Papers - Takahashi, Takao

Altered patterns of neuron production in the p27 knockout mouse

T. Goto, T. Mitsuhashi and T. Takahashi

Dev Neurosci 26 ( 2-4 ) 208 - 17 2004.03

Research paper (scientific journal), Accepted

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The number and distribution of neurons in the murine neocortex are altered by loss of function of p27Kip1, a cyclin-dependent kinase inhibitor that regulates cell cycle progression at the G1 phase. We show that a temporary decline in the production of non-GABAergic projection neurons occurs in the dorsomedial neopallium of the p27Kip1 knockout mouse during the mid-term of neuronogenesis. It is followed by an augmentation of neuron production later in neuronogenesis leading to an increased production of projection neurons for the upper layers of the neocortex (layers II-IV). p27Kip1 is likely to play a critical role in cell internal regulatory mechanisms of proliferation/differentiation behavior of neural progenitor cells and may be directly involved in the control of neuron number during the period when non-GABAergic projection neurons for layers II-IV are being produced.

クリニカルカンファレンス　外性器異常を有し生後3週まで社会的性を決定されなかった1例

TAKAHASHI TAKAO

小児科臨床 57 ( 1 ) 113-119 2004

Research paper (scientific journal), Joint Work

Somatic PTPN11 mutation with a heterogeneous clonal origin in children with juvenile myelomonocytic leukemia.

'TAKAHASHI TAKAOShimada H, Mori T, Shimasaki N, Shimizu K, Takahashi T, Kosaki K'

Leukemia 18 ( 6 ) 1142-1144 2004

Research paper (scientific journal), Joint Work

Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.

'TAKAHASHI TAKAOTaguchi T, Kiyokawa N, Takenouch H, Matsui J, Tang WR, Nakajima H, Suzuki K, Shiozawa Y, Saito M, Katagiri YU, Takahashi T, Karasuyama H, Matsuo Y, Okita H, Fujimoto J.'

Immunology 112 ( 4 ) 575-582 2004

Research paper (scientific journal), Joint Work

Holoprosencephaly--topologic variations in a Liveborn series: a general model based upon MRI analysis.

'TAKAHASHI TAKAOTakahashi Tsutomu, Kinsman S, Makris N, Grant E, Haselgrove C, McInerney S, Kennedy DN, Takahashi Takao, Fredrickson K, Mori S, Caviness VS'

J Neurocytol 33 ( 1 ) 23-35 2004

Research paper (scientific journal), Joint Work

Hyperinsulinemic hypoglucemia in a newborn infant with trisomy 13.

'TAKAHASHI TAKAOTamame T, Hori N, Homma H, Yoshida R, Inokuchi M, Kosaki K, Takahashi T, Hasegawa T'

Am J Med Genet 129A ( ? ) 321-322 2004

Research paper (scientific journal), Joint Work

Position-specific expression of Hox genes along the gastrointestinal tract.

'TAKAHASHI TAKAOYahagi N, Kosaki R, Ito T, Mitsuhashi T, Shimada H, Tomita M, Takahashi T, Kosaki K'

Congenit Anom 44 ( 1 ) 18-26 2004

Research paper (scientific journal), Joint Work

小児病棟における，インフルエンザ接触者へのオセルタミビル予防内服効果

TAKAHASHI TAKAO

感染症学雑誌　別刷 78 ( 3 )  2003.12

Research paper (scientific journal), Joint Work

p27kip1ノックアウトマウスにおける神経前駆細胞の分裂増殖・分化誘導に関する定量解析　大脳皮質発生異常の発症機序に関する研究

高橋 孝雄, 後藤 知英, 三橋 隆行

厚生労働省精神・神経疾患研究委託費総括研究報告書 発達期における高次脳機能障害の病態解明に関する研究 平成12年度   87 - 91 2003.03

Research paper (other academic), Joint Work

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細胞増殖因子p27^kiplを欠損したノックアウトマウス(p27KO)の大脳皮質発生異常の機序解明するため大脳皮質発生過程を定量解析した.生後21日のp27KOでは投射ニューロンが大脳皮質表層(II〜IV層)で特異的に増加すること,胎生14日の神経前駆細胞(NPC)細胞周期長に異常を認めず,NPCが分化を開始する確率(Q値)は低値であることが明らかになった.p27KOにおける大脳皮質形成異常は,投射ニューロンの産生過程において,NPCの分化誘導機構に障害が起こるためである

