Ikenoue, Satoru



School of Medicine, Department of Obstetrics and Gynecology (Obstetrics) Perinatology (Shinanomachi)


Assistant Professor/Senior Assistant Professor


Research Keywords 【 Display / hide

  • Developmental Origins of Health and Disease

  • Fetal body composition

  • Fetal Physiology

  • Fetal ultrasonography

Research Themes 【 Display / hide

  • Fetal liver blood flow, 


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    Association between fetal liver blood flow volume and fetal body composition and newborn adiposity

  • Fetal body composition, 


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    Evaluation of fetal body composition and fat deposition using fetal ultrasonography

Proposed Theme of Joint Research 【 Display / hide

  • Intrauterine condition (fetal growth restriction) and pediatric obesity

    Interested in joint research with industry (including private organizations, etc.),  Desired form: Technical Consultation, Funded Research, Cooperative Research


Papers 【 Display / hide

  • Obstetric outcomes after medroxyprogesterone acetate treatment for early stage endometrial cancer or atypical endometrial hyperplasia: a single hospital-based study.

    Oishi M, Kasuga Y, Fukuma Y, Hamuro A, Tamai J, Tanaka Y, Hasegawa K, Yoshimura T, Ikenoue S, Ochiai D, Yamagami W, Tanaka M

    International journal of clinical oncology  2023.01

    ISSN  1341-9625

  • Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study.

    Villar J, Soto Conti CP, Gunier RB, Ariff S, Craik R, Cavoretto PI, Rauch S, Gandino S, Nieto R, Winsey A, Menis C, Rodriguez GB, Savasi V, Tug N, Deantoni S, Fabre M, Martinez de Tejada B, Rodriguez-Sibaja MJ, Livio S, Napolitano R, Maiz N, Sobrero H, Peterson A, Deruelle P, Giudice C, Teji JS, Casale RA, Salomon LJ, Prefumo F, Cheikh Ismail L, Gravett MG, Vale M, Hernández V, Sentilhes L, Easter SR, Capelli C, Marler E, Cáceres DM, Albornoz Crespo G, Ernawati E, Lipschuetz M, Takahashi K, Vecchiarelli C, Hubka T, Ikenoue S, Tavchioska G, Bako B, Ayede AI, Eskenazi B, Thornton JG, Bhutta ZA, Kennedy SH, Papageorghiou AT, INTERCOVID-2022 International Consortium

    Lancet (London, England)  2023.01

    ISSN  0140-6736

  • Fetal growth restriction and a single umbilical artery are independent predictors of hypospadias during pregnancy

    Endo T., Iida M., Ichihashi Y., Oishi M., Ikenoue S., Kasuga Y., Sato T., Hida M., Ishii T., Asanuma H., Hasegawa T., Tanaka M., Ochiai D.

    Placenta (Placenta)  130   53 - 59 2022.12

    ISSN  01434004

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    Introduction: Little is known about the association between hypospadias and small fetuses, as well as the pathological implications of fetal growth restriction (FGR). Thus, we aimed to investigate the association between hypospadias and small fetuses using a database of fetal ultrasound and obstetric events. Methods: A cohort of male singleton infants delivered after 22 weeks of gestation at Keio University Hospital between 2013 and 2019 was retrospectively reviewed. FGR was defined according to the Delphi criteria. Logistic regression analysis was performed to identify the significant predictors of hypospadias. Placental pathology was reviewed in cases with hypospadias. Results: Of the 2,040 male infants included in the present study, 23 had hypospadias. The prevalences of a single umbilical artery (SUA), small for gestational age, maternal hypertensive disorders of pregnancy, and a small placenta, were significantly higher in infants with hypospadias. Multiple logistic regression analysis revealed that FGR (odds ratio [OR] = 9.39; 95% confidence interval [CI], 2.50–35.3) and the presence of a SUA (OR = 33.4; 95% CI, 8.00–139.5) were independently and significantly associated with hypospadias. When FGR was stratified by the time of onset, its association with hypospadias was significant regardless of the time of onset. Moreover, placental histological findings suggested that fetal vascular malperfusion might play a role in hypospadias. Discussion: FGR and SUAs are independent prenatal predictors of the development of hypospadias, and fetal vascular malperfusion of the placenta may be involved in the etiology of hypospadias.

  • Exponential increase of the gestational-age-specific incidence of preeclampsia onset (COPE study): a multicenter retrospective cohort study in women with maternal check-ups at <20 weeks of gestation in Japan

    Ohkuchi A., Suzuki H., Matsubara K., Watanabe K., Saitou T., Oda H., Obata S., Kondo S., Noda K., Miyoshi J., Ikenoue S., Nomiyama M., Seki H., Sukegawa S., Ichigo S., Ando H., Fuseya C., Shimomura T., Suzuki R., Mimura K., Yasuhi I., Fukuda M., Hara S., Kurashina R., Shiozaki A., Matsubara S., Saito S.

