Ikenoue, Satoru

写真a

Affiliation

School of Medicine, Department of Obstetrics and Gynecology (Obstetrics) Perinatology (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor

External Links
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Research Keywords 【 Display / hide 】

  • Developmental Origins of Health and Disease

  • Fetal body composition

  • Fetal Physiology

  • Fetal ultrasonography

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Research Themes 【 Display / hide 】

  • Fetal body composition, 

    2014.04
    -
    Present

    　View Summary

    Evaluation of fetal body composition and fat deposition using fetal ultrasonography

  • Fetal liver blood flow, 

    2014.04
    -
    Present

    　View Summary

    Association between fetal liver blood flow volume and fetal body composition and newborn adiposity

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Proposed Theme of Joint Research 【 Display / hide 】

  • Primary prevention of ealy onset metabolic syndrome from intrauterine period

    Interested in joint research with industry (including private organizations, etc.),  Desired form： Technical Consultation, Funded Research, Cooperative Research

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Books 【 Display / hide 】

  • 【人生最初の1000日間と疾患感受性】胎児発育からみた次世代の健康

    池ノ上 学, (株)ニュー・サイエンス社, 2023.07

    　View Summary

    出生体重は周産期予後の予測因子であるだけでなく,メタボリックシンドロームをはじめとした児の長期予後とも関連する(DOHaD)。これまでに新生児期の体脂肪率と,小児期の体脂肪率や肥満との関連が既に報告されている。さらに,妊娠後期における胎児脂肪量や肝血流量が新生児体脂肪率の有用な予測因子であることが,近年明らかとなっており,肥満の起原は胎児期まで遡る可能性がある。今後,胎児脂肪量の規定因子を解明していくことで,児の周産期予後のみでなく長期予後に関連する病態の解明や,早期発症メタボリックシンドロームの一次予防へとつながる可能性がある。(著者抄録)

  • 【超音波がもたらす産婦人科診療の新機軸】臨床への新たな活用法と工夫 妊娠糖尿病妊婦の胎児評価への応用

    池ノ上 学, (株)診断と治療社, 2023.02

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    ＜文献概要＞妊娠糖尿病(GDM)では,妊娠後期に体幹・上肢の脂肪量が増加し,肩甲難産のリスクが上昇する.そのような軟部組織量の増加した児では,特に胎児推定体重と出生体重の誤差が大きくなる傾向にある.GDMにおいて,従来の胎児推定体重の算出のみでなく,脂肪・骨格筋などの胎児軟部組織量の評価を行っていくことで,巨大児や肩甲難産の予測,さらには出生児の小児肥満やメタボリックシンドロームの一次予防へとつながる可能性がある.

  • 【胎児治療の進歩と今後の展望】胎児輸血の適応と方法

    葉室 明香, 池ノ上 学, (株)東京医学社, 2023.01

  • 【Controversies in perinatology 2023産科編】骨盤位の外回転術 施行しない

    池ノ上 学, (株)東京医学社, 2022.12

  • 【191の疑問に答える 周産期の栄養】産科編Q&A 妊娠初期(Question 70) 妊娠初期の採血で血糖値が115mg/dLと高めでした。食事で注意すべきことは何ですか?

    池ノ上 学, (株)東京医学社, 2022.11

    　View Summary

    ＜ポイント＞・糖質の摂取量は総エネルギーの55%程度を占めるようにし,脂質もエネルギー比率で20〜30%程度摂取する。・成人女性の蛋白質所要量は約50g/日であるが,妊娠初期には0g,中期には5g,後期には25g程度付加する。・エネルギー摂取量が不足した状態では,微量栄養素の摂取が不足することもあり,バランスよく摂取する必要がある。(著者抄録)

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Papers 【 Display / hide 】

  • Virtual telehealth visits for prenatal checkups during the COVID- 19 pandemic in Japan: a nationwide survey and feasibility study

    Kobayashi M., Nakagawa S., Kamei Y., Maenaka T., Hiramatsu K., Mimura K., Kimura T., Ueda Y., Fujii M., Endo M., Adachi K., Kurokawa S., Maeda T., Ikenoue S., Tanaka M., Kimura T.