特集けいれん，意識障害ハンドブック:けいれん時の脳代謝

'Takahashi Takao, Takeoka Masanori'

小児内科 35 ( 2 ) 130 2003.02

Research paper (scientific journal), Joint Work

FK506-associated limbic injury following umbilical cord blood transfusion.

'TAKAHASHI TAKAOYoshida Y, Shimada H, Mori T, Yoshihara M, Takeoka M, Takahashi T'

Bone Marrow Transplantation 32   523-525 2003

Research paper (scientific journal), Joint Work

大脳の発生から考える小児神経疾患

TAKAHASHI TAKAO

東京小児科医会報 22   28-30 2003

Research paper (scientific journal), Single Work

特集　小児の疼痛コントロール、鎮痛補助薬（抗うつ薬、抗不安薬、睡眠薬）

TAKAHASHI TAKAO

小児内科 35 ( 8 ) 1305-1310 2003

Research paper (scientific journal), Joint Work

特集　水・電解質異常症、中枢神経系疾患

TAKAHASHI TAKAO

小児内科 35 ( 11 ) 1822-1825 2003

Research paper (scientific journal), Single Work

クリニカルカンファレンス　小球性低色素性貧血を手がかりとして発見されたサラセミアの一家系

TAKAHASHI TAKAO

小児科臨床 56 ( 9 ) 1875-1879 2003

Research paper (scientific journal), Joint Work

Reference values for urinary steroids in Japanese newborn infants: gas chromatography/mass spectrometry in selected ion monitoring.

'TAKAHASHI TAKAOHomma K, Hasegawa T, Masumoto M, Takeshita E, Watanabe K, Chiba H, Kurosawa T, Takahashi T, Matsuo N'

Endocrine J 50 ( ? ) 783-792 2003

Research paper (scientific journal), Joint Work

Micropenis and the 5a-reductase-2 (SRD5A2) gene: mutation and V89L polymorphism analysis in 81 Japanese patients.

'TAKAHASHI TAKAOSasaki G, Ogata T, Ishii T, Kosaki K, Hasegawa T, Sato S, Homma K, Takahashi T, Matsuo N'

J Clin Endocrinol Metab 32 ( 5 ) 523-525 2003

Research paper (scientific journal), Joint Work

Semilobar holoprosencephaly with midline 'seam': a topologic and morphogenetic model based upon MRI analysis.

'TAKAHASHI TAKAOTakahashi Tsutomu, Kinsman S, Makris N, Grant E, Haselgrove C, McInerney S, Kennedy DN, Takahashi Takao, Fredrickson K, Mori S, Caviness VS'

Cereb Cortex 13 ( 12 ) 1299-1312 2003

Research paper (scientific journal), Joint Work

FK506-associated limbic injury following umbilical cord blood transplantation.

'TAKAHASHI TAKAOYoshida Y, Shimada H, Mori T, Yoshihara H, Takeoka M, Takahashi T'

Bone Marrow Transplant 32 ( 5 ) 523-525 2003

Research paper (scientific journal), Joint Work

Micropenis and the 5a-reductase-2 (SRD5A2) gene: mutation and V89L polymorphism analysis in 81 Japanese patients

'Sasaki Goro, Ogata Tsutomu, Ishii Tomohiro, Kosaki Kenjiro, Sato Seiji, Homma Keiko, Takahashi Takao, Hasegawa Tomonobu, Matsuo Nobutake'

Journal of clinical endocrinology and metabolism 88 ( 7 ) 3431-3436 2003

Research paper (scientific journal), Joint Work