    Hypertension Research (Hypertension Research)  45 ( 11 ) 1679 - 1689 2022.11

    ISSN  09169636

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    According to the 2004 Japanese definition, early-onset (EO) preeclampsia (PE) is defined as PE occurring at <32 weeks of gestation. This was based on the presence of “dual peaks” (30–31 and 34–35 weeks) in the prevalence of severe forms of hypertension. In contrast, the international definition adopted a cutoff of 34 weeks based on the consensus. Our aim was to investigate whether there were “dual peaks” in the gestational-age-specific incidence or prevalence of PE onset in pregnant women who underwent maternal check-ups at <20 weeks of gestation in a multicenter retrospective cohort study. Diagnoses of PE and superimposed preeclampsia (SPE) were based on the new Japanese definition. A total of 26,567 pregnant women with singleton pregnancy were investigated. The best fitting equations for the distribution of the onset of gestational-age-specific incidence (hazard) rates of PE/SPE, PE, and PE with severe hypertension (a systolic blood pressure ≥160 and/or a diastolic blood pressure ≥110 mmHg) were investigated using the curve estimation function in SPSS. PE/SPE occurred in 1.83% of the patients. EO-PE/SPE with onset at <32 and <34 weeks of gestation and preterm PE/SPE occurred in 0.38, 0.56, and 1.07% of the patients, respectively. Gestational-age-specific incidence rates of PE/SPE, PE, and PE with severe hypertension showed exponential increases, with very high R2 values (0.975, 0.976, and 0.964, respectively). There were no “dual peaks” in the prevalence rates of women with SPE/PE, PE, and PE with severe hypertension. In conclusion, the absence of “dual peaks” refutes the previous rationale of EO-PE being defined as PE at <32 weeks of gestation. Further studies to determine an appropriate definition of EO-PE/SPE are needed.

  • Effects of prenatal exposure to maternal COVID-19 and perinatal care on neonatal outcome: results from the INTERCOVID Multinational Cohort Study

    Giuliani F., Oros D., Gunier R.B., Deantoni S., Rauch S., Casale R., Nieto R., Bertino E., Rego A., Menis C., Gravett M.G., Candiani M., Deruelle P., García-May P.K., Mhatre M., Usman M.A., Abd-Elsalam S., Etuk S., Napolitano R., Liu B., Prefumo F., Savasi V., Do Vale M.S., Baafi E., Ariff S., Maiz N., Aminu M.B., Cardona-Perez J.A., Craik R., Tavchioska G., Bako B., Benski C., Hassan-Hanga F., Savorani M., Sentilhes L., Carola Capelli M., Takahashi K., Vecchiarelli C., Ikenoue S., Thiruvengadam R., Soto Conti C.P., Cetin I., Nachinab V.B., Ernawati E., Duro E.A., Kholin A., Teji J.S., Easter S.R., Salomon L.J., Ayede A.I., Cerbo R.M., Agyeman-Duah J., Roggero P., Eskenazi B., Langer A., Bhutta Z.A., Kennedy S.H., Papageorghiou A.T., Villar J.

    American Journal of Obstetrics and Gynecology (American Journal of Obstetrics and Gynecology)  227 ( 3 ) 488.e1 - 488.e17 2022.09

    ISSN  00029378

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    Background: The effect of COVID-19 in pregnancy on maternal outcomes and its association with preeclampsia and gestational diabetes mellitus have been reported; however, a detailed understanding of the effects of maternal positivity, delivery mode, and perinatal practices on fetal and neonatal outcomes is urgently needed. Objective: To evaluate the impact of COVID-19 on fetal and neonatal outcomes and the role of mode of delivery, breastfeeding, and early neonatal care practices on the risk of mother-to-child transmission. Study Design: In this cohort study that took place from March 2020 to March 2021, involving 43 institutions in 18 countries, 2 unmatched, consecutive, unexposed women were concomitantly enrolled immediately after each infected woman was identified, at any stage of pregnancy or delivery, and at the same level of care to minimize bias. Women and neonates were followed up until hospital discharge. COVID-19 in pregnancy was determined by laboratory confirmation and/or radiological pulmonary findings or ≥2 predefined COVID-19 symptoms. The outcome measures were indices of neonatal and perinatal morbidity and mortality, neonatal positivity and its correlation with mode of delivery, breastfeeding, and hospital neonatal care practices. Results: A total of 586 neonates born to women with COVID-19 diagnosis and 1535 neonates born to women without COVID-19 diagnosis were enrolled. Women with COVID-19 diagnosis had a higher rate of cesarean delivery (52.8% vs 38.5% for those without COVID-19 diagnosis, P<.01) and pregnancy-related complications, such as hypertensive disorders of pregnancy and fetal distress (all with P<.001), than women without COVID-19 diagnosis. Maternal diagnosis of COVID-19 carried an increased rate of preterm birth (P≤.001) and lower neonatal weight (P≤.001), length, and head circumference at birth. In mothers with COVID-19 diagnosis, the length of in utero exposure was significantly correlated to the risk of the neonate testing positive (odds ratio, 4.5; 95% confidence interval, 2.2–9.4 for length of in utero exposure >14 days). Among neonates born to mothers with COVID-19 diagnosis, birth via cesarean delivery was a risk factor for testing positive for COVID-19 (odds ratio, 2.4; 95% confidence interval, 1.2–4.7), even when severity of maternal conditions was considered and after multivariable logistic analysis. In the subgroup of neonates born to women with COVID-19 diagnosis, the outcomes worsened when the neonate also tested positive, with higher rates of neonatal intensive care unit admission, fever, gastrointestinal and respiratory symptoms, and death, even after adjusting for prematurity. Breastfeeding by mothers with COVID-19 diagnosis and hospital neonatal care practices, including immediate skin-to-skin contact and rooming-in, were not associated with an increased risk of newborn positivity. Conclusion: In this multinational cohort study, COVID-19 in pregnancy was associated with increased maternal and neonatal complications. Cesarean delivery was significantly associated with newborn COVID-19 diagnosis. Vaginal delivery should be considered the safest mode of delivery if obstetrical and health conditions allow it. Mother-to-child skin-to-skin contact, rooming-in, and direct breastfeeding were not risk factors for newborn COVID-19 diagnosis, thus well-established best practices can be continued among women with COVID-19 diagnosis.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 【191の疑問に答える 周産期の栄養】産科編Q&A 妊娠初期(Question 70) 妊娠初期の採血で血糖値が115mg/dLと高めでした。食事で注意すべきことは何ですか?