    BMC Pregnancy and Childbirth 25 ( 1 ) 476 2025.12

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    Background: We investigated the use of virtual telehealth visits (VV) for prenatal checkups in Japan during the coronavirus disease (COVID-19) pandemic, identified challenges associated with their use, and assessed the feasibility of future VV implementation for prenatal care. Methods: Surveys were conducted at birthing facilities across Japan and with pregnant women attending Osaka and Keio University hospitals. To assess the feasibility of VV, we compared the self-measured blood pressure, fundal height, urinary test results, and fetal heart rate of pregnant women with those measured by healthcare providers. Results: We received responses from 1,096 birthing facilities (49.5% response rate) and 96 women. Only 1.6% of birthing facilities implemented VV, mainly due toto a lack of human resources, costs, and low demand from both patients and healthcare providers. In contrast, 60.2% of pregnant women expressed anxiety about in-person visits during the pandemic, and 36.6% preferred the introduction of VV. The Pearson correlation coefficients between self-measured and provider-measured values systolic and diastolic blood pressure and fundal height were 0.68, 0.58, and 0.87, respectively. The concordance rates for proteinuria and urinary glucose were 91.6% and 98.9%, respectively. However, the correlation for fetal heart rate measurements was poor (-0.04). Bland–Altman analysis revealed 95% limits of agreement ranging from -42.6 to 65.6 bpm, indicating the need for methodological improvement. Conclusion: Despite maternal interest, VV has been limitedly implemented in Japan. Our study found that self-measured values, except for fetal heart rate, were highly correlated with those measured by healthcare providers. These findings are important for healthcare providers and government agencies when considering future prenatal checkups.

  • Maternal Serum 25-Hydroxyvitamin D as a Possible Modulator of Fetal Adiposity: A Prospective Longitudinal Study

    Akita K., Ikenoue S., Tamai J., Otani T., Fukutake M., Kasuga Y., Tanaka M.

    International Journal of Molecular Sciences 26 ( 9 )  2025.05

    ISSN  16616596

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    25-hydroxyvitamin D (25(OH)D) regulates lipid metabolism, and its decrease is proposed as a pathogenesis of metabolic syndrome, gestational diabetes mellitus (GDM), and eventually fetal adiposity. Decreased 25(OH)D is also linked with the development of gestational diabetes mellitus (GDM), which is associated with increased fetal adiposity. Fetuses are dependent on the supply of 25(OH)D from maternal circulation. However, the influence of maternal serum 25(OH)D on fetal adiposity remains unclear. This study aimed to investigate the association between maternal serum 25(OH)D and fetal adiposity. A prospective longitudinal study was conducted in a cohort of 89 (including 21 GDM) singleton pregnancies. Maternal blood samples were obtained at 10, 24, 30, and 36 weeks, and fetal ultrasonography was performed at 24, 30, and 36 weeks of gestation. Estimated fetal adiposity (EFA) was calculated as the average z-score of cross-sectional arm and thigh percentage fat area and anterior abdominal wall thickness as previously reported. The multiple linear regression analyses indicated that maternal 25(OH)D levels across gestation were not associated with EFA at 24 and 30 weeks, while maternal 25(OH)D at 24 weeks was inversely correlated with EFA at 36 weeks. Particularly, in the GDM group, maternal 25(OH)D levels at 10, 24, 30, and 36 weeks all showed a significant negative correlation with EFA at 36 weeks. Decreased maternal serum 25(OH)D level could be an early biomarker of increased fetal adiposity in late gestation, especially in diabetic pregnancies.

  • The Association Between Glucose Variability and Insulin Parameters in Gestational Diabetes Diagnosed After 24 Gestational Weeks

    Kasuga Y., Kajikawa K., Ishikawa N., Ogata Y., Takahashi M., Akita K., Tamai J., Fukuma Y., Tanaka Y., Otani T., Fukutake M., Ikenoue S., Tanaka M.

    Nutrients 17 ( 3 )  2025.02

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    Background/Objectives: Recently, it was reported that glucose variability (GV) calculated using the 75 g oral glucose tolerance test (OGTT) is associated with adverse perinatal outcomes. However, its role in gestational diabetes mellitus (GDM) remains unclear. We investigated the association between GV and insulin parameters in Japanese women diagnosed with GDM after 24 weeks of gestation (late GDM). Methods: A total of 280 mothers with late GDM cared for at Keio University Hospital were included in this study. Using 75 g OGTT, the initial increase and subsequent decrease were calculated as the GV. Results: The initial increase was significantly positively associated with 1 h plasma glucose level (PG) and 2 h PG with 75 g OGTT (p < 0.001), but fasting PG, insulinogenic index (IGI), and homeostasis model assessment—insulin resistance were negatively associated with the initial increase (all p < 0.001). The subsequent decrease was significantly positively correlated with 1 h PG (p < 0.001) but negatively correlated with 2 h PG (p < 0.001), IGI (p = 0.009), and the whole-body insulin sensitivity index derived from the OGTT (p = 0.02). Insulin Secretion-Sensitivity Index-2 was not associated with an initial increase or subsequent decrease. Conclusions: Since the initial increase might reflect insulin secretion and the subsequent decrease might reflect insulin sensitivity in Japanese women with late GDM, GV could alter several insulin parameters. Further studies are required to investigate the usefulness of GV in the management of GDM.

