases and Review of the Literature

    Yoshimura T., Nishio H., Sakai K., Nogami Y., Hayashi S., Yamagami W.

    Gynecology and Minimally Invasive Therapy 14 ( 1 ) 33 - 39 2025

    ISSN  22133070

    　View Summary

    Objectives: The initial learning curve is a barrier to introducing robotic surgery. Evidence regarding appropriate simulation programs that allow for a smooth introduction of gynecological robotic surgery remains limited. Materials and Methods: We retrospectively analyzed 149 patients who underwent robotic surgery for gynecologic diseases. Before their first procedure, the surgeons completed a robotic surgery training program. Assistant surgeons also completed simulation programs, including setup procedures and manipulation of the robotic arm. Results: The mean (± standard deviation) operative, setup, and console times were 170 ± 54 min, 22 ± 8 min, and 126 ± 51 min, respectively. No patient required blood transfusion or conversion to laparoscopy or laparotomy. Patients undergoing surgery by the same surgeon were divided into three groups (first-third, middle-third, and last-third of patients undergoing surgery) to assess chronological changes. No statistically significant differences were found between the operative and console times among these groups. The setup times for the middle and last third of patients were 20 ± 7 min and 18 ± 7 min, respectively, which were statistically significantly shorter than those for the first third of patients. No significant differences in the operative and console times done by five physicians who completed programs were observed between the first 75 and the latter 74 procedures; however, the setup times of the latter 74 procedures were significantly shorter than those of the first 74 procedures (25 ± 9 min vs. 19 ± 6 min; P < 0.001). Conclusion: The setup time was influenced by clinical experience. An appropriate simulation program allowed a safe implementation of robotic surgery.

  • Ⅰ. Immunotherapy in Cervical Cancer-Current Approaches and Future Horizons

    Iwata T., Matsui T., Matsuda R., Katoh Y., Sugawara M., Nogami Y., Nishio H., Yamagami W.

    Gan to Kagaku Ryoho Cancer Chemotherapy 51 ( 2 ) 134 - 137 2024.02

    ISSN  03850684

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 婦人科感染症のNGSを用いた真の起因菌の解析による新たな治療戦略の基盤的研究

    2021.04
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    2023.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

  • 骨盤内膿瘍に対するMRスペクトロスコピーとNGSを用いた新たな診断治療法の構築

    2018.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

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Courses Taught 【 Display / hide 】

  • LECTURE SERIES, GYNECOLOGY

    2026

  • CLINICAL CLERKSHIP IN GYNECOLOGY

    2026

  • LECTURE SERIES, GYNECOLOGY

    2025

  • LECTURE SERIES, GYNECOLOGY

    2024

  • LECTURE SERIES, GYNECOLOGY

    2023

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