Ikenoue, Satoru



School of Medicine, Department of Obstetrics and Gynecology Perinatology (Shinanomachi)




Research Keywords 【 Display / hide

  • Developmental Origins of Health and Disease

  • Fetal body composition

  • Fetal Physiology

  • Fetal ultrasonography

Research Themes 【 Display / hide

  • Fetal liver blood flow, 


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    Association between fetal liver blood flow volume and fetal body composition and newborn adiposity

  • Fetal body composition, 


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    Evaluation of fetal body composition and fat deposition using fetal ultrasonography

Proposed Theme of Joint Research 【 Display / hide

  • Intrauterine condition (fetal growth restriction) and pediatric obesity

    Interested in joint research with industry (including private organizations, etc.),  Desired form: Technical Consultation, Funded Research, Cooperative Research


Papers 【 Display / hide

  • In Utero Amniotic Fluid Stem Cell Therapy Protects Against Myelomeningocele via Spinal Cord Coverage and Hepatocyte Growth Factor Secretion

    Abe, Y., Ochiai, D., Masuda, H., Sato, Y., Otani, T., Fukutake, M., Ikenoue, S., Miyakoshi, K., Okano, H. and Tanaka, M.

    Stem Cells Transl Med (Stem Cells Translational Medicine)  8 ( 11 ) 1170 - 1179 2019.08

    ISSN  2157-6564

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    Despite the poor prognosis associated with myelomeningocele (MMC), the options for prenatal treatments are still limited. Recently, fetal cellular therapy has become a new option for treating birth defects, although the therapeutic effects and mechanisms associated with such treatments remain unclear. The use of human amniotic fluid stem cells (hAFSCs) is ideal with respect to immunoreactivity and cell propagation. The prenatal diagnosis of MMC during early stages of pregnancy could allow for the ex vivo proliferation and modulation of autologous hAFSCs for use in utero stem cell therapy. Therefore, we investigated the therapeutic effects and mechanisms of hAFSCs-based treatment for fetal MMC. hAFSCs were isolated as CD117-positive cells from the amniotic fluid of 15- to 17-week pregnant women who underwent amniocentesis for prenatal diagnosis and consented to this study. Rat dams were exposed to retinoic acid to induce fetal MMC and were subsequently injected with hAFSCs in each amniotic cavity. We measured the exposed area of the spinal cord and hepatocyte growth factor (HGF) levels at the lesion. The exposed spinal area of the hAFSC-treated group was significantly smaller than that of the control group. Immunohistochemical analysis demonstrated a reduction in neuronal damage such as neurodegeneration and astrogliosis in the hAFSC-treated group. Additionally, in lesions of the hAFSC-treated group, HGF expression was upregulated and HGF-positive hAFSCs were identified, suggesting that these cells migrated to the lesion and secreted HGF to suppress neuronal damage and induce neurogenesis. Therefore, in utero hAFSC therapy could become a novel strategy for fetal MMC. Stem Cells Translational Medicine 2019.

  • 日本人妊娠糖尿病既往女性における産後糖代謝異常発症予測因子に関する後方視的検討

    春日 義史, 宮越 敬, 税所 芳史, 池ノ上 学, 荒田 尚子, 田中 守

    糖尿病と妊娠 ((一社)日本糖尿病・妊娠学会)  19 ( 2 ) S - 67 2019.08

    ISSN  1347-9172

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    日本人妊娠糖尿病(Gestational Diabetes Mellitus:GDM)既往女性における産後糖代謝異常(Postpartum Abnormal Glucose Tolerance:pAGT)発症予測因子を検討した。対象は日本人GDM合併単胎妊婦のうち、分娩後1年以内に75gOGTTを受けた女性である(pAGT[n=59]、正常耐糖能型[n=154])。GDM診断時OGTT血糖値ならびに遺伝因子とpAGTとの関連解析を行ったところ、OGTT2時間値のpAGT発症予測能が高かった(AUC=0.72)。遺伝因子では4遺伝子がpAGT群においてリスクアレルを多く持つ傾向にあり、検出された4遺伝子中、3遺伝子はインスリン分泌関連遺伝子であった。日本人GDM既往女性において、GDM診断時OGTT 2時間値がpAGT発症予測に有用であり、遺伝学的にインスリン分泌不全の関与が示唆された。(著者抄録)