  • Efficacy of controlled-release dinoprostone vaginal insert for elective induction of labor before due date

    Tamai J., Ikenoue S., Akita K., Fukuma Y., Tanaka Y., Hasegawa K., Otani T., Kasuga Y., Tanaka M.

    Journal of Obstetrics and Gynaecology Research 50 ( 12 ) 2226 - 2230 2024.12

    ISSN  13418076

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    Aim: The induction of labor before due date has recently been proved to reduce the rate of cesarean sections and is not associated with increased risk of adverse perinatal outcomes as compared to expectant management. Controlled-release dinoprostone (PGE2) vaginal insert has recently been approved for use in Japan. However, evidence regarding its efficacy in cervical ripening and labor induction before due date remains limited. We aimed to compare the efficacy of PGE2 vaginal inserts and mechanical dilation for labor induction before due date. Methods: This retrospective cohort study included 206 mothers at 37, 38, and 39 weeks' gestation delivered at our institution between January 2021 and October 2022. Perinatal outcomes, including the success rate of vaginal delivery, were compared between the PGE2 (n = 46) and metreurynter/laminaria tent (non-PGE2) (n = 160) groups. The success rate of vaginal delivery was defined as the proportion of women who delivered vaginally within 48 h of initiating oxytocin augmentation. Results: The success rate of vaginal delivery was significantly higher in the PGE2 group (37/49, 80.4%) than in the non-PGE2 group (106/177, 66.2%). Emergency cesarean section related to non-reassuring fetal status was performed with none in the PGE2 group and with eight (5.0%) in the non-PGE2 group. Conclusions: The rate of vaginal delivery was significantly higher in the PGE2 group for elective labor induction between 37 and 39 weeks. The PGE2 vaginal insert could increase the success rate of vaginal delivery for elective induction of labor at 39 weeks.

  • Origins of obesity in the womb: Fetal adiposity and its determinants

    Ikenoue S., Tamai J., Akita K., Otani T., Kasuga Y., Tanaka M.

    Journal of Obstetrics and Gynaecology Research 50 ( 12 ) 2178 - 2182 2024.12

    ISSN  13418076

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    Birth weight is an important predictor of perinatal complications and long-term health outcomes of offspring. Fetal programming influenced by maternal obesity, overnutrition, and hyperglycemia has been proposed as the fuel overload hypothesis. Recent investigations related with fetal body composition have revealed that neonatal adiposity can be predicted by fetal fat mass, and that maternal insulin resistance and serum leptin level are indicators of fetal adiposity. Based on the current evidence, the origins of obesity can partly be traced back into the fetal life. Further clarification of the determinants of fetal fat mass may lead to the clinical interventions and treatment strategies for fetal growth and development. This effort potentially leads to the elucidation of pathological conditions related with long-term health outcomes and the primary prevention of childhood obesity and early onset metabolic syndrome.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 妊娠中体重減少が周産期予後に与える影響