    池ノ上 学

    周産期医学 ((株)東京医学社)  52 ( 増刊 ) 158 - 158 2022.11

    ISSN  0386-9881

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  • 妊娠糖尿病母体出生児における新生児低血糖発症リスク因子に関する検討

    春日 義史, 池ノ上 学, 田中 守

    糖尿病と妊娠 ((一社)日本糖尿病・妊娠学会)  22 ( 3 ) S - 90 2022.11

    ISSN  1347-9172

  • 早期分娩誘発におけるジノプロストン腟用剤の有用性についての検討

    池ノ上 学

    糖尿病と妊娠 ((一社)日本糖尿病・妊娠学会)  22 ( 3 ) S - 80 2022.11

    ISSN  1347-9172

  • 予後と関連付けた胎児・胎盤機能の基礎的・臨床的病態解明と治療戦略-レビュー- 超音波を用いた新たな胎児発育評価

    池ノ上 学

    日本産科婦人科学会雑誌 ((公社)日本産科婦人科学会)  74 ( 10 ) 1628 - 1641 2022.10

    ISSN  0300-9165

  • 自然妊娠成立後、経腟分娩に至ったOHVIRA症候群合併妊娠の1例

    林 宥希, 福間 優花, 春日 義史, 玉井 順子, 葉室 明香, 田中 雄也, 長谷川 慶太, 池ノ上 学, 小林 佑介, 青木 大輔, 田中 守

    関東連合産科婦人科学会誌 ((一社)関東連合産科婦人科学会)  59 ( 3 ) 339 - 339 2022.10

    ISSN  2186-0610

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Presentations 【 Display / hide

  • Maternal Insulin Resistance Affects Fetal Body Composition.

    Ikenoue, Satoru, Waffarn, Feizal, Sumiyoshi, Kaeko, Ohashi, Masanao, Ikenoue, Chigusa, Lindsey, Karen, Claudia, Buss, Entringer, Sonja, Wadhwa, Pathik D.



    Poster presentation

  • Prospective association of fetal liver blood flow at 30 weeks gestation with newborn adiposity

    Ikenoue, Satoru, Waffarn, Feizal, Ohashi, Masanao, Sumiyoshi, Kaeko, Ikenoue, Chigusa, Buss, Claudia, Gillen, Daniel L., Simhan, Hyagriv N., Entringer, Sonja, Wadhwa, Pathik D.



    Poster presentation

Research Projects of Competitive Funds, etc. 【 Display / hide

  • 胎児発育不全における胎児肝血流量および軟部組織量を用いた周産期予後の予測


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Principal investigator

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    胎児発育不全(FGR)は、周産期予後不良因子の一つであり、また生活習慣病などの児の長期予後にも関連する。FGRの管理や娩出時期については確立されたエビデンスは未だ乏しく、FGRの予後予測因子の解明が望まれている。 近年、胎児肝血流量が胎児の軟部組織量(脂肪量・骨格筋量)に関連し、胎児発育の予測に有用であることが報告されている。そこで本研究では、FGRにおいて肝血流量および軟部組織量を測定し、周産期予後との関連について検討を行う。胎児肝血流量や軟部組織量が周産期予後に関する新たなパラメーターとなれば、FGRにおける周産期予後の改善へ繋がる可能性がある。


Courses Taught 【 Display / hide











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