  • 妊娠糖尿病における抗Glutamic Acid Decarboxylase抗体と周産期事象との関連

    池ノ上 学, 宮越 敬, 遠藤 豊英, 大石 真希, 税所 芳史, 田中 守

    糖尿病と妊娠 ((一社)日本糖尿病・妊娠学会)  19 ( 2 ) S - 84 2019.08

    ISSN  1347-9172

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    抗Glutamic Acid Decarboxylase(GAD)抗体は、自己免疫性1型糖尿病の診断や発症予知に用いられる膵島関連自己抗体であるが、妊娠糖尿病(Gestational diabetes mellitus:GDM)との関連に関する知見は乏しい。今回、抗GAD抗体の測定を行ったGDM妊婦172例を対象とし、GDM妊婦におけるGAD抗体の陽性率と、その母体背景および周産期予後との関連について検討した。GDMにおけるGAD抗体陽性率は3.5%であり、抗GAD抗体陽性例では妊娠高血圧腎症が有意に高率であった。その他の周産期事象や母体背景には有意差を認めなかった。GDM妊婦において、抗GAD抗体は妊娠高血圧腎症のリスク因子となる可能性が示唆された。(著者抄録)

  • Changes in bone metabolic profile associated with pregnancy or lactation

    Miyamoto, T., Miyakoshi, K., Sato, Y., Kasuga, Y., Ikenoue, S., Miyamoto, K., Nishiwaki, Y., Tanaka, M., Nakamura, M. and Matsumoto, M.

    Sci Rep (Scientific Reports)  9 ( 1 ) 6787 2019.05

    ISSN  2045-2322

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    Calcium and nutrients are transferred from mothers to fetuses or infants during pregnancy or lactation, respectively, promoting metabolic changes in the mother, many uncharacterized. To evaluate these changes, we undertook two parallel studies. In one we analyzed fourteen clinical cases of vertebral fragility fractures, at or before three months after partum, in mothers who breastfed their infants. In the other, we enrolled 79 additional pregnant subjects, some who chose to breastfeed and others who did not, and analyzed changes in bone metabolic status starting between 34 and 36 weeks of gestation and ending one month after partum. In the larger group, bone-resorbing and bone-forming parameters such as serum TRACP5b and osteocalcin, respectively, significantly increased after partum. Among parameters that changed after partum, serum PTH and the bone-resorbing markers serum TRACP5b and urine NTX were significantly higher in mothers who only breastfed infants compared to mothers who fed infants formula or a mix of both. However, bone-forming parameters were comparable between breastfeeding and non-breast-feeding groups after partum, suggesting that elevated bone-resorption occurs only in the breastfeeding group. Radiographic analysis after partum demonstrated that no subject among the 79 analyzed showed vertebral fractures, even those who breastfed exclusively. Among fracture cases analyzed, subjects exhibited significantly lower bone mineral density than did non-fracture cases in breastfeeding-only subjects. We conclude that bone metabolic status significantly changes over the period between pregnancy and post-partum lactation, and that low bone mineral density seen in a small subset of breastfeeding-only cases likely causes post-partum vertebral fragility fractures.

  • Glycemic and metabolic features in gestational diabetes: singleton versus twin pregnancies

    Akiba, Y., Miyakoshi, K., Ikenoue, S., Saisho, Y., Kasuga, Y., Ochiai, D., Matsumoto, T. and Tanaka, M.

    Endocr J  2019.04

    ISSN  1348-4540

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    A number of data on gestational diabetes mellitus (GDM) in singleton pregnancy is available, however, little is known about the glycemic characteristics of twin pregnancy with GDM. The aim of this study was to compare the severity of dysglycemia between twin and singleton pregnancies with GDM (T-GDM and S-GDM). We retrospectively analyzed pregnancies with GDM defined by the Japan Diabetes Society criteria (T-GDM, n = 20; S-GDM, n = 451) in our hospital. During the study period, women with GDM underwent self-monitoring of blood glucose measurements as well as dietary management. Insulin treatment was initiated when dietary treatment did not achieve the glycemic goal. The glycemic and metabolic characteristics were compared between T-GDM and S-GDM, as follows: gestational week at the diagnosis of GDM, 75 g oral glucose tolerance test (OGTT) results, HbA1c, insulin secretion (i.e. insulinogenic index [IGI] and Insulin Secretion-Sensitivity Index-2 [ISSI-2]), and insulin requirement before delivery. The rate of one abnormal OGTT value in T-GDM was similar to that in S-GDM (60% vs. 71%). There were no significant differences in gestational week and levels of HbA1c at diagnosis, levels of IGI and ISSI-2 between T-GDM and S-GDM (median, 20 weeks vs. 17 weeks, 5.0% vs. 5.2%, 0.58 vs. 0.71, 1.7 vs. 1.8, respectively). The rate of insulin treatment and a median dosage of insulin needed before delivery was comparable between the two groups (T-GDM vs. S-GDM: 45% vs. 32% and 14 vs. 13 unit/day). Our data suggested that the severity of dysglycemia in T-GDM was similar to that in S-GDM during pregnancy.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 【血栓性微小血管症(TMA)の臨床】妊娠関連TMA(HELLP症候群を含む)