    木村 由実子, 春日 義史, 秋田 啓介, 玉井 順子, 福間 優花, 田中 雄也, 大谷 利光, 池ノ上 学, 山上 亘, 田中 守

    日本産科婦人科学会雑誌 ((公社)日本産科婦人科学会)  77 ( 臨増 ) S - 619 2025.02

    ISSN  0300-9165

  • 【鑑別フローチャートで症候ごとに考える　妊娠期別　産科救急ナビゲーション】(第2部)疾患編　(CHAPTER 10)子癇

    池ノ上 学

    ペリネイタルケア ((株)メディカ出版)   ( 2025新春増刊 ) 145 - 148 2025.01

    ISSN  0910-8718

  • 【鑑別フローチャートで症候ごとに考える　妊娠期別　産科救急ナビゲーション】(第2部)疾患編　(CHAPTER 20)HELLP症候群

    池ノ上 学

    ペリネイタルケア ((株)メディカ出版)   ( 2025新春増刊 ) 202 - 207 2025.01

    ISSN  0910-8718

  • 初期妊娠糖尿病におけるGlucose variabilityの検討

    梶川 かおる, 春日 義史, 福間 優花, 池ノ上 学, 田中 守

    糖尿病と妊娠 ((一社)日本糖尿病・妊娠学会)  24 ( 3 ) S - 108 2024.10

    ISSN  1347-9172

  • 侵襲性インフルエンザ桿菌感染により流産に至った1例

    白木 沙由理, 池ノ上 学, 金子 奈穂美, 梶川 かおる, 大谷 利光, 春日 義史, 山上 亘, 田中 守

    関東連合産科婦人科学会誌 ((一社)関東連合産科婦人科学会)  61 ( 3 ) 341 - 341 2024.10

    ISSN  2186-0610

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Presentations 【 Display / hide 】

  • 9番染色体トリソミーモザイクの胎児超音波所見

    酒井 美晴, 春日 義史, 秋田 啓介, 福間 優花, 玉井 順子, 田中 雄也, 長谷川 慶太, 大谷 利光, 池ノ上 学, 丸山 哲夫, 青木 大輔, 田中 守

    関東連合産科婦人科学会誌, 

    2023.05
    , 

    (一社)関東連合産科婦人科学会

  • Cushing症候群精査中に妊娠が判明し妊娠17週で副腎切除術を行った症例

    水谷 洋佑, 小林 佐紀子, 木内 謙一郎, 中村 俊文, 丸木 友美, 乃村 元子, 武田 利和, 玉井 順子, 池ノ上 学, 田中 守

    日本内分泌学会雑誌, 

    2023.05
    , 

    (一社)日本内分泌学会

  • 予後と関連付けた胎児・胎盤機能の基礎的・臨床的病態解明と治療戦略-レビュー- 超音波を用いた新たな胎児発育評価

    池ノ上 学

    日本産科婦人科学会雑誌, 

    2022.10
    , 

    (公社)日本産科婦人科学会

  • 妊娠初期の母体情報を利用したpreterm preeclampsiaの発症予知モデル作成

    鈴木 寛正, 大口 昭英, 松原 圭一, 渡辺 員支, 斉藤 拓也, 小田 英之, 小畑 聡一朗, 近藤 真也, 野田 清史, 三好 潤也, 池ノ上 学, 野見山 亮, 関 博之, 助川 幸, 市古 哲, 安藤 大史, 布施谷 千穂, 下村 卓也, 鈴木 りか, 味村 和哉, 安日 一郎, 福田 雅史, 原 澄子, 倉科 隆平, 塩崎 有宏, 松原 茂樹, 齋藤 滋

    日本妊娠高血圧学会雑誌, 

    2022.10
    , 

    (一社)日本妊娠高血圧学会

  • HELLP症候群に多発性肝被膜下出血と出血性ショックを伴い観血的止血術により母体救命し得た1例

    田中 優花, 池ノ上 学, 玉井 順子, 葉室 明香, 田中 雄也, 玉川 真澄, 長谷川 慶太, 春日 義史, 落合 大吾, 田中 守

    日本周産期・新生児医学会雑誌, 

    2022.06
    , 

    (一社)日本周産期・新生児医学会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 胎児発育不全における胎児肝血流量および軟部組織量を用いた周産期予後の予測

    2022.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Principal investigator

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    胎児発育不全(FGR)は、周産期予後不良因子の一つであり、また生活習慣病などの児の長期予後にも関連する。FGRの管理や娩出時期については確立されたエビデンスは未だ乏しく、FGRの予後予測因子の解明が望まれている。 近年、胎児肝血流量が胎児の軟部組織量(脂肪量・骨格筋量)に関連し、胎児発育の予測に有用であることが報告されている。そこで本研究では、FGRにおいて肝血流量および軟部組織量を測定し、周産期予後との関連について検討を行う。胎児肝血流量や軟部組織量が周産期予後に関する新たなパラメーターとなれば、FGRにおける周産期予後の改善へ繋がる可能性がある。

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Courses Taught 【 Display / hide 】

  • PATHOPHYSIOLOGICAL ISSUES IN ACUTE CARE

    2025

  • LECTURE SERIES, OBSTETRICS

    2025

  • PATHOPHYSIOLOGICAL ISSUES IN ACUTE CARE

    2024

  • LECTURE SERIES, OBSTETRICS

    2024

  • PATHOPHYSIOLOGICAL ISSUES IN ACUTE CARE

    2023

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