    池ノ上 学, 田中 守

    日本血栓止血学会誌 ((一社)日本血栓止血学会)  31 ( 1 ) 55 - 60 2020.02

    ISSN  0915-7441

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    血栓性微小血管症(thrombotic microangiopathy:TMA)は、微小血管症性溶血性貧血、消費性血小板減少、微小血管内血小板血栓による臓器症状を3主徴とする病態である。妊娠に関連したTMAとしては、ADAMTS13活性著減による血栓性血小板減少性紫斑症(thrombotic thrombocytopenic purpura:TTP)、補体制御異常による非典型的溶血性尿毒症症候群(atypical hemolytic uremic syndrome:aHUS)、HELLP症候群を含む二次性TMAが挙げられる。妊娠関連TMAでは、急性期の適切な診断と治療が予後に直結するため、溶血性貧血に伴い急激な血小板減少や臓器障害を認めた場合、早期からTMAを鑑別に挙げる必要がある。また、HELLP症候群が疑われた症例においても、非典型的に臓器症状が重症化・遷延した場合には、aHUSやTTPの可能性を考慮することが肝要である。(著者抄録)

  • 当院における広汎性子宮頸部摘出術後妊娠に対する取り組み

    春日 義史, 池ノ上 学, 西尾 浩, 仲村 勝, 落合 大吾, 岩田 卓, 田中 京子, 飛騨 麻里子, 浜谷 敏生, 宮越 敬, 勝又 徳子, 菊地 敦子, 田中 守, 青木 大輔

    日本周産期・新生児医学会雑誌 ((一社)日本周産期・新生児医学会)  55 ( 別冊 ) 32 - 33 2020.01

    ISSN  1348-964X

  • やせ妊娠糖尿病合併妊婦の糖代謝および臨床像に関する検討

    春日 義史, 宮越 敬, 佐藤 佑, 池ノ上 学, 税所 芳史, 田中 守

    糖尿病と妊娠 ((一社)日本糖尿病・妊娠学会)  19 ( 3 ) S - 85 2019.11

    ISSN  1347-9172

  • 新基準妊娠糖尿病に対する血糖管理の意義を胎児エピゲノムの観点から考える

    春日 義史, 河合 智子, 池ノ上 学, 落合 大吾, 税所 芳史, 飛彈 麻里子, 宮越 敬, 秦 健一郎, 田中 守

    日本女性栄養・代謝学会学術集会プログラム・抄録集 (日本女性栄養・代謝学会)  43回   54 - 54 2019.09

  • 妊娠中に発症した脳動脈解離の1例

    秋田 啓介, 玉川 真澄, 上條 慎太郎, 春日 義史, 池ノ上 学, 落合 大吾, 宮越 敬, 田中 守

    日本妊娠高血圧学会雑誌 (日本妊娠高血圧学会)  26   62 - 62 2019.09

    ISSN  1880-3172

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Presentations 【 Display / hide

  • Maternal Insulin Resistance Affects Fetal Body Composition.

    Ikenoue, Satoru, Waffarn, Feizal, Sumiyoshi, Kaeko, Ohashi, Masanao, Ikenoue, Chigusa, Lindsey, Karen, Claudia, Buss, Entringer, Sonja, Wadhwa, Pathik D.

    REPRODUCTIVE SCIENCES, 2018.03, Poster (general)

  • Prospective association of fetal liver blood flow at 30 weeks gestation with newborn adiposity

    Ikenoue, Satoru, Waffarn, Feizal, Ohashi, Masanao, Sumiyoshi, Kaeko, Ikenoue, Chigusa, Buss, Claudia, Gillen, Daniel L., Simhan, Hyagriv N., Entringer, Sonja, Wadhwa, Pathik D.



Courses Taught 【 Display / hide